The epidemiology and natural history of anal human papillomavirus infection in men who have sex with men

Sexual Health ◽  
2012 ◽  
Vol 9 (6) ◽  
pp. 527 ◽  
Author(s):  
Dorothy A. Machalek ◽  
Andrew E. Grulich ◽  
Fengyi Jin ◽  
David J. Templeton ◽  
I. Mary Poynten
Keyword(s):  
Risk Factors ◽  
Human Papillomavirus ◽  
Natural History ◽  
English Language ◽  
Epidemiological Data ◽  
Hpv Infection ◽  
Medline Search ◽  
Infection Dynamics ◽  
History Of ◽  
Sex With Men

Studies on the epidemiology and natural history of anal human papillomavirus (HPV) infection are essential to understand the significance of this virus in the aetiology of anal cancer in men who have sex with men (MSM). This paper presents a review of studies on anal HPV in MSM. For this review, a Medline search was performed to identify English-language articles published in peer-reviewed journals on the epidemiology, natural history and risk factors for anal HPV infection in MSM. Anal HPV prevalence is high in MSM and infection with multiple HPV types is common. The available prospective data suggest detection of new anal HPV infections may also be common. However, with limited epidemiological data available on infection dynamics and associated behavioural risk factors, it is difficult to draw conclusions on how persistent anal HPV infection is in this population.

Prevalence and risk factors of anogenital human papillomavirus infection in a community sample of men who have sex with men in Taiwan: baseline findings from a cohort study

2019 ◽  
Vol 96 (1) ◽  
pp. 62-66
Author(s):  
Carol Strong ◽  
Huachun Zou ◽  
Nai-Ying Ko ◽  
Ya-Lun Liang ◽  
Wen-Wei Ku ◽  
...  
Keyword(s):  
Risk Factors ◽  
Human Papillomavirus ◽  
Cost Effectiveness ◽  
Community Sample ◽  
Hpv Vaccination ◽  
Hpv Infection ◽  
Sex Partners ◽  
Anal Sex ◽  
The Past ◽  
Sex With Men

ObjectivesMen who have sex with men (MSM) are a highly neglected population in the current recommendation of girls-only human papillomavirus (HPV) vaccination programmes in many countries. To better assess the cost effectiveness of HPV vaccination among men requires data on the prevalence of HPV infection in MSM using a community sample, which is still sparse in several regions. We examined the prevalence of and factors associated with anogenital HPV infection among MSM in Taiwan.MethodsMSM 20 years of age and older were recruited from the community and social media in Taiwan in 2015–2016 and screened for HPV infection to detect 37 genotypes. MSM were seen at baseline and were/will be seen at 6, 12, 24 and 36 months. Men completed a questionnaire regarding their sexual experiences. Multivariable regression analyses were conducted to identify associated behavioural risk factors using the baseline data.ResultsA total of 253 MSM were recruited; 87 % were below 35 years of age. Diagnosis of HIV was reported in 4% of men; just over 20% had three or more anal sex partners in the past year. The prevalence of any tested HPV type was 29.4% at the anal site and 11% at the penile site. One quarter of MSM were infected with any of the 9-valent vaccine HPV types. Anal HPV detection was associated with having three or more receptive anal sex partners in the past year (adjusted odds ratio (aOR)=2.92, 95% CI 1.29 to 6.61) and having older sex partners (aOR=2.51, 95% CI 1.07 to 5.90).ConclusionsOur data provide the base to calculate the reproductive rate for HPV transmission in a low-risk community sample and cost-effectiveness to include men in HPV vaccination policies. Adding evidence from a community sample adds comprehensiveness for future estimates of disease transmission and vaccine effectiveness.

scholarly journals Human Papillomavirus and Genital Disease in Men: What We Have Learned from the HIM Study

2019 ◽  
Vol 63 (2) ◽  
pp. 109-117 ◽  
Author(s):  
Laura Sichero ◽  
Anna R. Giuliano ◽  
Luisa Lina Villa
Keyword(s):  
Human Papillomavirus ◽  
Natural History ◽  
The United States ◽  
Hpv Infection ◽  
Clinical Consequences ◽  
History Of ◽  
Crucial Information ◽  
Associated Risk Factors ◽  
The Relationship ◽  
Genital Disease

It is currently recognized that in addition to the major impact of human papillomavirus (HPV) infection in females, HPV causes considerable disease in men at the genitals, anal canal, and oropharynx. Specifically, genital HPV infections may progress to genital warts and penile carcinoma. Although studies concerning the natural history of HPV infections and associated neoplasias have mainly focused on women, during the last 2 decades considerable attention has been given in further understanding these infections in men. The HIM (HPV infection in men) Study, the only prospective multicenter study of male HPV natural history, consisted of a large prospective international cohort study in which men from Brazil, the United States, and Mexico were enrolled. The design and protocols of this study allowed unraveling crucial information regarding the relationship between HPV infection and clinical consequences in men, and associated risk factors at each of the anatomic sites where HPV is known to cause cancer in men.

scholarly journals Polymorphism in the promoter region of the Toll-like receptor 9 gene and cervical human papillomavirus infection

2013 ◽  
Vol 94 (8) ◽  
pp. 1858-1864 ◽  
Author(s):  
Lucas Boeno Oliveira ◽  
Karolina Louvanto ◽  
Agnihotram V. Ramanakumar ◽  
Eduardo L. Franco ◽  
Luisa L. Villa ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Natural History ◽  
Promoter Region ◽  
Pcr Amplification ◽  
Hpv Infection ◽  
Toll Like Receptor ◽  
Mediating Role ◽  
Papillomavirus Infection ◽  
Tlr9 Gene ◽  
History Of

Polymorphism in the Toll-like receptor (TLR) 9 gene has been shown to have a significant role in some diseases; however, little is known about its possible role in the natural history of human papillomavirus (HPV) infections. We investigated the association between a single-nucleotide polymorphism (SNP) (rs5743836) in the promoter region of TLR9 (T1237C) and type-specific HPV infections. Specimens were derived from a cohort of 2462 women enrolled in the Ludwig–McGill Cohort Study. We randomly selected 500 women who had a cervical HPV infection detected at least once during the study as cases. We defined two control groups: (i) a random sample of 300 women who always tested HPV negative, and (ii) a sample of 234 women who were always HPV negative but had a minimum of ten visits during the study. TLR9 genotyping was performed using bidirectional PCR amplification of specific alleles. Irrespective of group, the WT homozygous TLR9 genotype (TT) was the most common form, followed by the heterozygous (TC) and the mutant homozygous (CC) forms. There were no consistent associations between polymorphism and infection risk, either overall or by type or species. Likewise, there were no consistently significant associations between polymorphism and HPV clearance or persistence. We concluded that this polymorphism in the promoter region of TLR9 gene does not seem to have a mediating role in the natural history of the HPV infection.

scholarly journals Anal human papillomavirus infection and its relationship with abnormal anal cytology among MSM with or without HIV infection in Japan

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Daisuke Shiojiri ◽  
Daisuke Mizushima ◽  
Misao Takano ◽  
Koji Watanabe ◽  
Naokatsu Ando ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Hiv Infection ◽  
Hpv Vaccination ◽  
Epidemiological Data ◽  
Hpv Infection ◽  
Exclusion Criterion ◽  
Abnormal Cytology ◽  
Papillomavirus Infection ◽  
Hpv Genotypes ◽  
History Of

AbstractAnal high-risk human papillomavirus (hr-HPV) infection is widely considered a cause of anal cancer. However, epidemiological data are quite limited in Japan. This study investigated anal HPV infections and cytological abnormalities among MSM with or without HIV infection. Anal swabs were obtained, and cytological results were examined. Hybrid capture-based methodology was used for hr-HPV genotyping. The exclusion criterion was a history of vaccination against HPV. 644 subjects participated, and the overall prevalence of hr-HPV was 59.7% (95% CI 54.7–62.3), HIV-infected had higher prevalence than HIV-uninfected (68.9% vs 40.6%) p < .001. Among hr-HPV-infected participants, 82.8% (312/377) were infected with at least one of 9 valent vaccine-covered hr-HPV genotypes. From regression analysis, detection of abnormal cytology correlated positively with HIV infection (OR 2.17 [95% CI 1.51–3.13]), number of hr-HPV genotypes infected (OR 1.83 [1.59–2.10]), history of STI (OR 1.58 [1.14–2.22]) and No. of lifetime sexual partners (OR 1.56 [1.10–2.21]), albeit multivariate analysis identified the number of detected hr-HPV genotypes (adjusted OR 1.78 [1.54–2.06]) as the independent risk factor for abnormal cytology. High rates of anal hr-HPV infection, especially 9-valent HPV vaccine-preventable hr-HPV were detected among our MSM participants in Japan. HPV vaccination should also be encouraged for MSM in Japan.

scholarly journals Natural History of Cutaneous Human Papillomavirus (HPV) Infection in Men: The HIM Study

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e104843 ◽  
Author(s):  
Shalaka S. Hampras ◽  
Anna R. Giuliano ◽  
Hui-Yi Lin ◽  
Kate J. Fisher ◽  
Martha E. Abrahamsen ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Natural History ◽  
Hpv Infection ◽  
History Of

scholarly journals Prevalence of and Risk Factors for Human Papillomavirus (HPV) Infection Among HIV-Seronegative Men Who Have Sex With Men

2011 ◽  
Vol 203 (1) ◽  
pp. 66-74 ◽  
Author(s):  
S. Goldstone ◽  
J. M. Palefsky ◽  
A. R. Giuliano ◽  
E. D. Moreira ◽  
C. Aranda ◽  
...  
Keyword(s):  
Risk Factors ◽  
Human Papillomavirus ◽  
Hpv Infection ◽  
Sex With Men

scholarly journals Sex Differences in Risk Factors and Natural History of Oral Human Papillomavirus Infection

2016 ◽  
Vol 213 (12) ◽  
pp. 1893-1896 ◽  
Author(s):  
Gypsyamber D'Souza ◽  
Alicia Wentz ◽  
Nicole Kluz ◽  
Yuehan Zhang ◽  
Elizabeth Sugar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Sex Differences ◽  
Human Papillomavirus ◽  
Natural History ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
History Of

scholarly journals HPV Infection in Men

2007 ◽  
Vol 23 (4) ◽  
pp. 261-272 ◽  
Author(s):  
Joel M. Palefsky
Keyword(s):  
Natural History ◽  
Hpv Vaccination ◽  
Intraepithelial Neoplasia ◽  
Visual Assessment ◽  
Hpv Infection ◽  
Hiv Positive ◽  
History Of ◽  
Sex With Men ◽  
The Impact ◽  
Cervical Human Papillomavirus

While much is known about the natural history of cervical human papillomavirus (HPV) infection and its consequences, including cervical intraepithelial neoplasia and cervical cancer, relatively little is known about the natural history of anogenital HPV infection and diseases in men. In part this reflects difficulties in penile sampling and visual assessment of penile lesions. Anal HPV infection and disease also remain poorly understood. Although HPV is transmitted sexually and infects the genitals of both sexes, the cervix remains biologically more vulnerable to malignant transformation than does the penis or anus in men. An understanding of male HPV infection is therefore important in terms of reducing transmission of HPV to women and improving women's health. However, it is also important due to the burden of disease in men, who may develop both penile and anal cancer, particularly among HIV-positive men who have sex with men. Improved sampling techniques of the male genitalia and cohort studies in progress should provide important information on the natural history of anogenital HPV infection and disease in men, including risk factors for HPV acquisition and transmission. The impact of HPV vaccination in women on male anogenital HPV infection will also need to be assessed.

Sex Differences in the Incidence and Clearance of Anogenital Human Papillomavirus Infection in Liuzhou, China: An Observational Cohort Study

2019 ◽  
Vol 70 (1) ◽  
pp. 82-89 ◽  
Author(s):  
Feixue Wei ◽  
Meng Guo ◽  
Shoujie Huang ◽  
Mingqiang Li ◽  
Xuelian Cui ◽  
...  
Keyword(s):  
Sex Differences ◽  
Cohort Study ◽  
Human Papillomavirus ◽  
Natural History ◽  
Hpv Infection ◽  
Observational Cohort Study ◽  
Men And Women ◽  
History Of ◽  
Observational Cohort ◽  
Oncogenic Hpv

Abstract Background Human papillomavirus (HPV) causes anogenital warts and cancers in men and women. However, little is known about sex differences regarding the natural history of anogenital HPV infection. Methods Starting in May 2014, an observational cohort study including 2309 men and 2378 women aged 18–55 years was conducted in Liuzhou, China. Samples from anogenital sites were tested for HPV genotypes by multicolor real-time polymerase chain reaction and melting curve analysis biannually for ~1 year. Results The incidence of oncogenic HPV infection was similar in men and women (10.3 and 11.5/1000 person-months; P = .275), whereas the incidence of HPV-6/11 infection was higher in men than in women (2.0 vs 1.1; P = .018). The incidence of both oncogenic HPV and HPV-6/11 infections was significantly higher in women in the 18- to 25-year age group than in the older age groups (P = .006 and .011, respectively), whereas it did not vary by age among men (P = .552 and .425, respectively). Additionally, men were more likely than women to clear oncogenic infections (101.5 vs 58.6/1000 person-months; P &lt; .001), but no significant difference was found in the clearance of HPV-6/11 by sex (111.7 vs 84.8; P = .266). The median time to clearance of oncogenic type and type 6/11 infections was not age dependent for either sex (all P &gt; .05). Conclusions The natural history of oncogenic and nononcogenic HPV infection differs by sex, which implies that sex-specific vaccination strategies should be considered for oncogenic and nononcogenic HPV. Clinical Trials Registration NCT02188004.

scholarly journals Influence of Human Papillomavirus Infection on the Natural History of Cervical Intraepithelial Neoplasia 1: A Meta-Analysis

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Mingzhu Liu ◽  
Xiaolong Yan ◽  
Mei Zhang ◽  
Xiaoju Li ◽  
Shugang Li ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Natural History ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Negative Group ◽  
Positive Group ◽  
Increased Risk ◽  
History Of ◽  
High Risk Hpv

Objective. To provide a scientific basis for the prevention and treatment of cervical intraepithelial neoplasia grade 1 (CIN1). This study evaluated the impact of human papillomavirus (HPV) infection on the natural history of CIN1. Methods. Electronic databases of Cochrane Library, EMBASE, PubMed, CNKI, CBM, and Wanfang were searched in April 2016. The eligibility criteria were documented by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We used the Newcastle-Ottawa scale (NOS) to assess study quality. Results. Thirty-eight studies out of 3,246 identified papers were eligible for inclusion. The risk of CIN1 progression (relative risk [RR]: 3.04; 95% confidence interval [CI]: 2.41–3.83; P<0.00001) and persistence (RR: 1.48; 95% CI: 1.17–1.87; P=0.001) was higher in the HPV-positive group than HPV-negative group. Specifically, the risk of CIN1 progression (RR: 13.91; 95% CI: 3.46–55.90; P=0.000) was higher among persistent high-risk HPV-positive patients and the ratio of CIN1 regression (RR: 0.65; 95% CI: 0.59–0.71; P<0.00001) was lower in the HPV-positive group than HPV-negative group. Conclusion. HPV infection resulted in an increased risk of CIN1 progression and decreased disease reversibility. Persistent high-risk HPV infection resulted in a further increased risk of CIN1 progression.

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