scholarly journals Longer sustained Fontan circulation is associated with prolonged hepatic T1 relaxation time on T1 mapping

2021 ◽  
Vol 22 (Supplement_2) ◽  
Author(s):  
A Yanovskiy ◽  
T Ojala ◽  
R Kivisaari ◽  
L Martelius
Keyword(s):  
Relaxation Time ◽  
Liver Disease ◽  
T1 Mapping ◽  
Single Ventricle ◽  
Venous Pressure ◽  
Relaxation Times ◽  
Hemodynamic Parameters ◽  
T1 Relaxation Time ◽  
T1 Relaxation ◽  
Systemic Ventricle

Abstract Funding Acknowledgements Type of funding sources: None. Background Patients with single ventricle defects may develop Fontan-associated liver disease. T1 mapping has been successfully used for evaluating chronic liver disease in adults. Liver T1 mapping has been also studied in the pediatric patients with single ventricles, and these patients show higher T1 relaxation times compared to the healthy controls. Purpose Our objective was to study the relationship between the cardiac MRI (CMR) T1 mapping relaxation time of the liver and 1) CMR derived hemodynamic parameters, 2) peripheral venous pressure (PVP) measured from a cubital cannula 3) systemic ventricle morphology [LV vs. RV], 4) the age of patient, and 5) alanine transaminase (P-ALAT) levels. Methods This retrospective study included 46 patients with functional single ventricle, which underwent routine CMR at our hospital. Table 1 shows demographic and clinical data of the study population. Statistical analysis were performed with IBM SPSS Statistics v.25 software using independent samples t test, Mann-Whitney U-test or Pearson correlation as appropriate. A p-value less than 0.05 was considered significant. Results The average T1 relaxation time of the liver was longer in patients with RV morphology (p = 0.004). There was a significant moderate positive correlation between the age of the patients and hepatic T1 relaxation time (r = 0.45, p = 0.002), and between hepatic T1 relaxation time and P-ALAT levels (r = 0.5, p = 0.016) (Fig.1).  No significant correlations were detected between the T1 times of the liver and hemodynamic parameters of the heart (all tested parameters are listed in the Table1). Ejection fraction and PVP showed a non-significant weak correlation with a hepatic T1 relaxation times (r=-0.3, p = 0,056 and r = 0.3, p = 0,070, respectively). Conclusions  T1 mapping times of the liver may reflect Fontan-associated liver disease. We observed connections between the hepatic T1 relaxation times and 1) patients age, 2) systemic ventricle morphology and 3) P-ALAT levels.

MTR and T1 provide complementary information in MS NAWM, but not in lesions

2000 ◽  
Vol 6 (5) ◽  
pp. 327-331 ◽  
Author(s):  
C M Griffin ◽  
G JM Parker ◽  
G J Barker ◽  
A J Thompson ◽  
D H Miller
Keyword(s):  
Relaxation Time ◽  
White Matter ◽  
Mixed Model ◽  
Relaxation Times ◽  
Tissue Type ◽  
Tissue Characterisation ◽  
Complementary Information ◽  
T1 Relaxation Time ◽  
T1 Relaxation ◽  
The Relationship

MTR and T1 relaxation times are abnormal in MS lesions and NAWM, and may reflect tissue damage such as demyelination and axonal loss. Their relationship and potential to provide complementary information in tissue characterisation is explored. The aim of this study was to document the relationship between magnetisation transfer ratio (MTR) and T1 relaxation time in Multiple Sclerosis (MS) lesions and normal appearing white matter (NAWM) in order to determine whether the combination provides a more comprehensive tissue characterisation than either parameter in isolation. Ten patients with relapsing remitting MS and 10 age matched healthy controls underwent imaging using a protocol which included the measurement of both MTR and T1 relaxation times. The MTR and T1 values were compared statistically using a commonly adopted correlation approach and a mixed-model regression approach. There was a strong correlation between MTR and T1 in MS lesions (r=0.74). The correlation was seen equally in T1 hypointense and isointense lesions. The relationship was much weaker in MS NAWM (r=0.24) and no correlation was found in control white matter (r=0.06). Mixed-model regression analysis confirmed that the relationship between T1 and MTR is strongly dependent upon tissue type (MS lesion, MS NAWM, or control white matter). The relationship between MTR and T1 relaxation time measurements varies markedly between pathological and normal tissue types. In MS, the complementary information obtained from MTR and T1 is most apparent in NAWM. The results emphasise the potential for combinations of MR parameters to improve tissue characterisation, which in turn should improve understanding of disease pathology and treatment monitoring.

Single- vs. double-dose gadolinium contrast in delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in knee osteoarthritis: is dose reduction possible on 3-T MRI?

2018 ◽  
Vol 60 (6) ◽  
pp. 749-754
Author(s):  
Stine Hangaard ◽  
Jesper Sörensson Gade ◽  
Philip Hansen ◽  
Janus Damm Nybing ◽  
Henrik Gudbergsen ◽  
...  
Keyword(s):  
Relaxation Time ◽  
Single Dose ◽  
Knee Osteoarthritis ◽  
Weight Bearing ◽  
Relaxation Times ◽  
Lateral Compartment ◽  
Double Dose ◽  
Gadolinium Contrast ◽  
T1 Relaxation Time ◽  
T1 Relaxation

Background Reduction in gadolinium (Gd) contrast agents is wanted due to the uncertainty of the potential side effects. Purpose To investigate whether it is possible to reduce the contrast dose from conventional double dose to single dose when increasing the field strength from 1.5-T to 3-T for separating early cartilage degeneration from healthy cartilage, assessed by delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC). Material and Methods Nine patients with knee osteoarthritis (OA), Kellgren–Lawrence grade (KLG) 1–4, were recruited from an ongoing weight loss cohort study. dGEMRIC was performed at 3-T using single (0.1 mmoI/kg) and double (0.2 mmoI/kg) doses of intravenous (i.v.) Gd-DTPA2-. Regions of interest (ROls) were drawn around the posterior weight-bearing femoral knee cartilage in lateral and medial compartments. In five medial compartments ROIs could not be drawn due to severe degeneration of cartilage. T1-relaxation times were compared to previously published values from 1.5-T and to non-contrast values from 3-T. Results Mean dGEMRIC T1-relaxation time in the lateral compartment was 769 ms for single dose vs. 561 ms for double dose ( P < 0.0001); and 685 ms for single dose vs. 454 ms for double dose ( P = 0.004) in the medial compartment. Conclusion We found a dose-response relationship between single and double doses of Gd-DTPA2- using 3-T in knee OA patients, similar to the findings at 1.5-T. Compared to the T1-relaxation time at 3-T without contrast (1240 ms), this further separation between OA and normal cartilage indicates that “single dose” dGEMRIC could be sufficient for cartilage health assessment at 3-T.

Cardiac magnetic resonance using T1 mapping for assessment of late cancer therapeutics-related cardiotoxicity in childhood cancer survivors

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
R Panovsky ◽  
T Kepak ◽  
L Opatril ◽  
L Masarova ◽  
T Holecek ◽  
...  
Keyword(s):  
Heart Failure ◽  
Relaxation Time ◽  
T1 Mapping ◽  
Cardiac Involvement ◽  
Cancer Therapeutics ◽  
Childhood Cancer Survivors ◽  
Funding Source ◽  
T1 Relaxation Time ◽  
T1 Relaxation ◽  
Lv Ejection Fraction

Abstract Introduction Due to cardiotoxic treatment, childhood cancer survivors (CCS) are at 15-fold increased risk of developing chronic heart failure and are at 7-fold higher risk of premature death due to cardiac causes compared with the general population. Cardiac magnetic resonance (CMR) has the potential to detect early cardiac involvement with consecutive possibilities of preventive steps against the development of advanced stages of heart failure. So far, only a few studies using T1mapping in CCS monitoring have been published. Purpose This study aimed to assess early cardiac involvement in a population of CCS using T1 mapping. Methods One hundred five CCS of age 24,9±5,4 years were included, mean time since the end of cancer-therapeutics treatment was 12,2±5,8 years. One hundred of them underwent complete CMR examination at 1,5T scanner. Cine images for assessment of left ventricular (LV) volumetric and functional parameters, pre- and post-contrast Modified Look-Locker Inversion recovery (MOLLI) images were acquired for assessment of native T1 relaxation time and extracellular volume (ECV), and delayed postcontrast images for evaluation of late gadolinium enhancement (LGE). The measured parameters were compared between CCS patients and 50 healthy controls. Results CCS patients had not enlarged LV (end-diastolic volume 128±30ml vs 124±30ml, p=NS) and normal, although lower systolic LV function than the controls – LV ejection fraction 59±6% vs 67±5% (p&lt;0,05). In CCS group, only 3 (3%) patients had LV ejection fraction &lt;50%, four (4%) patients had regional LV hypokinesia, and small non-ischemic LGE was found in 4 (4%) patients. Mean native T1 relaxation time was not prolonged - 987±31 msec vs 986±24msec (p=NS), and mean ECV value was not increased – 24,6±5,3% vs 23,8±2,3% (p=NS). Conclusion In this study, the late cancer therapeutics-related cardiotoxicity was quite low. Native and postcontrast T1mapping did not show any significant subclinical myocardial involvement. Funding Acknowledgement Type of funding source: Public grant(s) – EU funding. Main funding source(s): Supported by the European Regional Development Fund - Project ENOCH (no. CZ.02.1.01/0.0/0.0/16_019/0000868)

scholarly journals Value of T1 Mapping on Gadoxetic acid-enhanced MRI for Microvascular Invasion of Hepatocellular Carcinoma: A Retrospective Study

2020 ◽  
Author(s):  
chenyi Rao ◽  
Xinquan Wang ◽  
Minda Li ◽  
Guofeng Zhou ◽  
Hongmei Gu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Relaxation Time ◽  
T1 Mapping ◽  
Operating Characteristic ◽  
Reduction Rate ◽  
Gadoxetic Acid ◽  
T1 Relaxation Time ◽  
T1 Relaxation ◽  
Enhanced Mri ◽  
Adc Values

Abstract Background: To evaluate the utility of non-invasive parameters driving from T1 mapping on gadoxetic acid-enhanced MRI for predicting microvascular invasion (MVI) of hepatocellular carcinoma (HCC) compared with diffusion-weighted imaging (DWI).Methods: A total of 94 patients with single HCC undergoing partial hepatectomy was included in the retrospective study, who underwent preoperative gadoxetic acid-enhanced MRI combined with DWI and T1 mapping. Parameters including precontrast, postcontrast and reduction rate of T1 relaxation time and ADC values were measured for differentiating MVI-positive HCCs (n=38) from MVI-negative HCCs (n=56). The receiver operating characteristic curve (ROC) was analyzed to compare the diagnostic performance of the calculated parameters.Results: The mean value of postcontrast T1 relaxation time were significantly higher in MVI-positive HCCs that MVI-negative HCCs (621.0 vs. 536.5, P <0.001). MVI-positive HCCs demonstrated significantly lower reduction rates of T1 relaxation time and lower ADC values than MVI-negative HCCs (39.4% vs 49.9, P<0.001; 1.495×10-3mm2/s vs 1.620×10-3mm2/s, P=0.003, respectively). The area under receiver operating characteristic curves were 0.587, 0.728, 0.824 and 0.690 for precontrast, postcontrast, reduction rate of T1 relaxation time and ADC, respectively. The reduction rate of T1 relaxation time was the most reliable feature with sensitivity, specificity and accuracy of the cut-off value (44.9%) of 79.0%, 73.2%, 75.5%, respectively.Conclusions: Reduction rate of T1 relaxation time on gadoxetic acid-enhanced MRI holds promise for evaluating MVI status of HCC.

scholarly journals P1604 T1 mapping in asymptomatic patients with extracardiac sarcoidosis

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
R Panovsky ◽  
M Doubkova ◽  
T Holecek ◽  
J Machal ◽  
V Feitova ◽  
...  
Keyword(s):  
Relaxation Time ◽  
Respiratory Tract ◽  
T1 Mapping ◽  
Left Ventricular ◽  
T1 Relaxation Time ◽  
Post Contrast ◽  
Native T1 ◽  
T1 Relaxation ◽  
Asymptomatic Patients ◽  
Molli Sequence

Abstract Funding Acknowledgements LQ1605 from the National Program of Sustainability II (MEYS CR) Introduction Sarcoidosis is a systemic granulomatous disease affecting in particular the respiratory tract. Estimated 5% of these patients have clinical symptoms of heart involvement. Real number of patients with cardiac sarcoidosis is thought to be higher (around 20-30%), because the granulomatous process is sometimes asymptomatic. Cardiac magnetic resonance (CMR) including T1 relaxation time measurement could potentially detect early asymptomatic stadia of sarcoidosis of the heart. Purpose The aim of this study was to assess T1 mapping in detection of early cardiac involvement in asymptomatic patients with sarcoidosis. Methods One hundred twenty patients with sarcoidosis of the respiratory tract and/or extrapulmonary sarcoidosis and without any heart disease history were included. One hundred thirteen of them underwent CMR examination at 3,0 MR scanner. Cine images for assessment of left ventricular (LV) volumetric and functional parameters, and pre- and post-contrast Saturation method using adaptive recovery times for cardiac T1 mapping (SMART1map) and Modified Look-Locker Inversion recovery (MOLLI) images were acquired for assessment of native T1 relaxation time and extracellular volume (ECV). The measured parameters were compared between sarcoidosis patients and 22 healthy controls. Results Sarcoidosis patients had not enlarged LV (end-diastolic volume 119 ± 24ml vs 97 ± 20ml, p = NS) and normal global and regional systolic LV function – LV ejection fraction (EF) 65 ± 5% vs 66 ± 7% (p = NS). Mean native T1 relaxation time was not prolonged - 1464 ± 93 msec vs 1482 ± 88msec (p = NS) measured by SMART1map and 1317 ± 60 msec vs 1313 ± 83msec (p = NS) measured using MOLLI sequence. Similarly, mean ECV value was not increased - 16,3 ± 3,4% vs 17,9 ± 3,7% (p = NS) measured by SMART1map and 30,9 ± 2,9msec vs 30,7 ± 5,0% (p = NS) measured using MOLLI sequence. Conclusion Myocardial native T1 relaxation time was not prolonged and ECV was not increased in asymptomatic patients with extracardiac sarcoidosis.

scholarly journals Magnetic Resonance Relaxometry for Tumor Cell Density Imaging for Glioma: An Exploratory Study via 11C-methionine PET and Its Validation via Stereotactic Tissue Sampling

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 4067
Author(s):  
Manabu Kinoshita ◽  
Masato Uchikoshi ◽  
Souichiro Tateishi ◽  
Shohei Miyazaki ◽  
Mio Sakai ◽  
...  
Keyword(s):  
Relaxation Time ◽  
Magnetic Resonance ◽  
Tumor Cell ◽  
Relaxation Times ◽  
Tissue Sampling ◽  
T2 Relaxation ◽  
T1 Relaxation Time ◽  
T1 Relaxation ◽  
Tumor Load ◽  
T1 And T2

One of the most crucial yet challenging issues for glioma patient care is visualizing non-contrast-enhancing tumor regions. In this study, to test the hypothesis that quantitative magnetic resonance relaxometry reflects glioma tumor load within tissue and that it can be an imaging surrogate for visualizing non-contrast-enhancing tumors, we investigated the correlation between T1- and T2-weighted relaxation times, apparent diffusion coefficient (ADC) on magnetic resonance imaging, and 11C-methionine (MET) on positron emission tomography (PET). Moreover, we compared the T1- and T2-relaxation times and ADC with tumor cell density (TCD) findings obtained via stereotactic image-guided tissue sampling. Regions that presented a T1-relaxation time of >1850 ms but <3200 ms or a T2-relaxation time of >115 ms but <225 ms under 3 T indicated a high MET uptake. In addition, the stereotactic tissue sampling findings confirmed that the T1-relaxation time of 1850–3200 ms significantly indicated a higher TCD (p = 0.04). However, ADC was unable to show a significant correlation with MET uptake or with TCD. Finally, synthetically synthesized tumor load images from the T1- and T2-relaxation maps were able to visualize MET uptake presented on PET.

scholarly journals Value of T1 Mapping on Gadoxetic acid-enhanced MRI for Microvascular Invasion of Hepatocellular Carcinoma: A Retrospective Study

2020 ◽  
Author(s):  
chenyi Rao ◽  
Xinquan Wang ◽  
Minda Li ◽  
Guofeng Zhou ◽  
Hongmei Gu
Keyword(s):  
Relaxation Time ◽  
T1 Mapping ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Reduction Rate ◽  
Gadoxetic Acid ◽  
T1 Relaxation Time ◽  
Adc Value ◽  
T1 Relaxation ◽  
Enhanced Mri

Abstract Background: To evaluate the utility of non-invasive parameters derived from T1 mapping and diffusion-weighted imaging (DWI) on gadoxetic acid-enhanced MRI for predicting microvascular invasion (MVI) of hepatocellular carcinoma (HCC).Methods: A total of 94 patients with single HCC undergoing partial hepatectomy was analyzed in this retrospective study. Preoperative T1 mapping and DWI on gadoxetic acid-enhanced MRI was performed. The parameters including precontrast, postcontrast and reduction rate of T1 relaxation time and apparent diffusion coefficient (ADC) values were measured for differentiating MVI-positive HCCs (n=38) from MVI-negative HCCs (n=56). The receiver operating characteristic curve (ROC) was analyzed to compare the diagnostic performance of the calculated parameters.Results: MVI-positive HCCs demonstrated a significantly lower reduction rate of T1 relaxation time than that of MVI-negative HCCs (39.4% vs 49.9, P<0.001). The areas under receiver operating characteristic curve (AUC) were 0.587, 0.728, 0.824, 0,690 and 0.862 for the precontrast, postcontrast, reduction rate of T1 relaxation time, ADC and the combination of reduction rate and ADC, respectively. The cut-off value of the reduction rate and ADC calculated through maximal Youden index in ROC analyses was 44.9% and 1553.5 s/mm2. To achieve a better diagnostic performance, the criteria of combining the reduction rate lower than 44.9% and the ADC value lower than 1553.5 s/mm2 was proposed with a high specificity of 91.8% and accuracy of 80.9%.Conclusions: The proposed criteria of combining the reduction rate of T1 relaxation time lower than 44.9% and the ADC value lower than 1553.5 s/mm2 on gadoxetic acid-enhanced MRI holds promise for evaluating MVI status of HCC.

scholarly journals Value of T1 Mapping on Gadoxetic acid-enhanced MRI for Microvascular Invasion of Hepatocellular Carcinoma: A Retrospective Study

2020 ◽  
Author(s):  
Chenyi Rao ◽  
Xinquan Wang ◽  
Minda Li ◽  
Guofeng Zhou ◽  
Hongmei Gu
Keyword(s):  
Relaxation Time ◽  
T1 Mapping ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Reduction Rate ◽  
Gadoxetic Acid ◽  
T1 Relaxation Time ◽  
Adc Value ◽  
T1 Relaxation ◽  
Enhanced Mri

Abstract Background: To evaluate the utility of non-invasive parameters driving from T1 mapping and diffusion-weighted imaging (DWI) on gadoxetic acid-enhanced MRI for predicting microvascular invasion (MVI) of hepatocellular carcinoma (HCC). Methods: A total of 94 patients with single HCC undergoing partial hepatectomy was analyzed in the retrospective study. Preoperative T1 mapping and DWI on gadoxetic acid-enhanced MRI was performed. The parameters including precontrast, postcontrast and reduction rate of T1 relaxation time and apparent diffusion coefficient (ADC) values were measured for differentiating MVI-positive HCCs (n=38) from MVI-negative HCCs (n=56). The receiver operating characteristic curve (ROC) was analyzed to compare the diagnostic performance of the calculated parameters. Results: MVI-positive HCCs demonstrated a significantly lower reduction rate of T1 relaxation time than that of MVI-negative HCCs (39.4% vs 49.9, P<0.001). The areas under receiver operating characteristic curve (AUC) were 0.587, 0.728, 0.824 and 0,690 for precontrast, postcontrast, reduction rate of T1 relaxation time and ADC, respectively. The cut-off value of the reduction rate and ADC calculated though maximal Youden index in ROC analyses was 44.9% and 1553.5 s/mm2. To achieve a better diagnostic performance, the criteria that combining the reduction rate lower than 44.9% and the ADC value lower than 1553.5 s/mm2 was proposed with a high specificity of 91.8% and accuracy of 80.9%. Conclusions: The criteria that combining the reduction rate of T1 relaxation time lower than 44.9% and the ADC value lower than 1553.5 s/mm2 on gadoxetic acid-enhanced MRI holds promise for evaluating MVI status of HCC.

scholarly journals T1 mapping of the liver and the spleen in patients with liver fibrosis—does normalization to the blood pool increase the predictive value?

2020 ◽  
Author(s):  
Verena Carola Obmann ◽  
Annalisa Berzigotti ◽  
Damiano Catucci ◽  
Lukas Ebner ◽  
Christoph Gräni ◽  
...  
Keyword(s):  
Relaxation Time ◽  
Liver Fibrosis ◽  
Portal Vein ◽  
Predictive Value ◽  
Good Predictor ◽  
Relaxation Times ◽  
Blood Pool ◽  
T1 Relaxation Time ◽  
T1 Relaxation ◽  
Significant Liver Fibrosis

Abstract Purpose To analyze whether the T1 relaxation time of the liver is a good predictor of significant liver fibrosis and whether normalization to the blood pool improves the predictive value. Methods This prospective study was conducted between 03/2016 and 02/2018. One hundred seventy-three patients underwent multiparametric liver MRI at 3 T. The T1 relaxation time was measured in the liver and the spleen, in the aorta, the portal vein, and the inferior vena cava (IVC). T1 relaxation times with and without normalization to the blood pool were compared between patients with (n = 26) and without (n = 141) significant liver fibrosis, based on a cutoff value of 3.5 kPa in MRE as the noninvasive reference standard. For statistics, Student’s t test, receiver operating characteristic (ROC) curve analysis, and Pearson’s correlation were used. Results The T1 relaxation time of the liver was significantly longer in patients with liver fibrosis, both with and without blood pool normalization (p < 0.001). T1 relaxation time of the liver allowed prediction of significant liver fibrosis (AUC = 0.88), while normalization to the IVC resulted in a slightly lower performance (AUC = 0.82). The lowest performance was achieved when the T1 relaxation times of the liver were normalized to the aorta (AUC = 0.66) and to the portal vein (AUC = 0.62). The T1 relaxation time of the spleen detected significant liver fibrosis with an AUC of 0.68, and 0.51–0.64 with normalization to the blood pool. Conclusion The T1 relaxation time of the liver is a good predictor of significant liver fibrosis. However, normalization of the blood pool did not improve the predictive value. Key Points • The T1 relaxation time of the liver is a good predictor of significant liver fibrosis. • Normalization to the blood pool did not improve the predictive value of T1 mapping. • If the blood pool normalization was weighted 30% to the aorta and 70% to the portal vein, the performance was better than normalization to the aorta alone but still lower than normalization to the IVC.

scholarly journals Value of T1 Mapping on Gadoxetic acid-enhanced MRI for Microvascular Invasion of Hepatocellular Carcinoma: A Retrospective Study

2020 ◽  
Author(s):  
chenyi Rao ◽  
Xinquan Wang ◽  
Minda Li ◽  
Guofeng Zhou ◽  
Hongmei Gu
Keyword(s):  
Relaxation Time ◽  
T1 Mapping ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Reduction Rate ◽  
Gadoxetic Acid ◽  
T1 Relaxation Time ◽  
Adc Value ◽  
T1 Relaxation ◽  
Enhanced Mri

Abstract Background: To evaluate the utility of non-invasive parameters derived from T1 mapping and diffusion-weighted imaging (DWI) on gadoxetic acid-enhanced MRI for predicting microvascular invasion (MVI) of hepatocellular carcinoma (HCC). Methods: A total of 94 patients with single HCC undergoing partial hepatectomy was analyzed in this retrospective study. Preoperative T1 mapping and DWI on gadoxetic acid-enhanced MRI was performed. The parameters including precontrast, postcontrast and reduction rate of T1 relaxation time and apparent diffusion coefficient (ADC) values were measured for differentiating MVI-positive HCCs (n=38) from MVI-negative HCCs (n=56). The receiver operating characteristic curve (ROC) was analyzed to compare the diagnostic performance of the calculated parameters. Results: MVI-positive HCCs demonstrated a significantly lower reduction rate of T1 relaxation time than that of MVI-negative HCCs (39.4% vs 49.9, P <0.001). The areas under receiver operating characteristic curve (AUC) were 0.587, 0.728, 0.824, 0,690 and 0.862 for the precontrast, postcontrast, reduction rate of T1 relaxation time, ADC and the combination of reduction rate and ADC, respectively. The cut-off value of the reduction rate and ADC calculated through maximal Youden index in ROC analyses was 44.9% and 1553.5 s/mm 2 . To achieve a better diagnostic performance, the criteria of combining the reduction rate lower than 44.9% and the ADC value lower than 1553.5 s/mm 2 was proposed with a high specificity of 91.8% and accuracy of 80.9%. Conclusions: The proposed criteria of combining the reduction rate of T1 relaxation time lower than 44.9% and the ADC value lower than 1553.5 s/mm 2 on gadoxetic acid-enhanced MRI holds promise for evaluating MVI status of HCC.

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