scholarly journals Risk factors for death within 90 days of Clostridium difficile infection

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
M K Koziol ◽  
M Z Z.urek

Abstract Background The conducted analysis emphasizes increasing problem of Clostridium difficile infections (CDI) in Poland. There are no other publications based on Polish healthcare data that would more precisely indicate the impact of risk factors for death after the infection. The purpose of the analysis was to present the incidence of CDI in the overall population of Poland in the years 2009-2018 and to evaluate the risk factors for death within 90 days after CDI infection. Methods In order to detect the incidence of CDI the data of the National Health Fund from years 2009-2018 were used. Code A04.7 from International Classification of Diseases (ICD-10) allowed to identify CDI. Risk factor analysis was based on 14 212 patients' hospitalizations in the year 2017. The risk factors were related to patient's medical history and demographic profile. Logistic regression was applied to estimate the impact of the defined variables on the death within 90 days after CDI infection. Results CDI incidence increased from 952 hospitalizations in 2009 to 14 582 hospitalizations in 2018. Morbidity of CDI infections (48,3/10 000 patient days in 2017) indicated Poland as the country with the highest prevalence in the European Union (average 2,38/10 000 patient days in 2016). 37,1% of the patients died within first 90 days after CDI infection in 2017. The most important factors that increases the chance of death are: age (>85 OR = 25,8, 65-84 OR = 10,5, 50-64 OR = 4,7 in comparison to age <50), AIDS/HIV (OR = 4,6), metastatic cancer (OR = 4,6), weight loss (OR = 2,6) and alcohol abuse (OR = 2,1). Conclusions The results indicated increasing problem of CDI in Poland. It is important to take precautions and use more effective treatment methods particularly in case of the most exposed populations. Furthermore, policy makers should pay attention to compliance with the principles of restricted sanitary procedures and increase awareness of CDI epidemiology among doctors. Key messages CDI is an increasing problem, unmentioned in health policy. Restricted sanitary procedures should be implemented in case of hospitalizations of older patients with comorbidities.

2021 ◽  
pp. bjophthalmol-2020-318420
Author(s):  
Sneh Patel ◽  
Natalia Tohme ◽  
Emmanuel Gorrin ◽  
Naresh Kumar ◽  
Brian Goldhagen ◽  
...  

BackgroundChalazia are common inflammatory eyelid lesions, but their epidemiology remains understudied. This retrospective case–control study examined the prevalence, risk factors and geographic distribution of chalazia in a large veteran population.MethodsData on all individuals seen at a Veterans Affairs (VA) clinic between October 2010 and October 2015 were extracted from the VA health database. Subjects were grouped based on International Classification of Diseases, Ninth Revision (ICD-9) code for chalazion. Univariable logistic regression modelling was used to identify clinical and demographic factors associated with chalazion presence, followed by multivariable modelling to examine which factors predicted risk concomitantly. All cases were mapped across the continental US using geographic information systems modelling to examine how prevalence rates varied geographically.ResultsOverall, 208 720 of 3 453 944 (6.04%) subjects were diagnosed with chalazion during the study period. Prevalence was highest in coastal regions. The mean age of the population was 69.32±13.9 years and most patients were male (93.47%), white (77.13%) and non-Hispanic (93.72%). Factors associated with chalazion risk included smoking (OR=1.12, p<0.0005), conditions of the tear film (blepharitis (OR=4.84, p<0.0005), conjunctivitis (OR=2.78, p<0.0005), dry eye (OR=3.0, p<0.0005)), conditions affecting periocular skin (eyelid dermatitis (OR=2.95, p<0.0005), rosacea (OR=2.50, p<0.0005)), allergic conditions (history of allergies (OR=1.56, p<0.0005)) and systemic disorders (gastritis (OR=1.54, p<0.0005), irritable bowel syndrome (OR=1.45, p<0.0005), depression (OR=1.35, p<0.0005), anxiety (OR=1.31, p<0.0005)). These factors remained associated with chalazion risk when examined concomitantly.ConclusionPeriocular skin, eyelid margin and tear film abnormalities were most strongly associated with risk for chalazion. The impact of environmental conditions on risk for chalazion represents an area in need of further study.


2020 ◽  
Vol 41 (12) ◽  
pp. 1461-1463
Author(s):  
Mohammed A. Alsuhaibani ◽  
Mohammed A. Alzunitan ◽  
Kyle E. Jenn ◽  
Michael B. Edmond ◽  
Angelique M. Dains ◽  
...  

AbstractWe performed a retrospective analysis of the impact of using the International Classification of Diseases, Tenth Revision procedure coding system (ICD-10) or current procedural terminology (CPT) codes to calculate surgical site infection (SSI) rates. Denominators and SSI rates vary depending on the coding method used. The coding method used may influence interhospital performance comparisons.


2020 ◽  
Author(s):  
Katalin Pungor ◽  
Pedro Sanchez ◽  
Sofia Pappa ◽  
Jerome Attal ◽  
Karolina Leopold ◽  
...  

Abstract Background: To understand the implications of switching from paliperidone palmitate 1-monthly (PP1M) to paliperidone palmitate 3-monthly (PP3M) treatment of schizophrenia from the perspective of four key stakeholders: patients, physicians, nurses and carers. Methods: PINC-Q was a cross-sectional, retrospective, non-interventional study comprising a one-time questionnaire for adult patients (aged ≥18 years) with schizophrenia (International Classification of Diseases; ICD-10) and their physician, nurse and carer. Questionnaires were developed in association with patient and carer advocacy groups (GAMIAN and EUFAMI) and following an advisory board formed of psychiatrists and nurses. The degree of alignment between stakeholders was also examined. Results: Responses were received from a total of 224 evaluable patients. For most patients (88.4%), responses were received from at least two other stakeholders. Patients were moderately ill with mild-to-moderate lack of insight and had received PP1M for a mean (standard deviation [SD]) of 23.9 (21.28) months before switching to PP3M (duration mean [SD] 12.8 [3.72] months). The most frequently reported reasons to switch from PP1M to PP3M were ‘to live life as normally as possible’ and ‘patient convenience’. Over 79% of responses within each stakeholder group stated that PP3M helped the patients, with increased patient activity and social involvement, improved frequency and quality of physician–patient and nurse–patient communication and decreased perceived stigma. Conclusions: The results of the PINC-Q study add to the increasing body of evidence supporting the benefits of PP3M in a population of patients with schizophrenia representative of real-world clinical practice.


Author(s):  
Paula Ariadna Corzo Pérez

ABSTRACTThe aim of this review is to illustrate through a case tried, the difficulties encountered while dealing with patients’ special cultures and beliefs, which require a culture assessment, given its special features. Also, this review aims at providing basic tools for understanding and analyzing the impact of the cultural environment. In the event that a health professional stands in front of cross culture context in his daily practice, one in which magical and spiritual elements dominate, he/she must have the ability to assess it in a scientifically, way but without interfering with the cultural belief of the individuals. The F44.3 The Trance and Possession Disorder (9) was included in the 1999 International Classification of Diseases (ICD-10) of the World Health Organization for epidemiological and planning purposes. However, this inclusion is not sufficient to describe the complexity of the behaviors and thought patterns related to all different culture beliefs.RESUMENEl objetivo de esta revisión es ilustrar, a través de un caso clínico, las dificultades que se presentan en el abordaje de los pacientes con diferentes culturas y creencias que por sus características especiales requieren de una evaluación trans-cultural. Asimismo, también se pretende proporcionar herramientas básicas para su comprensión y análisis ya que cuando un profesional de la salud encuentra en su consulta diaria un caso en el que predominan elementos mágicos, místicos y sobrenaturales que buscan una estrategia de sanación para el individuo y su grupo familia, éste debe estar en la capacidad de abordarlo de una manera científicamente acertada pero sin interferir con las creencias culturales de éstos. El F44.3 Trastorno de trance y posesión se incluyó en la Décima Clasificación Internacional de Enfermedades (CDI-10) de la Organización Mundial de la Salud de 1999(1) con fines epidemiológicos y de planeación. Sin embargo, esta inclusión no es suficiente para describir la complejidad de las conductas y estructuras de pensamiento relacionadas con creencias culturales.


Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Yogesh Moradiya ◽  
Devanshi Dharaiya ◽  
Santosh Murthy ◽  
Christa San Luis ◽  
Sneha Modi

Background and Purpose: Risk of venous thromboembolism (VTE) in stroke patients persists after discharge from hospital due to residual deficits. Quantification of VTE risk at various post-discharge intervals may have implications for surveillance and/or prophylactic strategies for high-risk individuals. We therefore, studied incidence rates and risk factors of deep venous thrombosis (DVT) and pulmonary embolism (PE) among stroke survivors after discharge from the hospital. Methods: Adults with principle diagnosis of ischemic stroke discharged alive from acute care hospitals in California State between January 2005 and December 2010 were followed up until December 2011 using state inpatient and emergency department databases for development of DVT and/or PE. Case ascertainment was done using International Classification of Diseases -9 codes. We calculated incidence rates of DVT and PE during first 30 days, 31-90 days, 91-365 days and >1-year after the discharge. We calculated independent risk factors for VTE within 90 days after discharge by using logistic regression controlling for baseline demographics, comorbidities, inpatient complications and procedures. Results: A total of 168,194 stroke survivors were followed up for a mean duration of 3.6+/-1.9 (SD) years after discharge. Among these, 6,179 (3.7%) developed DVT and 2,487 (1.5%) developed PE resulting in incidence rate of 1.02 and 0.41 per 100 person year for DVT and PE respectively. The incidence rates of DVT during first 30 days, 31-90 days, 91-365 days and >1-year post-discharge were 6.53, 2.91, 1.24 and 0.66 per 100 person year respectively. Similarly, the incidence of PE was 3.04, 1.13, 0.46 and 0.26 during first 30 days, 31-90 days, 91-365 days and >1-year after discharge respectively. Factors independently associated with VTE within 90 days were age>65 years, African-American race, higher Charlson comorbidity index, metastatic cancer, anemia, obesity, acute myocardial infarction, pneumonia, sepsis, hemodialysis, gastrostomy and mechanical ventilation during index admission. Conclusions: VTE risk remains high among stroke survivors even after discharge from the hospital. The risk is highest during first 30 days and remains high as long as 1 year after discharge.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Katalin Pungor ◽  
Pedro Sanchez ◽  
Sofia Pappa ◽  
Jerome Attal ◽  
Karolina Leopold ◽  
...  

Abstract Background To understand the implications of switching from paliperidone palmitate 1-monthly (PP1M) to paliperidone palmitate 3-monthly (PP3M) treatment of schizophrenia from the perspective of four key stakeholders: patients, physicians, nurses and carers. Methods This was a cross-sectional, retrospective, non-interventional study comprising a one-time questionnaire (PINC-Q) for adult patients (aged ≥18 years) with schizophrenia (International Classification of Diseases; ICD-10) and their physician, nurse and carer. Questionnaires were developed in association with patient and carer advocacy groups (GAMIAN and EUFAMI) and following an advisory board formed of psychiatrists and nurses. The degree of alignment between stakeholders was also examined. Results Responses were received from a total of 224 evaluable patients. For most patients (88.4%), responses were received from at least two other stakeholders. Patients were moderately ill with mild-to-moderate lack of insight and had received PP1M for a mean (standard deviation [SD]) of 23.9 (21.28) months before switching to PP3M (duration mean [SD] 12.8 [3.72] months). The most frequently reported reasons to switch from PP1M to PP3M were ‘to live life as normally as possible’ and ‘patient convenience’. Over 79% of responses within each stakeholder group stated that PP3M helped the patients, with increased patient activity and social involvement, improved frequency and quality of physician–patient and nurse–patient communication and decreased perceived stigma. Conclusions The results of this study add to the increasing body of evidence supporting the benefits of PP3M in a population of patients with schizophrenia representative of real-world clinical practice.


JMIR Cardio ◽  
10.2196/28015 ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. e28015
Author(s):  
Elma Dervic ◽  
Carola Deischinger ◽  
Nils Haug ◽  
Michael Leutner ◽  
Alexandra Kautzky-Willer ◽  
...  

Background Although men are more prone to developing cardiovascular disease (CVD) than women, risk factors for CVD, such as nicotine abuse and diabetes mellitus, have been shown to be more detrimental in women than in men. Objective We developed a method to systematically investigate population-wide electronic health records for all possible associations between risk factors for CVD and other diagnoses. The developed structured approach allows an exploratory and comprehensive screening of all possible comorbidities of CVD, which are more connected to CVD in either men or women. Methods Based on a population-wide medical claims dataset comprising 44 million records of inpatient stays in Austria from 2003 to 2014, we determined comorbidities of acute myocardial infarction (AMI; International Classification of Diseases, Tenth Revision [ICD-10] code I21) and chronic ischemic heart disease (CHD; ICD-10 code I25) with a significantly different prevalence in men and women. We introduced a measure of sex difference as a measure of differences in logarithmic odds ratios (ORs) between male and female patients in units of pooled standard errors. Results Except for lipid metabolism disorders (OR for females [ORf]=6.68, 95% confidence interval [CI]=6.57-6.79, OR for males [ORm]=8.31, 95% CI=8.21-8.41), all identified comorbidities were more likely to be associated with AMI and CHD in females than in males: nicotine dependence (ORf=6.16, 95% CI=5.96-6.36, ORm=4.43, 95% CI=4.35-4.5), diabetes mellitus (ORf=3.52, 95% CI=3.45-3.59, ORm=3.13, 95% CI=3.07-3.19), obesity (ORf=3.64, 95% CI=3.56-3.72, ORm=3.33, 95% CI=3.27-3.39), renal disorders (ORf=4.27, 95% CI=4.11-4.44, ORm=3.74, 95% CI=3.67-3.81), asthma (ORf=2.09, 95% CI=1.96-2.23, ORm=1.59, 95% CI=1.5-1.68), and COPD (ORf=2.09, 95% CI 1.96-2.23, ORm=1.59, 95% CI 1.5-1.68). Similar results could be observed for AMI. Conclusions Although AMI and CHD are more prevalent in men, women appear to be more affected by certain comorbidities of AMI and CHD in their risk for developing CVD.


2021 ◽  
Vol 8 ◽  
Author(s):  
Markus S. Jördens ◽  
Sven H. Loosen ◽  
Tobias Seraphin ◽  
Tom Luedde ◽  
Karel Kostev ◽  
...  

The COVID-19 pandemic has been a major burden for healthcare systems worldwide and has caused multiple changes and problems in outpatient care. The aim of this study was to investigate the impact of the COVID-19 pandemic on consultations and diagnoses in gastroenterology practices in Germany. To this end, we retrospectively analyzed data from the Disease Analyzer database (IQVIA) using the International Classification of Diseases, 10th revision (ICD-10). We included all patients aged ≥18 years with at least one visit to one of 48 gastroenterology practices in Germany between April and September 2019 and April and September 2020. A total of 63,914 patients in the 2nd quarter of 2019, 63,701 in the 3rd quarter of 2019, 55,769 in the 2nd quarter of 2020, and 60,446 in the 3rd quarter of 2020 were included. Overall, a clear downward trend in the number of visits to gastroenterologists was observed in the 2nd quarter of 2020 compared to 2019 (−13%, p = 0.228). The decrease in consultations was particularly pronounced in patients &gt;70 years of age (−17%, p = 0.096). This trend was evident for all gastrointestinal diagnoses except for tumors. Most notably, rates of gastrointestinal infections (−19%) or ulcers (−43%) were significantly lower in this period than in the same quarter of 2019. Reflecting the course of the pandemic, the differences between the 3rd quarter of 2020 and that of 2019 were less pronounced (−5%, p = 0.560). Our data show that the pandemic changed patients' behavior with respect to the health care system. Using the example of German gastroenterology practices, we show that the number of consultations as well as the number and range of diagnoses have changed compared to the same period in 2019.


JAMIA Open ◽  
2019 ◽  
Vol 3 (1) ◽  
pp. 126-131 ◽  
Author(s):  
Sheila V Kusnoor ◽  
Mallory N Blasingame ◽  
Annette M Williams ◽  
Spencer J DesAutels ◽  
Jing Su ◽  
...  

Abstract Objectives The United States transitioned to the tenth version of the International Classification of Diseases (ICD) system (ICD-10) for mortality coding in 1999 and to the International Classification of Diseases, Clinical Modification and Procedure Coding System (ICD-10-CM/PCS) on October 1, 2015. The purpose of this study was to conduct a narrative literature review to better understand the impact of the implementation of ICD-10/ICD-10-CM/PCS. Materials and Methods We searched English-language articles in PubMed, Web of Science, and Business Source Complete and reviewed websites of relevant professional associations, government agencies, research groups, and ICD-10 news aggregators to identify literature on the impact of the ICD-10/ICD-10-CM/PCS transition. We used Google to search for additional gray literature and used handsearching of the references of the most on-target articles to help ensure comprehensiveness. Results Impact areas reported in the literature include: productivity and staffing, costs, reimbursement, coding accuracy, mapping between ICD versions, morbidity and mortality surveillance, and patient care. With the exception of morbidity and mortality surveillance, quantitative studies describing the actual impact of the ICD-10/ICD-10-CM/PCS implementation were limited and much of the literature was based on the ICD-10-CM/PCS transition rather than the earlier conversion to ICD-10 for mortality coding. Discussion This study revealed several gaps in the literature that limit the ability to draw reliable conclusions about the overall impact, positive or negative, of moving to ICD-10/ICD-10-CM/PCS in the United States. Conclusion These knowledge gaps present an opportunity for future research and knowledge sharing and will be important to consider when planning for ICD-11.


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