Biomarkers of orthodontic tooth movement with fixed appliances and vibration appliance therapy: a pilot study

2020 ◽  
Vol 42 (4) ◽  
pp. 378-386 ◽  
Author(s):  
Stacey Reiss ◽  
Marie Claude Chouinard ◽  
Dasha Frias Landa ◽  
Ravindra Nanda ◽  
Taranpreet Chandhoke ◽  
...  
Keyword(s):  
Tooth Movement ◽  
Bone Remodelling ◽  
Orthodontic Tooth Movement ◽  
Small Sample ◽  
Fixed Appliance ◽  
Time Points ◽  
Salivary Biomarkers ◽  
Anterior Teeth ◽  
Fixed Appliances ◽  
Time Point

Summary Introduction The aim of this study was to investigate the effect of supplemental vibratory force on biomarkers of bone remodelling during orthodontic tooth movement, the rate of mandibular anterior alignment (RMAA), and compliance with a vibration device. Design, settings, and participants Forty patients between the ages 15–35 undergoing fixed appliance treatment that presented to a university orthodontic clinic were randomly allocated to supplemental use of an intraoral vibrational device (n = 20, AcceleDent®) or fixed appliance only (n = 20). Salivary multiplex assay was completed to analyse the concentration of selected biomarkers of bone remodelling before treatment (T0) and at three following time points (T1, T2, T3), 4–6 weeks apart. Irregularity of the mandibular anterior teeth and compliance was assessed at the same trial time points. Data were analysed blindly on an intention-to-treat basis with descriptive statistics, Mann–Whitney U-test, Wilcoxon signed-rank test, and linear mixed effects regression modelling. Results No difference in the changes in salivary biomarkers of bone remodelling and RMAA between groups at any time point over the trial duration was observed. No correlation was found between changes in irregularity and biomarker level from baseline to another time point. Lastly, there was no association between RMAA and compliance with the AcceleDent® device. Conclusions Supplemental vibratory force during orthodontic treatment with fixed appliances does not affect biomarkers of bone remodelling or the RMAA. Limitations The main limitation of the study was the small sample size and the large variability in the salivary biomarkers. Harms No harms were observed during the duration of the trial. Protocol The protocol was not published prior to trial commencement. Registration The study was registered in Clinical Trials.gov (NCT02119455) first posted on April 2014.

The Comparison of Ostecyte in the Pressure area and Tension area on Tooth Movement Because of Hyperbaric Oxygen Therapy

DENTA ◽  
2018 ◽  
Vol 12 (1) ◽  
pp. 34
Author(s):  
Arya Barahmanta ◽  
Muhammad Faizal Winaris ◽  
Pambudi Raharjo
Keyword(s):  
Hyperbaric Oxygen ◽  
Oxygen Therapy ◽  
Tooth Movement ◽  
Bone Remodelling ◽  
Orthodontic Tooth Movement ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Pressure Area

<p><strong><em>Background:</em></strong><em> Orthodontic tooth movement is a </em><em>interaction prosess</em><em> of resorption and deposition of bone remodeling. Orthodontic tooth movement by mechanical strength causes changes in alveolar bone. Osteocyte is an essential cell to respond bone remodelling. Hyperbaric Oxygen Therapy affects production of osteocyte because it can release Reactive Oxygen Species (ROS) and Nitrid Oxide (NO).  <strong>Purpose: </strong>To determine the difference number  of osteocyte in pressure and tension area during tooth movement by adjuvant of Hyperbaric Oxygen 2,4 ATA during 7 days starting on day 8 to day 14. <strong>Materials and Methods</strong>: This research used Completery Randomized Control Group Post Test Only Design. 36 cavia cobaya (male)  were divided into 3 groups randomly : the negative control groups, positive control group, and treatment group. Preparat staining used Hematoxylin Eosin (HE) and calculated on microscop 1000x with 20 field of view. Data analyses used one way ANOVA and LSD test then compared each area by using paired T test. <strong>Result:</strong> The data showed that the treatment group (P=10,67) tension area has the highest number of osteocyte than  negative control group (K-=3,67), positive control (K+=7,42). In the pressure area showed that negative control group (K-=5,00) has the highest  than positive control group (K+=3,83) and treatment (P=3,25). <strong>Conclusion: </strong>Therapy HBO 2,4 ATA 7 days starting on day 8 to day 14 is could increase osteocyte in the tissue to stimulate process of bone remodelling.</em></p><pre><strong> </strong></pre><p><strong><em>Keywords:</em></strong><em> Hyperbaric Oxygen, Tooth movement, Bone remodeling, </em><em>Osteocyte</em><em></em></p><p><em> </em></p><p><strong><em>Correspondence:</em></strong><em> </em><em>Arya Brahmanta</em><em>, Department of Orthodonty, Faculty of Dentistry, Hang Tuah University, Arif Rahman Hakim 150, Surabaya, Phone 031-5945864, Email:</em><em> </em><a href="mailto:[email protected]"><em>arya.brahmanta</em><em>@</em><em>hangtuah.ac.id</em></a></p>

scholarly journals Finite Element Analysis of Mandibular Anterior Teeth with Healthy, but Reduced Periodontium

2021 ◽  
Vol 11 (9) ◽  
pp. 3824
Author(s):  
Ioana-Andreea Sioustis ◽  
Mihai Axinte ◽  
Marius Prelipceanu ◽  
Alexandra Martu ◽  
Diana-Cristala Kappenberg-Nitescu ◽  
...  
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Periodontal Ligament ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Real Data ◽  
Element Analysis ◽  
Anterior Teeth ◽  
Applied Forces ◽  
Orthodontic Forces

Finite element analysis studies have been of interest in the field of orthodontics and this is due to the ability to study the stress in the bone, periodontal ligament (PDL), teeth and the displacement in the bone by using this method. Our study aimed to present a method that determines the effect of applying orthodontic forces in bodily direction on a healthy and reduced periodontium and to demonstrate the utility of finite element analysis. Using the cone-beam computed tomography (CBCT) of a patient with a healthy and reduced periodontium, we modeled the geometric construction of the contour of the elements necessary for the study. Afterwards, we applied a force of 1 N and a force of 0.8 N in order to achieve bodily movement and to analyze the stress in the bone, in the periodontal ligament and the absolute displacement. The analysis of the applied forces showed that a minimal ligament thickness is correlated with the highest value of the maximum stress in the PDL and a decreased displacement. This confirms the results obtained in previous clinical practice, confirming the validity of the simulation. During orthodontic tooth movement, the morphology of the teeth and of the periodontium should be taken into account. The effect of orthodontic forces on a particular anatomy could be studied using FEA, a method that provides real data. This is necessary for proper treatment planning and its particularization depends on the patient’s particular situation.

scholarly journals Biological Events in Periodontal Ligament and Alveolar Bone Associated with Application of Orthodontic Forces

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
L. Feller ◽  
R. A. G. Khammissa ◽  
I. Schechter ◽  
G. Thomadakis ◽  
J. Fourie ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Periodontal Ligament ◽  
Alveolar Bone ◽  
Tooth Movement ◽  
Bone Remodelling ◽  
Orthodontic Tooth Movement ◽  
Review Article ◽  
Tissue Changes ◽  
Induced Stresses ◽  
Orthodontic Forces

Orthodontic force-induced stresses cause dynamic alterations within the extracellular matrix and within the cytoskeleton of cells in the periodontal ligament and alveolar bone, mediating bone remodelling, ultimately enabling orthodontic tooth movement. In the periodontal ligament and alveolar bone, the mechanically induced tensile strains upregulate the expression of osteogenic genes resulting in bone formation, while mechanically induced compressive strains mediate predominantly catabolic tissue changes and bone resorption. In this review article we summarize some of the currently known biological events occurring in the periodontal ligament and in the alveolar bone in response to application of orthodontic forces and how these facilitate tooth movement.

scholarly journals Pain Experience with Micro-osteoperforations during Initial Orthodontic Alignment: A Randomized Clinical Trial.

2020 ◽  
Vol 9 (4) ◽  
pp. 309-318
Author(s):  
Azaitun Akma Shahrin ◽  
◽  
Sarah Haniza Abdul Ghani ◽  
Noraina Hafizan Norman ◽  
◽  
...  
Keyword(s):  
Clinical Trial ◽  
Repeated Measures ◽  
Pain Perception ◽  
Tooth Movement ◽  
Intervention Group ◽  
Orthodontic Tooth Movement ◽  
Control Group ◽  
Initial Alignment ◽  
Significant Difference ◽  
Fixed Appliances

Objetive: The objective of this clinical trial was to investigate the perception of pain during initial maxillary alignment with an adjunctive procedure of micro-osteoperforations (MOPs) compared to conventional orthodontics. Material and methods: This study design was a single-centre, two-arm parallel prospective randomised clinical trial. Thirty consecutive adult subjects (25 females and 5 males; mean age ± SD, 22.66 ± 3.27 years) with 5-8mm moderate upper labial segment crowding were randomly allocated using block randomisation into intervention and control group. All subjects had first premolar extractions, bonded conventional fixed appliances and 0.014-inch nickel-titanium archwire was placed for initial alignment. The intervention group received a 3-mm deep MOPs procedure under local anaesthesia using a Propel device (PROPEL Ortho Singapore) on the labiogingival aspect between the maxillary incisors. Both groups received a set of 100 mm visual analogue scale to complete over the first week, recording pain at 24 hours, 3 days and 1 week. Data were analysed using repeated-measures analysis of variance (ANOVA). Results: There was a statistically significant difference observed in perceived pain levels between MOPs and the control group on day 1, day 3 and day 7 postoperatively. Pain perception was significantly lower in the intervention group at all time points. Conclusion: Accelerating orthodontic tooth movement with MOPs did not accentuate pain perceived during initial maxillary alignment with fixed appliances.

scholarly journals P0012SHOULD WE DEFINE A NEW STANDARD PRESCRIPTION OF BICARBONATE (HCO3-) IN HEMODIALYSIS (HD)?

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Ana Rita Valerio Alves ◽  
Cátia Figueiredo ◽  
HernÂNi Ricardo Martins GonÇAlves ◽  
Karina Lopes ◽  
Flora Sofia ◽  
...  
Keyword(s):  
Renal Disease ◽  
Repeated Measures ◽  
Statistical Significance ◽  
Small Sample ◽  
Categorical Variables ◽  
Blood Levels ◽  
P Value ◽  
Disease Etiology ◽  
Time Points ◽  
Time Point

Abstract Background and Aims One of the aims of the regular, intermittent HD therapy prescribed for patients with end-stage chronic kidney disease, is correction of metabolic acidosis by addition of HCO3- to dialysate fluid. The KDOQI guidelines therapeutic goal is to maintain pre-dialysis HCO3-≥22mmol/L. The aim of the study was to evaluate an individualized HCO3-hemodialysis prescription as a preventing factor of metabolic changes in a HD facility and define a new standard HCO3-prescription. Method 36-month prospective study of patients on online high-flux hemodiafiltration. Every 3 months (13 time points) HCO3-, Calcium (Ca2+), Phosphorus (P+), intact Parathyroid hormone (iPTH) and protein C reactive (PCR) blood levels were analyzed. HCO3-prescription was changed using the following rules: The data collected comprised demographic information, renal disease etiology, comorbidities, HD treatment information and lab results. Categorical variables are presented as frequencies and percentages, continuous variables as means and standard deviations, or medians and interquartile ranges (IQR) for variables with skewed distributions. A p-value&lt;0.05 was considered statistically significant. Statistical analysis was performed using SPSS version 23 for Mac OS X. Results From the 50 patients that were evaluated at Time point 0, only 24 patients completed the follow-up period. Sixteen (66.7%) were males, 54.2% (n=13) diabetic and 58.3% (n=14) hypertensives and the median age was 76 years (IQR 13). At baseline (time point 0), median pH was 7.4 (IQR 0.09) and serum HCO3-26.5 mmol/L (IQR 2.32). At time point 12, pH was 7.35 (IQR 0.12) and serum HCO3-23.25mmol/L (IQR 1.93). A repeated measures ANOVA determined that prescribed HCO3- differed with statistical significance during time (F(2.787,83.308)=39.055, p=0.001), and the post Hoc tests confirmed those assumptions between time point 1 and all the others time points, as an example the mean difference between initial prescribed HCO3-and time point 12 was 5.39mmol/L (p=0.001). Wilcoxon Sign-Rank Tests determined that throughout the analyzed period the serum HCO3- approached the reference serum HCO3- (23mmol/L) that we have defined as ideal (at time point 0, median=26.5mmol/L, Z=4.144, p=0-001; at time point 12, median 23.25mmol/L, Z=1.243, p=0.214). On the other hand, a one sample T-Test determined that the HCO3- prescription differed more in each time point from the 32mmol/L defined as standard (at time point 12, t=-2.798, p=0.01) and approached a new suggested value of 26mmol/L. However, at time point 8, 62.5% (n=15) patients had a HCO3-prescription of 28mmol/L, (t(23)=0.001,p=1) and at that time we had hypothesized that that a prescription of 28 mmol/L should be the new standard. Gender, Diabetes Mellitus, Hypertension, and renal disease etiology did not influence the HCO3- prescription neither serum HCO3-. Conclusion HCO3-prescription and serum HCO3- were not influenced by comorbidities like DM and Hypertension. Our findings suggest that the standard HCO3- prescription of 32mmol/L should be rethought, as an individualized HCO3- prescription could be beneficial for the patient. At this time, we suggest that a prescription of 26 mmol/L should be the new standard. However, the limitations of our findings include the small sample size, so further studies with larger samples should be attempted.

scholarly journals Proteomic Analysis of Saliva Identifies Potential Biomarkers for Orthodontic Tooth Movement

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Mohd Faiz Ellias ◽  
Shahrul Hisham Zainal Ariffin ◽  
Saiful Anuar Karsani ◽  
Mariati Abdul Rahman ◽  
Shahidan Senafi ◽  
...  
Keyword(s):  
Orthodontic Treatment ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Differentially Expressed ◽  
Salivary Proteins ◽  
Niti Wire ◽  
Two Dimensional Gel Electrophoresis ◽  
Fixed Appliance ◽  
Maldi Tof ◽  
Whole Saliva

Orthodontic treatment has been shown to induce inflammation, followed by bone remodelling in the periodontium. These processes trigger the secretion of various proteins and enzymes into the saliva. This study aims to identify salivary proteins that change in expression during orthodontic tooth movement. These differentially expressed proteins can potentially serve as protein biomarkers for the monitoring of orthodontic treatment and tooth movement. Whole saliva from three healthy female subjects were collected before force application using fixed appliance and at 14 days after 0.014′′ Niti wire was applied. Salivary proteins were resolved using two-dimensional gel electrophoresis (2DE) over a pH range of 3–10, and the resulting proteome profiles were compared. Differentially expressed protein spots were then identified by MALDI-TOF/TOF tandem mass spectrometry. Nine proteins were found to be differentially expressed; however, only eight were identified by MALDI-TOF/TOF. Four of these proteins—Protein S100-A9, immunoglobulin J chain, Ig alpha-1 chain C region, and CRISP-3—have known roles in inflammation and bone resorption.

scholarly journals The effects of alveolar decortications on orthodontic tooth movement and bone remodelling in rats

2017 ◽  
Vol 40 (4) ◽  
pp. 423-429 ◽  
Author(s):  
Eliane H Dutra ◽  
Ahmad Ahmida ◽  
Alexandro Lima ◽  
Sydney Schneider ◽  
Ravindra Nanda ◽  
...  
Keyword(s):  
Tooth Movement ◽  
Bone Remodelling ◽  
Orthodontic Tooth Movement

scholarly journals Salivary leptin levels in normal weight and overweight individuals and their correlation with orthodontic tooth movement

2017 ◽  
Vol 87 (5) ◽  
pp. 739-744 ◽  
Author(s):  
Tamizhmani Jayachandran ◽  
Bhadrinath Srinivasan ◽  
Sridevi Padmanabhan
Keyword(s):  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Normal Weight ◽  
Time Intervals ◽  
Fixed Appliance ◽  
Premolar Extraction ◽  
Force Application ◽  
Overweight Group ◽  
Baseline Values ◽  
The Mean

ABSTRACT Objectives: To assess and compare the concentration of leptin in saliva between normal weight and overweight individuals and to evaluate the rate of orthodontic tooth movement. Materials and Methods: Thirty female subjects were divided into two groups: I (normal weight) and II (overweight group) based on their body mass index. All subjects underwent fixed appliance therapy requiring upper first premolar extraction and distal movement of the canine. Distal force was applied to the maxillary right canine using active lacebacks. Salivary samples were collected just before force application (T0), 1 hour (T1), and 1 month (T2) after force application. The rate of tooth movement was evaluated over 3 months and was measured on study models. Results: At all three time intervals, mean leptin concentration was greater in overweight individuals than normal weight individuals. In both groups at T1, the mean leptin concentration was found to increase significantly compared with the baseline value (T0), but at T2, the leptin concentration declined to values lesser than the baseline values (T0). Conclusions: Overweight individuals had greater salivary leptin concentration. There was a positive correlation between salivary leptin concentration and rate of tooth movement in both normal and overweight individuals. The rate of tooth movement is decreased in overweight individuals as compared with normal weight individuals.

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