scholarly journals Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis from 10 Prospective Cohort Studies in the Fatty Acids and Outcome Research Consortium (FORCE) (OR33-02-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Heidi Lai ◽  
Fumiaki Imamura ◽  
Andres Ardisson Korat ◽  
Rachel Murphy ◽  
Nathan Tintle ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Prospective Cohort ◽  
Pooled Analysis ◽  
Adjusted Relative Risk ◽  
Total Plasma ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Average Maximum

Abstract Objectives To assess prospective association between circulating biomarkers of individual trans fatty acids (TFAs) and incident type 2 diabetes (T2D) in diverse populations. Methods A harmonized analysis of individual level data was conducted for TFA biomarkers and incident T2D by pooling ten prospective cohort or nested-case-control studies from five countries (Australia, Germany, Iceland, UK, and USA). Fatty acids (FAs) were measured in plasma phospholipid, red blood cell membrane phospholipid, or total plasma collected between 1990–2008 from 22,711 participants aged ≥18 years without prevalent diabetes. Evaluated TFAs included trans-16:1n-9, sum of trans-18:1 isomers (trans-18:1n6 to trans-18:1n12), sum of trans-18:2 isomers (cis/trans-18:2, trans/cis-18:2, trans/trans-18:2), and individual trans-18:2 isomers. The multivariable-adjusted relative risk or odds ratio was estimated in each cohort by lipid compartments using a pre-specified protocol for definitions of exposures, covariates, and outcomes for statistical analysis. Association estimates were pooled using fixed-effects inverse-variance weighted meta-analysis. Results During an average maximum of 14 years of follow-up, 2244 cases of incident T2D were identified. Median levels of TFAs across cohorts were 0.05–0.18% total FAs for trans-16:1n-9, 0.09–2.05% for total trans-18:1, 0.10–0.73% for total trans-18:2, and 0.01–0.36% for individual trans-18:2 isomers. In overall pooled analysis, TFAs evaluated per inter-quintile range were not significantly associated with risk of T2D (Figure 1). Findings were consistent when TFAs were assessed categorically in study specific-quintiles, and when associations were pooled within lipid compartment (i.e., phospholipids vs. total plasma). Conclusions Overall, biomarker levels of TFAs were not significantly associated with risk of incident T2D in this international pooling project. Findings may be due to mixed TFA sources (industrial vs. ruminant), a general decline in TFA exposure during this period, or no effect of circulating TFA on diabetes. Associations of TFA biomarkers with T2D at higher exposures should be investigated. Funding Sources See Table 1. Supporting Tables, Images and/or Graphs

scholarly journals Erythrocyte n-6 Polyunsaturated Fatty Acids, Gut Microbiota, and Incident Type 2 Diabetes: A Prospective Cohort Study

Diabetes Care ◽  
2020 ◽  
Vol 43 (10) ◽  
pp. 2435-2443 ◽  
Author(s):  
Zelei Miao ◽  
Jie-sheng Lin ◽  
Yingying Mao ◽  
Geng-dong Chen ◽  
Fang-fang Zeng ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Cohort Study ◽  
Gut Microbiota ◽  
Polyunsaturated Fatty Acids ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Incident Type ◽  
Incident Type 2 Diabetes

scholarly journals Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies

2019 ◽  
Vol 109 (4) ◽  
pp. 1216-1223 ◽  
Author(s):  
Amanda M Fretts ◽  
Fumiaki Imamura ◽  
Matti Marklund ◽  
Renata Micha ◽  
Jason H Y Wu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Lower Risk ◽  
Saturated Fatty Acids ◽  
Pooled Analysis ◽  
Incident Diabetes ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Long Chain

ABSTRACT Background Saturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed. Objective We investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies. Methods Twelve studies that are part of the Fatty Acids and Outcomes Research Consortium participated in the analysis. Using Cox or logistic regression within studies and an inverse-variance-weighted meta-analysis across studies, we examined the associations of VLSFAs 20:0, 22:0, and 24:0 with incident diabetes among 51,431 participants. Results There were 14,276 cases of incident diabetes across participating studies. Higher circulating concentrations of 20:0, 22:0, and 24:0 were each associated with a lower risk of incident diabetes. Pooling across cohorts, the RR (95% CI) for incident diabetes comparing the 90th percentile to the 10th percentile was 0.78 (0.70, 0.87) for 20:0, 0.84 (0.77, 0.91) for 22:0, and 0.75 (0.69, 0.83) for 24:0 after adjustment for demographic, lifestyle, adiposity, and other health factors. Results were fully attenuated in exploratory models that adjusted for circulating 16:0 and triglycerides. Conclusions Results from this pooled analysis indicate that higher concentrations of circulating VLSFAs 20:0, 22:0, and 24:0 are each associated with a lower risk of diabetes.

[beta]eta-hydroxybutyrate and risk for incident type 2 diabetes: results from the prevend prospective cohort study

2019 ◽  
Author(s):  
Jose L Flores-Guerrero ◽  
Margery A Connelly ◽  
Dion Groothof ◽  
Eke G Gruppen ◽  
Stephan JL Bakker ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Incident Type ◽  
Incident Type 2 Diabetes

scholarly journals Serum Levels of Apolipoproteins and Incident Type 2 Diabetes: A Prospective Cohort Study

Diabetes Care ◽  
2016 ◽  
Vol 40 (3) ◽  
pp. 346-351 ◽  
Author(s):  
Adela Brahimaj ◽  
Symen Ligthart ◽  
M. Arfan Ikram ◽  
Albert Hofman ◽  
Oscar H. Franco ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Serum Levels ◽  
Incident Type ◽  
Incident Type 2 Diabetes

scholarly journals Relation of total sugars, fructose and sucrose with incident type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies

2017 ◽  
Vol 189 (20) ◽  
pp. E711-E720 ◽  
Author(s):  
Christine S. Tsilas ◽  
Russell J. de Souza ◽  
Sonia Blanco Mejia ◽  
Arash Mirrahimi ◽  
Adrian I. Cozma ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Cohort Studies ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Total Sugars ◽  
Incident Type ◽  
Prospective Cohort Studies ◽  
Incident Type 2 Diabetes

scholarly journals Periodontitis and incident type 2 diabetes: a prospective cohort study

2017 ◽  
Vol 44 (3) ◽  
pp. 266-274 ◽  
Author(s):  
Lewis Winning ◽  
Christopher C. Patterson ◽  
Charlotte E. Neville ◽  
Frank Kee ◽  
Gerard J. Linden
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Incident Type ◽  
Incident Type 2 Diabetes

scholarly journals Increased leisure-time physical activity associated with lower onset of diabetes in 44 828 adults with impaired fasting glucose: a population-based prospective cohort study

2018 ◽  
Vol 53 (14) ◽  
pp. 895-900 ◽  
Author(s):  
Xiang Qian Lao ◽  
Han-Bing Deng ◽  
Xudong Liu ◽  
Ta-Chien Chan ◽  
Zilong Zhang ◽  
...  
Keyword(s):  
Physical Activity ◽  
Type 2 Diabetes ◽  
Prospective Cohort ◽  
Leisure Time ◽  
Fasting Glucose ◽  
Leisure Time Physical Activity ◽  
Chinese Adults ◽  
Incident Type ◽  
Incident Type 2 Diabetes

AimsTo evaluate the effects of habitual leisure-time physical activity (LTPA) on incident type 2 diabetes in a prospective cohort of Chinese adults with impaired fasting glucose (IFG).Methods44 828 Chinese adults aged 20–80 years with newly detected IFG but free from cardiovascular and cerebrovascular disease were recruited and followed up from 1996 to 2014. Incident type 2 diabetes was identified by fasting plasma glucose ≥7 mmol/L. The participants were classified into four categories based on their self-reported weekly LTPA: inactive, low, moderate, or high. Hazard ratios (HRs) and population attributable fractions (PAFs) were estimated with adjustment for established diabetic risk factor.ResultsAfter 214 148 person-years of follow-up, we observed an inverse dose–response relationship between LTPA and diabetes risk. Compared with inactive participants, diabetes risk in individuals reporting low, moderate and high volume LTPA were reduced by 12% (HR 0.88, 95% CI 0.80 to 0.99; P=0.015), 20% (HR 0.80, 95% CI 0.71 to 0.90; P<0.001), and 25% (HR 0.75, 95% CI 0.67 to 0.83; P<0.001), respectively. At least 19.2% (PAF 19.2%, 95% CI 5.9% to 30.6%) of incident diabetes cases could be avoided if the inactive participants had engaged in WHO recommendation levels of LTPA. This would correspond to a potential reduction of at least 7 million diabetic patients in the Greater China area.ConclusionsOur results show higher levels of LTPA are associated with a lower risk of diabetes in IFG subjects. These data emphasise the urgent need for promoting physical activity as a preventive strategy against diabetes to offset the impact of population ageing and the growing obesity epidemic.

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