Human cholesteryl ester transfer protein measured by enzyme-linked immunosorbent assay with two monoclonal antibodies against rabbit cholesteryl ester transfer protein: plasma cholesteryl ester transfer protein and lipoproteins among Japanese hypercholesterolemic patients

Abstract Plasma cholesteryl ester transfer protein (CETP) concentrations were measured in Japanese subjects by an ELISA with two different monoclonal antibodies that were raised against rabbit CETP and cross-reacted against human CETP. Among 63 patients who consecutively underwent coronary angiography, the plasma CETP of 37 patients with luminal stenosis ≥50% in their coronary arteries was not significantly different from that of the 26 patients with luminal stenosis <50%. No other lipoprotein-related measurement except HDL-cholesterol differentiated the two groups. Among 40 hypercholesterolemic patients, no lipoprotein-related measurement other than LDL-cholesterol was found to positive correlate with the CETP. Before and after the treatment of 23 patients with simvastatin 5 mg a day for 4 weeks, plasma CETP markedly decreased in those whose pretreatment CETP was ≥3 mg/L; no change was observed for those with lower pretreatment CETP. In the former group, negative correlation between CETP and HDL-cholesterol was demonstrated only in the posttreatment plasma.

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Increased plasma cholesteryl ester transfer protein in obese subjects. A possible mechanism for the reduction of serum HDL cholesterol levels in obesity.

Arteriosclerosis and Thrombosis A Journal of Vascular Biology ◽

10.1161/01.atv.14.7.1129 ◽

1994 ◽

Vol 14 (7) ◽

pp. 1129-1136 ◽

Cited By ~ 112

Author(s):

T Arai ◽

S Yamashita ◽

K Hirano ◽

N Sakai ◽

K Kotani ◽

...

Keyword(s):

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Hdl Cholesterol ◽

Transfer Protein ◽

Cholesterol Levels ◽

Plasma Cholesteryl Ester ◽

Obese Subjects

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Antiproteinuric therapy decreases LDL-cholesterol as well as HDL-cholesterol in non-diabetic proteinuric patients: relationships with cholesteryl ester transfer protein mass and adiponectin

Expert Opinion on Therapeutic Targets ◽

10.1517/14728220902905865 ◽

2009 ◽

Vol 13 (5) ◽

pp. 497-504 ◽

Cited By ~ 10

Author(s):

JA Krikken ◽

F Waanders ◽

GM Dallinga-Thie ◽

LD Dikkeschei ◽

L Vogt ◽

...

Keyword(s):

Cholesteryl Ester ◽

Cholesteryl Ester Transfer Protein ◽

Ldl Cholesterol ◽

Hdl Cholesterol ◽

Protein Mass ◽

Transfer Protein

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A common mutation in cholesteryl ester transfer protein gene and plasma HDL cholesterol level before and after hormone replacement therapy in Korean postmenopausal women

The Korean Journal of Internal Medicine ◽

10.3904/kjim.2002.17.2.83 ◽

2002 ◽

Vol 17 (2) ◽

pp. 83-87 ◽

Cited By ~ 4

Author(s):

Ki Ok Han ◽

Chang Hoon Yim ◽

Ho Yeon Jung ◽

Hak Chul Jang ◽

Hyun Ku Yoon ◽

...

Keyword(s):

Hormone Replacement Therapy ◽

Cholesteryl Ester ◽

Replacement Therapy ◽

Cholesteryl Ester Transfer Protein ◽

Protein Gene ◽

Hormone Replacement ◽

Hdl Cholesterol ◽

Common Mutation ◽

Transfer Protein ◽

Before And After

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Cholesteryl Ester Transfer Protein Gene Polymorphisms and Longevity Syndrome

The Open Cardiovascular Medicine Journal ◽

10.2174/1874192401004010014 ◽

2010 ◽

Vol 4 (1) ◽

pp. 14-19 ◽

Cited By ~ 19

Author(s):

Genovefa Kolovou ◽

Marianna Stamatelatou ◽

Katherine Anagnostopoulou ◽

Peggy Kostakou ◽

Vana Kolovou ◽

...

Keyword(s):

Cholesteryl Ester ◽

Allele Frequency ◽

Cholesteryl Ester Transfer Protein ◽

Gene Polymorphisms ◽

Ldl Cholesterol ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Transfer Protein ◽

History Of

Purpose:High levels of high density lipoprotein (HDL) cholesterol are associated with a decreased risk of coronary heart disease (CHD). Subjects with high levels of HDL cholesterol (>70 mg/dl; 1.79 mmol/l) as well as high levels of low density lipoprotein (LDL) cholesterol, could represent a group with longevity syndrome (LS). Since HDL particles are influenced by cholesteryl ester transfer protein (CETP) activity, it is worth studying the CETP polymorphism. The aim of the study was to detect whether 2 genetic variants of the CETP are associated with the LS.Subjects and Methods:The study population consisted of 136 unrelated men and women with no personal and family history of CHD; 69 met the criteria for LS and 67 did not meet these criteria and had “normal” HDL cholesterol (>40 and <70 mg/dl; >1.03 and <1.79 mmol/l). All patients were genotyped for the TaqIB and I405V polymorphisms.Results:The B2 allele frequency of TaqIB polymorphism was higher in the LS in comparison with the non-LS group (p=0.03) whereas B1 allele frequency was higher in the non-LS group (p=0.03).Conclusions:Gene polymorphisms could help decide whether individuals who have increased levels of both LDL cholesterol and HDL cholesterol require treatment. Some of the prerequisites could include that subjects with LS should not only have very high levels of HDL cholesterol but also favorable gene polymorphisms. However, further investigations with a larger sample and including other gene polymorphisms, are needed.

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