scholarly journals P432 Effects and safety of a colon-long absorbing budesonide product in patients with mild to moderate ulcerative colitis

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S393-S394
Author(s):  
D Pigniczki ◽  
K Szántó ◽  
M Rutka ◽  
K Farkas ◽  
A Bálint ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Body Composition ◽  
Side Effects ◽  
Disease Activity ◽  
The Body ◽  
Composition Analysis ◽  
Hormonal Changes ◽  
Aminosalicylic Acid ◽  
Laboratory Parameters ◽  
Body Composition Analysis

Abstract Background Budesonide is an oral corticosteroid, which is widely used in moderate-to-severe ulcerative colitis (UC) to obtain and maintain remission in those cases, where 5-aminosalicylic-acid was ineffective. Unlike previous forms of budesonide absorbing from the ileal and ascending colon region, the new-generation budesonide-MMX contains a formula, that allows absorption throughout the whole colon, and therefore in the whole potentially inflamed area in UC. We aimed to evaluate the effects and safety of budesonide-MMX in our UC patients who meet the above mentioned therapeutic demands in a real-life study. Methods We enrolled 22 patients with mild to severe UC in this single-centre prospective study until August of 2019. Patients received 9 mg oral budesonide-MMX once daily until 8 weeks. Laboratory parameters (cholesterol, triglyceride, CRP) and serum hormone levels (parathormone [PTH], dehydroepiandrosterone [DHEA] and cortisol) were monitored before and after the 8-week therapy to follow metabolic and hormonal changes. During these visits, body composition analysis was also performed with InBody 770 machine to observe the adverse steroid effects of budesonide-MMX in respect of body fat mass, body mass index, protein content of the body and bone mineral content. Disease activity was followed by the partial Mayo (pMayo) score. Statistical analysis was performed by paired t-test and Wilcoxon signed-rank test with SigmaPlot 1.25. Results The total of 22 patients (age: 44.4 ± 15.1 years, 6 male and 16 female patients) had received the 2-month budesonide-MMX therapy (2.0 ± 0.3 months). Mean disease duration was 8.3 years. By the end of follow-up, 15 (68.2%) patients experienced remission and 7 patients (31.8%) were primary non-responders. The disease activity decreased significantly from the mean of 3.95 to 1.64 (p < 0.001). No significant changes were observable in case of any body composition analysis parameter. Regarding the laboratory parameters, serum cholesterin level showed a significant increase (p < 0.001), while triglyceride and CRP showed did not show significant changes. Serum cortisol levels were elevated (p < 0.001), while PTH and DHEA showed no significant decrease. Only two patients experienced side effects: one of them hypertonia, headache and acnes, while the other patient experienced mild diarrhoea. One patient had a relapse during the treatment. Conclusion In our study, budesonide-MMX proved to be safe by bringing up a low number of side effects, while more than two-thirds of the patients could reach remission with this short-term therapy. Hormonal changes were not mentionable, although the drug’s effects on serum lipid content have to be examined further.

scholarly journals BODY COMPOSITION ANALYSIS; A SURGE IN DEMAND FOR SPORTS REHABILITATION

2020 ◽  
Vol 9 (1) ◽  
pp. 47-50
Author(s):  
Irfan Niazi
Keyword(s):  
Body Composition ◽  
Muscle Mass ◽  
Fat Mass ◽  
Athletic Performance ◽  
The Body ◽  
Composition Analysis ◽  
Comparison Analysis ◽  
Body Composition Analysis ◽  
Risk Of Injury ◽  
The Ideal

Abstract This special report aims to highlight the role and practice of Body Composition Analysis in sports rehabilitation to enhance athletic performance by studying its various aspects such as fat mass, lean mass, and water content in the body. This report identified Inbody 770 as the ideal gadget for Body Composition Analysis. Fat mass analysis revealed that Body Mass Index is not an appropriate tool to determine the levels of obesity as it does not differentiate between fat mass and muscle mass, rather categorises a healthy muscular individual as obese. Furthermore, Body Composition Analysis enables to investigate the proportions of muscle mass and fat mass in a specific region as well as perform comparison analysis to identify the region of weakness and potential risk of injury. Water analysis helps to identify the cause of edema and proportions of intracellular and extracellular fluids

scholarly journals Stav antropometrických parametrů a tělesného složení u studentů Vojenského oboru UK FTVS v Praze

2015 ◽  
Vol 9 (2) ◽  
pp. 57-67 ◽  
Author(s):  
Ivana Kinkorová ◽  
Matěj Vrba
Keyword(s):  
Body Composition ◽  
Body Fat ◽  
The Body ◽  
Whole Body ◽  
Composition Analysis ◽  
Extracellular Water ◽  
Body Composition Analysis ◽  
Segmental Analysis ◽  
Total Body ◽  
General Physical

The aim of our study was the measurement of selected anthropometric variables, respectively determining somatotype, body composition analysis of students Military Department (MD) at UK FTVS in Prague and compared to similar studies. The group consisted of 22 probands, men ranging in age from 19–27 years (mean age = 22,9 ± 2,6 years, height = 179,9 ± 6,0 cm, weight = 76,8 ± 7,0 kg, BMI = 23,8 ± 1,5 kg.m–2). In terms of measured average somatotype (1,7 – 7,3 – 2,5), the students MD have very good preconditions for general physical fitness. We used BIA-Tanita MC 980 for the body composition analysis (whole body and segmental analysis). The students MD showed a high proportion of lean body mass (70,5 ± 6,1 kg) and low proportion of fat mass (8,3 ± 3,0 %). The authors emphasize the importance of monitoring and other parameters of body composition, e.g. total body water (TBW), extracellular water (ECW), intracellular water (ICW), segmental analysis of muscle mass and body fat.

scholarly journals P546 The safety and efficacy of the new-generation budesonide-MMX in the aspect of the cytochrome P-450 enzyme genotype

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S516-S516
Author(s):  
T Resál ◽  
K Farkas ◽  
T Molnár
Keyword(s):  
Body Composition ◽  
Serum Cortisol ◽  
The Body ◽  
Composition Analysis ◽  
Hormonal Changes ◽  
Cytochrome P450 3A ◽  
Safety And Efficacy ◽  
Mayo Score ◽  
Significant Difference ◽  
New Generation

Abstract Background Unlike previous forms of budesonide absorbing from the ileal and ascending colon region, the new-generation budesonide-MMX contains a formula, that allows absorption throughout the whole colon. Budesonide is degraded in the liver by cytochrome P450 3A enzyme, but so far, there is no study examining the relationship between the budesonide’s effect and the enzyme activity. CYP3A5 is absent in 90% of the European/caucasian population due to a functional loss mutation (CYP3A5*3), whereas patients with the wild-type CYP3A5*1 allele may be expected to have increased metabolism. The most common genetic polymorphisms in CYP3A4 (CYP3A4*1B and CYP3A4*22) result in increased and decreased expression, respectively. Methods We enrolled 33 patients with UC in this prospective study until January of 2021. Patients received 9 mg oral budesonide-MMX once daily until 8 weeks. Laboratory parameters (cholesterol, triglyceride, CRP) and serum hormone levels (parathormone, dehydroepiandrosterone and cortisol) were monitored before and after the 8-week therapy to follow metabolic and hormonal changes. During these visits, body composition analysis was also performed with InBody 770 machine to observe the adverse effects of budesonide-MMX in respect of body fat mass, body mass index, protein content of the body and bone mineral content. We examined the CYP450 3A (CYP3A5 and CYP3A4) enzyme genotype of the patients, to see, whether the different alleles of this drug-degrading enzyme affect the efficacy and safety. Results 33 patients had received the 2-month therapy. By the end of follow-up, based on partial Mayo score, 26 (78.8%) patients experienced remission and 6 patients (18.2%) were primary non-responders. Mean pMayo score decreased from 4.18 to 1.63 (p<0.001). No significant changes were observable regarding body composition. Serum cholesterol level showed significant increase (p<0.001), while triglyceride and CRP did not show significant changes. Serum cortisol levels were decreased (p<0.001), while PTH and DHEA showed no significant decrease. Only two patients experienced side effects: one of them hypertonia, headache and acnes, while the other mild diarrhoea. 3 patients have CYP3A5*1/*3 genotype, and 16 have CYP3A5*3/*3. There was no significant difference between the two groups, regarding safety and efficacy. Only 1 patient have CYP3A4*1B genotype, while the rest have CYP3A4*1, hence, no statistics could be performed. Conclusion In our study, budesonide-MMX proved to be safe and effective in the therapy of UC, however, cholesterol was elevated in the serum. Based on our cohort, different genotypes of CYP3A don’t have an impact on the effect of the drug, however, CYP3A allele variants are rare, therefore, further examinations should be performed.

scholarly journals The importance of the compartment model of body composition analysis in women with severe obesity

2021 ◽  
Vol 69 (4) ◽  
pp. e86035
Author(s):  
Renato Vidal-Linhares ◽  
Mônica Barros-Costa ◽  
Felipe Monnerat Marino-Rosa ◽  
José Carlos Do Vale-Quaresma ◽  
José Fernandes-Filho ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Body Composition ◽  
Muscle Mass ◽  
Compartment Model ◽  
The Body ◽  
Morbidly Obese ◽  
Composition Analysis ◽  
Moderate Correlation ◽  
Body Composition Analysis ◽  
Total Fat

Introduction: Usually, the diagnosis of obesity is only based on body mass index (BMI), which may lead to a non-reliable body composition analysis. Objective: To analyze the body characteristics of morbidly obese (class III) women referred to bariatric surgery using the compartment model of body composition analysis. Materials and methods: Cross-sectional study conducted in 2017 in 14 morbidly obese women aged between 25 and 51 years who were undergoing clinical and physical therapy assessment prior to undergoing bariatric surgery at a university hospital in Rio de Janeiro, Brazil. Body composition analysis was performed using an octopolar bioimpedance scale. The Pearson's correlation coefficient was used to analyze the correlation between variables, with a significance level of p<0.5. Results: A high mean percentage of fat body was observed (51.2%), mainly in the trunk. BMI was correlated with total fat in kilograms (r=0.63), and muscle mass (r=0.60); besides, a moderate correlation with the waist-to-hip ratio (WHR) was found (r=0.55). WHR showed a correlation with TBF% (r=0.60) and a moderate correlation with total fat in kilograms (r=0.57). In addition, the sarcopenia index was correlated with muscle mass (r=0.79) and total body water (r=0.78). All these correlations were statistically significant (p<0.05). There were no sarcopenia cases. Conclusion: A higher concentration of fat in the trunk and the upper limbs was observed in the study population, however none of the participants had sarcopenia. On the other hand, BMI showed a greater correlation with both total fat (kg) and TBF% than with WHR. Such findings suggest that assessing these patients based only on BMI or WHR may hinder the development individualized treatment strategies.

scholarly journals Application of standards and models in body composition analysis

2015 ◽  
Vol 75 (2) ◽  
pp. 181-187 ◽  
Author(s):  
Manfred J. Müller ◽  
Wiebke Braun ◽  
Maryam Pourhassan ◽  
Corinna Geisler ◽  
Anja Bosy-Westphal
Keyword(s):  
Body Composition ◽  
Clinical Decision Making ◽  
Compartment Model ◽  
Clinical Decision ◽  
Whole Body ◽  
Composition Analysis ◽  
Body Composition Analysis ◽  
Physical Functions ◽  
Body Components

The aim of this review is to extend present concepts of body composition and to integrate it into physiology. In vivo body composition analysis (BCA) has a sound theoretical and methodological basis. Present methods used for BCA are reliable and valid. Individual data on body components, organs and tissues are included into different models, e.g. a 2-, 3-, 4- or multi-component model. Today the so-called 4-compartment model as well as whole body MRI (or computed tomography) scans are considered as gold standards of BCA. In practice the use of the appropriate method depends on the question of interest and the accuracy needed to address it. Body composition data are descriptive and used for normative analyses (e.g. generating normal values, centiles and cut offs). Advanced models of BCA go beyond description and normative approaches. The concept of functional body composition (FBC) takes into account the relationships between individual body components, organs and tissues and related metabolic and physical functions. FBC can be further extended to the model of healthy body composition (HBC) based on horizontal (i.e. structural) and vertical (e.g. metabolism and its neuroendocrine control) relationships between individual components as well as between component and body functions using mathematical modelling with a hierarchical multi-level multi-scale approach at the software level. HBC integrates into whole body systems of cardiovascular, respiratory, hepatic and renal functions. To conclude BCA is a prerequisite for detailed phenotyping of individuals providing a sound basis for in depth biomedical research and clinical decision making.

Sign in / Sign up

Export Citation Format

Share Document