scholarly journals Association of long-term body weight variability with dementia: a prospective study

2021 ◽  
Author(s):  
Hui Chen ◽  
Tianjing Zhou ◽  
Jie Guo ◽  
John S Ji ◽  
Liyan Huang ◽  
...  
Keyword(s):  
Body Weight ◽  
Prospective Study ◽  
Weight Change ◽  
The Body ◽  
Body Weight Change ◽  
Cox Proportional Hazard ◽  
Incident Dementia ◽  
A Prospective Study

Abstract Background Body weight variability (BWV) refers to intraindividual weight loss and gain over a period. The association of long-term BWV with dementia remains unclear and whether this association is beyond body weight change is undetermined. Methods In the Health and Retirement Study (HRS), a total of 5,547 dementia-free participants (56.7% women; mean [SD] age, 71.1 [3.2] years) at baseline (2008) were followed up to 8 years (mean=6.8 years) to detect incident dementia. Body weight was self-reported biennially from 1992-2008. BWV was measured as the coefficient of variation utilizing the body weight reported 9 times across 16 years before baseline. Cox proportional hazard model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI). Results Among the 5,547 participants, a total of 427 incident dementia cases were identified during follow-up. Greater long-term BWV was significantly associated with a higher risk of dementia (HR comparing extreme quartiles: 2.01, 95% CI: 1.48-2.72; HR of each SD increment: 1.21, 95% CI: 1.10-1.32; P-trend<0.001) independent of mean body weight and body weight change. This significant association was even observed for BWV estimated approximately 15 years preceding dementia diagnosis (HR of each SD increment: 1.13, 95% CI: 1.03-1.23) and was more pronounced for that closer to diagnosis. Conclusions Our prospective study suggested that greater BWV may be a novel risk factor for dementia.

scholarly journals Association of long-term body weight variability with dementia: a prospective study

2021 ◽  
Author(s):  
Hui Chen ◽  
Tianjing Zhou ◽  
Jie Guo ◽  
John S. Ji ◽  
Liyan Huang ◽  
...  
Keyword(s):  
Body Weight ◽  
Risk Factor ◽  
Prospective Study ◽  
Population Based ◽  
Dementia Diagnosis ◽  
Temporal Relationships ◽  
Incident Dementia ◽  
A Prospective Study ◽  
Retirement Study

Introduction: We aimed to investigate whether long-term body weight variability (BWV) is associated with late-life dementia and to further assess their potential temporal relationships. Methods: In 5,547 participants in Health and Retirement Study (HRS), a population-based prospective cohort, we quantified BWV as coefficient of variation using self-reported body weight from 1992 to 2008 and followed their dementia status from 2008 to 2016. Results: A total of 427 incident dementia cases were identified. Larger long-term BWV was significantly associated with higher risk of dementia (HR comparing extreme quartiles: 2.01, 95% CI: 1.48-2.72; HR of each SD increment: 1.21, 95% CI,1.10-1.32; p-trend<0.001). This significant association was even observed for BWV estimated approximately 15 years preceding dementia diagnosis (HR of each SD increment: 1.13, 95% CI: 1.03-1.23) and was more pronounced for that closer to diagnosis. Discussion: Our findings suggested that large BWV could be a novel risk factor for dementia.

scholarly journals The Association Between Obesity and Visit-to-visit Variability in Systolic Blood Pressure: A Prospective Study

2017 ◽  
Vol 18 (s1) ◽  
pp. 67-74
Author(s):  
Sanja Stojanovic ◽  
Marina Deljanin Ilic ◽  
Stevan Ilic ◽  
Nebojša Tasic ◽  
Bojan Ilic ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Prospective Study ◽  
Systolic Blood Pressure ◽  
Obese Patients ◽  
Hypertensive Patients ◽  
Prevalence Of Obesity ◽  
A Prospective Study

Abstract With the prevalence of obesity and all accompanying health risks, both prevention and health education, as well as identifying predictors for the development of obesity-related diseases are primary. Th e pathophysiological relationship between obesity and visit-to-visit variability in systolic blood pressure (SBPV) has not been completely resolved. To investigate the association between obesity and SBPV in hypertensive patients. Th e prospective study comprised three visits was performed at the hypertension outpatient clinic during the follow up period of 22-months between March 2014 and January 2016. Th is study included 300 randomly selected hypertensive patients (average 67.76±9.84 years), who were divided in groups of obese/non-obese examinees. SBPV was defined as the standard deviation (SD) from three values of SBP. Th e values of SBP and SBP-SD were significantly higher in the group of obese hypertensive patients than in the group of non-obese patients (126.67±8.22 vs 120.45±7.79 mmHg, 11.00±5.64 vs 7.34±3.96; p<0.01). Th e highest SBPV was recorded in the 4th quartile in obese patients (43.13±7.50 mmHg). Th ere was statistically stronger correlation between SBPV and BMI/Waist cirumferences (WC) (ρο=0.425/ ρο=0.356, p<0.01). During 22-months follow up there was a significant decrease of SBPV for 8.2 mmHg, BP for 31/8 mmHg, BMI for 3.8 kg/m2, WC for 10 cm and body weight for 8.24 kg. During 22-months follow-up, reduction of body weight was associated with reduction of blood pressure variability in hypertensive patients. Persistently decrease both body weight and long term visit-to-visit variability may explain lower cardiovascular risk in obese-related disease.

scholarly journals Steatocrit Value in New-Born Babies

2018 ◽  
Vol 35 (7-8) ◽  
pp. 190-3
Author(s):  
Johnwan Usman ◽  
Irfan Abdullah ◽  
Muhazar Muhazar ◽  
Atan Baas Sinuhaji ◽  
A. H. Sutanto
Keyword(s):  
Body Weight ◽  
Breast Milk ◽  
Prospective Study ◽  
The Body ◽  
Milk Formula ◽  
Preterm Newborn ◽  
Formula Milk ◽  
Diet Patterns ◽  
Significant Difference ◽  
A Prospective Study

A prospective study on steatocrit value in full-term or preterm newborn babies of~ 2 days of age in Dr. Pimgadi Hospital, Medan is reported. This study was conducted from December 7, 1992, to February 7, 1993; there were 72 newborn babies (37 males and 35 females). The body weight was> 2500 gin 60 babies and s. 2500 gin 12 babies. The median steatocrit value in babies with body weight of> 2500 g was 9%, and it was 32% in babies less than 2500 g of body weight. The proportion of babies with > 25% steatocrit value was larger in babies less than 2500 g than that in 2500 g by the diet patterns of breast milk, breast milk and milk formula, milk formula. The proportion of babies with < 25% steatocrit value was higher in babies with body weight of< 2500 g than that in babies > 2500 g for those who had either breast milk, breast milk and milk formula or milk formula. There was significant difference (p<0,05) in the steatocrit levels between babies with the body weight of > 2500 g and those who had body weight of ≤ 2500 g.

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