scholarly journals Growth Hormone and Sex Steroid Effects on Bone Metabolism and Bone Mineral Density in Healthy Aged Women and Men

2002 ◽  
Vol 57 (1) ◽  
pp. M12-M18 ◽  
Author(s):  
C. Christmas ◽  
K. G. O'Connor ◽  
S. M. Harman ◽  
J. D. Tobin ◽  
T. Munzer ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Growth Hormone ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Sex Steroid ◽  
Mineral Density

scholarly journals Growth Hormone Replacement Is Important for the Restoration of Parathyroid Hormone Sensitivity and Improvement in Bone Metabolism in Older Adult Growth Hormone-Deficient Patients

2005 ◽  
Vol 90 (6) ◽  
pp. 3371-3380 ◽  
Author(s):  
H. D. White ◽  
A. M. Ahmad ◽  
B. H. Durham ◽  
A. Patwala ◽  
P. Whittingham ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Growth Hormone ◽  
Circadian Rhythm ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Target Organ ◽  
Type I ◽  
Mineral Density ◽  
Amino Terminal ◽  
Nephrogenous Camp

Alterations in PTH circadian rhythm and PTH target-organ sensitivity exist in adult GH-deficient (AGHD) patients and may underlie the pathogenesis of AGHD-related osteoporosis. GH replacement (GHR) results in increased bone mineral density, but its benefit in AGHD patients over 60 yr old has been debated. To examine the effect of age on changes in PTH circadian rhythm and target-organ sensitivity after GHR, we recruited 22 AGHD patients (12 were <60 yr of age, and 10 were >60 yr of age). Half-hourly blood samples were collected for PTH, calcium, phosphate, nephrogenous cAMP (marker of renal PTH activity), type-I collagenβ C-telopeptide (bone resorption marker), and procollagen type-I amino-terminal propeptide (bone formation marker) before and after 1, 3, 6, and 12 months of treatment with GHR. Significant PTH circadian rhythms were present in both age groups throughout the study. After GHR, PTH decreased and nephrogenous cAMP, adjusted calcium, and bone turnover markers increased in both groups, suggesting increased PTH target-organ sensitivity. In younger patients, the changes were significant after 1 month of GHR, but, in older patients, the changes were delayed until 3 months, with maximal changes at 12 months. Older AGHD patients derive benefit from GHR in terms of improvement in PTH sensitivity and bone metabolism. Their response appears delayed and may explain why previous studies have not shown a positive effect of GHR on bone mineral density in older AGHD patients.

The effects of prolonged growth hormone replacement on bone metabolism and bone mineral density in hypopituitary adults

1995 ◽  
Vol 42 (3) ◽  
pp. 249-254 ◽  
Author(s):  
Salem A. Beshyah ◽  
Patricia Kyd ◽  
Elizabeth Thomas ◽  
Angela Fairney ◽  
Desmond G. Johnston
Keyword(s):  
Bone Mineral Density ◽  
Growth Hormone ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Hormone Replacement ◽  
Growth Hormone Replacement ◽  
Mineral Density

Body composition and adipokines influence upon bone mineral density and bone metabolism in renal transplant receivers

2020 ◽  
Author(s):  
Anca Matei ◽  
Stefana Bilha ◽  
Daniela Constantinescu ◽  
Petru Cianga ◽  
Adrian Covic ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Renal Transplant ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Mineral Density

Review of the Literature Examining the Association of Serum Uric Acid with Osteoporosis and Mechanistic Insights into Its Effect on Bone Metabolism

2019 ◽  
Vol 19 (3) ◽  
pp. 259-273 ◽  
Author(s):  
Neelam Kaushal ◽  
Divya Vohora ◽  
Rajinder K Jalali ◽  
Sujeet Jha
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Uric Acid ◽  
Bone Metabolism ◽  
Serum Uric Acid ◽  
Bone Mineral ◽  
Molecular Mechanisms ◽  
Association Studies ◽  
Mineral Density ◽  
Age Related

Background And Objective:Osteoporosis is a common bone disorder that increases susceptibility to fragility bone fractures. The clinical and public health repercussions of osteoporosis are huge due to the morbidity, mortality, and cost of medical care linked with fragility fractures. Clinical assessment of osteoporotic risk factors can help to identify candidates at an early stage that will benefit from medical intervention and potentially lowering the morbidity and mortality seen with fractures and complications. Given this, research is ongoing to evaluate the association of osteoporosis with some novel or less well-studied risk factors/bio-markers such as uric acid (UA).Discussion:Uric acid’s antioxidant activity has been proposed to be one of the factors responsible for increasing longevity and lowering rates of age-related cancers during primate evolution, the level of which increased markedly due to loss of uricase enzyme activity (mutational silencing). Accumulated evidence shows that oxidative stress is the fundamental mechanism of age-related bone loss and acts via enhancing osteoclastic activity and increasing bone resorption. Antioxidant substances such as ascorbic acid scavenge free radicals are positively related to bone health. Thus, it is hypothesized that uric acid holds bone-protective potential owing to its potent antioxidative property. Several correlation studies have been conducted globally to investigate the relationship between serum uric acid with bone mineral density and osteoporosis. Few pre-clinical studies have tried to investigate the interaction between uric acid and bone mineral density and reported important role played via Runt-related transcription factor 2 (RUNX2)/core-binding factor subunit alpha-1 (CBF-alpha-1), Wingless-related integration site (Wnt)-3a/β-catenin signaling pathway and 11β Hydroxysteroid Dehydrogenase type 1.Conclusion:In this review, the authors provided a comprehensive summary of the literature related to association studies reported in humans as well work done until date to understand the potential cellular and molecular mechanisms that interplay between uric acid and bone metabolism.

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