The Coalescent and Infinite-Site Model of a Small Multigene Family
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Abstract The infinite-site model of a small multigene family with two duplicated genes is studied. The expectations of the amounts of nucleotide variation within and between two genes and linkage disequilibrium are obtained, and a coalescent-based method for simulating patterns of polymorphism in a small multigene family is developed. The pattern of DNA variation is much more complicated than that in a single-copy gene, which can be simulated by the standard coalescent. Using the coalescent simulation of duplicated genes, the applicability of statistical tests of neutrality to multigene families is considered.
1988 ◽
Vol 263
(20)
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pp. 9913-9916
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2003 ◽
Vol 10
(4)
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pp. 520-524
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1990 ◽
Vol 265
(4)
◽
pp. 2352-2357
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