scholarly journals Significance of various parameters derived from biological variability of lipoprotein(a), homocysteine, cysteine, and total antioxidant status

1997 ◽  
Vol 43 (10) ◽  
pp. 1958-1964 ◽  
Author(s):  
Christa Cobbaert ◽  
Johannes C Arentsen ◽  
Paul Mulder ◽  
Nicoline Hoogerbrugge ◽  
Jan Lindemans
Keyword(s):  
Antioxidant Status ◽  
Healthy Adult ◽  
Total Antioxidant Status ◽  
Biological Variability ◽  
Inverse Relation ◽  
Individual Values ◽  
Men And Women ◽  
Lipoprotein A ◽  
Outpatient Group ◽  
Total Antioxidant

Abstract Analytical and biological components of variability and various derived indices have been determined for lipoprotein(a) [Lp(a)], homocysteine (Hcy), cysteine (Cys), and total antioxidant status (TAOS) in ostensibly healthy adult Caucasians and in stable outpatients with an increased serum Lp(a). In healthy Caucasians, average intraindividual biological CVs (CVb) were 20.0% for Lp(a), 9.4% for Hcy, 5.9% for Cys, and 2.8% for TAOS, CVbs being similar in men and women. In the outpatient group, CVbs were comparable for Hcy, Cys, and TAOS, but significantly lower for Lp(a) (7.5% vs 20.0%; P <0.0001). Moreover, a significant inverse relation between both biological and analytical CVs (CVa) and serum Lp(a) concentrations was demonstrated. We conclude that average CVa and CVb values, and hence average derived indices, are adequate for Hcy, Cys, and TAOS, whereas individual values should be used for Lp(a).

A Suggested Method for the Prediction of the Oxidation Resistance of Low Density Lipoprotein by Determination of the Lag Time

2002 ◽  
Vol 16 (2) ◽  
pp. 107-112 ◽  
Author(s):  
M.R. Naghii
Keyword(s):  
Antioxidant Status ◽  
Healthy Adult ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Total Antioxidant Status ◽  
Lag Time ◽  
Lag Phase ◽  
Adult Males ◽  
Total Antioxidant

A simple clinical blood test, which measures the total antioxidant status of Low Density Lipoprotein (LDL) and therefore its vulnerability to oxidative stress is suggested, and as a first stage this was tried on a small sample of eight healthy adult males. The body's natural defence and repair systems try to handle all free radicals, but these systems are not hundred percent effective. Thereby, the role of antioxidants (particularly natural antioxidants) becomes evident and vitamins such as Vitamin C, Vitamin E, and compounds like beta-carotene are under especially extensive study. Vitamin C is the most abundant water-soluble antioxidant acting in extracellular fluid, while Vitamin E is the most abundant fat-soluble antioxidant, and it protects the polyunsaturated fatty acids within the LDL from oxidation and helps to prevent the process of atherogenesis. The determination of ‘lag-phase’ during continuous monitoring of oxidation of LDL in vitro is a convenient and objective procedure for determining the susceptibility of LDL from different donors towards oxidation as well as of pro- and anti-oxidants. The Lag-time for LDL samples, obtained from eight healthy adult males was found to be between 40–50 minutes. The measurement of this Lag-phase could be a highly promising routine method for measuring the total antioxidant status of LDL.

scholarly journals The pork meat enriched with organic selenium and its effect on selenium concentration and total antioxidant status in healthy volunteers

2011 ◽  
Vol 27 (3) ◽  
pp. 791-798
Author(s):  
B. Bobcek ◽  
J. Mrázová ◽  
J. Mlynek ◽  
O. Bucko ◽  
I. Imrich
Keyword(s):  
Functional Food ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Selenium Concentration ◽  
Control Group ◽  
Feed Mixture ◽  
Men And Women ◽  
Organic Selenium ◽  
Total Antioxidant ◽  
And Control

It is known that organic selenium (Sel Plex) supplemented to pig feed mixture is significant for effective transport of essential element selenium to the food chain. It enables to create important body deposits of selenium in skeletal muscles and it also increases selenium transfer in natural metabolic form of selenomethionine into functional food. The intake of feed mixture with increased organic selenium at the dose of 0.3 mg kg-1 probably increases selenium concentration in MSM (musculus semimembranosus) - experimental selenium group 1.293 mg kg-1 and control group 0.513 mg kg-1 and in MLT (musculus longissimus thoracis) - experimental selenium group 1.364 mg kg-1 and control group 0.506 mg kg-1. The aim of this study was to evaluate the selenium and total antioxidant status (TAS) in a selected group of healthy people. Twenty-five volunteers consumed pork meat enriched with organic selenium three times a week during one month (average age in 9 men was 51.2 years, in 16 women 39.06 years, respectively). Daily selenium intake of 110 ?g was calculated by Alimenta software, version 4.3 on the basis of nutrition statement. Recommended daily selenium intake of 50 - 200 ?g was stated by the World Health Organization (WHO). During the research, the volunteers consumed pork enriched with 35 ?g of selenium. At the begining the mean selenium concentration in blood serum was at 75.41 ? 14.18?g l-1 in men, 75.21 ? 15.20?g l-1 in women. After two weeks of consumption pork enriched with selenium, the average selenium concentration in blood serum in men and women increased to 86.69 ? 11.72 ?g l-1 and 87.93 ? 16.22 ?g l-1 respectively. At the end of the study the average selenium concentration decreased in men and women to 85.75 ? 2.72 ?g l-1 to 84.07 ? 15.62 ?g l-1 respectively. In the selected group of healthy people the total antioxidant status increased from 1,68 mmol.l-1 to 1,86 mmol.l-1 after two weeks of consumption of pork enriched with selenium. However, at the end of the research the decrease in TAS was recorded. Improvement in selenium status has positive impact on human health, and thus our results could contribute to the new trends in the production of functional food.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

Antioxidant status of blood in patients with vibration disease

2019 ◽  
pp. 978-982 ◽  
Author(s):  
N. N. Malyutina ◽  
A. F. Bolotova ◽  
R. B. Eremeev ◽  
A. Zh. Gilmanov ◽  
D. Yu. Sosnin
Keyword(s):  
Antioxidant Activity ◽  
Blood Serum ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Main Group ◽  
Biologically Active ◽  
Antioxidant Systems ◽  
Control Group ◽  
Vibration Disease ◽  
Total Antioxidant

Introduction. The overwhelming number of publications contains only data on the content of individual antioxidants, but not on the overall antioxidant activity of the blood in patients with vibration disease.The aim of the study was to determine the total antioxidant activity of blood serum in patients with vibration disease.Materials and methods. Th e main group consisted of 30 people diagnosed with “Vibration disease” of 1 degree (n=21) and 2 degrees (n=9). Th e control group consisted of 30 clinically healthy men, comparable in age with the main group (p=0.66). Th e total activity of antioxidant systems of blood plasma was evaluated photometrically using the test system “Total antioxidant status-Novo” (“Vector-best”, Russia).Results. The indicator of the total antioxidant status (TAS) was 1,038±0.232 mmol/l in the examined main group, against 1,456±0.225 mmol/l in the examined control group (p<0.000001). Th e coefficient of variation (CV) in patients with vibration disease was 22.35%, 1.45 times higher than in the control group (15.45%). In the main group there was a positive correlation between age and TAS (R=0.525), in the control group there was no such relationship (R=0.095). Th e degree of decrease depended on the severity of vibration disease.Conclusions. 1. The development of vibration disease is accompanied by a decrease in the antioxidant status of blood serum. 2. Th e degree of decrease in the antioxidant status of blood serum correlates with the severity of vibration disease. 3. Reduction of TAS can serve as a pathogenetic justification of the need to include drugs and/or biologically active additives with antioxidant activity in therapy

scholarly journals Are insulin-resistance and oxidative stress cause or consequence of aging

2020 ◽  
Vol 245 (14) ◽  
pp. 1260-1267
Author(s):  
Sylwia Dzięgielewska-Gęsiak ◽  
Dorota Stołtny ◽  
Alicja Brożek ◽  
Małgorzata Muc-Wierzgoń ◽  
Ewa Wysocka
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Antioxidant Status ◽  
Antioxidant Defense ◽  
Total Antioxidant Status ◽  
Thiobarbituric Acid ◽  
Elderly Individuals ◽  
Total Antioxidant ◽  
Antioxidant Defense Systems ◽  
Antioxidant Markers

Insulin resistance (IR) may be associated with oxidative stress and leads to cardiovascular disorders. Current research focuses on interplay between insulin-resistance indices and oxidant-antioxidant markers in elderly individuals with or without insulin-resistance. The assessment involved anthropometric data (weight, height, BMI, percentage of body fat (FAT)) and biochemical tests (glucose, lipids, serum insulin and plasma oxidant-antioxidant markers: Thiobarbituric Acid-Reacting Substances (TBARS), Cu,Zn-superoxide dismutase (SOD-1) and total antioxidant status). Insulin resistance index (IR) assuming a cut-off point of 0.3 allows to divides groups into: insulin sensitive group (InsS) IR < 0,3 ( n = 35, median age 69.0 years) and insulin-resistant group (InsR) IR ≥ 0.3 ( n = 51, median age 71.0 years). Lipids and antioxidant defense system markers did not differentiate the investigated groups. In the InsR elderly group, the FAT was increased ( P < 0.000003) and TBARS ( P = 0.008) concentration decreased in comparison with InsS group. A positive correlation for SOD-1 and total antioxidant status ( P < 0.05; r =  0.434) and a negative correlation for TBARS and age ( P < 0.05 with r = −0.421) were calculated in InsR individuals. In elderly individuals, oxidative stress persists irrespective of insulin-resistance status. We suggest that increased oxidative stress may be consequence of old age. An insulin action identifies those at high risk for atherosclerosis, via congruent associations with oxidative stress and extra- and intra-cellular antioxidant defense systems. Thus, we maintain that insulin-resistance is not the cause of aging. Impact statement Insulin resistance is associated with oxidative stress leading to cardiovascular diseases. However, little research has been performed examining elderly individuals with or without insulin-resistance. We demonstrate that antioxidant defense systems alone is not able to abrogate insulin action in elderly individuals at high risk for atherosclerosis, whereas the combined oxidant-antioxidant markers (thiobarbituric acid-reacting substances (TBARS), Cu,Zn-superoxide dismutase (SOD-1), and total antioxidant status (TAS)) might be more efficient and perhaps produce better clinical outcome. In fact, a decrease in oxidative stress and strong interaction between antioxidant defense can be seen only among insulin-resistant elderly individuals. This is, in our opinion, valuable information for clinicians, since insulin-resistance is considered strong cardiovascular risk factor.

Serum oxidizability, total antioxidant status and albumin serum levels in patients with aneurysmal or arterial occlusive disease

2008 ◽  
Vol 41 (9) ◽  
pp. 706-711 ◽  
Author(s):  
Ioannis Delimaris ◽  
Sotiris Georgopoulos ◽  
Christos Kroupis ◽  
Ariadni Zachari ◽  
Maria Liberi ◽  
...  
Keyword(s):  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Serum Levels ◽  
Arterial Occlusive Disease ◽  
Occlusive Disease ◽  
Total Antioxidant
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