scholarly journals Association of Walking Energetics With Amyloid Status: Findings From the Baltimore Longitudinal Study of Aging

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 371-371
Author(s):  
Fangyu Li ◽  
Amal Wanigatunga ◽  
Qu Tian ◽  
Eleanor Simonsick ◽  
Murat Bilgel ◽  
...  
Keyword(s):  
Energy Cost ◽  
Emission Tomography ◽  
Energetic Cost ◽  
Overground Walking ◽  
Cross Sectional ◽  
Pittsburgh Compound B ◽  
Men And Women ◽  
Positron Emission ◽  
Baltimore Longitudinal Study ◽  
Physiological Indicator

Abstract Higher energetic costs for mobility are associated with slow and declining gait speed. Slow gait is linked to cognitive decline and Alzheimer’s disease (AD), but the physiological underpinnings are note well-understood. We investigated the cross-sectional association between the energetic cost of walking and amyloid status (+/-) in 174 cognitively unimpaired men and women (52%) aged 78.5±8.6 years. The energetic cost of walking was assessed as the average oxygen consumption (VO2) during 2.5 minutes of customary-paced overground walking. Amyloid status was determined from 11C-Pittsburgh compound B (PiB) positron emission tomography (PET) imaging. Average energetic cost of walking was .169±.0379 ml/kg/m and 30% of the sample was PiB+. In logistic regression adjusted for demographics, APOE-e4, body composition and comorbidities, each 0.01ml/kg/m higher energy cost was associated with 12% increased odds of being PiB+ (OR=1.12; 95% CI:1.01-1.24). Inefficient walking may be a clinically meaningful physiological indicator of emerging AD-related pathology.

scholarly journals Az Alzheimer-kór molekuláris képi megjelenítése

2019 ◽  
Vol 160 (33) ◽  
pp. 1289-1295 ◽  
Author(s):  
Annamária Albert ◽  
Katalin Borbély
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Morphological Changes ◽  
Emission Tomography ◽  
Clinical Form ◽  
Pittsburgh Compound B ◽  
Metabolic Pattern ◽  
Functional Changes ◽  
Positron Emission ◽  
Β Amyloid

Abstract: The ever-growing average age of the society significantly increases the occurrence of Alzheimer’s disease. The increased prevalence represents considerable social and economic burden, which urges the development of diagnostic and therapeutic methods in the field. The most common cause of dementia is Alzheimer’s disease, the typical histopathological abnormality of which are well known. The detection of functional changes results in the early diagnosis of the disease, which precedes the morphological changes by years. Positron-emission tomography plays an important role in the demonstration of metabolic changes. The glucose metabolic pattern differs significantly in each clinical form of dementia. The most important β-amyloid-binding radiopharmaceuticals that should be highlighted are [11C]Pittsburgh compound B that is widely used in the research and [18F]florbetapir that is commonly approved in diagnostics. Tracers visualising neurofibrillary tangles consisting of tau protein appeared most recently. The development continues; newer and newer radiopharmaceuticals appear. These tracers play an important role in both the research and the diagnostics. Orv Hetil. 2019; 160(33): 1289–1295.

Two cases of dementias with motor neuron disease evaluated by Pittsburgh compound B-positron emission tomography

2011 ◽  
Vol 33 (1) ◽  
pp. 87-92 ◽  
Author(s):  
Yoshihiro Yamakawa ◽  
Hiroyuki Shimada ◽  
Suzuka Ataka ◽  
Akiko Tamura ◽  
Hideki Masaki ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Emission Tomography ◽  
Pittsburgh Compound B ◽  
Positron Emission

scholarly journals Associations Between Perceived Fatigability and Amyloid Status in the Baltimore Longitudinal Study of Aging

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 208-209
Author(s):  
Ryan Dougherty ◽  
Amal Wanigatunga ◽  
Murat Bilgel ◽  
Yang An ◽  
Eleanor Simonsick ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Perceived Exertion ◽  
Volume Ratio ◽  
Rating Of Perceived Exertion ◽  
Pittsburgh Compound B ◽  
Brain Volumes ◽  
Positron Emission ◽  
Baltimore Longitudinal Study ◽  
Distribution Volume Ratio ◽  
Cortical Distribution

Abstract Higher level of and greater longitudinal increase in perceived fatigability are linked to cognitive decline and lower brain volumes in older adults. However, it remains unclear whether perceived fatigability is associated with Alzheimer’s disease-related brain pathology. In the BLSA, 163 participants without neurological disease or cognitive impairment (aged 74.7+/-8.4 years, 45% men) were assessed for perceived fatigability using rating of perceived exertion after a 5-minute (0.67 m/s) treadmill walk and Aß burden using 11C-Pittsburgh compound B (PiB) positron emission tomography. Forty-four participants were PiB+ based on a mean cortical distribution volume ratio (DVR) cut point of 1.066. After adjusting for demographics, body composition, comorbidities and ApoE-e4, higher perceived fatigability was not associated with PiB+ status (OR=0.84; 95% CI: 0.69, 1.05). Results suggest perceived fatigability may contribute to cognitive decline through pathways other than Aß pathology. Future studies should target other mechanisms linking perceived fatigability and cognitive decline.

Sign in / Sign up

Export Citation Format

Share Document