scholarly journals Association Between Late-Life Hypertension and Resilience to Alzheimer Dementia Among Older Adults

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 304-305
Author(s):  
Mo-kyung Sin ◽  
Yan Cheng
Keyword(s):  
Older Adults ◽  
Late Life ◽  
Braak Stage ◽  
Clinical Dementia Rating ◽  
Chi Square ◽  
Alzheimer Dementia ◽  
Student’S T ◽  
The Relationship ◽  
Untreated Hypertension

Abstract While midlife hypertension is known as one contributing factor for cognitive impairment and Alzheimer dementia in late-life older adults, less is known about the role of late-life hypertension in resilience to Alzheimer dementia. We examined the relationship between late-life hypertension and Alzheimer dementia resilience among older adults using the National Alzheimer’s Coordinating Center data from 2005-2020 (n=3,170). Hypertension, captured within 5 years prior to death, was defined as blood pressure (BP) ≥ 140/90 mmHg in at least two visits and/or ever treated with anti-hypertensive agents. Resilience was defined as positive Alzheimer disease (AD) pathology (CERAD score moderate or severe and BRAAK stage V or VI) from autopsy and Clinical Dementia Rating (CDR) - Sum of Boxes (SOB): 0.5-2.5 or CDR global (0-0.5) from last data point before autopsy. Student’s t-tests and Chi-square tests were conducted to compare patients with and without resilience. A multivariate logistic regression was conducted to estimate the association between late-life hypertension and resilience, adjusting for covariates of demographics and neuropathological characteristics. We had 55 resilient cases among 1,195 positive AD pathology cases. Those resilient were older (88±6.7) and had higher systolic BP (136 ± 18.2 mmHg) than non-resilient (82±7.9 years old, 130±20 mmHg. Untreated hypertension had a protective effect on resilience (adjusted OR: 3.69 (1.10-13.5, p=0.05). Patients with a systolic BP in the range of 135-145 mmHg and a diastolic BP in the range of 65-75 mmHg had the highest resilience possibility. Unlike midlife hypertension, late-life hypertension may have different effect on dementia, prompting further studies.

scholarly journals Association between late-life hypercholesterolemia and progression of dementia severity among older adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 876-876
Author(s):  
Mo-kyung Sin ◽  
Yan Cheng ◽  
Ali Ahmed ◽  
Edward Zamrini
Keyword(s):  
Older Adults ◽  
Cox Regression ◽  
Late Life ◽  
Clinical Dementia Rating ◽  
Future Studies ◽  
Dementia Severity ◽  
Kaplan Meier ◽  
Point Increase ◽  
Race Ethnicity ◽  
The Relationship

Abstract Progression of dementia severity varies widely by individuals and multiple factors might influence the progression. The aim of this study was to examine the relationship between late-life hypercholesterolemia and progression of dementia severity in older adults. We used prospectively collected longitudinal data from 2,686 adults aged ≥65 years in the National Alzheimer’s Coordinating Center. Progression of dementia severity was measured using both Clinical Dementia Rating (CDR) - Sum of Boxes (SOB) and Global scores. Kaplan Meier curves were plotted to estimate the association between hypercholesterolemia and progression of dementia severity. We also conducted multivariate Cox regression models to estimate the association of hypercholesterolemia with the outcomes adjusting for age, gender, race, ethnicity, marital status, living status, education, smoking, heart failure, atrial fibrillation, blood pressure, and diabetes. Hypercholesterolemia had significant association with CDR-SOB ≥ 1 point increase (unadjusted HR, 1.23; 95% CI, 1.13-1.35; p<0.001; adjusted HR, 1.17; 95% CI, 1.07-1.28; p<0.001). In addition, hypercholesterolemia had significant association with CDR-Global ≥ 0.5 point increase (unadjusted HR, 1.14; 95% CI, 1.04-1.25; p<0.001; adjusted HR, 1.11; 95% CI, 1.01-1.22 p=0.036). If these findings can be replicated in future studies, future studies need to examine if proper management of cholesterol may reduce the risk of Alzheimer’s dementia in late-life older adults.

scholarly journals The moderating role of personality factors in the relationship between depression and neuropsychological functioning among older adults

2009 ◽  
Vol 24 (9) ◽  
pp. 1010-1019 ◽  
Author(s):  
Brian J. Ayotte ◽  
Guy G. Potter ◽  
Heather T. Williams ◽  
David C. Steffens ◽  
Hayden B. Bosworth
Keyword(s):  
Older Adults ◽  
Neuropsychological Functioning ◽  
Personality Factors ◽  
The Relationship ◽  
Moderating Role

scholarly journals Cognitive Functioning and Late-Life Depression

2014 ◽  
Vol 20 (5) ◽  
pp. 461-467 ◽  
Author(s):  
Aaron M. Koenig ◽  
Rishi K. Bhalla ◽  
Meryl A. Butters
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Cognitive Functioning ◽  
Neuropsychological Assessment ◽  
Cognitive Deficits ◽  
Late Life ◽  
Cognitive Outcomes ◽  
Review Of The Literature ◽  
Late Life Depression ◽  
The Relationship

AbstractThis brief report provides an introduction to the topic of cognitive functioning in late-life depression (LLD). In addition to providing a review of the literature, we present a framework for understanding the heterogeneity of cognitive outcomes in this highly prevalent disorder. In addition, we discuss the relationship between LLD and dementia, and highlight the importance of regularly assessing cognitive functioning in older adults who present with depressive symptoms. If cognitive deficits are discovered during a neuropsychological assessment, we recommend referral to a geriatric psychiatrist or cognitive neurologist, for evaluation and treatment of the patient’s symptoms. (JINS, 2014, 20, 1–7)

scholarly journals Evaluation of Neospora caninum-Associated Abortion in a Seroepidemiological Study of Cattles Using IFAT Method

2020 ◽  
Vol 1 (1) ◽  
pp. 7-10
Author(s):  
Seyed Razi Bahavarnia ◽  
Pedram Ahli ◽  
Arash Rasouli
Keyword(s):  
Neospora Caninum ◽  
Farming System ◽  
Chi Square ◽  
Related Risk ◽  
Coccidian Parasites ◽  
Chi Square Test ◽  
Relationship Of ◽  
Cattle Farms ◽  
The Relationship

Background: Neospora caninum is a cyst forming coccidian parasites and one of the important factors in abortion of cows and neurologic disease in dogs around the world. This study was conducted to investigate the seroprevalence of N. caninum in dairy cows of Tabriz city using immunofluorescence method and related risk factors. Methods: In this study conducted in 2018, 100 samples from industrial cattle farms and 100 samples from traditional cattle farms of Tabriz were randomly collected. By fixing tachyzoites cultured in a culture medium, the kit was prepared in this study and the slides were examined by fluorescence microscopy (Zeiss). The results obtained in relation to the study variables (type of farming system, age, contact with dogs, and abortion history) were analyzed using SPSS software and chi-square test. Results: Neospora caninum antibodies were detected in 33 samples (16.5%). The relationship of positive serums with abortion and contact with dogs was significant statistically (P<0.05). Conclusions: Due to the significant relationship of infection rate in cows with abortion history and contact with dogs, further studies are needed to determine the exact role of Neospora in abortion of cows.

scholarly journals Sports potential modeling of young basketball players: a preliminary analysis

2019 ◽  
Vol 21 ◽  
Author(s):  
Dilson Borges Ribeiro Junior ◽  
Jeferson Macedo Vianna ◽  
André de Assis Lauria ◽  
Emerson Filipino Coelho ◽  
Francisco Zacaron Werneck
Keyword(s):  
Adult Height ◽  
High Potential ◽  
Basketball Players ◽  
Chi Square ◽  
Chi Square Test ◽  
Student’S T ◽  
The Relationship ◽  
Student’S T Test ◽  
Adult Stature

Abstract The aims of this study were: 1) to evaluate the sports potential of young basketball players; 2) to identify variables that discriminate sports potential assessed by coaches; 3) to verifythe relationship between classification of the multidimensional profile of athletes and classification of the sports potential by coaches. Sixty-two young basketball players aged 15.6±1.1 years from U-15 (n = 24) and U-17 (n = 38) categories participated in the study. A test battery was applied to evaluate sports potential indicators: 1) anthropometric; 2) physicomotor; 3) psychological;4) skills;5) socio-environmental;6) maturational and 7) sports potential.Clusteranalysis was performed in three groups: high, medium and low potential. Student’s t-test was used for the comparison between athletes evaluated by the coach as excellent and the others and the Chi-Square test to verify the relationship between sports potential classifications. It was observed that in the high-potential group, athletes were chronologically older, with higher % predicted adult height (PMS), competitive and determined sports orientation, higher body size, lower skinfold summation, and greater physicomotor performance. In comparison with other athletes, high-potential basketball players presented higher stature, wider wingspan,longer limb length, greater predicted adult stature and higher Z score of the % PMS. It could be concluded that the multidimensional approach was useful for the evaluation of the sports potential of young basketball players, requiring the use of multidimensional variables, in addition to coaches’ opinion regarding the potential of their athletes.

Duration of Poverty and Subsequent Cognitive Function and Decline Among Older Adults in China, 2005–2018

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000012343
Author(s):  
Xuexin Yu ◽  
Wei Zhang ◽  
Lindsay C. Kobayashi
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Late Life ◽  
Tobit Regression ◽  
Annual Household Income ◽  
Middle Income ◽  
Healthy Longevity ◽  
Rate Of Decline ◽  
Statistical Yearbook

Objective:To investigate the relationship between late-life duration of poverty exposure and cognitive function and decline among older adults in China.Methods:Data were from 3,209 participants aged ≥64 in the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Duration of poverty, defined according to urban and rural regional standards from the China Statistical Yearbook, was assessed based on annual household income from 2005-2011 (never in poverty; 1/3 of the period in poverty; ≥2/3 of the period in poverty). Cognitive function was measured by the Chinese Mini Mental State Exam (CMMSE) from 2011-2018. We used attrition-weighted, multivariable mixed-effects Tobit regression to examine the association of duration of poverty with cognitive function and rate of decline.Results:A total of 1,162 individuals (36.21%) were never in poverty over the period from 2005-2011, 1,172 (36.52%) were in poverty 1/3 of the period, and 875 (27.27%) were in poverty ≥2/3 of the period. A longer poverty duration was associated with lower subsequent CMMSE scores with a dose-response relationship (1/3 vs. never in poverty: β = -0.98; 95% CI: -1.61 to -0.35; ≥2/3 vs. never in poverty: β = -1.55; 95% CI: -2.29 to -0.81). However, a longer duration of poverty was associated with a slower rate of CMMSE score decline over time from 2011-2018.Conclusion:These findings provide valuable evidence on the role of cumulative late-life poverty in relation to cognitive health among older adults in a rapidly urbanizing and aging middle-income country. Our findings may support a compensation hypothesis for cognitive reserve in this setting.

scholarly journals Subjective wellbeing as a determinant of glycated hemoglobin in older adults: longitudinal findings from the English Longitudinal Study of Ageing

2019 ◽  
Vol 50 (11) ◽  
pp. 1820-1828 ◽  
Author(s):  
Lydia Poole ◽  
Ruth A. Hackett ◽  
Laura Panagi ◽  
Andrew Steptoe
Keyword(s):  
Older Adults ◽  
Longitudinal Study ◽  
Subjective Wellbeing ◽  
Glycated Hemoglobin ◽  
Linear Regression Models ◽  
Clinical Factors ◽  
Subclinical Disease ◽  
The Relationship ◽  
English Longitudinal Study

AbstractBackgroundPrevious research has shown an association between subjective wellbeing and incident diabetes. Less is known about the role of wellbeing for subclinical disease trajectories as captured via glycated hemoglobin (HbA1c). We aimed to explore the association between subjective wellbeing and future HbA1c levels, and the role of sociodemographic, behavioral and clinical factors in this association.MethodsWe used data from the English Longitudinal Study of Ageing for this study (N = 2161). Subjective wellbeing (CASP-19) was measured at wave 2 and HbA1c was measured 8 years later at wave 6. Participants were free from diabetes at baseline. We conducted a series of analyses to examine the extent to which the association was accounted for by a range of sociodemographic, behavioral and clinical factors in linear regression models.ResultsModels showed that subjective wellbeing (CASP-19 total score) was inversely associated with HbA1c 8 years later after controlling for depressive symptoms, age, sex, and baseline HbA1c (B = −0.035, 95% CI −0.060 to –0.011, p = 0.005). Inclusion of sociodemographic variables and behavioral factors in models accounted for a large proportion (17.0% and 24.5%, respectively) of the relationship between wellbeing and later HbA1c; clinical risk factors explained a smaller proportion of the relationship (3.4%).ConclusionsPoorer subjective wellbeing is associated with greater HbA1c over 8 years of follow-up and this relationship can in part be explained by sociodemographic, behavioral and clinical factors among older adults.

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