scholarly journals Fine Mapping and Characterization of Linked Quantitative Trait Loci Involved in the Transition of the Maize Apical Meristem From Vegetative to Generative Structures

Genetics ◽  
1999 ◽  
Vol 153 (2) ◽  
pp. 993-1007 ◽  
Author(s):  
Cristian Vlăduţu ◽  
John McLaughlin ◽  
Ronald L Phillips
Keyword(s):  
Quantitative Trait ◽  
Positional Cloning ◽  
Apical Meristem ◽  
Node Number ◽  
Factors Affecting ◽  
Developmental Factors ◽  
Introgressed Segment ◽  
Determinate Growth ◽  
Trait Locus ◽  
Pollen Shed

AbstractQuantitative trait locus (QTL) mapping has detected two linked QTL in the 8L chromosome arm segment introgressed from Gaspé Flint (a Northern Flint open-pollinated population) into the background of N28 (a Corn Belt Dent inbred line). Homozygous recombinant lines, with a variable length of the introgressed segment, confirmed the presence of the two previously identified, linked QTL. In the N28 background, Gaspé Flint QTL alleles at both loci induce a reduction in node number, height, and days to anthesis (pollen shed). Given the determinate growth pattern of maize, the phenotypic effects indicate that the two QTL are involved in the transition of the apical meristem from vegetative to generative structures. Relative to the effects of the two QTL in the background of N28, we distinguish two general developmental factors affecting the timing of pollen shed. The primary factor is the timing of the transition of the apical meristem. The second, derivative factor is the global extent of internode elongation. Having separated the two linked QTL, we have laid the foundation for the positional cloning of the QTL with a larger effect.

scholarly journals Positional Cloning of a Type 2 Diabetes Quantitative Trait Locus; Tomosyn-2, a Negative Regulator of Insulin Secretion

PLoS Genetics ◽  
2011 ◽  
Vol 7 (10) ◽  
pp. e1002323 ◽  
Author(s):  
Sushant Bhatnagar ◽  
Angie T. Oler ◽  
Mary E. Rabaglia ◽  
Donald S. Stapleton ◽  
Kathryn L. Schueler ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Quantitative Trait Locus ◽  
Insulin Secretion ◽  
Quantitative Trait ◽  
Positional Cloning ◽  
Negative Regulator ◽  
Trait Locus

scholarly journals Morphological Trait QTL Mapping in Tomato Recombinant Inbred Line Population

HortScience ◽  
1995 ◽  
Vol 30 (4) ◽  
pp. 788D-788
Author(s):  
I. Paran ◽  
I.L. Goldman ◽  
D. Zamir
Keyword(s):  
Plant Height ◽  
Quantitative Trait ◽  
Recombinant Inbred ◽  
Morphological Traits ◽  
Recombinant Inbred Lines ◽  
Rflp Analysis ◽  
Leaf Length ◽  
Node Number ◽  
Marker Loci ◽  
Trait Locus

Quantitative trait loci influencing morphological traits were identified by restriction fragment length polymorphism (RFLP) analysis in a population of recombinant inbred lines (RIL) derived from a cross of the cultivated tomato (Lycopersicon esculentum) with a related wild species (L. cheesmanii). One-hundred-thirty-two polymorphic RFLP loci spaced throughout the tomato genome were scored for 97 RIL families. Morphological traits, including plant height, fresh weight, node number, first flower-bearing node, leaf length at nodes three and four, and number of branches, were measured in replicated trials during 1991, 1992, and 1993. Significant (P ≤ 0.01 level) quantitative trait locus (QTL) associations of marker loci were identified for each trait. Lower plant height, more branches, and shorter internode length were generally associated with RFLP alleles from the L. cheesmanii parent. QTL with large effects on a majority of the morphological traits measured were detected at chromosomes 2, 3, and 4. Large additive effects were measured at significant marker loci for many of the traits measured. Several marker loci exhibited significant associations with numerous morphological traits, suggesting their possible linkage to genes controlling growth and development processes in Lycopersicon.

Moo1 obesity quantitative trait locus in BTBR T+ Itpr3tf/J mice increases food intake

2013 ◽  
Vol 45 (5) ◽  
pp. F191-F199 ◽  
Author(s):  
Subashini Karunakaran ◽  
Akiff Manji ◽  
Chenhua Serena Yan ◽  
Zi-Jun John Wu ◽  
Susanne M. Clee
Keyword(s):  
Quantitative Trait Locus ◽  
Food Intake ◽  
Quantitative Trait ◽  
Factors Affecting ◽  
New Therapeutic Approaches ◽  
Diet Induced Obesity ◽  
Clinical Consequences ◽  
Prevalence Of Obesity ◽  
Obesity In Mice ◽  
Trait Locus

The rising prevalence of obesity is one of the greatest health challenges facing the world today. Discovery of genetic factors affecting obesity risk will provide important insight to its etiology that could suggest new therapeutic approaches. We have previously identified the Modifier of obese 1 ( Moo1) quantitative trait locus (QTL) in a cross between leptin-deficient BTBR T+ Itpr3tf/J (BTBR) and C57BL/6J (B6) mice. Understanding the mechanism by which this locus acts will aid in the identification of candidate genes. Here we refined the location of this QTL and sought to determine the mechanism by which Moo1 affects body weight. We found that the effects of Moo1 also alter high fat diet-induced obesity in mice having functional leptin. In detailed metabolic analyses we determined that this locus acts by increasing food intake in BTBR mice, without affecting energy expenditure. The expression levels of the main molecular mediators of food intake in the hypothalamus were not altered, suggesting this locus affects an independent pathway, consistent with its identification in mice lacking functional leptin. Finally, we show that the increased adiposity resulting from Moo1 is sufficient to affect glucose tolerance. These studies show that the Moo1 obesity QTL affects food intake, likely through a novel mechanism, and indicate that modulation of the underlying pathway may not only ameliorate obesity but also its clinical consequences.

Positional cloning of a quantitative trait locus contributing to pain sensitivity: possible mediation by Tyrp1

2010 ◽  
Vol 9 (8) ◽  
pp. 856-867 ◽  
Author(s):  
A. Fortin ◽  
E. Diez ◽  
J. Ritchie ◽  
S. G. Sotocinal ◽  
M.-P. Dube ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Quantitative Trait ◽  
Positional Cloning ◽  
Pain Sensitivity ◽  
Trait Locus

Quantitative trait locus mapping and genetic improvement to strengthen drought tolerance in sorghum.

2021 ◽  
pp. 433-443
Author(s):  
Tariq Shehzad ◽  
Kazutoshi Okuno
Keyword(s):  
Quantitative Trait Locus ◽  
Drought Tolerance ◽  
Quantitative Trait ◽  
Genetic Improvement ◽  
Positional Cloning ◽  
Crop Improvement ◽  
New Paradigm ◽  
High Throughput Phenotyping ◽  
Trait Locus ◽  
Locus Mapping

Abstract This chapter overviews the approaches to and application of quantitative trait locus (QTL) mapping and positional cloning of genes controlling important traits related to drought tolerance in sorghum (Sorghum bicolor), which ultimately yields crop improvement and genetic modification. The use of high-throughput phenotyping will help better understand the mechanism involved in response to drought stress by plants. The new paradigm of scientific research should focus on the integration of physiology, genetics, genomics, soil characteristics and breeding to deal with the challenges of food security in the coming years.

Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma

2003 ◽  
Vol 34 (2) ◽  
pp. 181-186 ◽  
Author(s):  
Youming Zhang ◽  
Nicholas I Leaves ◽  
Gavin G Anderson ◽  
Chris P Ponting ◽  
John Broxholme ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Quantitative Trait ◽  
Positional Cloning ◽  
Immunoglobulin E ◽  
Chromosome 13Q14 ◽  
Trait Locus

scholarly journals A chromosome 16 quantitative trait locus regulates allogeneic bone marrow engraftment in nonmyeloablated mice

Blood ◽  
2009 ◽  
Vol 114 (1) ◽  
pp. 202-210 ◽  
Author(s):  
Thai M. Cao ◽  
Alun Thomas ◽  
Yuanyuan Wang ◽  
Schickwann Tsai ◽  
Kathryn Logronio ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Quantitative Trait Locus ◽  
Quantitative Trait ◽  
Positional Cloning ◽  
Resistance Mechanisms ◽  
Allogeneic Bone ◽  
Chromosome 16 ◽  
Intermediate Phenotypes ◽  
Trait Locus ◽  
Bone Marrow Engraftment

Abstract Identifying genes that regulate bone marrow (BM) engraftment may reveal molecular targets for overcoming engraftment barriers. To achieve this aim, we applied a forward genetic approach in a mouse model of nonmyeloablative BM transplantation. We evaluated engraftment of allogeneic and syngeneic BM in BALB.K and B10.BR recipients. This allowed us to partition engraftment resistance into its intermediate phenotypes, which are firstly the immune-mediated resistance and secondly the nonimmune rejection of donor BM cells. We observed that BALB.K and B10.BR mice differed with regard to each of these resistance mechanisms, thereby providing evidence that both are under genetic control. We then generated a segregating backcross (n = 200) between the BALB.K and B10.BR strains to analyze for genetic linkage to the allogeneic BM engraftment phenotype using a 127-marker genome scan. This analysis identified a novel quantitative trait locus (QTL) on chromosome 16, termed Bmgr5 (logarithm of odds 6.4, at 11.1 cM). The QTL encodes susceptibility alleles, from the BALB.K strain, that are permissive for allogeneic BM engraftment. Further identification of Bmgr5 genes by positional cloning may reveal new and effective approaches for overcoming BM engraftment obstacles.

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