The Association of Caffeine Metabolite with Obesity and Low-Density Lipoprotein Level
Abstract Objectives To examine if waist circumference mediated the relationship between 1, 7-dimethylxanthine (a caffeine metabolite) and serum LDL level, adjusting for age, gender, race/ethnicity, smoking, and alcohol consumption. Methods A secondary data analysis study was conducted using data from the National Health and Examination Survey (NHANES) 2009–2010 data collection wave. The final sample included 1976 weighted respondents. Structural equation modeling was used to examine the objectives of this study. Results Structural equation modeling found that levels of 1, 7-dimethylxanthine were not associated with levels of LDL, and that WC was not a mediator of the relationship, adjusting for the covariates. None of the covariates were associated with LDL level, controlling for WC. Conclusions Further longitudinal studies are needed to more thoroughly examine the role of central obesity on the relationship between caffeine and LDL level. Funding Sources None.