scholarly journals Is HBA1C reliable in diagnosing diabetes in the acute phase of acute coronary syndromes?

2021 ◽  
Vol 10 (Supplement_1) ◽  
Author(s):  
M Stratinaki ◽  
K Milaki ◽  
S Stavrakis ◽  
M Pitarokoilis ◽  
E Charitakis ◽  
...  
Keyword(s):  
Acute Phase ◽  
Acute Coronary Syndromes ◽  
Rank Correlation ◽  
Mean Value ◽  
Gensini Score ◽  
Funding Sources ◽  
Spearman’S Rank Correlation ◽  
Coronary Syndromes ◽  
One Way Anova

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Hospitalization due to acute coronary syndromes (ACS) usually is the occasion that leads to diagnosis of type 2 diabetes mellitus (T2DM). Current literature suggests that the severity of the ACS could be associated with the presence and the severity of DM. Purpose To study the reliability of HbA1c in the diagnosis of T2DM in the acute phase of ACS, as well as the presence of possible correlation between the HbA1c and the severity of ACS. Methods We evaluated 160 consecutive patients admitted due to ACS. HbA1c was measured on day 1 and day 90. HbA1c >6.5% was used to diagnose T2DM and HbA1c 5.7-6.4% was used to diagnose pre-diabetes. The severity of ACS was assessed via Gensini score. Results are interpreted as mean ± SD. Comparisons were made by one way ANOVA(p < 0.05 was regarded statistically significant).Spearman’s rank correlation was used to study the correlation between Gensini score and the other parameters. Results Mean age was 59.73 ± 12.21 years. 103/160(64.37%) were male and 57/160(35.63%) were female. 19/160(11.87%) were diagnosed as STEMI and 141/160(88.13%) as NSTEMI. Mean BMI was 29.55 ± 8.41 kg/m2 and mean Hb 12.62 ± 2.08 g/dl. On day 1, 43/160 (26.87%) had HbA1c > 6.5% and 41/160(25.62%) HbA1c 5.7-6.4%. On day 90, 28/160 (17.5%) had HbA1c > 6.5% and 52/160(32.5%) HbA1c 5.7-6.4%. Gensini score varied between 0-144 with mean value 40.26 ±35.9. A strong correlation was found between Gensini score and HbA1c on admission as well as on day 90 (rho-0.36, p < 0.05 and rho = 0.32, p < 0.05 respectively). Conclusion HbA1c seems to be reliable in the identification of pre-diabetes but not T2DM in the acute phase of ACS. The correlation of the severity between ACS and HbA1c seems to relate with the worst prognosis of T2DM patients.

scholarly journals Deregulation of lncRNA HIST1H2AG-6 and AIM1-3 in peripheral blood mononuclear cells is associated with newly diagnosed type 2 diabetes

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Hui Jiang ◽  
Peian Lou ◽  
Xiaoluo Chen ◽  
Chenguang Wu ◽  
Shihe Shao
Keyword(s):  
Roc Curve ◽  
Multivariate Logistic Regression Analysis ◽  
Rank Correlation ◽  
Differentially Expressed ◽  
Healthy Controls ◽  
Biological Functions ◽  
Multivariate Logistic Regression ◽  
Spearman’S Rank Correlation ◽  
Spearman’S Rank Correlation Coefficient

Abstract Background Type 2 diabetes mellitus (T2DM) is mainly affected by genetic and environmental factors; however, the correlation of long noncoding RNAs (lncRNAs) with T2DM remains largely unknown. Methods Microarray analysis was performed to identify the differentially expressed lncRNAs and messenger RNAs (mRNAs) in patients with T2DM and healthy controls, and the expression of two candidate lncRNAs (lnc-HIST1H2AG-6 and lnc-AIM1-3) were further validated using quantitative real-time polymerase chain reaction (qRT-PCR). Spearman’s rank correlation coefficient was used to measure the degree of association between the two candidate lncRNAs and differentially expressed mRNAs. Furthermore, the KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway and GO (Gene Ontology) enrichment analysis were used to reveal the biological functions of the two candidate lncRNAs. Additionally, multivariate logistic regression analysis and receiver operating characteristic (ROC) curve analysis were performed. Results The microarray analysis revealed that there were 55 lncRNAs and 36 mRNAs differentially expressed in patients with T2DM compared with healthy controls. Notably, lnc-HIST1H2AG-6 was significantly upregulated and lnc-AIM1-3 was significantly downregulated in patients with T2DM, which was validated in a large-scale qRT-PCR examination (90 controls and 100 patients with T2DM). Spearman’s rank correlation coefficient revealed that both lncRNAs were correlated with 36 differentially expressed mRNAs. Furthermore, functional enrichment (KEGG and GO) analysis demonstrated that the two lncRNA-related mRNAs might be involved in multiple biological functions, including cell programmed death, negative regulation of insulin receptor signal, and starch and sucrose metabolism. Multivariate logistic regression analysis revealed that lnc-HIST1H2AG-6 and lnc-AIM1-3 were significantly correlated with T2DM (OR = 5.791 and 0.071, respectively, both P = 0.000). Furthermore, the ROC curve showed that the expression of lnc-HIST1H2AG-6 and lnc-AIM1-3 might be used to differentiate patients with T2DM from healthy controls (area under the ROC curve = 0.664 and 0.769, respectively). Conclusion The profiles of lncRNA and mRNA were significantly changed in patients with T2DM. The expression levels of lnc-HIST1H2AG-6 and lnc-AIM1-3 genes were significantly correlated with some features of T2DM, which may be used to distinguish patients with T2DM from healthy controls and may serve as potential novel biomarkers for diagnosis in the future.

Does climate change affect the chronobiological trends in occurrence of acute coronary syndromes?

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
L Kuzma ◽  
A Kurasz ◽  
M Niwinska ◽  
EJ Dabrowski ◽  
M Swieczkowski ◽  
...  
Keyword(s):  
Climate Change ◽  
Acute Coronary Syndromes ◽  
Hospital Admissions ◽  
Global Climate ◽  
Weather Conditions ◽  
Temperature Changes ◽  
Funding Sources ◽  
Relative Risks ◽  
Coronary Syndromes ◽  
Atmospheric Changes

Abstract Funding Acknowledgements Type of funding sources: None. Background Acute coronary syndromes (ACS) are the leading cause of death all over the world, in the last years chronobiology of their occurrence has been changing. Purpose The aim of this study was to assess the influence of climate change on hospital admissions due to ACS. Methods Medical records of 10,529 patients hospitalized for ACS in 2008–2017 were examined. Weather conditions data were obtained from the Institute of Meteorology. Results Among the patients, 3537 (33.6%) were hospitalized for STEMI, 3947 (37.5%) for NSTEMI, and 3045 (28.9%) for UA. The highest seasonal mean for ACS was recorded in spring (N = 2782, mean = 2.52, SD = 1.7; OR 1.07; 95% CI 1.0-1.2; P = 0.049) and it was a season with the highest temperature changes day to day (Δ temp.=11.7). On the other hand, every 10ºC change in temperature was associated with an increased admission due to ACS by 13% (RR 1.13; 95% CI 1.04-1.3; P = 0.008). Analysis of weekly changes showed that the highest frequency of ACS occurred on Thursday (N = 1703, mean = 2.7, SD = 1.9; OR 1.16; 95% CI 1.0-1.23; P = 0.004), in STEMI subgroup it was Monday (N = 592, mean = 0.9, SD = 1.6, OR 1.2; 95% CI 1.1-1.4; P = 0.002). Sunday was associated with decreased admissions due to all types of ACS (N = 1098, mean = 1.7, SD = 1.4; OR 0.69; 95% CI 0.6-0.8, P < 0.001). In the second half of the study period (2013-2018) the relative risks of hospital admissions due to ACS were 1.043 (95%CI: 1.009-1.079, P = 0.014, lag 0) and 0.957 (95%CI: 0.925-0.990, P = 0.010, lag 1) for each 10ºC decrease in temperature; 1.049 (95% CI: 1.015-1.084, P = 0.004, lag 0) and 1.045 (95%CI: 1.011-1.080, P = 0.008, lag 1) for each 10 hPa decrease in atmospheric pressure and 1.180 (95% CI: 1.078-1.324, P = 0.007, lag 0) for every 10ºC change in temperature. For the first half of the study the risk was significantly lower. Conclusion We observed a shift in the seasonal peak of ACS occurrence from winter to spring which may be related to temperature fluctuation associated with climate change in this season. The lowest frequency of ACS took place on weekends. Atmospheric changes had a much more pronounced effect on admissions due to ACS in the second half of the analyzed period, which is in line with the dynamics of global climate change.

scholarly journals Validation of the French version of the Wisconsin Quality of Life (WISQOL) questionnaire for patients with urolithiasis

2020 ◽  
Vol 15 (4) ◽  
Author(s):  
Naeem Bhojani ◽  
Ghizlane Moussaoui ◽  
David-Dan Nguyen ◽  
Mei Juan Trudel ◽  
Garo-Shant Topouzian ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Internal Consistency ◽  
Tertiary Care ◽  
Rank Correlation ◽  
French Version ◽  
Spearman’S Rank Correlation ◽  
Significant Difference ◽  
Back Translation ◽  
One Way Anova

Introduction: The Wisconsin Stone Quality of Life (WISQOL) questionnaire has been recently developed to objectively assess QOL in patients with urolithiasis. However, French version of the questionnaire was lacking. Therefore, the aim of the present study was to develop and validate the French version of this tool. Methods: The French version of the WISQOL (F-WISQOL) was developed in a multi-step process involving primary translation, back-translation and pilot testing amongst a group of patients (n=12). Urolithiasis patients from two tertiary care institutions were recruited into this study and completed 3 questionnaires: Perceived Stress Scale-10, medical history form and either the WISQOL or F-WISQOL. Internal consistency was assessed using Cronbach’s α and inter-domain associations were evaluated using Spearman’s rank correlation (r). One-way ANOVA was used to compare scores from the two groups (WISQOL and F-WISQOL). Results: A total of 210 patients were enrolled in this study; 68 in the WISQOL group and 148 in the F-WISQOL group. Internal consistency was high for all domains in both groups (F-WISQOL: 0.924-0.970; WISQOL: 0.888-0.965). No statistically significant difference was found between the two groups’ scores. Inter-domain association, measured by Spearman correlation, was moderate to very strong between all of the domains in the F-WISQOL. Values ranged from r=0.676-0.915, with acceptable correlation between D1, D2 and D3, but weaker correlation between D4 (vitality) and the 3 other domains r=0.676-0.729. Conclusions: In the present study, the French version of the WISQOL questionnaire (F-WISQOL) was validated at two academic institutions.

scholarly journals Editor’s Choice- Diagnosis of type 2 diabetes and prediabetes among patients with acute coronary syndromes

2016 ◽  
Vol 6 (8) ◽  
pp. 744-749 ◽  
Author(s):  
Thorarinn A Bjarnason ◽  
Linda B Kristinsdottir ◽  
Erna S Oskarsdottir ◽  
Steinar O Hafthorsson ◽  
Isleifur Olafsson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Acute Coronary Syndromes ◽  
Coronary Syndromes

Heat Production of Atherosclerotic Plaques and Inflammation Assessed by the Acute Phase Proteins in Acute Coronary Syndromes

2000 ◽  
Vol 32 (1) ◽  
pp. 43-52 ◽  
Author(s):  
Christodoulos Stefanadis ◽  
Leonidas Diamantopoulos ◽  
John Dernellis ◽  
Emanuel Economou ◽  
Eleftherios Tsiamis ◽  
...  
Keyword(s):  
Acute Phase ◽  
Heat Production ◽  
Acute Coronary Syndromes ◽  
Acute Phase Proteins ◽  
Atherosclerotic Plaques ◽  
Coronary Syndromes

scholarly journals Clinical, Instrumental, Serological and Histological Findings Suggest That Hemophilia B May be Less Severe Than Hemophilia A

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 4682-4682
Author(s):  
Giancarlo Castaman ◽  
Daniela Melchiorre ◽  
Silvia Linari
Keyword(s):  
Synovial Tissue ◽  
Hemophilia A ◽  
Conflicts Of Interest ◽  
Severe Disease ◽  
Rank Correlation ◽  
Mean Value ◽  
Hemophilia B ◽  
Severe Hemophilia ◽  
Chi Square ◽  
Spearman’S Rank Correlation

Abstract Background: Recent evidences suggest that patients with severe hemophilia B (HB) may have a less severe disease compared to severe hemophilia A (HA). Objectives: to investigate clinical, radiological, laboratory and histological differences in the arthropathy of severe HA and HB. Patients/Methods: 70 HA and 35 HB patients with at least one joint bleeding were consecutively enrolled. In all patients were assessed: joint bleedings (<10, 10-50, >50), regimen of treatment (prophylaxis/on demand), WFH, Pettersson and ultrasound (US) scores, serum sRANKL and OPG. Expression of RANK, RANKL and OPG was also evaluated in synovial tissue from 18 HA and 4 HB patients. Chi-square test, T-test, Mann-Whitney and Spearman's rank correlation coefficient were performed. Results: The percentage of patients with either 10-50 or >50 hemarthrosis was greater in HA than in HB (p< 0.001 and p = 0.03, respectively); that with <10 hemarthrosis was higher in HB (p < 0.0001). The mean value of WFH (36.6 vs 20.2;p <0.0001) and US scores (10.9 vs 4.3;p <0.0001) were significantly higher in HA patients. Serum OPG and s RANKL were decreased in HA versus HB (p<0.0001 and p=0.006, respectively) and also in HA patients with>50 hemarthrosis. The expression of OPG was markedly reduced in synovial tissue from HA patients. Conclusions: The reduced number of hemarthrosis, the lower WFH and US scores and higher OPG levels in serum and expression in synovial tissue in HB suggest that HB is a less severe disease than HA. OPG reduction seems to play a pivotal role in the progression of arthropathy in HA. Disclosures No relevant conflicts of interest to declare.

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