Andrographolide: A Review of Analytical Methods

2020 ◽  
Author(s):  
Rashmi Patil ◽  
Vandana Jain
Keyword(s):  
Biological Samples ◽  
Analytical Methods ◽  
Pharmaceutical Formulations ◽  
Andrographis Paniculata ◽  
Hyphenated Techniques ◽  
Chemiluminescence Method ◽  
Plant Materials ◽  
Electroanalytical Method ◽  
Anti Inflammatory

Abstract Bicyclic diterpenoid lactone andrographolide is regarded as a “natural antibiotic” as it is known to exhibit a range of bioactivities including anti-inflammatory, antibacterial, antipyretic, antineoplastic, cardioprotective, hepatoprotective and hypoglycaemic, and is present in Andrographis paniculata. The aim of this article is to review the information on analytical methods for andrographolide in biological samples, pharmaceutical formulations and plant materials. This article includes various techniques such as Spectrophotometry, Chemiluminescence method, Electroanalytical method, Chromatography and various hyphenated techniques.

scholarly journals Review on analytical methods for quantification of ADHD drugs in human biological samples

2020 ◽  
Vol 39 (1) ◽  
pp. 130-156
Author(s):  
J. Sundari ◽  
S. Amuthalakshmi ◽  
C.N. Nalini
Keyword(s):  
Biological Samples ◽  
Analytical Methods ◽  
Impulse Control ◽  
Developmental Disorder ◽  
Species Differences ◽  
Pharmaceutical Formulations ◽  
Pharmacokinetic Studies ◽  
Hyperactivity Disorder ◽  
Oral Fluids ◽  
Attention Memory

AbstractAttention deficit hyperactivity disorder (ADHD) is a common neuro-developmental disorder. The symptoms of ADHD include difficulty in attention, memory and impulse control. Many pharmaceutical formulations (stimulants and non-stimulants) are available on the market to treat ADHD symptoms. The most commonly used drugs for treatment are amphetamine, methylphenidate, atomoxetine, bupropion, guanfacine and clonidine. In the field of pharmaceuticals, bioanalysis is an important tool used for the quantification of drugs and their metabolites present in biological samples using various analytical methods. Although a number of analytical methods were reported for the quantification of these drugs in biological samples of experimental animals, due to species differences, it is important to develop analytical methods to quantify these drugs in human biological samples to aid forensic and pharmacokinetic studies. In this review, we compile the bio-analytical methods such as spectrophotometry, spectrofluorimetry, mass spectrometry, electrophoresis, liquid chromatography and gas chromatography used for the quantification of ADHD drugs in human biological samples such as blood, plasma, serum, oral fluids, sweat, hair and urine based on earlier published articles from various journals.

A Review of Analytical Methods for the Determination of Tibolone: Pharmacokinetics and Pharmaceutical Formulations Analysis and Application in Doping Control

2020 ◽  
Vol 17 (1) ◽  
pp. 31-39
Author(s):  
Marilene Lopes Ângelo ◽  
Fernanda de Lima Moreira ◽  
Ana Laura Araújo Santos ◽  
Hérida Regina Nunes Salgado ◽  
Magali Benjamim de Araújo
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Analytical Methods ◽  
Estrogenic Activity ◽  
Biological Fluids ◽  
Pharmaceutical Formulations ◽  
Doping Control ◽  
Specific Effects ◽  
In Doping

Background:: Tibolone is a synthetic steroid commercialized by Organon under the brand name Livial (Org OD14), which is used in hormone therapy for menopause management and treatment of postmenopausal osteoporosis. Tibolone is defined as a selective tissue estrogenic activity regulator (STEAR) demonstrating tissue-specific effects on several organs such as brain, breast, urogenital tract, endometrium, bone and cardiovascular system. Aims:: This work aims to (1) present an overview of important published literature on existing methods for the analysis of tibolone and/or its metabolites in pharmaceutical formulations and biological fluids and (2) to conduct a critical comparison of the analytical methods used in doping control, pharmacokinetics and pharmaceutical formulations analysis of tibolone and its metabolites. Results and conclusions: : The major analytical method described for the analysis of tibolone in pharmaceutical formulations is High Pressure Liquid Chromatography (HPLC) coupled with ultraviolet (UV) detection, while Liquid Chromatography (LC) or Gas Chromatography (GC) used in combination with Mass Spectrometry (MS) or tandem mass spectrometry (MS/MS) is employed for the analysis of tibolone and/or its metabolites in biological fluids.

Research progress in electroanalytical techniques for determination of antimalarial drugs in pharmaceutical and biological samples

RSC Advances ◽  
2016 ◽  
Vol 6 (62) ◽  
pp. 57580-57602 ◽  
Author(s):  
Neeta Thapliyal ◽  
Tirivashe E. Chiwunze ◽  
Rajshekhar Karpoormath ◽  
Rajendra N. Goyal ◽  
Harun Patel ◽  
...  
Keyword(s):  
Biological Samples ◽  
Critical Analysis ◽  
Pharmaceutical Formulations ◽  
Antimalarial Drugs ◽  
Research Progress ◽  
Electroanalytical Methods ◽  
Biological Matrices

The review focusses on the role of electroanalytical methods for determination of antimalarial drugs in biological matrices and pharmaceutical formulations with a critical analysis of published voltammetric and potentiometric methods.

Sample pre-treatment techniques for use with ICP-MS hyphenated techniques for elemental speciation in biological samples

2017 ◽  
Vol 32 (1) ◽  
pp. 58-77 ◽  
Author(s):  
Han Wang ◽  
Xiaolan Liu ◽  
Kai Nan ◽  
Beibei Chen ◽  
Man He ◽  
...  
Keyword(s):  
Biological Samples ◽  
State Of The Art ◽  
Sample Pretreatment ◽  
The State ◽  
Elemental Speciation ◽  
Hyphenated Techniques ◽  
Treatment Techniques ◽  
Icp Ms ◽  
Pre Treatment

This review will focus specifically on the state of the art of novel sample pretreatment methods which have been combined with ICP-MS based hyphenated techniques for elemental speciation in biological samples.

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