scholarly journals Memory Deficits Precede Increases in Depressive Symptoms in Later Adulthood

2018 ◽  
Vol 74 (6) ◽  
pp. 943-953 ◽  
Author(s):  
Stephen Aichele ◽  
Paolo Ghisletta
Keyword(s):  
Depressive Symptoms ◽  
Sex Education ◽  
Structural Equation ◽  
Structural Equation Models ◽  
Memory Performance ◽  
Memory Deficits ◽  
Community Dwelling ◽  
Depression Symptoms ◽  
Age Related ◽  
Increased Risk

Abstract Objectives We examined bidirectional, time-ordered associations between age-related changes in depressive symptoms and memory. Method Data came from 107,599 community-dwelling adults, aged 49–90 years, who participated in the Survey of Health, Ageing, and Retirement in Europe (SHARE). Depressive symptoms were measured with the EURO-D inventory, and memory was evaluated as delayed recall of a 10-word list. Participants were assessed up to five times at 2-year intervals. Dynamic structural equation models were used to estimate longitudinal and time-ordered (lead-lag) relations between depressive symptoms and memory performance. Results Depressive symptoms increased and memory scores decreased across the observed age range, with worsening mostly evident after age 62 years. These long-term changes were moderately negatively correlated (r = −.53, p < .001). A time-ordered effect emerged such that age-specific memory deficits preceded shorter-term increases in depression symptoms. This effect can be translated such that each 1-point decrement on a 10-point memory scale at a given age predicted a 14.5% increased risk for depression two years later. Statistical adjustment for covariates (sex, education, re-test, smoking, and body mass index) had little influence on these associations. Conclusion In later adulthood, lower memory performance at a given age predicts subsequent 2-year increases in depressive symptoms.

scholarly journals Stress-related anhedonia is associated with ventral striatum reactivity to reward and transdiagnostic psychiatric symptomatology

2015 ◽  
Vol 45 (12) ◽  
pp. 2605-2617 ◽  
Author(s):  
N. S. Corral-Frías ◽  
Y. S. Nikolova ◽  
L.J. Michalski ◽  
D. A. A. Baranger ◽  
A. R. Hariri ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Alcohol Use ◽  
Structural Equation ◽  
Ventral Striatum ◽  
Structural Equation Models ◽  
Depression Symptoms ◽  
Problematic Alcohol ◽  
Increased Risk ◽  
Problematic Alcohol Use ◽  
The Relationship

BackgroundEarly life stress (ELS) is consistently associated with increased risk for subsequent psychopathology. Individual differences in neural response to reward may confer vulnerability to stress-related psychopathology. Using data from the ongoing Duke Neurogenetics Study, the present study examined whether reward-related ventral striatum (VS) reactivity moderates the relationship between retrospectively reported ELS and anhedonic symptomatology. We further assessed whether individual differences in reward-related VS reactivity were associated with other depressive symptoms and problematic alcohol use via stress-related anhedonic symptoms and substance use-associated coping.MethodBlood oxygen level-dependent functional magnetic resonance imaging (fMRI) was collected while participants (n = 906) completed a card-guessing task, which robustly elicits VS reactivity. ELS, anhedonic symptoms, other depressive symptoms, coping behavior, and alcohol use behavior were assessed with self-report questionnaires. Linear regressions were run to examine whether VS reactivity moderated the relationship between ELS and anhedonic symptoms. Structural equation models examined whether this moderation was indirectly associated with other depression symptoms and problematic alcohol use through its association with anhedonia.ResultsAnalyses of data from 820 participants passing quality control procedures revealed that the VS × ELS interaction was associated with anhedonic symptoms (p = 0.011). Moreover, structural equation models indirectly linked this interaction to non-anhedonic depression symptoms and problematic alcohol use through anhedonic symptoms and substance-related coping.ConclusionsThese findings suggest that reduced VS reactivity to reward is associated with increased risk for anhedonia in individuals exposed to ELS. Such stress-related anhedonia is further associated with other depressive symptoms and problematic alcohol use through substance-related coping.

Self-Criticism and Self-Warmth: An Imagery Study Exploring Their Relation to Depression

2006 ◽  
Vol 20 (2) ◽  
pp. 183-200 ◽  
Author(s):  
Paul Gilbert ◽  
Mark W. Baldwin ◽  
Chris Irons ◽  
Jodene R. Baccus ◽  
Michelle Palmer
Keyword(s):  
Depressive Symptoms ◽  
Data Analysis ◽  
Structural Equation ◽  
Structural Equation Models ◽  
The Self ◽  
Therapeutic Interventions ◽  
Imagery Task ◽  
Increased Risk ◽  
Negative Feelings

When things go wrong for people, those who are self-critical, compared to those who self-reassure, are at increased risk of psychopathology. However, little is known of the internal processes involved in self-criticism and self-reassurance, such as the ease of eliciting critical imagery, and the power, emotion and vividness of self-criticalness and self-reassurance. This study used a self-imagery task to investigate trait self-criticism and trait self-reassurance in relation to the ease and clarity of generating self-critical and self-reassuring images, and the felt power and emotion of self-critical and self-reassuring imagery. We also explored these in relation to depressive symptoms in students. Results suggested that trait self-criticism is associated with ease and clarity in generating hostile and powerful self-critical images, while trait self-reassurance is associated with ease and clarity of generating warm and supportive images of the self. Data analysis using structural equation models also suggests that difficulties in generating self-reassurance and compassionate images about the self with self-directed warmth, may also contribute to depressive symptoms. Thus self-critics may not only suffer for elevated negative feelings about the self but may also struggle to be able to generate self-supportive images and feelings for the self, and these difficulties could be a focus of therapeutic interventions.

scholarly journals Psychosocial Pathways to Racial/Ethnic Inequalities in Late-Life Memory Trajectories

2017 ◽  
Vol 74 (3) ◽  
pp. 409-418 ◽  
Author(s):  
Laura B Zahodne ◽  
Ketlyne Sol ◽  
Zarina Kraal
Keyword(s):  
Depressive Symptoms ◽  
Locus Of Control ◽  
Structural Equation ◽  
Structural Equation Models ◽  
Perceived Discrimination ◽  
External Locus ◽  
Memory Decline ◽  
Increased Risk ◽  
External Locus Of Control ◽  
Racial Ethnic

Abstract Objectives Blacks and Hispanics are at increased risk for dementia, even after socioeconomic and vascular factors are taken into account. This study tests a comprehensive model of psychosocial pathways leading to differences in longitudinal cognitive outcomes among older blacks and Hispanics, compared to non-Hispanic whites. Methods Using data from 10,173 participants aged 65 and older in the Health and Retirement Study, structural equation models tested associations among race/ethnicity, perceived discrimination, depressive symptoms, external locus of control, and 6-year memory trajectories, controlling for age, sex, educational attainment, income, wealth, and chronic diseases. Results Greater perceived discrimination among blacks was associated with lower initial memory level via depressive symptoms and external locus of control, and with faster memory decline directly. Greater depressive symptoms and external locus of control among Hispanics were each independently associated with lower initial memory, but there were no pathways from Hispanic ethnicity to memory decline. Discussion Depression and external locus of control partially mediate racial/ethnic differences in memory trajectories. Perceived discrimination is a major driver of these psychosocial pathways for blacks, but not Hispanics. These results can inform the development of policies and interventions to reduce cognitive morbidity among racially/ethnically diverse older adults.

scholarly journals Depressive symptoms and glycated hemoglobin A1c: a reciprocal relationship in a prospective cohort study

2015 ◽  
Vol 46 (5) ◽  
pp. 945-955 ◽  
Author(s):  
N. Schmitz ◽  
S. Deschênes ◽  
R. Burns ◽  
K. J. Smith
Keyword(s):  
Depressive Symptoms ◽  
Structural Equation ◽  
Hemoglobin A1c ◽  
Structural Equation Models ◽  
Glycated Hemoglobin ◽  
Reciprocal Relationship ◽  
Glycated Hemoglobin A1c ◽  
Increased Risk ◽  
Cardiometabolic Factors ◽  
Hba1c Levels

BackgroundThe aim of this study was to evaluate the dynamic association between depressive symptoms and glycated hemoglobin A1c (HbA1c) levels using data from the English Longitudinal Study of Ageing (ELSA).MethodThe sample was comprised of 2886 participants aged ⩾50 years who participated in three clinical assessments over an 8-year period (21% with prediabetes and 7% with diabetes at baseline). Structural equation models were used to address reciprocal associations between depressive symptoms and HbA1c levels and to evaluate the mediating effects of lifestyle-related behaviors and cardiometabolic factors.ResultsWe found a reciprocal association between depressive symptoms and HbA1c levels: depressive symptoms at one assessment point predicted HbA1c levels at the next assessment point (standardized β = 0.052) which in turn predicted depressive symptoms at the following assessment point (standardized β = 0.051). Mediation analysis suggested that both lifestyle-related behaviors and cardiometabolic factors might mediate the association between depressive symptoms and HbA1c levels: depressive symptoms at baseline predicted lifestyle-related behaviors and cardiometabolic factors at the next assessment, which in turn predicted HbA1c levels 4 years later. A similar association was observed for the other direction: HbA1c levels at baseline predicted lifestyle-related behaviors and cardiometabolic factors at the next assessment, which in turn predicted depressive symptoms 4 years later.ConclusionsOur results suggest a dynamic relationship between depressive symptoms and HbA1c which might be mediated by both lifestyle and cardiometabolic factors. This has important implications for investigating the pathways which could link depressive symptoms and increased risk of diabetes.

scholarly journals Paucity of Entorhinal Cortex Pathology of the Alzheimer’s Type in SuperAgers with Superior Memory Performance

2021 ◽  
Author(s):  
Tamar Gefen ◽  
Allegra Kawles ◽  
Beth Makowski-Woidan ◽  
Janessa Engelmeyer ◽  
Ivan Ayala ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Entorhinal Cortex ◽  
Memory Performance ◽  
Amyloid Plaques ◽  
Memory Capacity ◽  
Relative Magnitude ◽  
Age Related ◽  
Increased Risk ◽  
Superior Memory ◽  
Normal Controls

Abstract Advancing age is typically associated with declining memory capacity and increased risk of Alzheimer’s disease (AD). Markers of AD such as amyloid plaques (AP) and neurofibrillary tangles (NFTs) are commonly found in the brains of cognitively average elderly but in more limited distribution than in those at the mild cognitive impairment and dementia stages of AD. Cognitive SuperAgers are individuals over age 80 who show superior memory capacity, at a level consistent with individuals 20–30 years their junior. Using a stereological approach, the current study quantitated the presence of AD markers in the memory-associated entorhinal cortex (ERC) of seven SuperAgers compared with six age-matched cognitively average normal control individuals. Amyloid plaques and NFTs were visualized using Thioflavin-S histofluorescence, 6E10, and PHF-1 immunohistochemistry. Unbiased stereological analysis revealed significantly more NFTs in ERC in cognitively average normal controls compared with SuperAgers (P < 0.05) by a difference of ~3-fold. There were no significant differences in plaque density. To highlight relative magnitude, cases with typical amnestic dementia of AD showed nearly 100 times more entorhinal NFTs than SuperAgers. The results suggest that resistance to age-related neurofibrillary degeneration in the ERC may be one factor contributing to preserved memory in SuperAgers.

scholarly journals Age Cohort Differences and Depressive Symptoms Among Community-Dwelling Older Americans

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 61-61
Author(s):  
Ethan Siu Leung Cheung ◽  
Ada Mui
Keyword(s):  
Depressive Symptoms ◽  
Short Form ◽  
Cognitive Status ◽  
Community Dwelling ◽  
Independent Effect ◽  
Depression Symptoms ◽  
Older Americans ◽  
Age Cohorts ◽  
Cohort Differences ◽  
Age Cohort

Abstract This study uses Wave 3 National Social Life, Health and Aging Project to examine the correlation between age cohorts [60s (n=1204); 70s (n=1176); 80 and older (n= 724)], cognitive status, and depression symptoms. In the total sample, 53.90% were females, 76.15% Whites, 15.29% Blacks, and 8.56% Asians. Compared to the 60s and 70s cohorts, 80+ cohort was cognitively more impaired [Mean (SD) of MoCA Short Form were 10.7(2.9), 10.0(3.2), and 8.1(3.6)]. There were no age cohorts’ differences in depressive symptoms experienced (Mean of CESD Short Form = 21.03; SD = 4.06). In order to identify predictors of depression, multiple hierarchical regressions were performed. The 60s sample was the reference group to compare with 70s and 80s cohorts. Results showed that age cohort variables had a significant independent effect as well as a joint effect with cognitive status in explaining depression scores. For each age cohort group, parallel regression analyses were conducted and all models were significant. Findings suggest that ADL impairment was the only common predictor for depressive symptoms for the three cohort groups, and the association was the strongest for the 60s cohort (b = .31). Other unique predictors for 60s cohort were lower-income, more IADLs impairment, higher stress and cognitive impairment. For the 70s cohort, unique predictors of depressive symptoms were female gender, unmarried, and less socialization. For the 80 and above group, correlates of depression are female, White, and high stress level. Findings highlight the necessity of age-sensitive programs on depression support for community-dwelling older Americans.

scholarly journals LONGITUDINAL ASSOCIATIONS OF DEPRESSIVE SYMPTOM AND SUBJECTIVE MEMORY FACTORS WITH OBJECTIVE MEMORY PERFORMANCE

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S648-S648
Author(s):  
Wonjeong Haavisto ◽  
Julie Blaskewicz Boron ◽  
Sherry Willis ◽  
Warner Schaie
Keyword(s):  
Depressive Symptoms ◽  
Depressive Symptom ◽  
Memory Performance ◽  
Memory Deficits ◽  
Somatic Complaints ◽  
Specific Factor ◽  
Prior Work ◽  
Subjective Memory ◽  
Self Evaluation ◽  
Longitudinal Associations

Abstract Prior research demonstrated a history of depressive symptoms predicted oncoming memory deficits, and that self-evaluation of memory was associated with forthcoming memory difficulties. However, prior work lacks consistent consideration of multifaceted depressive symptoms in regards to longitudinal associations with objective memory (OM). Structural models were examined to determine how latent factors of depressive symptoms (via the CES-D) and SM factors predicted memory deficits at later time points when taking into account baseline OM performance [n=270; RMSEA=.034; CFI=.974; TLI=.965] in the Seattle Longitudinal Study (mean Age=70.33; SD=7.29; mean Education=15.30; SD=2.72; 61.9% female). The somatic complaints CES-D factor showed a significant longitudinal association with OM performance after seven years (β = -.25, p < .05), while none of CES-D factors showed cross-sectional associations with the baseline OM. The general frequency of forgetting SM factor was positively associated with OM performance at baseline (β = .26, p < .001), suggesting that those performing better at recalling words reported fewer memory problems. None of SM factors showed longitudinal associations with OM measured seven years later, indicating that self-evaluation of memory had no impact on future memory deficits. Overall findings suggested that a key CES-D factor, somatic complaints, was detected and that people endorsing more somatic issues experienced greater memory decline over a seven year period. Thus, extending prior work, the current study suggests that although both subjective memory and depressive symptom factors showed concurrent associations, only a specific factor of depressive symptoms, somatic complaints, was influential in regards to predicting later memory performance

Assessment of Cognitively Stimulating Activity in a Spanish Population

Assessment ◽  
2018 ◽  
Vol 27 (6) ◽  
pp. 1310-1319 ◽  
Author(s):  
Manuel Morales Ortiz ◽  
Aaron Fernández
Keyword(s):  
Structural Equation ◽  
Older Persons ◽  
Structural Equation Models ◽  
Theoretical Models ◽  
Well Being ◽  
The Elderly ◽  
Hierarchical Regression ◽  
Active Ageing ◽  
Age Related ◽  
Effect Of Age

Theoretical models of active ageing and cognitive reserve emphasize the importance of leading an active life to delay age-related cognitive deterioration and maintain good levels of well-being and personal satisfaction in the elderly. The objective of this research was to construct a scale to measure cognitively stimulating activities (CSA) in the Spanish language. The sample consisted of a total of 453 older persons. The scale was constructed from a list of 28 items and validated using structural equation models. The scale obtained showed a negative correlation with age and a positive correlation with education and physical activity. Using hierarchical regression models, CSAs were found to have a significant effect on attention when controlling for the effect of age and education. Likewise, a significant interaction between age and CSA was found on the measure of episodic memory. The validated CSA scale will enable the relationships between changes in cognitive functions and stimulating activities to be studied.

scholarly journals INFLUENCING FACTORS OF SUBJECTIVE AGE: FINDINGS FROM THE KUSATSU LONGITUDINAL STUDY ON AGING AND HEALTH

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S695-S696
Author(s):  
Tomoko Ikeuchi ◽  
Satoshi Seino ◽  
Yu Taniguchi ◽  
Miki Narita ◽  
Takumi Abe ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Cognitive Function ◽  
Influencing Factors ◽  
Community Dwelling ◽  
Chronological Age ◽  
Social Changes ◽  
Subjective Age ◽  
Age Related ◽  
Years Of Schooling

Abstract Background: Subjective age (SA) has been found to be a biopsychosocial marker of aging, yet little is known about factors that influence SA development. This study examined factors influencing SA using longitudinal data of community-dwelling older Japanese. Methods: Data drawn from the Kusatsu Longitudinal Study were collected during annual health check-ups in 2017 and 2018 from participants (aged 65-95) who completed all the measurement items used for this analysis (N=981). SA was indexed by asking participants to specify in years how old they felt. Proportional discrepancy scores ((subjective age - chronological age)/chronological age ×100) were calculated to indicate younger or older SAs and used as a dependent variable. As influencing factors of SA, chronological age, sex, years of schooling, history of smoking, cognitive function (using MMSE scores, range 14-30 at baseline), depressive symptoms, physical function (gait speed), and social function (employment status) were examined. Analyses were performed with random-effects GLS regression models. Results: Significant partial regression coefficients were found for cognitive function (0.48%, CI: 0.18, 0.79), years of schooling (-0.42%, CI: -0.69, -0.15), depressive symptoms (0.32%, CI: 0.11, 0.53), and chronological age (-0.18%, CI: -0.30, -0.68). Implications: This study found that older age and longer years of schooling were associated with younger SA, while better cognition and depressive symptoms were linked to older SA. Better cognition being associated with older SA was inconsistent with existing studies. This may be due in part to the association of better cognition and the level of satisfaction influenced by awareness of age-related physical/social changes.

scholarly journals Identifying the Factors Related to Depressive Symptoms Amongst Community-Dwelling Older Adults with Mild Cognitive Impairment

2019 ◽  
Vol 16 (18) ◽  
pp. 3449 ◽  
Author(s):  
Dan Song ◽  
Doris S.F. Yu ◽  
Polly W.C. Li ◽  
Qiuhua Sun
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Depressive Symptoms ◽  
Mild Cognitive Impairment ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Community Dwelling ◽  
Cross Sectional ◽  
Increased Risk ◽  
Community Dwelling Older Adults

High-level depressive symptoms have been reported in individuals with mild cognitive impairment (MCI), resulting in increased risk of progression to dementia. However, studies investigating the correlates of depressive symptoms among this population are scarce. This study aimed to investigate the significant socio-demographic, lifestyle-related and disease-related correlates of depressive symptoms among this cohort. Cross-sectional data were obtained from a sample of 154 Chinese community-dwelling older adults with MCI. MCI subjects were screened by the Montreal Cognitive Assessment. Depressive symptoms were measured by the Geriatric Depression Scale. Possible correlates of depressive symptoms in individuals with MCI were explored by multiple linear regressions. The prevalence of depressive symptoms among Chinese older adults with MCI was 31.8%. In multiple regression analysis, poor perceived positive social interaction, small social network, low level of physical activity, poor functional status, subjective memory complaint, and poor health perception were correlated with depressive symptoms. The findings highlight that depressive symptoms are sufficient to warrant evaluation and management in older adults with MCI. Addressing social isolation, assisting this vulnerable group in functional and physical activities, and cultivating a positive perception towards cognitive and physical health are highly prioritized treatment targets among individuals with MCI.

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