scholarly journals The Surveillance for Enteric Fever in Asia Project (SEAP), Severe Typhoid Fever Surveillance in Africa (SETA), Surveillance of Enteric Fever in India (SEFI), and Strategic Typhoid Alliance Across Africa and Asia (STRATAA) Population-based Enteric Fever Studies: A Review of Methodological Similarities and Differences

2020 ◽  
Vol 71 (Supplement_2) ◽  
pp. S102-S110 ◽  
Author(s):  
Megan E Carey ◽  
William R MacWright ◽  
Justin Im ◽  
James E Meiring ◽  
Malick M Gibani ◽  
...  
Keyword(s):  
Disease Surveillance ◽  
Large Scale ◽  
Enteric Fever ◽  
Low Cost ◽  
Lessons Learned ◽  
Sub Saharan Africa ◽  
Surveillance Systems ◽  
Physician Practices ◽  
Surveillance Studies ◽  
Salmonella Infections

Abstract Building on previous multicountry surveillance studies of typhoid and others salmonelloses such as the Diseases of the Most Impoverished program and the Typhoid Surveillance in Africa Project, several ongoing blood culture surveillance studies are generating important data about incidence, severity, transmission, and clinical features of invasive Salmonella infections in sub-Saharan Africa and South Asia. These studies are also characterizing drug resistance patterns in their respective study sites. Each study answers a different set of research questions and employs slightly different methodologies, and the geographies under surveillance differ in size, population density, physician practices, access to healthcare facilities, and access to microbiologically safe water and improved sanitation. These differences in part reflect the heterogeneity of the epidemiology of invasive salmonellosis globally, and thus enable generation of data that are useful to policymakers in decision-making for the introduction of typhoid conjugate vaccines (TCVs). Moreover, each study is evaluating the large-scale deployment of TCVs, and may ultimately be used to assess post-introduction vaccine impact. The data generated by these studies will also be used to refine global disease burden estimates. It is important to ensure that lessons learned from these studies not only inform vaccination policy, but also are incorporated into sustainable, low-cost, integrated vaccine-preventable disease surveillance systems.

Evaluating Chronic Disease Surveillance Systems: Lessons Learned From Applying a Framework to Assess the Alaska Behavioral Risk Factor Surveillance System

2020 ◽  
Vol 41 (3) ◽  
pp. 420-431
Author(s):  
Katie Cueva ◽  
Andrea Fenaughty ◽  
Jessica Aulasa Liendo ◽  
Samantha Hyde-Rolland
Keyword(s):  
Risk Factors ◽  
Chronic Disease ◽  
Surveillance System ◽  
Disease Surveillance ◽  
Lessons Learned ◽  
Behavioral Risk ◽  
Surveillance Systems ◽  
Behavioral Risk Factor ◽  
Behavioral Risk Factor Surveillance ◽  
Risk Factor Surveillance

Chronic diseases with behavioral risk factors are now the leading causes of death in the United States. A national Behavioral Risk Factor Surveillance System (BRFSS) monitors those risk factors; however, there is a need for national and state evaluations of chronic disease surveillance systems. The Department of Health and Human Services/Centers for Disease Control and Prevention (CDC) has developed a framework on evaluating noncommunicable disease–related surveillance systems; however, no implementation of this framework has yet been published. This article describes the process of, and offers lessons learned from, implementing the evaluation framework to assess the Alaska BRFSS. This implementation evaluation may inform assessments of other state and regional chronic disease surveillance systems and offers insight on the positive potential to consult key stakeholders to guide evaluation priorities.

scholarly journals Pilot Low-Cost Concentrating Solar Power Systems Deployment in Sub-Saharan Africa: A Case Study of Implementation Challenges

2020 ◽  
Vol 12 (15) ◽  
pp. 6223
Author(s):  
Emmanuel Wendsongre Ramde ◽  
Eric Tutu Tchao ◽  
Yesuenyeagbe Atsu Kwabla Fiagbe ◽  
Jerry John Kponyo ◽  
Asakipaam Simon Atuah
Keyword(s):  
Electricity Generation ◽  
Power Plants ◽  
Large Scale ◽  
Solar Power ◽  
Low Cost ◽  
Sub Saharan Africa ◽  
Tracking Systems ◽  
Concentrating Solar Power ◽  
Solar Power Plants ◽  
Sub Saharan

Electricity is one of the most crucial resources that drives any given nation’s growth and development. The latest Sustainable Development Goals report indicates Africa still has a high deficit in electricity generation. Concentrating solar power seems to be a potential option to fill the deficit. That is because most of the components of concentrating solar power plants are readily available on the African market at affordable prices, and there are qualified local persons to build the plants. Pilot micro-concentrating solar power plants have been implemented in Sub-Saharan Africa and have shown promising results that could be expanded and leveraged for large-scale electricity generation. An assessment of a pilot concentrating solar power plant in the sub-region noticed one noteworthy obstacle that is the failure of the tracking system to reduce the operating energy cost of running the tracking control system and improve the multifaceted heliostat focusing behavior. This paper highlights the energy situation and the current development in concentrating solar power technology research in Africa. The paper also presents a comprehensive review of the state-of-the-art solar tracking systems for central receiver systems to illustrate the current direction of research regarding the design of low-cost tracking systems in terms of computational complexity, energy consumption, and heliostat alignment accuracy.

scholarly journals PO 8581 ZOONOTIC VIRAL ANTIGENS SURVEILLANCE IN HEALTHY POPULATIONS LIVING IN LAMBARÉNÉ, GABON

2019 ◽  
Vol 4 (Suppl 3) ◽  
pp. A58.2-A58
Author(s):  
Emmanuel Bache ◽  
Marguerite M Loembe ◽  
Selidji T Agnandji
Keyword(s):  
Disease Transmission ◽  
Disease Surveillance ◽  
Vaccine Trial ◽  
Viral Rna ◽  
Sub Saharan Africa ◽  
Surveillance Systems ◽  
Rt Pcr ◽  
Zoonotic Infections ◽  
Viral Antigens ◽  
Sub Saharan

BackgroundWorldwide, viral zoonotic infections such as filoviruses, flaviviruses, nairoviruses and arenaviruses cause self-limiting to severe diseases. They are endemic in sub-Saharan Africa, causing sporadic outbreaks warranting the development of sustainable surveillance systems. In Gabon, Ebola outbreaks occurred from 1994 to 2002 causing 214 human cases and 150 deaths, while Dengue, Zika and Chikungunya virus outbreaks occurred between 2007 and 2010. Beyond these outbreaks, little is known about the epidemiology. Recently, in collaboration with the Japanese government, the Research and Health Ministries of Gabon supported the implementation of a biosecurity level-3 (BSL-3) laboratory at CERMEL in Lambaréné as a zoonotic disease surveillance unit. Start-off involved antigen detection and characterisation of circulating antibodies to targeted viral antigens in healthy populations. This study reports data from healthy participants (18–50 years) in a phase I rVSV-ZEBOV-GP Ebola vaccine trial.MethodsHundred-six (106) baseline samples were screened for Ebola, Dengue (serotypes) 1–4 and Chikungunya viral RNA by RT-PCR on serum. IgG ELISA on plasma was used to identify antibodies against: Zaire-Ebola-(EBOV-GP and EBOV-VP40), Marburg-(MARV-GP and MARV-VP40), Crimean Congo Haemorrhagic Fever-(CCHFV-GP), Lasa-(LASV-GPC and LASV-NP), Yellow Fever-(YFV-NS1), West-Nile-(WNV-NS1), Zika virus-(ZIKV-NS1), Chikungunya-(CHIKV-VLP) and Dengue-(DENV1-NS1,DENV2-NS1,DENV3-NS1,DENV4-NS1) virus antigens.ResultsNo viral RNA was isolated by RT-PCR in 106 samples. About 9% (10/106), 3% (3/106), 6% (6/106), 24% (25/106), 51% (54/106), 38% (40/106) and 36% (38/106) participants were seropositive for antibodies specific to EBOV-GP, MARV-GP, CCHFV-GP, YFV-NS1, WNV-NS1, ZIKV-NS1 and CHIKV-VLP, respectively. Twelve percent (12%; 13/106) of participants possessed antibodies specific to Zika, Chikungunya and Dengue 1–4 antigens. Six percent (6%; 6/106) of participants were seropositive for EBOV-GP and CCHFV-GP.ConclusionWe found antibodies to viral zoonotic infections among our healthy volunteers. Further assays, including neutralisation assays are being performed to ascertain the specificity of the antibodies. These findings, once confirmed, will provide insights into disease surveillance, vaccine trial designs, evaluation of post-vaccine immune responses, variability in adverse events and overall disease transmission patterns.

scholarly journals Converting the existing disease surveillance from a paper-based to an electronic-based system using District Health Information System (DHIS-2) for real-time information: The Lebanese experience

2021 ◽  
Author(s):  
dalal Ali youssef
Keyword(s):  
Real Time ◽  
Disease Surveillance ◽  
Lessons Learned ◽  
Surveillance Systems ◽  
Medical Centers ◽  
Before And After ◽  
Reported Data ◽  
Real Time Information ◽  
Time Information ◽  
Roll Out

Abstract Introduction:The Ministry of Public Health in Lebanon is in the process of converting the surveillance reporting from a cumbersome paper-based system to a web-based electronic platform (DHIS-2) to have real-time information for early detection of alerts and outbreaks and for initiating a prompt response.Objectives:This paper aimed to document the Lebanese experience in implementing DHIS-2 for the disease surveillance system. It also targets to assess the improvement of reporting rates and timeliness of the reported data and to disclose the encountered challenges and opportunities. MethodologyThis is a retrospective description of processes involved in the implementation of the DHIS-2 tool in Lebanon. Initially, it was piloted for the school-based surveillance in 2014; then its use was extended in May 2017 to cover other specific surveillance systems. This included all surveillance programs collecting aggregate data from hospitals, medical centers, dispensaries, or laboratories at the first stage. As part of the national roll-out process, the online application was developed. The customized aggregated-based datasets, organization units, user accounts, specific and generic dashboards were generated. More than 80 training sessions were conducted throughout the country targeting 1290 end-users including health officers at the national and provincial levels, focal persons working in all public and private hospitals, laboratories, and medical centers as well. Completeness and timeliness of reported data were compared before and after the implementation of DHIS-2. Challenges and lessons learned during the roll-out process are listed.ResultsFor laboratory-based surveillance, completeness of reporting increased from 70.8% in May to 89.6% in October. Timeliness has improved from 25% to 74%. For medical centers, an improvement of 8.1% for completeness and 9.4% in timeliness was recorded before and after training sessions. For zero reporting, completeness remains the same (88%) and timeliness has improved from 74% to 87%. The main challenges faced during the implementation of DHIS-2 were mainly infrastructural and system-related in addition to poor internet connectivity and limited workforce and frequent changes to DHIS-2 versions.ConclusionImplementation of DHIS-2 improved timeliness and completeness for aggregated data reporting. Continued on-site support, monitoring, and system enhancement are needed to improve the performance of DHIS-2.

scholarly journals The use of low-cost ruggedized Android tablets to augment in-service training of community health workers in Mukono, Uganda: perspectives and lessons learned from the field

2021 ◽  
Vol 21 (3) ◽  
pp. 1482-1490
Author(s):  
Christina E Stiles ◽  
Edward O’Neil Jr ◽  
Kenneth Kabali ◽  
James O’Donovan
Keyword(s):  
Community Health ◽  
Community Health Workers ◽  
Health Workers ◽  
Low Cost ◽  
Local Level ◽  
Scale Up ◽  
Lessons Learned ◽  
Sub Saharan Africa ◽  
Refresher Training ◽  
Service Training

Background: Despite potential for community health workers (CHWs) to effectively reduce morbidity and mortality in sub-Saharan Africa, they still face multiple barriers including access to on-going and refresher training. Digital technology offers a potential solution to improve the provision of ongoing training for CHWs. Objectives: This report shares participant insights and experiences following the implementation of a mobile health (mHealth) assisted Integrated Community Case Management (iCCM) refresher training programme for CHWs in Mukono, Uganda. We seek to document benefits and challenges of such an approach. Methods: CHWs were trained to recognize, treat and prevent childhood pneumonia via locally made videos preloaded onto low cost, ruggedized Android tablets. Subsequent interviews were compiled with key stakeholders including CHWs, CHW leaders and programme supervisors to better understand the strengths, barriers and lessons learned following the interven- tion. Results: Success factors included the establishment of CHW leadership structures, the ability to use the tablets to learn on an “any pace, any place” basis and using the tablets to conduct community teaching and outreach. Barriers included appro- priate consideration of the implementation timeline and avoiding a “one size fits all” approach to digital literacy training. Conclusions: The strength of the program stemmed from a grassroots approach that prioritized stakeholder input at all stages. Leadership at a local level, a history of local engagement and trust built up over a period time were also integral. As organizations aim to scale up digitally enhanced training initiatives, it is paramount that attention is paid to these human factors which are key for program success. Keywords: Low-cost ruggedized Android tablets; in-service training; community health workers; Mukono.

scholarly journals COVID-19 Crisis in Africa: Revisiting the Contributing Factors

2021 ◽  
Vol 1 (1) ◽  
pp. 64-67
Author(s):  
Ugochukwu A Eze ◽  
Kingsley I Ndoh ◽  
Kehinde K Kanmodi
Keyword(s):  
Disease Surveillance ◽  
Democratic Republic Of Congo ◽  
The United States ◽  
Sub Saharan Africa ◽  
Surveillance Systems ◽  
Contributing Factors ◽  
African Countries ◽  
The World ◽  
Control And Prevention ◽  
Sub Saharan

Abstract The COVID-19 pandemic has been a major threat to people and healthcare systems around the world. Each region of the world has had unique factors such as culture, demographics, socioeconomic and the political landscape that has either fueled or mitigated the severity of the pandemic. For example, the 2021 Indian Kumbh Mela festival fueled a devastating wave of the pandemic in India. Similarly, the pandemic in the United States has in part been fueled an epidemic of disinformation that led to a growing number of anti-vaxxers, and those who are opposed to COVID-19 prevention guidelines set by agencies like the Centers for Disease Control and Prevention. In Africa, burial practices in Liberia and the Democratic Republic of Congo once fueled the Ebola epidemic. Likewise, in the context of COVID-19, there are factors that are unique to Africa that may have either fueled or mitigated the severity of the pandemic. The anti-COVID-19 measures in many African countries significantly affected household income without commensurate deployment of palliative measures to cushion the effect. Fortunately, the pandemic has run a relatively milder course in sub-Saharan Africa—defying earlier devastating projections. Therefore, to be prepared for the next pandemic, African governments must involve critical stakeholders such as religious and traditional leaders, strengthen current disease surveillance systems and invest in systems that encourage private investments in local vaccine manufacturing.

scholarly journals An affordable anti-SARS-COV-2 spike protein ELISA test for early detection of IgG seroconversion suited for large-scale surveillance studies in low-income countries

2020 ◽  
Author(s):  
Renata G. F. Alvim ◽  
Tulio M. Lima ◽  
Danielle A. S. Rodrigues ◽  
Federico F. Marsili ◽  
Vicente B. T. Bozza ◽  
...  
Keyword(s):  
Low Income ◽  
Large Scale ◽  
Low Cost ◽  
Venous Blood ◽  
Hek293 Cells ◽  
Epidemiological Surveillance ◽  
Low Income Countries ◽  
Serological Tests ◽  
S Protein ◽  
Surveillance Studies

AbstractBackgroundAccurate serological tests are essential tools to allow adequate monitoring and control of COVID-19 spread. Production of a low-cost and high-quality recombinant viral antigen can enable the development of reliable and affordable serological assays, which are urgently needed to facilitate epidemiological surveillance studies in low-income economies.MethodsTrimeric SARS-COV-2 spike (S) protein was produced in serum-free, suspension-adapted HEK293 cells. Highly purified S protein was used to develop an ELISA, named S-UFRJ test. It was standardized to work with different types of samples: (i) plasma or serum from venous blood samples; (ii) eluates from dried blood spots (DBS) obtained by collecting blood drops from finger prick.FindingsWe developed a cost-effective, scalable technology to produce S protein based on its stable expression in HEK293 cells. Using this recombinant antigen we presented a workflow for test development in the setting of a pandemic, starting from limited amounts of samples up to reaching final validation with hundreds of samples. Test specificity was determined to be 98.6%, whereas sensitivity was 95% for samples collected 11 or more days after symptoms onset. A ROC analysis allowed optimizing the cut-off and confirming the high accuracy of the test. Endpoint titers were shown to correlate with virus neutralization assessed as PRNT90. There was excellent agreement between plasma and DBS samples, significantly simplifying sample collection, storing and shipping. An overall cost estimate revealed that final retail price could be in the range of one US dollar.InterpretationThe S-UFRJ assay developed herein meets the quality requirements of high sensitivity and specificity. The low cost and the use of mailable DBS samples allow for serological surveillance of populations regardless of geographical and socio-economic aspects, with special relevance for public health policy actions in low-income countries.FundingCTG, Senai DN/CETIQT, FAPERJ, CNPq, CAPES and Instituto Serrapilheira.

scholarly journals Intestinal Schistosomiasis and Giardiasis Co-Infection in Sub-Saharan Africa: Can a One Health Approach Improve Control of Each Waterborne Parasite Simultaneously?

2020 ◽  
Vol 5 (3) ◽  
pp. 137 ◽  
Author(s):  
John Archer ◽  
Lisa O’Halloran ◽  
Hajri Al-Shehri ◽  
Shannan Summers ◽  
Tapan Bhattacharyya ◽  
...  
Keyword(s):  
Disease Surveillance ◽  
Large Scale ◽  
One Health ◽  
Control Strategies ◽  
Integrated Control ◽  
Sub Saharan Africa ◽  
Middle Income ◽  
Intestinal Schistosomiasis ◽  
Sanitation And Hygiene ◽  
Sub Saharan

Both intestinal schistosomiasis and giardiasis are co-endemic throughout many areas of sub-Saharan Africa, significantly impacting the health of millions of children in endemic areas. While giardiasis is not considered a neglected tropical disease (NTD), intestinal schistosomiasis is formally grouped under the NTD umbrella and receives significant advocacy and financial support for large-scale control. Although there are differences in the epidemiology between these two diseases, there are also key similarities that might be exploited within potential integrated control strategies permitting tandem interventions. In this review, we highlight these similarities and discuss opportunities for integrated control of giardiasis in low and middle-income countries where intestinal schistosomiasis is co-endemic. By applying new, advanced methods of disease surveillance, and by improving the provision of water, sanitation and hygiene (WASH) initiatives, (co)infection with intestinal schistosomiasis and/or giardiasis could not only be more effectively controlled but also better understood. In this light, we appraise the suitability of a One Health approach targeting both intestinal schistosomiasis and giardiasis, for if adopted more broadly, transmission of both diseases could be reduced to gain improvements in health and wellbeing.

scholarly journals Nowcasting Influenza-like Illness Trends in Cameroon

2020 ◽  
Author(s):  
Elaine O. Nsoesie ◽  
Olubusola Oladeji ◽  
Aristide S. Abah Abah ◽  
Martial L. Ndeffo-Mbah
Keyword(s):  
Disease Surveillance ◽  
Respiratory Infections ◽  
Sub Saharan Africa ◽  
Digital Data ◽  
Surveillance Systems ◽  
African Countries ◽  
Influenza Like Illness ◽  
Search Data ◽  
Sub Saharan ◽  
Google Search

ABSTRACTAlthough acute respiratory infections are a leading cause of mortality in sub-Saharan Africa, surveillance of diseases such as influenza is mostly neglected. Evaluating the usefulness of influenza-like illness (ILI) surveillance systems and developing approaches for forecasting future trends is important for pandemic preparedness. We applied statistical and machine learning models to forecast 2012 to 2018 trends in ILI cases reported by the Cameroon Ministry of Health (MOH), using Google searches for influenza symptoms, treatments, natural or traditional remedies as well as, infectious diseases with a high burden (i.e., AIDS, malaria, tuberculosis). The variance explained by the models based on Google search data were 87.7%, 79.1% and 52.0% for the whole country, the Littoral and Centre regions respectively. Our study demonstrates the need for developing contextualized approaches when using digital data for disease surveillance and demonstrates the potential usefulness of search data for monitoring ILI in sub-Saharan African countries.

scholarly journals Strengthening Maternal Death Surveillance Systems for Evidence-Based Decision Making in Sub-Saharan Africa: The Case of the Center Region in Cameroon

2021 ◽  
Vol 10 (2) ◽  
pp. 258-268
Author(s):  
Anastasia Bongajum Yenban ◽  
Pascal Foumane ◽  
Charlotte Moussi ◽  
Noel Vogue ◽  
Hycinth Banseka ◽  
...  
Keyword(s):  
Public Health ◽  
Global Health ◽  
Maternal Death ◽  
Public Health Practice ◽  
Lessons Learned ◽  
Sub Saharan Africa ◽  
Surveillance Systems ◽  
District Health ◽  
Data Set ◽  
Center Region

Background: The article seeks to document the experience of implementing Maternal Death Surveillance and Response (MDSR) in the Center Region of Cameroon. The paper raises awareness on the need for implementing MDSR, shares progress and lessons learned and reflects on the implications for public health practice. Methods: A desk research involving the collection and analysis of secondary data using tables with specific themes in excel, following the review of existing resources at the Regional Delegation of Public Health-Center from the year 2016 to 2019. Results: The findings depict the existence of MDSR policies and sub-regional committees. Although, the number of regional maternal death notifications increased from 19 to 188 deaths between 2016 and 2019, the implementation of death review recommendations was only estimated at 10% in 2019. While 66% of deaths occurred in Yaoundé, 72% of these were deaths reported to have occurred in tertiary institutions out of which 75% were attributed to late referrals. Hemorrhage constituted 70/144 (48.6%) of the known direct causes of death. Maternal death related co-factors such as the use of partograph during labor had a high non-response rate (84%) and represents a weakness in the data set. Conclusion and Global Health Implications: Across the board, stakeholder engagement towards MDSR was increased through continuous awareness-raising, dissemination of surveillance tools, the institutionalization of the District Health Information Software (DHIS 2) and the “No Name No Blame” policy. However, the reporting and investigation of deaths for informed decisions remain a daunting challenge. For a resource-scarce setting with limited access to blood banks, the application of life-saving cost-effective interventions such as the use of partographs and the institution of a functional referral system among health units is likely to curb the occurrence of deaths from hemorrhage and other underlying causes. The success of these will require a robust strengthening of the health system.   Copyright © 2021 Bongajum, et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.

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