Metabolic Syndrome Trajectories and Objective Physical Performance in Mid-To-Early Late Life: The Study of Women’s Health Across the Nation (SWAN)

2021 ◽  
Author(s):  
Jenna M Napoleone ◽  
Robert M Boudreau ◽  
Brittney S Lange-Maia ◽  
Samar R El Khoudary ◽  
Kelly R Ylitalo ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
African American ◽  
Women’S Health ◽  
Women's Health ◽  
Old Age ◽  
Physical Performance ◽  
Physical Functioning ◽  
Gait Speed ◽  
Performance Outcomes ◽  
Early Old Age

Abstract Background Little is known about how adverse, midlife metabolic profiles impact future physical functioning. We hypothesized that a higher number of midlife metabolic syndrome (MetS) components are associated with poorer physical performance in early old age for multi-ethnic women. Methods MetS status from 1996-2011 (8 visits) and objective physical performance in 2015/2016 (short physical performance battery (SPPB; 0-12), 40-foot walk (m/s), 4-meter gait speed (m/s), chair stands (sec), stair climb (sec)) were assessed in the Study of Women’s Health Across the Nation (SWAN; n=1722; age 65.4±2.7 years; 26.9% African American, 10.1% Chinese, 9.8% Japanese, 5.5% Hispanic). Poisson latent class growth modeling identified MetS component trajectory groups: none (23.9%), 1=low-MetS (28.7%), 2=mid-MetS (30.9%), and >3=high-MetS (16.5%). Adjusted linear regression related MetS groups to physical performance outcomes. Results High-MetS versus none had higher BMI, pain, financial strain, and lower physical activity and self-reported health (p<0.0001). Compared to White, African American and Hispanic women were more likely to be in the high-MetS groups and had worse physical functioning along with Chinese women (SPPB, chair stand, stair climb, and gait speed - not Hispanic). After adjustments, high-MetS versus none demonstrated significantly worse 40-ft walk (β:-0.08; 95% CI:-0.13, -0.03), gait speed (β:-0.09; 95% CI:-0.15, -0.02), SPPB (β:-0.79; 95% CI: -1.15, -0.44), and chair stands (β:0.69; 95% CI: 0.09, 1.28), but no difference in stair climb. Conclusions Midlife MetS groups were related to poor physical performance in early old age multi-ethnic women. Midlife management of metabolic function may improve physical performance later in life.

scholarly journals Metabolic Syndrome and Objective Physical Performance Measures in Mid-to-Early Late Life Women: SWAN

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 879-880
Author(s):  
Elsa Strotmeyer ◽  
Robert Boudreau ◽  
Brittney Lange-Maia ◽  
Samar El Khoudary ◽  
Kelly Ylitalo ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Physical Performance ◽  
Physical Functioning ◽  
Gait Speed ◽  
Latent Class ◽  
Chinese Women ◽  
Density Lipoprotein ◽  
Late Life ◽  
Financial Strain ◽  
Early Late

Abstract Metabolic syndrome (MetS) is a cluster of factors (hypertension, abdominal obesity, impaired fasting glucose, low high-density lipoprotein, hypertriglyceridemia). How midlife MetS impacts future physical functioning is uncertain. We hypothesized that higher midlife MetS components are associated with poorer physical performance in early late life for multi-ethnic women. MetS status from 1996-2011 (8 visits) and objective physical performance (2015/16; short physical performance battery (SPPB; 0-12), 40-foot walk (m/s), 4-meter gait speed (m/s), chair stands (sec), stair climb (sec)) were assessed in the Study of Women’s Health Across the Nation (SWAN; n=1722; age 65.4±2.7 years; 26.9% Black, 10.1% Chinese, 9.8% Japanese, 5.5% Hispanic). Poisson latent class growth modeling identified trajectory groups distinguishable by number of MetS components: none (23.9%), 1=low-MetS (28.7%), 2=mid-MetS (30.9%), >3=high-MetS (16.5%). High-MetS versus none had higher body mass index, pain, financial strain, and lower physical activity and self-reported health (p < 0.0001). Black and Hispanic women were more likely to be in high-MetS and had worse physical functioning, along with Chinese women, versus White (all p<0.05, except gait speed in Hispanic). Adjusted linear regression related MetS groups to physical performance. High-MetS versus none demonstrated adjusted worse 40-ft walk (β:-0.08; 95% CI:-0.13, -0.03), gait speed (β:-0.09; 95% CI:-0.15, -0.02), SPPB (β:-0.79; 95% CI: -1.15, -0.44), and chair stands (β:0.69; 95% CI: 0.09, 1.28), but not stair climb, with race significantly related to all except 40-ft walk. Midlife MetS trajectories related to poor physical performance in early late life multi-ethnic women. Managing midlife metabolic function may improve physical performance in late life.

Symptom Clusters Predict Risk of Metabolic-Syndrome and Diabetes in Midlife: The Study of Women's Health Across the Nation

2021 ◽  
Author(s):  
Alexis N. Reeves ◽  
Michael R. Elliott ◽  
Maria M. Brooks ◽  
Carrie A. Karvonen-Gutierrez ◽  
Irina Bondarenko ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Women’S Health ◽  
Women's Health ◽  
Symptom Clusters

Abstract P189: Associations between Lactation and Maternal Measures of Total and Regional Adiposity 15 Years Postpartum: Results from the Study of Women’s Health Across the Nation

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Candace K McClure ◽  
Christina M Shay ◽  
Ping G Tepper ◽  
Molly B Conroy ◽  
Barbara Sternfeld ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Women’S Health ◽  
Women's Health ◽  
Menopausal Status ◽  
Lower Leg ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Regional Adiposity

Objective: It has been reported that mothers who do not breastfeed are at an increased risk of T2DM, metabolic syndrome, and CVD. We hypothesize that lactation may influence cardio-metabolic risk by altering maternal body composition. We examined the extent to which lactation was associated with regional and total adiposity in a sample of US women 15 years after their last birth. Study Design : Cross-sectional analysis of data provided by 1,268 women aged 45-58 who enrolled in the Study of Women’s Health Across the Nation (1996 -1997). Adiposity was assessed using dual-energy X-ray absorptiometry. History of lactation was self-reported and categorized into three groups: mothers who breastfed for ≥3 months after every birth, those who discontinued lactation within 3 months of some births, and those who never breastfed. Results: Compared with mothers who breastfed after every birth for at least 3 months, mothers who never breastfed had 0.87 kg greater trunk fat mass (FM), 1.3% greater % trunk FM, 1.3% lower % leg FM, and 0.075 greater trunk to leg FM ratio after adjustment for age, parity, height, years since last birth, race/ethnicity, socioeconomic, lifestyle, psychological, and family history variables, maximum gestational weight gain, and menopausal status. After additional adjustment for current BMI, women who never breastfed had 0.40 kg greater trunk FM and 0.053 greater trunk to leg FM ratio than mothers who breastfed every child for ≥3 months. Similarly, mothers who discontinued lactation within 3 months of some births had 0.28 kg greater trunk FM and 0.87% lower % leg FM than mothers who consistently breastfed. Conclusion : Women who did not breastfeed for at least 3 months after every birth exhibit less favorable body fat distributions 15 years postpartum. These results provide a potential physiologic basis for prior findings that women who do not breastfeed their children face increased risk of diabetes, the metabolic syndrome, and cardiovascular disease. Given existing disparities in rates of lactation, obesity and CVD, these findings have great clinical relevance and suggest the need for targeted lactation support for women at risk of cardiovascular disease.

scholarly journals Detectable Changes in Physical Performance Measures in Elderly African Americans

2010 ◽  
Vol 90 (6) ◽  
pp. 921-927 ◽  
Author(s):  
Kathleen Kline Mangione ◽  
Rebecca L. Craik ◽  
Alyson A. McCormick ◽  
Heather L. Blevins ◽  
Meaghan B. White ◽  
...  
Keyword(s):  
Older Adults ◽  
African American ◽  
Physical Performance ◽  
Performance Measures ◽  
Gait Speed ◽  
Intraclass Correlation ◽  
Assistive Device ◽  
Minimal Detectable Change ◽  
6Mwt Distance ◽  
African American Older Adults

Background African American older adults have higher rates of self-reported disability and lower physical performance scores compared with white older adults. Measures of physical performance are used to predict future morbidity and to determine the effect of exercise. Characteristics of performance measures are not known for African American older adults. Objective The purpose of this study was to estimate the standard error of measurement (SEM) and minimal detectable change (MDC) for the Short Physical Performance Battery (SPPB), Timed “Up & Go” Test (TUG) time, free gait speed, fast gait speed, and Six-Minute Walk Test (6MWT) distance in frail African American adults. Design This observational measurement study used a test-retest design. Methods Individuals were tested 2 times over a 1-week period. Demographic data collected included height, weight, number of medications, assistive device use, and Mini-Mental Status Examination (MMSE) scores. Participants then completed the 5 physical performance tests. Results Fifty-two participants (mean age=78 years) completed the study. The average MMSE score was 25 points, and the average body mass index was 29.4 kg/m2. On average, participants took 7 medications, and the majority used assistive devices. Intraclass correlation coefficients (ICC [2,1]) were greater than .90, except for the SPPB score (ICC=.81). The SEMs were 1.2 points for the SPPB, 1.7 seconds for the TUG, 0.08 m/s for free gait speed, 0.09 m/s for fast gait speed, and 28 m for 6MWT distance. The MDC values were 2.9 points for the SPPB, 4 seconds for the TUG, 0.19 m/s for free gait speed, 0.21 m/s for fast gait speed, and 65 m for 6MWT distance. Limitations The entire sample was from an urban area. Conclusions The SEMs were similar to previously reported values and can be used when working with African American and white older adults. Estimates of MDC were calculated to assist in clinical interpretation.

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