Antibiotic consumption and healthcare associated infection in a third level Italian hospital

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
F Gori ◽  
N Vonci ◽  
A Tinturini ◽  
C Basagni ◽  
G Messina ◽  
...  
Keyword(s):  
Infection Control ◽  
Teaching Hospital ◽  
General Medicine ◽  
Venous Catheter ◽  
Antibiotic Consumption ◽  
Healthcare Associated Infection ◽  
Peripheral Venous Catheter ◽  
Control And Prevention ◽  
Medical Wards ◽  
Clinical Records

Abstract Background The extended length of stay (LoS) is one of the main causes of hospital infections (HAI), followed by an increase in antibiotics consumption. The final step is the development of multiresistant microorganisms, with a consequent increase in costs for the national healthcare system. Aim of this study is to evaluate the prevalence of HAI and to analyze ATB consumption in a teaching hospital Methods Between 17-21 June 2019 the infection control team collected the clinical records of 425 patients to perform a point of prevalence analysis (PPA). Eligible patients were hospitalized in surgical and medical wards of the teaching Hospital (615 beds) in Siena, Italy. For each patients according to guidelines of European Centers for Disease Control and Prevention (ECDC 4.2) we searched for evidence of HAI and for all indication of ATB consumption. Data were processed using Stata12 Results Overall 425 patients have been analyzed (48.24% female), mean age was 60.88 (SD 26.11) years, mean LoS 8.37 (min 1 max 86) days. Patients were admitted mostly in General Medicine wards (48.94%); 34% underwent surgery. 63.8% of patients had Peripheral Venous Catheter, 20% Central Venous Catheter and 31.06% Urinary Catheter. Twenty-nine HAI were discovered (PPA 6.82%); the higher prevalence (19.23%) was in Intensive Care Unit. LoS (OR:1.07;IC95%1.04-1.1) and devices (OR:2.17;IC95%1.39-3.37) were the two variables that significantly influenced the infection risk. Forty-six percent of all patients received ATB, the most used were third generation Cephalosporines (26,18%), followed by Penicillines (24,73%). The main use was to treat community infections (62.12%), followed by medical prophylaxis (30.81%) Conclusions PPA of HAI was 6.82%, comparable to 2017 national PPA (6.5%); prolonged LoS is probably the main cause of this result. Our analysis showed that ATB consumption was quite high, in agreement with the Italian prevalence (44.9%), but the percentage of medical prophylaxis was still high. Key messages The way to achieve the health care infection control is still long, the length of the hospitalization could be a field to be improved. High consumption of antibiotics for prophylaxis is still the main point to fight in the battle against the multiresistant microorganisms.

Device-Associated Infection Rate and Mortality in Intensive Care Units of 9 Colombian Hospitals: Findings of the International Nosocomial Infection Control Consortium

2006 ◽  
Vol 27 (4) ◽  
pp. 349-356 ◽  
Author(s):  
Carlos Álvarez Moreno ◽  
Victor D. Rosenthal ◽  
Narda Olarte ◽  
Wilmer Villamil Gomez ◽  
Otto Sussmann ◽  
...  
Keyword(s):  
Intensive Care ◽  
Infection Control ◽  
Intensive Care Units ◽  
Latin American ◽  
Venous Catheter ◽  
Attributable Mortality ◽  
Healthcare Associated Infection ◽  
Prospective Surveillance ◽  
Control And Prevention ◽  
Device Associated Infection

Objective.To perform active targeted prospective surveillance to measure device-associated infection (DAI) rates, attributable mortality due to DAI, and the microbiological and antibiotic resistance profiles of infecting pathogens at 10 intensive care units (ICUs) in 9 hospitals in Colombia, all of which are members of the International Infection Control Consortium.Methods.We conducted prospective surveillance of healthcare-associated infection in 9 hospitals by using the definitions of the US Centers for Disease Control and Prevention National Nosocomial Surveillance System (NNIS). DAI rates were calculated as the number of infections per 100 ICU patients and per 1,000 device-days.Results.During the 3-year study, 2,172 patients hospitalized in an ICU for an aggregate duration of 14,603 days acquired 266 DAIs, for an overall DAI rate of 12.2%, or 18.2 DAIs per 1,000 patient-days. Central venous catheter (CVC)–related bloodstream infection (BSI) (47.4% of DAIs; 11.3 cases per 1,000 catheter-days) was the most common DAI, followed by ventilator-associated pneumonia (VAP) (32.3% of DAIs; 10.0 cases per 1,000 ventilator-days) and catheter-associated urinary tract infection (CAUTI) (20.3% of DAIs; 4.3 cases per 1,000 catheter-days). Overall, 65.4% of all Staphylococcus aureus infections were caused by methicillin-resistant strains; 40.0% of Enterobacteriaceae isolates were resistant to ceftriaxone and 28.3% were resistant to ceftazidime; and 40.0% of Pseudomonas aeruginosa isolates were resistant to fluoroquinolones, 50.0% were resistant to ceftazidime, 33.3% were resistant to piperacillin-tazobactam, and 19.0% were resistant to imipenem. The crude unadjusted attributable mortality was 16.9% among patients with VAP (relative risk [RR], 1.93; 95% confidence interval [CI], 1.24-3.00; P = .002); 18.5 among those with CVC-associated BSI (RR, 2.02; 95% CI, 1.42-2.87; P<.001); and 10.5% among those with CAUTI (RR, 1.58; 95% CI, 0.78-3.18; P = .19).Conclusion.The rates of DAI in the Colombian ICUs were lower than those published in some reports from other Latin American countries and were higher than those reported in US ICUs by the NNIS. These data show the need for more-effective infection control interventions in Colombia.

Six-year study on peripheral venous catheter–associated BSI rates in 262 ICUs in eight countries of South-East Asia: International Nosocomial Infection Control Consortium findings

2020 ◽  
pp. 112972982091725
Author(s):  
Víctor Daniel Rosenthal ◽  
Ider Bat-Erdene ◽  
Debkishore Gupta ◽  
Prasad Rajhans ◽  
Sheila Nainan Myatra ◽  
...  
Keyword(s):  
Intensive Care ◽  
Nosocomial Infection ◽  
Infection Control ◽  
East Asia ◽  
Bloodstream Infections ◽  
Venous Catheter ◽  
South East Asia ◽  
Short Term ◽  
Peripheral Venous Catheter ◽  
East Asia Region

Background: Short-term peripheral venous catheter–associated bloodstream infection rates have not been systematically studied in Asian countries, and data on peripheral venous catheter–associated bloodstream infections incidence by number of short-term peripheral venous catheter days are not available. Methods: Prospective, surveillance study on peripheral venous catheter–associated bloodstream infections conducted from 1 September 2013 to 31 May 2019 in 262 intensive care units, members of the International Nosocomial Infection Control Consortium, from 78 hospitals in 32 cities of 8 countries in the South-East Asia Region: China, India, Malaysia, Mongolia, Nepal, Philippines, Thailand, and Vietnam. For this research, we applied definition and criteria of the CDC NHSN, methodology of the INICC, and software named INICC Surveillance Online System. Results: We followed 83,295 intensive care unit patients for 369,371 bed-days and 376,492 peripheral venous catheter-days. We identified 999 peripheral venous catheter–associated bloodstream infections, amounting to a rate of 2.65/1000 peripheral venous catheter-days. Mortality in patients with peripheral venous catheter but without peripheral venous catheter–associated bloodstream infections was 4.53% and 12.21% in patients with peripheral venous catheter–associated bloodstream infections. The mean length of stay in patients with peripheral venous catheter but without peripheral venous catheter–associated bloodstream infections was 4.40 days and 7.11 days in patients with peripheral venous catheter and peripheral venous catheter–associated bloodstream infections. The microorganism profile showed 67.1% were Gram-negative bacteria: Escherichia coli (22.9%), Klebsiella spp (10.7%), Pseudomonas aeruginosa (5.3%), Enterobacter spp. (4.5%), and others (23.7%). The predominant Gram-positive bacteria were Staphylococcus aureus (11.4%). Conclusions: Infection prevention programs must be implemented to reduce the incidence of peripheral venous catheter–associated bloodstream infections.

scholarly journals Antibiotic usage and stewardship in patients with COVID-19: too much antibiotic in uncharted waters?

2020 ◽  
pp. 175717742097681
Author(s):  
Terry John Evans ◽  
Harriet Claire Davidson ◽  
Jen Mae Low ◽  
Marina Basarab ◽  
Amber Arnold
Keyword(s):  
Teaching Hospital ◽  
Antibiotic Consumption ◽  
Antibiotic Usage ◽  
Antibiotic Prescribing ◽  
National Guidelines ◽  
Definitive Evidence ◽  
Prescribing Practice ◽  
History Of ◽  
Medical Wards ◽  
The Uk

Background: Antimicrobial usage and stewardship programmes during COVID-19 have been poorly studied. Prescribing practice varies despite national guidelines, and there is concern that stewardship principles have suffered. Aim: To analyse antibiotic prescriptions during the COVID-19 pandemic at a teaching hospital and to propose improved approaches to stewardship. Methods: We reviewed COVID-19 admissions to medical wards and intensive care units (ICUs) in a London teaching hospital to assess initial antibiotic usage and evidence of bacterial co-infection, and to determine if our current antibiotic guidelines were adhered to. Findings: Data from 130 inpatients (76% medical and 24% ICU) were obtained. On admission, 90% were treated with antibiotics. No microbiological samples taken on admission provided definitive evidence of respiratory co-infection. In 13% of cases, antibiotics were escalated, usually without supporting clinical, radiological or laboratory evidence. In 16% of cases, antibiotics were stopped or de-escalated within 72 h. Blood results and chest radiographs were characteristic of COVID-19 in 20% of ward patients and 42% of ICU patients. Overall mortality was 25% at 14 days – similar to rates described for the UK as a whole. Conclusion: The majority of patients received antibiotics despite limited evidence of co-infection. Most patients received narrower spectrum antibiotics than recommended by NICE. As understanding of the natural history of COVID-19 infections progresses, stewardship programmes will need to evolve; however, at this point, we feel that a more restrictive antibiotic prescribing approach is warranted. We propose strategies for effective stewardship and estimate the effect this may have on antibiotic consumption.

scholarly journals Evaluation of Surgical Site Infections and Analysis of Risk Factors

ANKEM Dergisi ◽  
2020 ◽  
Author(s):  
Özgür Dağlı ◽  
Fatma Tosun ◽  
Arife Kılıç
Keyword(s):  
Risk Factors ◽  
Length Of Stay ◽  
Infection Control ◽  
High Risk Patient ◽  
Surgical Site Infections ◽  
Venous Catheter ◽  
H2 Receptor Antagonist ◽  
Peripheral Venous Catheter ◽  
Patient Profile ◽  
Gynecology And Obstetrics

Surgical site infections (SSI) extend the patient’s length of stay, causing unnecessary complications and increase mortality, morbidity and cost. In each hospital, these infections take place in hospital infection surveillance and show changes specific to hospitals. In this study, the files of 402 patients; hospitalized between 2016 and 2018 in the surgical clinics of the Health Sciences University Bursa High Specialization Training and Research Hospital were analyzed retrospectively in terms of SSI, patient profile, length of stay, underlying diseases, risk factors and causative microorganisms. In the study, patients in gynecology and obstetrics, pediatric surgery, cardiovascular surgery, orthopedics, general surgery, urology, and neurosurgery services were included in the surgeries that were followed up on the basis of the procedures in accordance with the decisions of the infection control committee. The most frequently isolated microorganisms in SSI were coagulase negative staphylococci (14.7 %) Escherichia coli (11.7 %), Staphylococcus aureus (6 %) Klebsiella spp. (7 %) and Pseudomonas spp. (3.5 %), while the rate of culture negative SSI cases was determined as (41.5 %). In statistical analysis; presence of a foreign body prosthesis, coronary artery disease, diabetes mellitus, hypertension, hemodialysis, H2 receptor antagonist use, chest tube, peripheral artery catheter, central venous catheter, nasogastric catheter, surgical drain, transfusion, urinary catheter, peripheral venous catheter, mechanical ventilation and endotracheal intubation were statistically significant in the development of SSI. In the analyzes on length of stay, it was found that the length of stay significantly increased as the depth increased in the SSI classification. Identifying risk factors for SSI is critical to reduce the incidence of SSI and identify high-risk patient populations that may require more surveillance for postoperative infection and to develop quality improvement strategies and infection control interventions.

scholarly journals Hospital acquired infection, evaluation of point of prevalence in a 147 beds italian hospital

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
F Gori ◽  
N Vonci ◽  
G Santoriello ◽  
C Quercioli ◽  
G Messina ◽  
...  
Keyword(s):  
Excellent Result ◽  
General Medicine ◽  
Venous Catheter ◽  
Prevalence Study ◽  
Third Generation ◽  
Chi Square ◽  
Peripheral Venous Catheter ◽  
Hospital Acquired Infections ◽  
The Third ◽  
Hospital Acquired

Abstract Background Hospital Acquired Infections (HAI) have become a public health priority worldwide, leading to higher medical costs, prolonged hospital stays, and increased mortality. The point of prevalence analysis (PPA) of HAI and antibiotics (ATB) consumption is extremely relevant for its social and economic impact. Aim of this study is to evaluate the prevalence of HAI and to analyze ATB consumption in 147 beds hospital. Material and Methods This prevalence study was conduced on March 23, 2018, we analyzed the clinical documentation of 78 patients hospitalized in the Hospital of Val D’Elsa, Siena, Italy and searched for evidence of HAI and for all indication of ATB therapy in all hospital wards. HAI were defined according to guidelines of European Centers for Disease Control and Prevention (ECDC 4.2) using Stata 12. Results We analyzed a total of 78 patients (51,3% female), average age was 71,6 (sd ± 23,4) years, mean lenght of stay 7,2 (sd ± 7,9) days. Patients included in the study were recovered mostly in General Medicine ward (62,8%); 23% of patients underwent surgery. Fifty-one point three of patients had Peripheral Venous Catheter, 17,9% Central Venous Catheter and 47,4% Urinary Catheter. Three infections were discovered (PPA 3,8%); 2 HAIs were found in Medicine ward, the third one in the Intensive Care Unit. The chi-square test did not show statistically significant differences with the last year’s results in the same wards (p = 0.3305). Fifty-four percent of all patients received ATB, the most used class were third generation Cephalosporines (50%), followed by Carbapenems (19%) and Fluoroquinolones (7%). Conclusions PPA of HAI was 3,8%, comparable to last year’s (3,5%). This is a positive result when compared to regional and national point prevalence study realized by ECDC in 2012 (6,2% in Tuscany Region, 6% in Italy). Our analysis showed that ATB consumption was quite high: and it is in agreement with those provided by the Tuscany Region. Key messages in our hospital we report an excellent result about the pint of prevalence of hospital acquired infections 3,8%. The antibiotics consumption in our hospital is quite high, the most frequently used antibiotic class is the third generation Cephalosporines.

scholarly journals Healthcare-associated infection in the Grey’s Hospital paediatric intensive care unit: does an Infection Control Programme work?

2018 ◽  
Vol 33 (5) ◽  
Author(s):  
Anne L. Armour ◽  
Mark E. Patrick ◽  
Zelda Reddy ◽  
Wilbert Sibanda ◽  
Logandran Naidoo ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Infection Control ◽  
Bloodstream Infections ◽  
Venous Catheter ◽  
Control Programme ◽  
Healthcare Associated Infections ◽  
Healthcare Associated Infection ◽  
Tract Infections ◽  
Healthcare Associated ◽  
Infection Control Programme

Background: Healthcare-associated infections are an important cause of morbidity and mortality globally. Grey’s Hospital introduced an Infection Control Programme in August 2016, which included Best Care Always bundles for reducing the occurrence of central line-associated bloodstream infections, catheter-associated urinary tract infections and ventilatorassociated pneumonia. Methods: An observational before–after quasi-experiment was conducted retrospectively reviewing healthcare-associated infection rates in the Grey’s Hospital paediatric intensive care unit a year prior to (August 2015 to July 2016) and after (September 2016 to August 2017) implementation of an Infection Control Programme.Results: There was an absolute decrease in healthcare-associated infection from 102 to 81 and a statistically significant decrease in bloodstream infections per 1 000 central venous catheter days from 36/1 000–15/1 000 after intervention (RR 0.42, 95% CI 0.23–0.79, p = 0.004). The rate of healthcare-associated infection decreased from 23/100 admissions prior to the intervention to 20/100 admissions after the intervention (RR 0.87, 95% CI 0.51–1.48, p = 0.61) and from 40/1 000 patient days to 32/1 000 patient days (RR 0.80, 95% CI 0.51–1.26, p = 0.34). Reductions in healthcare-associated infection were also seen in bloodstream infections and urinary tract infections.Conclusion: The observed downward trend in overall healthcare-associated infections, bloodstream infections and urinary tract infections did not reach statistical significance except for bloodstream infections per 1 000 central venous catheter days. Further research or audit is needed to ascertain reasons for this less than expected decrease in healthcare-associated infections. In the meantime, meticulous adherence to bundles should be encouraged.

Sign in / Sign up

Export Citation Format

Share Document