Activities of creatine kinase and its isoenzymes in serum in various skeletal muscle disorders.

1988 ◽  
Vol 34 (12) ◽  
pp. 2460-2462 ◽  
Author(s):  
J Arenas ◽  
V Diaz ◽  
G Liras ◽  
E Gutierrez ◽  
I Santos ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Clinical Features ◽  
Principal Factor ◽  
Isoenzyme Pattern ◽  
Type I ◽  
Isoenzyme Analysis ◽  
Muscle Disorders ◽  
Total Creatine ◽  
Skeletal Muscle Disorders

Abstract We studied possible correlations between anatomopathological and clinical features and the values for total creatine kinase (CK; EC 2.7.3.2) and its isoenzymes, including the proportion of CK-MB, in a population displaying several neuromuscular pathologies. Although we observed no specific isoenzyme pattern associated with the different myopathies, we found isoenzyme analysis useful in studying the histopathological evolution of illness. We also considered whether the pathology was regenerative or nonregenerative, and what type of fiber (I or II) was involved. High CK-MB percentages (greater than 6%) were associated with regenerative and type I fiber myopathies, with regenerative type tissues being the principal factor associated with an increasing proportion of CK-MB. Studying the changes in CK-MB percentage in serum appears to be useful in discriminating neuromuscular from myocardial pathologies.

scholarly journals Reinfections with strains of Trypanosoma cruzi, of different biodemes as a factor of aggravation of myocarditis and myositis in mice

2006 ◽  
Vol 39 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Sonia Gumes Andrade ◽  
Rozália Figueira Campos ◽  
Karina Souza Castro Sobral ◽  
Juracy Barbosa Magalhães ◽  
Ricardo S. Pereira Guedes ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Trypanosoma Cruzi ◽  
Cellular Response ◽  
Type I ◽  
Isoenzyme Analysis ◽  
Aggravation Factor ◽  
Strain Type ◽  
Triple Infection ◽  
Muscle Lesions ◽  
Cardiac Manifestations

Reinfections with Trypanosoma cruzi in patients from endemic areas have been claimed to be an aggravation factor of cardiac manifestations in Chagas' disease. In the present study, the influence of triple infections with strains of different biodemes, on cardiac and skeletal muscle lesions was experimentally tested. Fifty eight mice chronically infected with the Colombian strain (Biodeme Type III) were successively reinfected as follows: 1st group - reinfected with 21 SF strain (Type II) followed by Y strain (Type I ); 2nd - group reinfections with Y strain followed by 21SF strain. Isoenzyme analysis of parasites from hemocultures obtained from triple infected mice, revealed the patterns of three distinct zymodemes in the same animal. Each Trypanosoma cruzi strain was reisolated after four passages in mice on either the 7th, 14th or 30th day after inoculation with the blood of triple infected mice. Histopathology results demonstrated a significant exacerbation of cardiac and skeletal muscle inflammatory lesions, confirmed by morphometric evaluation, in mice with triple infection. No aggravation of parasitism was detected. The possibility of an enhancement of cellular response in the triple infected mice is suggested.

scholarly journals Maturation of Mitochondrial and other Isoenzymes of Creatine Kinase in Skeletal Muscle of Preterm Born Infants

1992 ◽  
Vol 29 (3) ◽  
pp. 302-306 ◽  
Author(s):  
J Smeitink ◽  
W Ruitenbeek ◽  
T v Lith ◽  
R Sengers ◽  
F Trijbels ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Protein Content ◽  
Human Skeletal Muscle ◽  
Specific Activity ◽  
Prenatal Development ◽  
Quadriceps Muscle ◽  
Mitochondrial Creatine Kinase ◽  
Total Creatine ◽  
Preterm Born

We studied pre- and postnatal changes in total creatine kinase (CK) activity, mitochondrial creatine kinase (Mi-CK) activity and immunochemical reactivity with anti-Mi-CK antibodies in skeletal muscle specimens from 12 infants, 10 of them preterm born, after a pregnancy varying between 28 and 40 weeks. Our results demonstrate that Mi-CK is present in fetal human quadriceps muscle and that the specific activity of Mi-CK increases during prenatal development from week 28 to 40 by a factor about two. Generally, adult levels have not been reached at birth, indicating a further postnatal increase of the activity of the enzyme. The Mi-CK protein content also increases during prenatal development. These results suggest that in human skeletal muscle the expression and accumulation of Mi-CK starts at mid-gestation, later than is known to occur for cytosolic CK.

scholarly journals Is Gene-Size an Issue for the Diagnosis of Skeletal Muscle Disorders?

2020 ◽  
Vol 7 (3) ◽  
pp. 203-216 ◽  
Author(s):  
Marco Savarese ◽  
Salla Välipakka ◽  
Mridul Johari ◽  
Peter Hackman ◽  
Bjarne Udd
Keyword(s):  
Skeletal Muscle ◽  
Muscle Disorders ◽  
Gene Size ◽  
Skeletal Muscle Disorders

Gene Therapy of Skeletal Muscle Disorders Using Viral Vectors

Muscle ◽  
2012 ◽  
pp. 1045-1051 ◽  
Author(s):  
Andrea L.H. Arnett ◽  
Julian N. Ramos ◽  
Jeffrey S. Chamberlain
Keyword(s):  
Skeletal Muscle ◽  
Gene Therapy ◽  
Viral Vectors ◽  
Muscle Disorders ◽  
Skeletal Muscle Disorders

scholarly journals Impact of Melatonin on Skeletal Muscle and Exercise

Cells ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 288 ◽  
Author(s):  
Alessandra Stacchiotti ◽  
Gaia Favero ◽  
Luigi Fabrizio Rodella
Keyword(s):  
Quality Of Life ◽  
Skeletal Muscle ◽  
Human Aging ◽  
Muscle Disorders ◽  
Age Related ◽  
Anti Oxidant ◽  
Therapeutic Tools ◽  
Skeletal Muscle Disorders ◽  
Preclinical And Clinical Studies

Skeletal muscle disorders are dramatically increasing with human aging with enormous sanitary costs and impact on the quality of life. Preventive and therapeutic tools to limit onset and progression of muscle frailty include nutrition and physical training. Melatonin, the indole produced at nighttime in pineal and extra-pineal sites in mammalians, has recognized anti-aging, anti-inflammatory, and anti-oxidant properties. Mitochondria are the favorite target of melatonin, which maintains them efficiently, scavenging free radicals and reducing oxidative damage. Here, we discuss the most recent evidence of dietary melatonin efficacy in age-related skeletal muscle disorders in cellular, preclinical, and clinical studies. Furthermore, we analyze the emerging impact of melatonin on physical activity. Finally, we consider the newest evidence of the gut–muscle axis and the influence of exercise and probably melatonin on the microbiota. In our opinion, this review reinforces the relevance of melatonin as a safe nutraceutical that limits skeletal muscle frailty and prolongs physical performance.

Transforming growth factor-?2 is elevated in skeletal muscle disorders

1999 ◽  
Vol 22 (7) ◽  
pp. 889-898 ◽  
Author(s):  
Nobuyuki Murakami ◽  
Ian S. McLennan ◽  
Ikuya Nonaka ◽  
Kyoko Koishi ◽  
Christina Baker ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Muscle Disorders ◽  
Skeletal Muscle Disorders

scholarly journals Proteomic profiling of animal models mimicking skeletal muscle disorders

2007 ◽  
Vol 1 (9) ◽  
pp. 1169-1184 ◽  
Author(s):  
Philip Doran ◽  
Joan Gannon ◽  
Kathleen O'Connell ◽  
Kay Ohlendieck
Keyword(s):  
Skeletal Muscle ◽  
Animal Models ◽  
Proteomic Profiling ◽  
Muscle Disorders ◽  
Skeletal Muscle Disorders

scholarly journals Muscling in on the third dimension

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Mohsen Afshar Bakooshli ◽  
Penney M Gilbert
Keyword(s):  
Skeletal Muscle ◽  
Muscle Tissue ◽  
Human Skeletal Muscle ◽  
Three Dimensional ◽  
Dimensional Model ◽  
Three Dimensional Model ◽  
Muscle Disorders ◽  
The Third ◽  
Third Dimension ◽  
Skeletal Muscle Disorders

The development of a functional three-dimensional model of human skeletal muscle tissue could accelerate progress towards new and personalized treatments for skeletal muscle disorders.

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