scholarly journals Modifier Genes of the Sex Ratio Trait in Drosophila pseudoobscura

Genetics ◽  
1987 ◽  
Vol 116 (2) ◽  
pp. 275-283
Author(s):  
Gary Cobbs
Keyword(s):  
Sex Ratio ◽  
Y Chromosome ◽  
X Chromosome ◽  
High Frequency ◽  
Sex Chromosome ◽  
Drosophila Pseudoobscura ◽  
Sterile Male ◽  
Very High Frequency ◽  
Very High ◽  
Chromosome Nondisjunction

ABSTRACT The msr trait of Drosophila pseudoobscura occurs when "sex-ratio" males produce a very high frequency of null-X sperm which give rise to sterile male (X/O) progeny. The trait involves dramatically lowered fecundity due to spermiogenic failure. The msr trait is multigenic and the genes are located on autosomes II, III and IV of the L116 laboratory stock. This stock also carries genes on the Y chromosome that lower the level of msr. When the genes on the L116 autosomes are present together or with those on the Y chromosome of other stocks, they interact cooperatively to produce very high levels of msr. The msr genes require the presence of a sex-ratio X chromosome to have any effect and thus may be regarded as modifiers of the "sex-ratio" phenotype. Crosses show that the genes causing msr are primarily recessive but have some expression when heterozygous. Sex chromosome nondisjunction is proposed as the mechanism underlying the msr trait.

scholarly journals The potential for a released autosomal X-shredder becoming a driving-Y chromosome and invasively suppressing wild populations of malaria mosquitoes

2019 ◽  
Author(s):  
Yehonatan Alcalay ◽  
Silke Fuchs ◽  
Roberto Galizi ◽  
Federica Bernardini ◽  
Roya Elaine Haghighat-Khah ◽  
...  
Keyword(s):  
Sex Ratio ◽  
Y Chromosome ◽  
X Chromosome ◽  
Sex Chromosome ◽  
Unexpected Event ◽  
Meiotic Sex Chromosome Inactivation ◽  
Ratio Distortion ◽  
High Fraction ◽  
Malaria Mosquitoes ◽  
Population Suppression

AbstractSynthetic sex-ratio distorters based on X-chromosome shredding are predicted to be more efficient than sterile males for population suppression of malaria mosquitoes using genetic control. X-chromosome shredding operates through the targeted elimination of X-chromosome-bearing gametes during male spermatogenesis, resulting in males that have a high fraction of male offspring. Strains harboring autosomal constructs containing a modified endonuclease I-PpoI have now been developed in the malaria mosquito Anopheles gambiae, resulting in strong sex-ratio distortion towards males. Data are being gathered for these strains for submission of regulatory dossiers for contained use and subsequent field release in West Africa. Since autosomal X-shredders are transmitted in a Mendelian fashion and can be selected against their frequency in the population is expected to decline once releases are halted. However, any unintended transfer of the X-shredder to the Y-chromosome could theoretically change these dynamics: This could lead to 100% transmission of the newly Y-linked X-shredder to the predominant male-biased offspring and its insulation from negative selection in females, resulting in its potential spread in the population and ultimately to suppression. Here, we analyze plausible mechanisms whereby an autosomal X-shredder could become linked to the Y-chromosome after release and provide data regarding its potential for activity should it become linked to the Y-chromosome. Our results strongly suggest that Y-chromosome linkage through remobilization of the transposon used for the initial genetic transformation is unlikely, and that, in the unexpected event that the X-shredder becomes linked to the Y-chromosome, expression and activity of the X-shredder would likely be inhibited by meiotic sex chromosome inactivation. We conclude that a functioning X-shredding-based Y-drive resulting from a naturally induced transposition or translocation of the transgene onto the Y-chromosome is unlikely.

The Jumping SHOX Gene—Crossover in the Pseudoautosomal Region Resulting in Unusual Inheritance of Leri-Weill Dyschondrosteosis

2011 ◽  
Vol 96 (2) ◽  
pp. E356-E359 ◽  
Author(s):  
Sarina G. Kant ◽  
Hetty J. van der Kamp ◽  
Marjolein Kriek ◽  
Egbert Bakker ◽  
Boudewijn Bakker ◽  
...  
Keyword(s):  
Genetic Counseling ◽  
Y Chromosome ◽  
X Chromosome ◽  
Sex Chromosome ◽  
Recombination Frequency ◽  
Pseudoautosomal Region ◽  
Shox Gene ◽  
Mesomelic Dysplasia ◽  
Very High ◽  
Meiosis I

abstract Context: During meiosis I, the recombination frequency in the pseudoautosomal region on Xp and Yp (PAR1) in males is very high. As a result, mutated genes located within the PAR1 region can be transferred from the Y-chromosome to the X-chromosome and vice versa. Patients: Here we describe three families with SHOX abnormalities resulting in Leri-Weill dyschondrosteosis or Langer mesomelic dysplasia. Results: In about half of the segregations investigated, a transfer of the SHOX abnormality to the alternate sex chromosome was demonstrated. Conclusions: Patients with an abnormality of the SHOX gene should receive genetic counseling as to the likelihood that they may transmit the mutation or deletion to a son as well as to a daughter.

scholarly journals CYTOGENETIC ANALYSIS OF A SEGMENT OF THE Y CHROMOSOME OF DROSOPHILA MELANOGASTER

Genetics ◽  
1984 ◽  
Vol 107 (4) ◽  
pp. 591-610
Author(s):  
Robert W Hardy ◽  
Dan L Lindsley ◽  
Kenneth J Livak ◽  
Barbara Lewis ◽  
Annegrethe L Siversten ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Y Chromosome ◽  
X Chromosome ◽  
Sex Chromosomes ◽  
Sex Chromosome ◽  
Male Sterile ◽  
Metaphase Chromosomes ◽  
Chromosome Nondisjunction ◽  
In Cells

ABSTRACT Males carrying a large deficiency in the long arm of the Y chromosome known to delete the fertility gene kl-2 are sterile and exhibit a complex phenotype: (1) First metaphase chromosomes are irregular in outline and appear sticky; (2) spermatids contain micronuclei; (3) the nebenkerns of the spermatids are nonuniform in size; (4) a high molecular weight protein ordinarily present in sperm is absent; and (5) crystals appear in the nucleus and cytoplasm of spermatocytes and spermatids. In such males that carry Ste  + on their X chromosome the crystals appear long and needle shaped; in Ste males the needles are much shorter and assemble into star-shaped aggregates. The large deficiency may be subdivided into two shorter component deficiencies. The more distal is male sterile and lacks the high molecular weight polypeptide; the more proximal is responsible for the remainder of the phenotype. Ste males carrying the more proximal component deficiency are sterile, but Ste  + males are fertile. Genetic studies of chromosome segregation in such males reveal that (1) both the sex chromosomes and the large autosomes undergo nondisjunction, (2) the fourth chromosomes disjoin regularly, (3) sex chromosome nondisjunction is more frequent in cells in which the second or third chromosomes nondisjoin than in cells in which autosomal disjunction is regular, (4) in doubly exceptional cells, the sex chromosomes tend to segregate to the opposite pole from the autosomes and (5) there is meiotic drive; i.e., reciprocal meiotic products are not recovered with equal frequencies, complements with fewer chromosomes being recovered more frequently than those with more chromosomes. The proximal component deficiency can itself be further subdivided into two smaller component deficiencies, both of which have nearly normal spermatogenic phenotypes as observed in the light microscope. Meiosis in Ste  + males carrying either of these small Y deficiencies is normal; Ste males, however, exhibit low levels of sex chromosome nondisjunction with either deficient Y. The meiotic phenotype is apparently sensitive to the amount of Y chromosome missing and to the Ste constitution of the X chromosome.

scholarly journals AN INVESTIGATION OF THE GENETICS OF "MALE SEX-RATIO" PHENOTYPE IN DROSOPHILA PSEUDOOBSCURA

Genetics ◽  
1986 ◽  
Vol 113 (2) ◽  
pp. 355-365
Author(s):  
Gary Cobbs
Keyword(s):  
Sex Ratio ◽  
Y Chromosome ◽  
High Frequency ◽  
Laboratory Strain ◽  
Drosophila Pseudoobscura ◽  
Male Sex

ABSTRACT A laboratory strain of Drosophila pseudoobscura (L116) is studied that, when crossed to sex-ratio homozygous females, produces sons that exhibit varying levels of the male sex-ratio (msr) phenotype. The msr phenotype occurs only in sex-ratio males and is due to the production of a high frequency of nullo-XY sperm. The level of the msr phenotype is variable, and new variability is generated in one father-son transmission. Pedigree studies indicate the genes for msr reside on the Y chromosome or the autosomes of the L116 stock.

Experimental Investigation of very High Frequency Slot Antenna on M-60A-1 Tank

1977 ◽  
Author(s):  
D. V. Campbell ◽  
William Kennebeck ◽  
A. Zanella ◽  
Paul Sexton
Keyword(s):  
Experimental Investigation ◽  
High Frequency ◽  
Slot Antenna ◽  
Very High Frequency ◽  
Very High

A collision feedback based multiple access control protocol for very high frequency data exchange system in E-navigation

2021 ◽  
pp. 1-16
Author(s):  
Xu Hu ◽  
Bin Lin ◽  
Ping Wang ◽  
Hongguang Lyu ◽  
Tie-Shan Li
Keyword(s):  
Access Control ◽  
High Frequency ◽  
Multiple Access ◽  
Data Exchange ◽  
High Frequency Data ◽  
Frequency Data ◽  
Exchange System ◽  
Very High Frequency ◽  
Time Division ◽  
Very High

Abstract The very high frequency data exchange system (VDES) is promising in promoting electronic navigation (E-navigation) and improving navigation safety. The multiple access control (MAC) protocol is crucial to the transmission performance of VDES. The self-organising time division multiple access (SOTDMA) protocol, as the only access mode given by current recommendations, leads to a high rate of transmission collisions in the traditional automatic identification system (AIS), especially with heavy traffic loads. This paper proposes a novel feedback based time division multiple access (FBTDMA) protocol to address the problems caused by SOTDMA, such that collision of transmissions can be avoided in information transmission among vessels. Simulation results demonstrate that the proposed FBTDMA outperforms the traditional SOTDMA in terms of channel utilisation and throughput, and significantly reduces the transmission collision rate. The study is expected to provide insights into VDES standardisation and E-navigation modernisation.

scholarly journals Measurement of Electrical Properties of Superconducting YBCO Thin Films in the VHF Range

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3360
Author(s):  
Yakir Dahan ◽  
Eldad Holdengreber ◽  
Elichai Glassner ◽  
Oz Sorkin ◽  
Shmuel E. Schacham ◽  
...  
Keyword(s):  
Thin Films ◽  
Theoretical Model ◽  
Quality Factor ◽  
High Frequency ◽  
Unit Length ◽  
Superconducting Thin Films ◽  
Electrical Parameters ◽  
Very High Frequency ◽  
Production Constraints ◽  
Very High

A new measurement technique of electrical parameters of superconducting thin films at the Very High Frequency (VHF) range is described, based on resonators with microstrip (MS) structures. The design of an optimal resonator was achieved, based on a thorough theoretical analysis, which is required for derivation of the exact configuration of the MS. A theoretical model is presented, from which an expression for the attenuation of a MS line can be derived. Accordingly, simulations were performed, and an optimal resonator for the VHF range was designed and implemented. Production constraints of YBa2Cu3O7 (YBCO) limited the diameter of the sapphire substrate to 3″. Therefore, a meander configuration was formed to fit the long λ/4 MS line on the wafer. By measuring the complex input reflection coefficients of a λ/4 resonator, we extracted the quality factor, which is mainly affected by the dielectric and conductor attenuations. The experimental results are well fitted by the theoretical model. The dielectric attenuation was calculated using the quasi-static analysis of the MS line. An identical copper resonator was produced and measured to compare the properties of the YBCO resonator in reference to the copper one. A quality factor of ~6·105 was calculated for the YBCO resonator, three orders of magnitude larger than that of the copper resonator. The attenuation per unit length of the YBCO layer was smaller by more than five orders of magnitude than that of the copper.

Da eine oder mehrere betroffen …

2020 ◽  
Vol 48 (1) ◽  
pp. 47-100
Author(s):  
Melitta Gillmann
Keyword(s):  
High Frequency ◽  
Formal Language ◽  
Subordinate Clause ◽  
Matrix Clause ◽  
Very High Frequency ◽  
Corpus Study ◽  
Causal Relations ◽  
Legal Texts ◽  
The Matrix ◽  
Very High

AbstractBased on a corpus study conducted using the GerManC corpus (1650–1800), the paper sketches the functional and sociosymbolic development of subordinate clause constructions introduced by the subjunctor da ‘since’ in different text genres. In the second half of the 17th and the first half of the 18th century, the da clauses were characterized by semantic vagueness: Besides temporal, spatial and causal relations, the subjunctor established conditional, concessive, and adversative links between clauses. The corpus study reveals that different genres are crucial to the readings of da clauses. Spatial and temporal usages, for example, occur more often in sermons than in other genres. The conditional reading, in contrast, strongly tends to occur in legal texts, where it displays very high frequency. This could be the reason why da clauses carry indexical meaning in contemporary German and are associated with formal language. Over the course of the 18th century, the causal usages increase in all genres. Surprisingly, these causal da clauses tend to be placed in front of the matrix clause despite the overall tendency of causal clauses to follow the matrix clause.

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