Is basic science falling behind? A mixed methods study of bibliometric data and expert interviews in the field of cardiovascular research

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M Lichtenauer

Abstract Introduction Scientists in the field of cardiovascular research face many difficulties today and find themselves under considerable pressure to be successful with their projects and publish their results on a regular basis (the publish or perish aphorism). Purpose The objective of this mixed methods study that included quantitative and qualitative research methods was to analyse prospects of scientific success and how scientists see opportunities, risks and how they try to adapt to the current publication system. Methods An analysis of all publications that were published by our department in the years 2014–2019 (total of 104 publications) was performed. Publications were allocated to the sub-categories basic science, clinical science, register studies/database studies and others (letters, reviews, editorials). Further specific characteristics (impact factor, number of authors/institutions, utilization of an animal model and project costs) were also collected. Furthermore, a total of 14 interviews with experts in the field of cardiovascular research were conducted. Interviews were recorded and transcribed. For quantitative text analysis MaxQDA software and the method proposed by Philipp Mayring was used. Results When analysing the publication output of our department we found that achieved impact factors points were equally distributed between basic science, clinical science and register/database studies. Project costs were considerable higher for basic science studies compared to clinical studies and even more to register/database studies (p=0.0001). A correlation between costs and impact factor was found for basic science studies only (r=0.66, p=0.004). A multivariable regression analysis showed that project costs, number of authors and the use of an animal model, but not the number of institutions, was associated with a higher impact factor. Experts in the field shared the opinion that it might be “easier” to be successful with clinical science studies as they require less resources such as grant money, personnel and technical equipment. Moreover, upcoming risks such as competition for grant money, pressure to publish results, inadequacy of the impact factor system, securing ones job, rising publication costs and more pressure of time due to patient care, research and teaching duties for academic personnel were also highlighted to worsen the situation. Conclusion Based on own data and the views of experts it seems much more effort- and cost-efficient to pursue projects in clinical science. Researchers in the current academic system are pressured by multiple risks. After interpretation of the obtained quantitative and qualitative material, one could hypothesize that it might be easier to be successful with focussing on clinical studies when starting ones research career. These data give support to the concerns that the field of basic science might fall behind and less young scientists would opt for a career path in this field. Funding Acknowledgement Type of funding source: None

2018 ◽  
Vol 29 (2) ◽  
pp. 148-157 ◽  
Author(s):  
Edoardo Villani ◽  
Stela Vujosevic ◽  
Claudia Specchia ◽  
Filippo Tresca Carducci ◽  
Stefano De Cillà ◽  
...  

Purpose: To investigate the 2- and 5-year publication rates of abstracts presented at major international ophthalmology meetings. Methods: We analyzed a random selection of 20% of free papers and posters presented at the 2010 meeting of the Association for Research in Vision and Ophthalmology, the American Academy of Ophthalmology, the European Association for Vision and Eye Research, the Asia-Pacific Academy of Ophthalmology, and the 2009 European Society of Ophthalmology meeting. The PubMed (MEDLINE) database was searched to identify matching journal articles. Data collection included: topic, geographic origin, presentation type, publication status, and impact factor. A multivariate logistic regression model was used to assess odds of publication and impact factor. Results: Our analysis included 1742 research abstracts. The overall 2- and 5-year publication rates were 33.3% (n = 579) and 47.2% (n = 823), respectively. The highest publication rates were found for Association for Research in Vision and Ophthalmology (36.1% and 51.9%, p < 0.0001), paper presentations (44.5% and 60.5%, p < 0.0001), researches from Oceania (35.8% and 57.1%, p < 0.05) and North America (36.2% and 50.5%, p < 0.05), and Basic science studies (44% and 60.3%, p < 0.01). After adjustments, higher odds of publication were shown by the Association for Research in Vision and Ophthalmology and the American Academy of Ophthalmology meetings (p < 0.0001), papers (p < 0.0001), and Basic science (p < 0.05). The median impact factor was 3.20 (interquartile range = 1.90–3.40). Conclusion: Less than half of abstracts presented at the major ophthalmology meetings reach publication within 5 years of their initial presentation. Professionals attending meetings may consider adopting a more critical approach to the preliminary results reported in presented abstracts. Increasing publication rates and reducing potential publication bias is of interest.


2020 ◽  
Vol 116 (12) ◽  
pp. e165-e168
Author(s):  
Adam M Sheikh ◽  
Heather Y Small ◽  
Charalambos Antoniades ◽  
Tomasz J Guzik

2021 ◽  
Vol 53 (1) ◽  
pp. 3-19
Author(s):  
Robert Lücking

AbstractPeter D. Crittenden served as senior editor of The Lichenologist, the flagship journal in the field of lichenological research, for a period of two decades, between 2000 and 2019. A review of the development of the journal and the publication output during this period is provided. The number of papers published during this period (1197) matches that of all papers published under the three previous senior editors, Peter W. James, David L. Hawksworth and Dennis H. Brown, during a much longer period of 42 years from 1958 to 1999. Peter oversaw important editorial changes to the layout and content of the journal: an increased size with a modern cover design, leaving behind the classic mint-coloured cover of more than 40 years; the addition of ‘thematic issues’ and encouragement of large monographs; implementation of substantial changes to the Code, such as effective electronic publication and obligate registration of new fungal names; and more recently a new policy to reject so-called ‘single naked species descriptions’. Shortly before Peter took over as senior editor, The Lichenologist had received its first impact factor, and Peter managed to continuously increase this measure from around 0.9 to lately up to over 1.5, higher than most other competing journals. The 1197 papers between 2000 and 2019 were published by a total of 1138 different authors, more than half of whom appeared just once as author, whereas a small number participated in numerous (up to 93) papers. There was a continuous increase in the mean number of authors per paper per year, from below 2.5 to around 3.5, the highest numbers ranging between 11 and 30; still, c. 75% of all papers between 2000 and 2019 were single-authored or had up to three authors. Based on affiliations at the time of publication, two thirds of author contributions came from Europe (66%), 13% from North America, 9% from Asia and 7% from Latin America. Likewise, almost half of the study areas were located in Europe and around 10% each in North America, South America and Asia. The countries with the highest number of studies included, in descending order, the United States, Spain, the United Kingdom, Norway and Sweden. North America and Europe were over-represented in terms of author contributions, whereas Africa, Latin America, Australia and Oceania were over-represented in terms of study areas. The 1197 papers analyzed encompassed a broad diversity of topics, classified into 32 categories. Taxonomy of lichenized fungi was the most frequent component, representing the focal point in almost half of all studies, followed by phylogeny and evolution, ecology, and the taxonomy of lichenicolous fungi. Around two thirds of the currently accepted genera of lichenized fungi were treated, with a significant correlation between known species richness and the number of papers in which a genus was treated, underlining the taxonomic representativity of papers published in the journal during the past two decades. Examples of genera that were treated more frequently than expected included commonly studied model organisms, such as Lobaria, and those frequently featured in ecological or other non-taxonomic studies, such as Xanthoria. Species-rich tropical genera, particularly in the Graphidaceae, were generally under-represented. Mean number of authors per paper per volume and total number of country origins of authors per volume were the best predictors of impact factor, followed by diversity of study countries per volume, mean number of study countries per paper per volume, mean number of topics per paper per volume, and proportion of studies with phylogenetic components per volume. Individual papers that contributed to high impact factors included broad-scale revisionary treatments and worldwide keys to species-rich taxa, substantial phylogenetic reclassifications of known taxonomic groups, papers dealing with novel methodological approaches of broad interest, and broad-scale studies related to environmental change and lichen biomonitoring.


2020 ◽  
Vol 10 (2) ◽  
pp. 20-28
Author(s):  
Alka Gupta ◽  
Rabindra Man Shrestha ◽  
Sujita Shrestha ◽  
Asal Acharya ◽  
Nashib Pandey

Introduction: The spread of COVID-19 pandemic has gripped the entire world and caused widespread public health concerns, hampered economics and education system immensely. Online classes have been an alternative to give continuity to the theory classes. The objective of this study is to assess the various aspects of online classes and perception of Bachelor of Dental Surgery (BDS) students of Kathmandu University (KU) during COVID-19 pandemic. Materials and Method: Cross-sectional, questionnaire based descriptive study using online Google form was distributed among the BDS students of KU. The questionnaire was distributed via social media. Frequency distribution of the descriptive data was done. Chi-square test was done to assess the difference in perception about online classes between the basic science and clinical science students. Result: 89% of the students had never attended any online classes before online education due to COVID-19 pandemic. 76.9% agreed that the online class is distracting. 57.5% used smartphone for seeking online class and medium most frequently used was Zoom platform. 70.2% students could ask questions, communicate & receive response during online class. 55.4% students disagreed that online classes are more effective. Statistical significant differences were seen in students submitting assignments, communication and practical simulation among basic science and clinical science students. Conclusion: Online class can serve as an alternative effective educational tool. With more practice, system upgrading, capacity building of the student-teacher; it is bound to be more effective as well as efficient. The online class should be designed in such a way that student can focus and find it more interesting and should introduce various strategies to increase the interaction between students and teachers. Further, training on online class is required for both course recipients and providers.


Spine ◽  
1999 ◽  
Vol 24 (23) ◽  
pp. 2419 ◽  
Author(s):  
Kotaro Nishida ◽  
James D. Kang ◽  
Lars G. Gilbertson ◽  
Seong-Hwan Moon ◽  
Jun-Kyo Suh ◽  
...  

2019 ◽  
Vol 28 (153) ◽  
pp. 190029 ◽  
Author(s):  
Toyoshi Yanagihara ◽  
Seidai Sato ◽  
Chandak Upagupta ◽  
Martin Kolb

Idiopathic pulmonary fibrosis is a fatal age-related lung disease characterised by progressive and irreversible scarring of the lung. Although the details are not fully understood, there has been tremendous progress in understanding the pathogenesis of idiopathic pulmonary fibrosis, which has led to the identification of many new potential therapeutic targets. In this review we discuss several of these advances with a focus on genetic susceptibility and cellular senescence primarily affecting epithelial cells, activation of profibrotic pathways, disease-enhancing fibrogenic cell types and the role of the remodelled extracellular matrix.


2020 ◽  
Vol 8 (8) ◽  
pp. 232596712094531 ◽  
Author(s):  
Matthew J. Kraeutler ◽  
Gianna M. Aliberti ◽  
Anthony J. Scillia ◽  
Eric C. McCarty ◽  
Mary K. Mulcahey

Background: Microfracture (MFx) is one of the most common techniques used for the treatment of articular cartilage defects, although recently there has been a trend toward the use of drilling rather than MFx for the treatment of these defects. Purpose: To perform a systematic review of basic science studies to determine the effect of microfracture versus drilling for articular cartilage repair. Study Design: Systematic review. Methods: A systematic review was performed by searching PubMed, the Cochrane Library, and EMBASE to identify basic science studies comparing outcomes of MFx versus drilling. The search phrase used was microfracture AND (drilling OR microdrilling). Inclusion criteria were basic science studies that directly compared the effect of MFx versus drilling on subchondral bone, bone marrow stimulation, and cartilage regeneration. Results: A total of 7 studies met the inclusion criteria and were included in this systematic review. Of these, 4 studies were performed in rabbits, 1 study in sheep, and 2 studies in humans. All of the included studies investigated cartilage repair in the knee. In the animal studies, microfracture produced fractured and compacted bone and led to increased osteocyte necrosis compared with drilling. Deep drilling (6 mm) was superior to both shallow drilling (2 mm) and MFx in terms of increased subchondral hematoma with greater access to marrow stroma, improved cartilage repair, and increased mineralized bone. However, the overall quality of cartilage repair tissue was poor regardless of marrow stimulation technique. In 2 studies that investigated repair tissue after MFx and/or drilling in human patients with osteoarthritis and cartilage defects, the investigators found that cartilage repair tissue did not achieve the quality of normal hyaline articular cartilage. Conclusion: In the limited basic science studies that are available, deep drilling of cartilage defects in the knee resulted in improved biological features compared with MFx, including less damage to the subchondral bone and greater access to marrow stroma. Regardless of marrow stimulation technique, the overall quality of cartilage regeneration was poor and did not achieve the characteristics of native hyaline cartilage. Overall, there is a general lack of basic science literature comparing microfracture versus drilling for focal chondral defects.


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