DOZ047.17: Characterization of esophageal motility in children with operated esophageal atresia using high-resolution impedance manometry and pressure flow analysis

2019 ◽  
Vol 32 (Supplement_1) ◽  
Author(s):  
O Courbette ◽  
T Omari ◽  
A Aspirot ◽  
C Faure
Keyword(s):  
High Resolution ◽  
Esophageal Atresia ◽  
Esophageal Motility ◽  
Flow Analysis ◽  
Esophageal Pressure ◽  
Pressure Flow ◽  
Impedance Ratio ◽  
Group A ◽  
Group B

Abstract Background Esophageal dysmotility is common in patients with esophageal atresia (EA). High-resolution impedance manometry (HRIM) and pressure flow analysis (PFA) allow characterization of biomechanical bolus flow and swallow properties. The aim of this study was to characterize esophageal motility and bolus flow propulsion in children who underwent surgical EA repair. Patients and Methods HRIM was used in 14 children with EA (type C, n = 13; type A, n = 1). Study was performed at a median (range) age of 11 years (5–17). The HRIM recordings were analyzed using conventional esophageal pressure topography and PFA (AIMplot software deployed via the open access Swallow Gateway application) and were compared with 13 patient controls (median age 14 years, range 5.75–17; P = NS vs patients) who underwent HRIM considered as normal according to Chicago classification and for whom the manometry results did not lead to treatment changes. Medical charts were reviewed for medical/surgical history and symptoms were assessed by standardized questionnaires. Results Esophageal peristaltic motor patterns were abnormal in all EA patients and were subdivided in two groups: Group A with presence of distal contraction in ≥ 50% of the swallows (n = 6) and Group B with presence of distal contractions in < 50% of the swallows (n = 8). IRP4s was similar in EA and controls. Bolus transport was impaired as shown by the higher impedance ratio (IR) in EA than in controls (0.47 vs 0.22, P < 0.001). In Group A, proximal and distal contractile integrals were lower than in controls (P < 0.001) and distal contractile velocity was shorter in EA (P < 0.01). IR was lower in Group A than in Group B (P < 0.01). In this sample, symptoms of dysphagia and presence of gastric metaplasia or esophagitis were not correlated with any of the measures determined. Conclusions Bolus transport as measured by impedance ratio is severely altered in EA patients but is not predictive of symptoms. The presence of residual distal contractions is associated with a more efficient bolus propulsion. Whether this is associated with a better outcome warrants further studies.

Characterization of Esophageal Motility Following Esophageal Atresia Repair Using High-Resolution Esophageal Manometry

2013 ◽  
Vol 56 (6) ◽  
pp. 609-614 ◽  
Author(s):  
Caroline Lemoine ◽  
Ann Aspirot ◽  
Gaelle Le Henaff ◽  
Hugues Piloquet ◽  
Dominique Lévesque ◽  
...  
Keyword(s):  
High Resolution ◽  
Esophageal Atresia ◽  
Esophageal Motility ◽  
Esophageal Manometry

scholarly journals Dominance of the ON1 Genotype of RSV-A and BA9 Genotype of RSV-B in Respiratory Cases from Jeddah, Saudi Arabia

Genes ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 1323
Author(s):  
Hessa A. Al-Sharif ◽  
Sherif A. El-Kafrawy ◽  
Jehad M. Yousef ◽  
Taha A. Kumosani ◽  
Mohammad A. Kamal ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Respiratory Infections ◽  
Hypervariable Region ◽  
Genotype Distribution ◽  
Potential Development ◽  
The Usa ◽  
Group A ◽  
Syncytial Virus ◽  
Group B

Human respiratory syncytial virus (HRSV) is a main cause of hospital admission for lower respiratory tract infection. In previous studies from Saudi Arabia, higher prevalence of the NA1 genotype in group A was observed from Riyadh and Taif. This study recruited respiratory cases from Jeddah during January to December, 2017. RSV represented 13.4% in the recruited cases with 64% of them belonging to group A and 36% to group B. All group A cases in this study were ON1 type characterized by duplication of 72 nucleotides, 24 amino acids in the C-terminal in the second hypervariable region of the G gene. In addition, for group B all of the cases were clustered under BA9, which had uniquely characterized as duplication of 60 nucleotides in the G protein. Our sequences showed similarity with earlier sequences from Saudi Arabia, Kuwait, Thailand, South Africa, Spain, the USA and Cyprus. Some amino acid substitutions in the investigated sequences would cause a change in potential O-glycosylation and N-glycosylation profiles from prototype ON1. The predominance of the ON1 and BA9 genotype of RSV-A in Jeddah compared to previous Saudi studies showing predominance of the NA1 genotype for group A. This difference in genotype prevalence could be due to fast spread of the ON1 genotype worldwide or due to the flux of travelers through Jeddah during hajj/umrah compared to Riyadh and Taif. This shift in genotype distribution requires continuous surveillance for genetic characterization of circulating respiratory infections including RSV. These findings may contribute to the understanding of RSV evolution and to the potential development of a vaccine against RSV.

Preoperative magnetic resonance imaging in Type 2 trigeminal neuralgia

2010 ◽  
Vol 113 (3) ◽  
pp. 511-515 ◽  
Author(s):  
Andrew C. Zacest ◽  
Stephen T. Magill ◽  
Jonathan Miller ◽  
Kim J. Burchiel
Keyword(s):  
High Resolution ◽  
Mr Imaging ◽  
Facial Pain ◽  
Neurovascular Compression ◽  
Imaging Reconstruction ◽  
Group A ◽  
Group B ◽  
3D Mr Imaging

Object Trigeminal neuralgia (TN) is a neuropathic pain syndrome that is often associated with neurovascular compression of the trigeminal nerve and may be effectively treated with microvascular decompression (MVD). The authors used high-resolution MR imaging with 3D reconstruction in patients with constant facial pain (Type 2 TN) to determine the presence/absence of neurovascular compression and thus a potential MVD benefit. They retrospectively contacted patients to evaluate outcome. Methods All patients who reported spontaneous onset of constant facial pain (Type 2 TN), which occurred at least 50% of the time, who had undergone high-resolution 3-T MR imaging with 3D reconstruction were retrospectively selected for this study. Clinical history, facial pain questionnaire data, physical examination findings, and results from 3-T 3D MR imaging reconstruction were recorded for all patients. Intraoperative findings and clinical pain outcome were recorded for all patients who underwent MVD. Results Data obtained in 27 patients were assessed. On the basis of history and 3D MR imaging reconstruction findings, 13 patients were selected for MVD (Group A) and 14 underwent conservative treatment (Group B). Typical or suspected artery- or vein-induced neurovascular compression was predicted preoperatively in 100% of Group A patients and in 0% of Group B patients. At the time of MVD, definitive neurovascular compression was confirmed in 11 (84.6%) of 13 Group A patients. Following MVD, facial pain was completely relieved in 3 (23%), improved in 7 (53.8%), and no better in 3 (23%) of 13 Group A patients. A history of episodic (Type 1 TN) pain at any time was reported in 100 and 50% of Group A and Group B patients, respectively. A Type 1 TN pain component was reportedly improved/relieved in all Group A patients, but the Type 2 TN pain component was improved in only 7 (53.8%) of 13 patients. The mean postoperative follow-up duration was 13 months. Conclusions High-resolution 3D MR imaging reconstruction in patients with constant facial pain (Type 2 TN) can help determine the presence/absence of neurovascular compression. Surgical selection based on both clinical and radiological criteria has the potential to improve surgical outcome in patients with Type 2 TN who may potentially benefit from MVD. However, even in such selected patients, pain relief is likely to be incomplete.

Clinical presentation and molecular characterization of group B rotaviruses in diarrhoea patients in Bangladesh

2011 ◽  
Vol 60 (4) ◽  
pp. 529-536 ◽  
Author(s):  
Farjana Saiada ◽  
H. N. Ashiqur Rahman ◽  
Sayra Moni ◽  
M. Manjurul Karim ◽  
Mahmoud Reza Pourkarim ◽  
...  
Keyword(s):  
Continuous Monitoring ◽  
Diarrhoeal Disease ◽  
Specific Pattern ◽  
Severe Dehydration ◽  
Animal Group ◽  
Group A ◽  
Stool Samples ◽  
Group B ◽  
Rotavirus Infections

A total of 1106 stool samples collected from diarrhoea patients admitted to Dhaka hospital of the International Centre for Diarrhoeal Disease Research, Bangladesh, during January–December 2008 were analysed for the presence of rotavirus-specific RNA by PAGE. The group B-specific RNA migration pattern was detected in 26 patients (2.4 %) and group A-specific pattern in 259 patients (23.4 %). Clinical data from group A and group B rotavirus-infected patients indicated that episodes did not differ much in the prevalence of diarrhoea, number of stools, outcome or differences in gender. However, abdominal pain was more common in group B rotavirus infections (36 vs 15 %, P=0.02) and the virus was responsible for more severe dehydration compared with group A-infected patients (12 vs 3 %, P=0.04). Sequence analyses of VP4, VP7 and NSP2 indicated that an Indian–Bangladeshi lineage of the virus, which is different from both the prototype (Chinese) lineage and from the animal group B rotaviruses, has been circulating in Bangladesh. Continuous monitoring of group B rotaviruses both in hospitals and in the community will be helpful to determine the true burden of group B rotaviruses.

scholarly journals Morphological, Biochemical And Hematological Characterization Of Endangered Balkan Donkey Breed

2015 ◽  
Vol 65 (1) ◽  
pp. 125-136 ◽  
Author(s):  
STANIŠIĆ Ljubodrag ◽  
DIMITRIJEVIĆ Vladimir ◽  
SIMEUNOVIĆ Predrag ◽  
LAKIĆ Nada ◽  
RADOVIĆ Ivica ◽  
...  
Keyword(s):  
Age Groups ◽  
Biochemical Parameter ◽  
Reference Ranges ◽  
Morphometric Analyses ◽  
Group A ◽  
Study Population ◽  
Biochemical Profiles ◽  
Group B ◽  
Two Age Groups

Abstract The aim of the study was to establish morphometric, biochemical and hematological values for the endangered Balkan donkey breed (Serbia) and to explore the possible age dependence of the parameters tested. Inter-breed similarity of morphometric parameters was assessed by comparing the data obtained for the Balkan donkey with morphometric measurements of several previously characterized domestic donkey breeds. The study population included 74 donkeys, divided in two age groups (group A ≤ 3 years; group B > 3 years). In total, 18 morphometric, 13 hematological and 14 biochemical parameters were assessed. Significant morphometric differences (p<0.05) in body length, head length, chest circumference and body weight were found between the two age groups. Significant differences in morphological parameters were revealed among the Balkan donkey and other donkey breeds (Catalonian, Croatian and Albanian), but results of cluster analysis demonstrated the smallest distance between the Balkan donkey and Albanian donkeys. The results of morphometric analyses showed consistency of the obtained values within the breed, and diversity as compared to other donkey breeds, and, thus, could be taken as referent for the Balkan donkey. Hematological and biochemical profiles obtained for the Balkan donkey were consistent with previous reports and within the recommended reference ranges. White blood cell, mid cell and granulocyte counts, showed significantly higher (p<0.05) values in donkeys under 3 years of age, while the only biochemical parameter affected by age was alkaline phosphatase. The information gained through characterization of the Balkan donkey breed provides a basis for conservation and development of the breed standard.

scholarly journals Effect of Esophageal Endoscopic Submucosal Dissection on Motility and Symptoms: A Prospective Study

2018 ◽  
Vol 2018 ◽  
pp. 1-10
Author(s):  
Tsutomu Takeda ◽  
Kenshi Matsumoto ◽  
Akihito Nagahara ◽  
Hiroyuki Komori ◽  
Yoichi Akazawa ◽  
...  
Keyword(s):  
Endoscopic Submucosal Dissection ◽  
Symptom Score ◽  
Esophageal Motility ◽  
High Resolution Manometry ◽  
Submucosal Dissection ◽  
Significant Difference ◽  
Before And After ◽  
Group A ◽  
Integrated Relaxation Pressure ◽  
Group B

Background.Endoscopic submucosal dissection (ESD) of esophageal tumors can cause stenosis, yet the effect of esophageal ESD on motility remains unclarified. This study aimed to compare esophageal motility and symptoms, before and after ESD, using high-resolution manometry (HRM) and symptom scoring.Methods.Twenty-eight patients with 35 cT1a cancers were prospectively enrolled between December 2014 and February 2016. Pre- and post-ESD symptom score and HRM were recorded. Based on circumferential resection (CR), patients were divided into group A (n=17, <2/3 CR) or B (n=11, 2/3 CR or greater). HRM parameters evaluated were distal contractile integral (DCI), contractile front velocity (CFV), intrabolus pressure, integrated relaxation pressure, distal latency, and peristaltic breaks.Results.Symptom scores worsened after ESD in 8/11 patients in group B, and 0/17 patients in group A. There was no significant difference in any HRM parameter after ESD in the whole study group but mean DCI tended to increase (p=0.07). In group B, DCI increased significantly after ESD (p=0.04), and CFV tended to decrease after ESD (p=0.08).Conclusions.DCI tended to increase after esophageal ESD. ESD affected the symptom score and esophageal motility in cases with 2/3 CR or greater. This trial is registered withUMIN000015829.

Genetic characterization of coagulase-positive staphylococci isolated from healthy pigeons

2015 ◽  
Vol 18 (3) ◽  
pp. 627-634 ◽  
Author(s):  
M. Kizerwetter-Świda ◽  
D. Chrobak-Chmiel ◽  
M. Rzewuska ◽  
A. Antosiewicz ◽  
B. Dolka ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Genetic Relatedness ◽  
Genetic Characterization ◽  
Restriction Patterns ◽  
Feral Pigeons ◽  
Group A ◽  
Biochemical Identification ◽  
Group B ◽  
Coagulase Positive Staphylococci

AbstractCoagulase-positive staphylococci (CoPS) are opportunistic veterinary pathogens, of whichStaphylococcus aureus,S. delphiniandS. intermediuscan be isolated from pigeons. The biochemical identification ofS. delphiniandS. intermediusisolates may be incorrect, because of their phenotypic similarity. The purpose of the present study was to isolate and identify CoPS from domestic and feral pigeons and to determine their genetic relatedness by PFGE. A total number of 31 isolates of CoPS were obtained, 15 were identified asS. delphinigroup B, six asS. aureus,four asS. delphinigroup A, three asS. intermediusand three asS. schleiferisubsp.coagulans. The results indicate that S.delphinigroup B is the predominant CoPS species among pigeons studied. PFGE restriction patterns ofS. delphinigroup A andS. delphinigroup B form separate clusters, demonstrating their genetic heterogeneity. Indistinguishable or very similar PFGE patterns observed amongS. delphinigroup B isolates from domestic and feral pigeons confirm the possibility of CoPS transmission between these birds.

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