scholarly journals Systematic Severe Acute Respiratory Syndrome Coronavirus 2 Screening at Hospital Admission in Children: A French Prospective Multicenter Study

2020 ◽  
Author(s):  
Julie Poline ◽  
Jean Gaschignard ◽  
Claire Leblanc ◽  
Fouad Madhi ◽  
Elsa Foucaud ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Confidence Interval ◽  
Hospital Admission ◽  
Multicenter Study ◽  
Hospitalized Children ◽  
Testing Strategy ◽  
Prospective Multicenter Study ◽  
Systematic Screening

Abstract To assess the relevance of systematic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) screening of all children admitted to hospital, we conducted a prospective multicenter study including 438 consecutive hospitalized children. A symptom-based SARS-CoV-2 testing strategy failed to identify 45% (95% confidence interval, 24%–68%) of hospitalized children infected by SARS-CoV-2. To limit intrahospital transmission, a systematic screening of children admitted to hospital should be considered.

scholarly journals Assessment of spread of SARS-CoV-2 by RT-PCR and concomitant serology in children in a region heavily affected by COVID-19 pandemic

2020 ◽  
Author(s):  
Robert Cohen ◽  
Camille Jung ◽  
Naim Ouldali ◽  
Aurélie Sellam ◽  
Christophe Batard ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Antibody Response ◽  
Multicenter Study ◽  
Nasopharyngeal Swab ◽  
Healthy Controls ◽  
Rt Pcr ◽  
Positive Serology ◽  
Prospective Multicenter Study ◽  
Cross Sectional ◽  
Epidemic Wave

AbstractBackgroundSeveral studies indicated that children seem to be less frequently infected with SARS-CoV-2 and potentially less contagious. To examine the spread of SARS-CoV-2 we combined both RT-PCR testing and serology in children in the most affected region in France, during the COVID-19 epidemic.MethodsFrom April 14, 2020 to May 12, 2020, we conducted a cross-sectional prospective, multicenter study. Healthy controls and pauci-symptomatic children from birth to age 15 years were enrolled by 27 ambulatory pediatricians. A nasopharyngeal swab was taken for detection of SARS-CoV-2 by RT-PCR and a microsample of blood for micro-method serology.ResultsAmong the 605 children, 322 (53.2%) were asymptomatic and 283 (46.8%) symptomatic. RT-PCR testing and serology were positive for 11 (1.8%) and 65 (10.7%) of all children, respectively. Only 3 children were RT-PCR–positive without any antibody response have been detected. The frequency of positivity on RT-PCR for SARS-CoV-2 was significantly higher in children with positive serology than those with a negative one (12.3% vs 0.6%, p<0.001). Contact with a person with proven COVID-19 increased the odds of positivity on RT-PCR (OR 7.8, 95% confidence interval [1.5; 40.7]) and serology (15.1 [6.6; 34.6]).ConclusionIn area heavily affected by COVID-19, after the peak of the first epidemic wave and during the lockdown, the rate of children with positive SARS-CoV-2 RT-PCR was very low (1.8%), but the rate of positive on serology was higher (10.7%). Most of PCR positive children had at the same time, positive serology suggesting a low risk of transmission.

scholarly journals Five-year overall survival of metastatic renal cell carcinoma patients treated with everolimus after progression on bevacizumab: a prospective multicenter study CRAD001LRU02T

2018 ◽  
Vol 13 (4) ◽  
pp. 40-44 ◽  
Author(s):  
S. Z. Safina ◽  
S. A. Varlamov ◽  
A. V. Snegovoy ◽  
I. S. Varlamov ◽  
L. I. Gurina ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Overall Survival ◽  
Survival Rate ◽  
Confidence Interval ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Median Duration ◽  
Multicenter Study ◽  
Renal Cell ◽  
Prospective Multicenter Study

Background. In a CRAD001LRU02T study of everolimus for metastatic renal cell carcinoma patients previously treated with bevacizumab ±  interferon, median overall survival (OS) was 17.4 months (95 % confidence interval 13.5–21.3 month).Objective of final analysis was to evaluate 5-year OS and long-term toxicity in this study.Materials and methods. Survival data were collected from 37 patients with bevacizumab-refractory metastatic renal cell carcinoma who received everolimus in a completed prospective multicenter study. Patients were predominantly male, 89 % had ECOG performance status of 0/1, 51 % received previous bevacizumab in combination with interferon, and 38/62% had MSKCC favorable/intermediate risk disease.Results. The 5-year survival rate was 16.2% (95 % confidence interval 14.1–18.3 %), with a median follow-up of 5 years. The 1-, and 3-year OS rates were 81.0 and 43.0 %, respectively. The median duration of second-line of everolimus was 315 (range 61–569) days. 11 (29.7 %) patients received third-line therapy with a median duration of 3.6 months. Confirmed objective tumor responses were seen in 5 (14.0 %) patients. 70.0 % (n = 26) patients had a stable disease. 1 (2.7 %) patient achieved complete response after 4 years of therapy. One (2.7 %) patient  discontinued everolimus therapy on their own accord due to relapse of systemic lupus erythematosus and one (2.7 %)  patient had 14-days interruption of an everolimus therapy due to grade 3 hyperglycemia. No grade 4 treatment-related toxicity was found.Conclusions. Everolimus provided an estimated 5-year survival rate of 16.2 % for bevacizumab-resistant metastatic renal cell carcinoma. Prolonged everolimus was not associated with new types or increased severity of adverse events.

Causes of Hospital Admission in Low Risk Community-Acquired Pneumonia (CAP): A Prospective Multicenter Study

CHEST Journal ◽  
2011 ◽  
Vol 140 (4) ◽  
pp. 898A
Author(s):  
Pedro Marcos ◽  
Iria Vidal ◽  
Francisco Barcala ◽  
Pilar Sanjuán ◽  
Carlos Rábade ◽  
...  
Keyword(s):  
Hospital Admission ◽  
Multicenter Study ◽  
Community Acquired Pneumonia ◽  
Low Risk ◽  
Prospective Multicenter Study

A prospective multicenter study of factors associated with hospital admission among adults with acute asthma

2002 ◽  
Vol 113 (5) ◽  
pp. 371-378 ◽  
Author(s):  
Ellen J Weber ◽  
Robert A Silverman ◽  
Michael L Callaham ◽  
Charles V Pollack ◽  
Prescott G Woodruff ◽  
...  
Keyword(s):  
Hospital Admission ◽  
Multicenter Study ◽  
Acute Asthma ◽  
Prospective Multicenter Study ◽  
Factors Associated

Predictive factors of grade 3-5 toxicity in older patients with cancer treated with chemotherapy: A prospective multicenter study.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 11509-11509
Author(s):  
Jaime Feliu Batlle ◽  
Laura Basterretxea ◽  
Maria Dolores Torregrosa ◽  
Elisenda Llabres ◽  
Beatriz Losada Vila ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Creatinine Clearance ◽  
Predictive Factors ◽  
Multicenter Study ◽  
Odds Ratio ◽  
Older Patients ◽  
Psychological State ◽  
Prospective Multicenter Study ◽  
Chemotherapy Dose ◽  
Grade 3

11509 Background: Older patients have increased risk of toxicity from chemotherapy. The purpose of this study was to analyse predictive factors for developing grade 3-5 toxicity in older patients treated with chemotherapy. Methods: This prospective multicenter study included 500 cancer patients ≥ 70 years between Feb 2014 and Jun 2018. A prechemotherapy assessment including sociodemographics, tumor/treatment variables, laboratory test results, and geriatric assessment variables (function, comorbidity, cognition, psychological state, social activity/support, and nutritional status) was performed. Logistic regression was used to examine the association between these factors and the development of grade 3-5 toxicity. Results: Mean age of the patients was 77 years (70-92), ECOG PS 0/1/2: 25%/63%/12%. 223 (45%) had a primary dose reduction.167 (33%) patients developed grade 3-5 toxicity (28% grade 3, 5% grade 4, 1% grade 5). Univariate analysis found a higher risk of grade 3-5 toxicity in patients with creatinine clearance ≤ 60 mL/min, IADL ≤7, VES13 ≥ 6, and the administration of standard chemotherapy doses. In multivariable analysis, only the chemotherapy dose (odds ratio [OR] 1.179; 95% confidence interval [CI] 1.215–2.655) and creatinine clearance (odds ratio [OR] 0.989; 95% confidence interval [CI] 0.981–0.997) were independently associated with toxicity. Conclusions: Renal function and chemotherapy dose were significant predictors of grade 3-5 toxicity among older patients treated with chemotherapy.

EFFECTIVENESS AND TOLERABILITY OF VERY LOW VOLUME PREPARATION FOR COLONOSCOPY: A PROSPECTIVE, MULTICENTER STUDY

2019 ◽  
Author(s):  
M Maida ◽  
G Morreale ◽  
E Sinagra ◽  
M Manganaro ◽  
D Schillaci ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Prospective Multicenter Study ◽  
Low Volume
Sign in / Sign up

Export Citation Format

Share Document