scholarly journals Oncogenic human papillomavirus imposes an instructive pattern of DNA methylation changes which parallel the natural history of cervical HPV infection in young women

2012 ◽  
Vol 33 (7) ◽  
pp. 1286-1293 ◽  
Author(s):  
S. M. Leonard ◽  
W. Wei ◽  
S. I. Collins ◽  
M. Pereira ◽  
A. Diyaf ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Human Papillomavirus ◽  
Natural History ◽  
Young Women ◽  
Hpv Infection ◽  
History Of

scholarly journals Human Papillomavirus and Genital Disease in Men: What We Have Learned from the HIM Study

2019 ◽  
Vol 63 (2) ◽  
pp. 109-117 ◽  
Author(s):  
Laura Sichero ◽  
Anna R. Giuliano ◽  
Luisa Lina Villa
Keyword(s):  
Human Papillomavirus ◽  
Natural History ◽  
The United States ◽  
Hpv Infection ◽  
Clinical Consequences ◽  
History Of ◽  
Crucial Information ◽  
Associated Risk Factors ◽  
The Relationship ◽  
Genital Disease

It is currently recognized that in addition to the major impact of human papillomavirus (HPV) infection in females, HPV causes considerable disease in men at the genitals, anal canal, and oropharynx. Specifically, genital HPV infections may progress to genital warts and penile carcinoma. Although studies concerning the natural history of HPV infections and associated neoplasias have mainly focused on women, during the last 2 decades considerable attention has been given in further understanding these infections in men. The HIM (HPV infection in men) Study, the only prospective multicenter study of male HPV natural history, consisted of a large prospective international cohort study in which men from Brazil, the United States, and Mexico were enrolled. The design and protocols of this study allowed unraveling crucial information regarding the relationship between HPV infection and clinical consequences in men, and associated risk factors at each of the anatomic sites where HPV is known to cause cancer in men.

The natural history of human papillomavirus infection as measured by repeated DNA testing in adolescent and young women

1998 ◽  
Vol 132 (2) ◽  
pp. 277-284 ◽  
Author(s):  
Anna-Barbara Moscicki ◽  
Stephen Shiboski ◽  
Jeannette Broering ◽  
Kimberly Powell ◽  
Lisa Clayton ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Natural History ◽  
Young Women ◽  
Dna Testing ◽  
Repeated Dna ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
History Of

scholarly journals Early Natural History of Incident, Type-Specific Human Papillomavirus Infections in Newly Sexually Active Young Women

2010 ◽  
Vol 20 (4) ◽  
pp. 699-707 ◽  
Author(s):  
Rachel L. Winer ◽  
James P. Hughes ◽  
Qinghua Feng ◽  
Long Fu Xi ◽  
Stephen Cherne ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Natural History ◽  
Young Women ◽  
Sexually Active ◽  
Papillomavirus Infections ◽  
Incident Type ◽  
History Of

Natural history of cervical human papillomavirus infection in young women: a longitudinal cohort study

The Lancet ◽  
2001 ◽  
Vol 357 (9271) ◽  
pp. 1831-1836 ◽  
Author(s):  
Ciaran BJ Woodman ◽  
Stuart Collins ◽  
Heather Winter ◽  
Andrew Bailey ◽  
John Ellis ◽  
...  
Keyword(s):  
Cohort Study ◽  
Human Papillomavirus ◽  
Natural History ◽  
Young Women ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
History Of ◽  
Cervical Human Papillomavirus

scholarly journals Polymorphism in the promoter region of the Toll-like receptor 9 gene and cervical human papillomavirus infection

2013 ◽  
Vol 94 (8) ◽  
pp. 1858-1864 ◽  
Author(s):  
Lucas Boeno Oliveira ◽  
Karolina Louvanto ◽  
Agnihotram V. Ramanakumar ◽  
Eduardo L. Franco ◽  
Luisa L. Villa ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Natural History ◽  
Promoter Region ◽  
Pcr Amplification ◽  
Hpv Infection ◽  
Toll Like Receptor ◽  
Mediating Role ◽  
Papillomavirus Infection ◽  
Tlr9 Gene ◽  
History Of

Polymorphism in the Toll-like receptor (TLR) 9 gene has been shown to have a significant role in some diseases; however, little is known about its possible role in the natural history of human papillomavirus (HPV) infections. We investigated the association between a single-nucleotide polymorphism (SNP) (rs5743836) in the promoter region of TLR9 (T1237C) and type-specific HPV infections. Specimens were derived from a cohort of 2462 women enrolled in the Ludwig–McGill Cohort Study. We randomly selected 500 women who had a cervical HPV infection detected at least once during the study as cases. We defined two control groups: (i) a random sample of 300 women who always tested HPV negative, and (ii) a sample of 234 women who were always HPV negative but had a minimum of ten visits during the study. TLR9 genotyping was performed using bidirectional PCR amplification of specific alleles. Irrespective of group, the WT homozygous TLR9 genotype (TT) was the most common form, followed by the heterozygous (TC) and the mutant homozygous (CC) forms. There were no consistent associations between polymorphism and infection risk, either overall or by type or species. Likewise, there were no consistently significant associations between polymorphism and HPV clearance or persistence. We concluded that this polymorphism in the promoter region of TLR9 gene does not seem to have a mediating role in the natural history of the HPV infection.

scholarly journals Natural History of Cutaneous Human Papillomavirus (HPV) Infection in Men: The HIM Study

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e104843 ◽  
Author(s):  
Shalaka S. Hampras ◽  
Anna R. Giuliano ◽  
Hui-Yi Lin ◽  
Kate J. Fisher ◽  
Martha E. Abrahamsen ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Natural History ◽  
Hpv Infection ◽  
History Of

Sex Differences in the Incidence and Clearance of Anogenital Human Papillomavirus Infection in Liuzhou, China: An Observational Cohort Study

2019 ◽  
Vol 70 (1) ◽  
pp. 82-89 ◽  
Author(s):  
Feixue Wei ◽  
Meng Guo ◽  
Shoujie Huang ◽  
Mingqiang Li ◽  
Xuelian Cui ◽  
...  
Keyword(s):  
Sex Differences ◽  
Cohort Study ◽  
Human Papillomavirus ◽  
Natural History ◽  
Hpv Infection ◽  
Observational Cohort Study ◽  
Men And Women ◽  
History Of ◽  
Observational Cohort ◽  
Oncogenic Hpv

Abstract Background Human papillomavirus (HPV) causes anogenital warts and cancers in men and women. However, little is known about sex differences regarding the natural history of anogenital HPV infection. Methods Starting in May 2014, an observational cohort study including 2309 men and 2378 women aged 18–55 years was conducted in Liuzhou, China. Samples from anogenital sites were tested for HPV genotypes by multicolor real-time polymerase chain reaction and melting curve analysis biannually for ~1 year. Results The incidence of oncogenic HPV infection was similar in men and women (10.3 and 11.5/1000 person-months; P = .275), whereas the incidence of HPV-6/11 infection was higher in men than in women (2.0 vs 1.1; P = .018). The incidence of both oncogenic HPV and HPV-6/11 infections was significantly higher in women in the 18- to 25-year age group than in the older age groups (P = .006 and .011, respectively), whereas it did not vary by age among men (P = .552 and .425, respectively). Additionally, men were more likely than women to clear oncogenic infections (101.5 vs 58.6/1000 person-months; P < .001), but no significant difference was found in the clearance of HPV-6/11 by sex (111.7 vs 84.8; P = .266). The median time to clearance of oncogenic type and type 6/11 infections was not age dependent for either sex (all P > .05). Conclusions The natural history of oncogenic and nononcogenic HPV infection differs by sex, which implies that sex-specific vaccination strategies should be considered for oncogenic and nononcogenic HPV. Clinical Trials Registration NCT02188004.

The epidemiology and natural history of anal human papillomavirus infection in men who have sex with men

Sexual Health ◽  
2012 ◽  
Vol 9 (6) ◽  
pp. 527 ◽  
Author(s):  
Dorothy A. Machalek ◽  
Andrew E. Grulich ◽  
Fengyi Jin ◽  
David J. Templeton ◽  
I. Mary Poynten
Keyword(s):  
Risk Factors ◽  
Human Papillomavirus ◽  
Natural History ◽  
English Language ◽  
Epidemiological Data ◽  
Hpv Infection ◽  
Medline Search ◽  
Infection Dynamics ◽  
History Of ◽  
Sex With Men

Studies on the epidemiology and natural history of anal human papillomavirus (HPV) infection are essential to understand the significance of this virus in the aetiology of anal cancer in men who have sex with men (MSM). This paper presents a review of studies on anal HPV in MSM. For this review, a Medline search was performed to identify English-language articles published in peer-reviewed journals on the epidemiology, natural history and risk factors for anal HPV infection in MSM. Anal HPV prevalence is high in MSM and infection with multiple HPV types is common. The available prospective data suggest detection of new anal HPV infections may also be common. However, with limited epidemiological data available on infection dynamics and associated behavioural risk factors, it is difficult to draw conclusions on how persistent anal HPV infection is in this population.

scholarly journals Influence of Human Papillomavirus Infection on the Natural History of Cervical Intraepithelial Neoplasia 1: A Meta-Analysis

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Mingzhu Liu ◽  
Xiaolong Yan ◽  
Mei Zhang ◽  
Xiaoju Li ◽  
Shugang Li ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Natural History ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Negative Group ◽  
Positive Group ◽  
Increased Risk ◽  
History Of ◽  
High Risk Hpv

Objective. To provide a scientific basis for the prevention and treatment of cervical intraepithelial neoplasia grade 1 (CIN1). This study evaluated the impact of human papillomavirus (HPV) infection on the natural history of CIN1. Methods. Electronic databases of Cochrane Library, EMBASE, PubMed, CNKI, CBM, and Wanfang were searched in April 2016. The eligibility criteria were documented by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We used the Newcastle-Ottawa scale (NOS) to assess study quality. Results. Thirty-eight studies out of 3,246 identified papers were eligible for inclusion. The risk of CIN1 progression (relative risk [RR]: 3.04; 95% confidence interval [CI]: 2.41–3.83; P<0.00001) and persistence (RR: 1.48; 95% CI: 1.17–1.87; P=0.001) was higher in the HPV-positive group than HPV-negative group. Specifically, the risk of CIN1 progression (RR: 13.91; 95% CI: 3.46–55.90; P=0.000) was higher among persistent high-risk HPV-positive patients and the ratio of CIN1 regression (RR: 0.65; 95% CI: 0.59–0.71; P<0.00001) was lower in the HPV-positive group than HPV-negative group. Conclusion. HPV infection resulted in an increased risk of CIN1 progression and decreased disease reversibility. Persistent high-risk HPV infection resulted in a further increased risk of CIN1 progression.

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