P2336Dynamic changes in non-culprit coronary atherosclerotic lesion morphology: a longitudinal OCT study

Abstract Background Lp(a) and LDL-C are both risk factors of atherosclerotic cardiovascular disease (ASCVD). But there was a contradiction point in LDL-C and Lp(a) control. The appropriate level of LDL-C and Lp(a) in the prevention of ASCVD is still pending. Objective To investigate the correlation of Lp(a) and coronary atherosclerotic lesion, and find out the balance point in LDL-C and Lp(a) control. Method 3449 patients were divided to coronary atherosclerotic heart disease (CAHD) Group and Non-CAHD Group based on the result of coronary angiography. The clinical characteristics were compared, and Logistic regressions were applied to find the CAHD risk factors in total, High-LDL-C Group (LDL-C ≥ 100 mg/dL) and Low-LDL-C Group (LDL-C < 100 mg/dL) patients. Spearman correlation analysis of Lp(a), LDL-C and Gensini Score was performed in patients with different LDL-C concentration. Results Except male and diabetes, the traditional CAHD risk factors were well matched between two groups. But triglyceride, LDL-C and Lp(a) were higher, HDL-C and Apo-A1 were lower in CAHD group (2771). In the Logistic regression analysis, diabetes, LDL-C and Lp(a) are risk factors of CAHD in all patients, while in High-LDL-C Group, they were age, LDL-C, non-HDL-C and ApoB, in Low-LDL-C Group, they were age, Lp(a) and ApoB. Lp(a) correlated with Gensini with coefficient r = 0.41 in all patients, 0.67 in Low-LDL-C Group and 0.32 in High-LDL-C Group. The coefficient r for Lp(a) and Gensini decreased, while the r for LDL-C and Gensini increased with LDL-C concentration increasing. The two fitted lines of rs crossed at LDL-C = 2.7 mmol/L (104 mg/dL). Conclusion Lp(a) was the risk factor of CAHD in patients with LDL-C < 100 mg/dL. The correlation between Lp(a) and Gensini was influenced by LDL-C concentration, and the correlation was stronger than LDL-C when LDL-C < 104 mg/dl.

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Early and Long-term results of surgical treatment of combined carotid and coronary atherosclerotic lesion

Kardiologiya i serdechno-sosudistaya khirurgiya ◽

10.17116/kardio201710122-27 ◽

2017 ◽

Vol 10 (1) ◽

pp. 22 ◽

Cited By ~ 1

Author(s):

E. R. Charchyan ◽

A. B. Stepanenko ◽

A. P. Gens ◽

M. M. Turaev ◽

A. A. Skvortsov ◽

...

Keyword(s):

Surgical Treatment ◽

Atherosclerotic Lesion ◽

Long Term Results ◽

Coronary Atherosclerotic Lesion

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Participation of macrophages in atherosclerotic lesion morphology in LDLr−/−mice

The Journal of Lipid Research ◽

10.1194/jlr.m400036-jlr200 ◽

2004 ◽

Vol 45 (8) ◽

pp. 1398-1409 ◽

Cited By ~ 15

Author(s):

Natalie K. Schiller ◽

Audrey S. Black ◽

Gary P. Bradshaw ◽

David J. Bonnet ◽

Linda K. Curtiss

Keyword(s):

Atherosclerotic Lesion ◽

Lesion Morphology

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Association of circulating microRNA-122 with presence and severity of atherosclerotic lesions

PeerJ ◽

10.7717/peerj.5218 ◽

2018 ◽

Vol 6 ◽

pp. e5218 ◽

Cited By ~ 4

Author(s):

Yu-Long Wang ◽

Wen Yu

Keyword(s):

Acid Metabolism ◽

Atherosclerotic Lesion ◽

Control Group ◽

Circulating Microrna ◽

Chain Reaction ◽

Non Invasive ◽

Atherosclerotic Lesions ◽

Coronary Atherosclerotic Plaque ◽

Polymerase Chain ◽

Coronary Atherosclerotic Lesion

Objective MicroRNA (miR)-122 is highly expressed in the liver, where it has been implicated as a regulator of fatty-acid metabolism. A recent study reported that miR-122 plays a role in pathogenesis of atherosclerosis; however, whether it connects with severity of atherosclerotic lesion is still controversial. We therefore investigated the association between miR-122 expression and presence and severity of coronary atherosclerotic plaque. Methods During January–November 2017, we included 300 patients with coronary heart disease (CHD) and 100 subjects as the control group. MiR-122 content was detected by quantitative real-time polymerase chain reaction. MiR-122 level was identified in all subjects, and the Spearman correlation between miR-122 and severity of atherosclerosis was analyzed. Results Patients with CHD had higher miR-122 expression than in control group (2.61, 0.91–8.86 vs. 1.62, 0.71–3.45, p < 0.001). Gensini score was significantly associated with miR-122 expression (r = 0.7964, p < 0.001). The odds ratio of miR-122 solely was 0.12 (95% CI [0.05–0.43]) and factors such as cholesterol, triglyceride together with miR-122 level were closely associated with atherosclerosis (all p < 0.001). Conclusions The serum level of miR-122 may be used to differentiate between mild and severe coronary atherosclerotic lesion. Use of this marker might allow non-invasive diagnosis the degree of coronary atherosclerosis.

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