scholarly journals Artificial intelligence with multi-functional machine learning platform development for better healthcare and precision medicine

Database ◽  
2020 ◽  
Vol 2020 ◽  
Author(s):  
Zeeshan Ahmed ◽  
Khalid Mohamed ◽  
Saman Zeeshan ◽  
XinQi Dong

Abstract Precision medicine is one of the recent and powerful developments in medical care, which has the potential to improve the traditional symptom-driven practice of medicine, allowing earlier interventions using advanced diagnostics and tailoring better and economically personalized treatments. Identifying the best pathway to personalized and population medicine involves the ability to analyze comprehensive patient information together with broader aspects to monitor and distinguish between sick and relatively healthy people, which will lead to a better understanding of biological indicators that can signal shifts in health. While the complexities of disease at the individual level have made it difficult to utilize healthcare information in clinical decision-making, some of the existing constraints have been greatly minimized by technological advancements. To implement effective precision medicine with enhanced ability to positively impact patient outcomes and provide real-time decision support, it is important to harness the power of electronic health records by integrating disparate data sources and discovering patient-specific patterns of disease progression. Useful analytic tools, technologies, databases, and approaches are required to augment networking and interoperability of clinical, laboratory and public health systems, as well as addressing ethical and social issues related to the privacy and protection of healthcare data with effective balance. Developing multifunctional machine learning platforms for clinical data extraction, aggregation, management and analysis can support clinicians by efficiently stratifying subjects to understand specific scenarios and optimize decision-making. Implementation of artificial intelligence in healthcare is a compelling vision that has the potential in leading to the significant improvements for achieving the goals of providing real-time, better personalized and population medicine at lower costs. In this study, we focused on analyzing and discussing various published artificial intelligence and machine learning solutions, approaches and perspectives, aiming to advance academic solutions in paving the way for a new data-centric era of discovery in healthcare.

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Paul G. M. Knoops ◽  
Athanasios Papaioannou ◽  
Alessandro Borghi ◽  
Richard W. F. Breakey ◽  
Alexander T. Wilson ◽  
...  

Abstract Current computational tools for planning and simulation in plastic and reconstructive surgery lack sufficient precision and are time-consuming, thus resulting in limited adoption. Although computer-assisted surgical planning systems help to improve clinical outcomes, shorten operation time and reduce cost, they are often too complex and require extensive manual input, which ultimately limits their use in doctor-patient communication and clinical decision making. Here, we present the first large-scale clinical 3D morphable model, a machine-learning-based framework involving supervised learning for diagnostics, risk stratification, and treatment simulation. The model, trained and validated with 4,261 faces of healthy volunteers and orthognathic (jaw) surgery patients, diagnoses patients with 95.5% sensitivity and 95.2% specificity, and simulates surgical outcomes with a mean accuracy of 1.1 ± 0.3 mm. We demonstrate how this model could fully-automatically aid diagnosis and provide patient-specific treatment plans from a 3D scan alone, to help efficient clinical decision making and improve clinical understanding of face shape as a marker for primary and secondary surgery.


2021 ◽  
Vol 29 (Supplement_1) ◽  
pp. i18-i18
Author(s):  
N Hassan ◽  
R Slight ◽  
D Weiand ◽  
A Vellinga ◽  
G Morgan ◽  
...  

Abstract Introduction Sepsis is a life-threatening condition that is associated with increased mortality. Artificial intelligence tools can inform clinical decision making by flagging patients who may be at risk of developing infection and subsequent sepsis and assist clinicians with their care management. Aim To identify the optimal set of predictors used to train machine learning algorithms to predict the likelihood of an infection and subsequent sepsis and inform clinical decision making. Methods This systematic review was registered in PROSPERO database (CRD42020158685). We searched 3 large databases: Medline, Cumulative Index of Nursing and Allied Health Literature, and Embase, using appropriate search terms. We included quantitative primary research studies that focused on sepsis prediction associated with bacterial infection in adult population (>18 years) in all care settings, which included data on predictors to develop machine learning algorithms. The timeframe of the search was 1st January 2000 till the 25th November 2019. Data extraction was performed using a data extraction sheet, and a narrative synthesis of eligible studies was undertaken. Narrative analysis was used to arrange the data into key areas, and compare and contrast between the content of included studies. Quality assessment was performed using Newcastle-Ottawa Quality Assessment scale, which was used to evaluate the quality of non-randomized studies. Bias was not assessed due to the non-randomised nature of the included studies. Results Fifteen articles met our inclusion criteria (Figure 1). We identified 194 predictors that were used to train machine learning algorithms to predict infection and subsequent sepsis, with 13 predictors used on average across all included studies. The most significant predictors included age, gender, smoking, alcohol intake, heart rate, blood pressure, lactate level, cardiovascular disease, endocrine disease, cancer, chronic kidney disease (eGFR<60ml/min), white blood cell count, liver dysfunction, surgical approach (open or minimally invasive), and pre-operative haematocrit < 30%. These predictors were used for the development of all the algorithms in the fifteen articles. All included studies used artificial intelligence techniques to predict the likelihood of sepsis, with average sensitivity 77.5±19.27, and average specificity 69.45±21.25. Conclusion The type of predictors used were found to influence the predictive power and predictive timeframe of the developed machine learning algorithm. Two strengths of our review were that we included studies published since the first definition of sepsis was published in 2001, and identified factors that can improve the predictive ability of algorithms. However, we note that the included studies had some limitations, with three studies not validating the models that they developed, and many tools limited by either their reduced specificity or sensitivity or both. This work has important implications for practice, as predicting the likelihood of sepsis can help inform the management of patients and concentrate finite resources to those patients who are most at risk. Producing a set of predictors can also guide future studies in developing more sensitive and specific algorithms with increased predictive time window to allow for preventive clinical measures.


Author(s):  
Deeksha Kaul ◽  
Harika Raju ◽  
B. K. Tripathy

In this chapter, the authors discuss the use of quantum computing concepts to optimize the decision-making capability of classical machine learning algorithms. Machine learning, a subfield of artificial intelligence, implements various techniques to train a computer to learn and adapt to various real-time tasks. With the volume of data exponentially increasing, solving the same problems using classical algorithms becomes more tedious and time consuming. Quantum computing has varied applications in many areas of computer science. One such area which has been transformed a lot through the introduction of quantum computing is machine learning. Quantum computing, with its ability to perform tasks in logarithmic time, aids in overcoming the limitations of classical machine learning algorithms.


Author(s):  
Jayant Kumar A Rathod ◽  
Naveen Bhavani ◽  
Prenita Prinsal Saldanha ◽  
Preethi M Rao ◽  
Prasad Patil

Artificial Intelligence and Machine Learning are two fields that are causing substantial development in every field specifically in the field of medical sciences; for the stupendous potential that it can provide to assist the clinicians, researchers, in clinical decision making, automate time consuming procedures, medical imaging, and more. Most implementations of AI/ML rely on static data set, and this where the big data steps in. That is, these models are developed and trained on a data set that is already recorded and have been diligently reviewed for accuracy; leading to a precise decision-making process. Experts foresee that AI/ML based overarching care system will develop high-quality patient care and innovative research, aiding advanced decision support tools. In this paper we shall realize what are the current devices that are build and are being used for real time problem solving, also discuss the impact of Software as a Medical Device (SAMD) in future of medical sciences. [2,3,11]


Author(s):  
Deeksha Kaul ◽  
Harika Raju ◽  
B. K. Tripathy

In this chapter, the authors discuss the use of quantum computing concepts to optimize the decision-making capability of classical machine learning algorithms. Machine learning, a subfield of artificial intelligence, implements various techniques to train a computer to learn and adapt to various real-time tasks. With the volume of data exponentially increasing, solving the same problems using classical algorithms becomes more tedious and time consuming. Quantum computing has varied applications in many areas of computer science. One such area which has been transformed a lot through the introduction of quantum computing is machine learning. Quantum computing, with its ability to perform tasks in logarithmic time, aids in overcoming the limitations of classical machine learning algorithms.


Artificial intelligence (AI) and machine learning are at the moment measured to be the unique widespread inventions. Artificial Intelligence rummage-sale to stand an unbelievable conception from science fiction, but nowadays it’s flattering a day-to-day authenticity. On the other hand, a neural network emulates the procedure of actual neurons in the brain that are parquet the track near innovations in machine learning, baptised deep learning. Machine learning can cosiness us living cheerier, improved, and additional dynamic conscious, if the power of the Deep learning concepts and its proper utilization as an industrial revolution that harness mental and cognitive ability. Currently lots of research papers deal with the Artificial Intelligence of deep learning in various real time applications that includes intelligent gaming, smart driving, and environmental protection and so on. Irrespective of all applications an intelligent decision making must be done timely to improve the accuracy in one end and simultaneously on the other end to consume energy and system efficiency. This paper presents the various applications using deep learning efficiently by better decision making and also how to visualize the problems in order to take a conclusion for better solution. The analysis of such real time problems is done by logically in the form of using artificial neurons through supervised and unsupervised data.


2020 ◽  
Vol 28 ◽  
Author(s):  
Valeria Visco ◽  
Germano Junior Ferruzzi ◽  
Federico Nicastro ◽  
Nicola Virtuoso ◽  
Albino Carrizzo ◽  
...  

Background: In the real world, medical practice is changing hand in hand with the development of new Artificial Intelligence (AI) systems and problems from different areas have been successfully solved using AI algorithms. Specifically, the use of AI techniques in setting up or building precision medicine is significant in terms of the accuracy of disease discovery and tailored treatment. Moreover, with the use of technology, clinical personnel can deliver a very much efficient healthcare service. Objective: This article reviews AI state-of-the-art in cardiovascular disease management, focusing on diagnostic and therapeutic improvements. Methods: To that end, we conducted a detailed PubMed search on AI application from distinct areas of cardiology: heart failure, arterial hypertension, atrial fibrillation, syncope and cardiovascular rehabilitation. Particularly, to assess the impact of these technologies in clinical decision-making, this research considers technical and medical aspects. Results: On one hand, some devices in heart failure, atrial fibrillation and cardiac rehabilitation represent an inexpensive, not invasive or not very invasive approach to long-term surveillance and management in these areas. On the other hand, the availability of large datasets (big data) is a useful tool to predict the development and outcome of many cardiovascular diseases. In summary, with this new guided therapy, the physician can supply prompt, individualised, and tailored treatment and the patients feel safe as they are continuously monitored, with a significant psychological effect. Conclusion: Soon, tailored patient care via telemonitoring can improve the clinical practice because AI-based systems support cardiologists in daily medical activities, improving disease detection and treatment. However, the physician-patient relationship remains a pivotal step.


2020 ◽  
Author(s):  
Avishek Choudhury

UNSTRUCTURED Objective: The potential benefits of artificial intelligence based decision support system (AI-DSS) from a theoretical perspective are well documented and perceived by researchers but there is a lack of evidence showing its influence on routine clinical practice and how its perceived by care providers. Since the effectiveness of AI systems depends on data quality, implementation, and interpretation. The purpose of this literature review is to analyze the effectiveness of AI-DSS in clinical setting and understand its influence on clinician’s decision making outcome. Materials and Methods: This review protocol follows the Preferred Reporting Items for Systematic Reviews and Meta- Analyses reporting guidelines. Literature will be identified using a multi-database search strategy developed in consultation with a librarian. The proposed screening process consists of a title and abstract scan, followed by a full-text review by two reviewers to determine the eligibility of articles. Studies outlining application of AI based decision support system in a clinical setting and its impact on clinician’s decision making, will be included. A tabular synthesis of the general study details will be provided, as well as a narrative synthesis of the extracted data, organised into themes. Studies solely reporting AI accuracy an but not implemented in a clinical setting to measure its influence on clinical decision making were excluded from further review. Results: We identified 8 eligible studies that implemented AI-DSS in a clinical setting to facilitate decisions concerning prostate cancer, post traumatic stress disorder, cardiac ailment, back pain, and others. Five (62.50%) out of 8 studies reported positive outcome of AI-DSS. Conclusion: The systematic review indicated that AI-enabled decision support systems, when implemented in a clinical setting and used by clinicians might not ensure enhanced decision making. However, there are very limited studies to confirm the claim that AI based decision support system can uplift clinicians decision making abilities.


2020 ◽  
Vol 34 (10) ◽  
pp. 13849-13850
Author(s):  
Donghyeon Lee ◽  
Man-Je Kim ◽  
Chang Wook Ahn

In a real-time strategy (RTS) game, StarCraft II, players need to know the consequences before making a decision in combat. We propose a combat outcome predictor which utilizes terrain information as well as squad information. For training the model, we generated a StarCraft II combat dataset by simulating diverse and large-scale combat situations. The overall accuracy of our model was 89.7%. Our predictor can be integrated into the artificial intelligence agent for RTS games as a short-term decision-making module.


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