scholarly journals Circadian Rest and Activity Rhythms and Cognitive Change in the Baltimore Longitudinal Study of Aging

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 445-446
Author(s):  
Yang An ◽  
Sarah Wanigatunga ◽  
Vadim Zipunnikov ◽  
Mark Wu ◽  
Eleanor Simonsick ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Later Life ◽  
Cognitive Change ◽  
Longitudinal Change ◽  
Visuospatial Ability ◽  
Memory Decline ◽  
Activity Rhythms ◽  
Random Intercept ◽  
Wrist Actigraphy ◽  
Baltimore Longitudinal Study

Abstract Alterations in 24-hour movement patterns, or circadian rest/activity rhythms (RARs), commonly occur with aging. Using linear mixed effects (LME) modeling, we examined associations of baseline RARs with longitudinal change in cognition. Participants (N=424; 47% male, baseline age 72.8±10.1 years) were from the Baltimore Longitudinal Study of Aging and completed 5.6±0.8 nights of wrist actigraphy at baseline. Tests of memory, executive function, attention, language, and visuospatial ability were administered at baseline and subsequent visits (3.7±1.7 years of follow-up in those with >1 visit (n=295)). In unadjusted random intercept and slope LME models, greater RAR stability predicted slower memory decline, and higher activity during participants’ least active 5 hours (L5) predicted slower decline in visuospatial ability. After covariate adjustment, higher activity in participants’ most active 10 hours (M10) and higher L5 predicted slower decline in visuospatial ability (p<.05). Further research is needed on RARs as risk factors for later-life cognitive decline.

scholarly journals Apathy as a behavioural marker of cognitive impairment in Parkinson’s disease: a longitudinal analysis

2019 ◽  
Vol 267 (1) ◽  
pp. 214-227 ◽  
Author(s):  
Glen P. Martin ◽  
Kathryn R. McDonald ◽  
David Allsop ◽  
Peter J. Diggle ◽  
Iracema Leroi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Psychiatric Symptoms ◽  
Cognitive Change ◽  
Longitudinal Change ◽  
Random Intercept ◽  
Behavioural Factors ◽  
Over Time

Abstract Background Understanding the longitudinal course of non-motor symptoms, and finding markers to predict cognitive decline in Parkinson’s disease (PD), are priorities. Previous work has demonstrated that apathy is one of the only behavioural symptoms that differentiates people with PD and intact cognition from those with mild cognitive impairment (MCI-PD). Other psychiatric symptoms emerge as dementia in PD develops. Objective We explored statistical models of longitudinal change to detect apathy as a behavioural predictor of cognitive decline in PD. Methods We followed 104 people with PD intermittently over 2 years, undertaking a variety of motor, behavioural and cognitive measures. We applied a linear mixed effects model to explore behavioural factors associated with cognitive change over time. Our approach goes beyond conventional modelling based on a random-intercept and slope approach, and can be used to examine the variability in measures within individuals over time. Results Global cognitive scores worsened during the two-year follow-up, whereas the longitudinal evolution of self-rated apathy scores and other behavioural measures was negligible. Level of apathy was negatively (− 0.598) correlated with level of cognitive impairment and participants with higher than average apathy scores at baseline also had poorer cognition. The model indicated that departure from the mean apathy score at any point in time was mirrored by a corresponding departure from average global cognitive score. Conclusion High levels of apathy are predictive of negative cognitive and behavioural outcomes over time, suggesting that apathy may be a behavioural indicator of early cognitive decline. This has clinical and prognostic implications.

scholarly journals LONGITUDINAL CHANGE OF PHYSICAL AND COGNITIVE FUNCTIONS IN BLSA

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S579-S579
Author(s):  
Pei-Lun Kuo ◽  
Morgan Levine ◽  
Michelle Shardell ◽  
Susan Resnick ◽  
Eleanor M Simonsick ◽  
...  
Keyword(s):  
Executive Function ◽  
Longitudinal Study ◽  
Sex Difference ◽  
Sex Education ◽  
Cognitive Functions ◽  
Gait Speed ◽  
Longitudinal Change ◽  
Physiological Measures ◽  
Baltimore Longitudinal Study ◽  
Usual Gait Speed

Abstract Optimally integrating metrics of aging requires evaluating the metrics’ change with aging. We investigated longitudinal changes of physical and cognitive functions in the Baltimore Longitudinal Study of Aging. Usual gait speed declined -0.08 m/s (p<0.001) per decade at age 60 years, -0.10 m/s (p<0.001) per decade at 65 years, and -0.13 m/s (p<0.001) per decade at 70 years, after adjusting for sex and height. No sex difference of gait speed decline was observed after adjustment for height. Time to finish Trails B, an indicator of executive function, increased 11.3 seconds per decade at 60 years, 17.7 seconds (p<0.001) per decade at 65 years, and 24.1 seconds (p<0.001) per decade at 70 years, after adjusting for sex, education, and race. No sex difference of longitudinal decline in executive function was observed. Linking these findings to physiological measures may unveil an important mechanism of aging.

scholarly journals Association Between Visuospatial Ability and Vestibular Function in the Baltimore Longitudinal Study of Aging

2015 ◽  
Vol 63 (9) ◽  
pp. 1837-1844 ◽  
Author(s):  
Robin T. Bigelow ◽  
Yevgeniy R. Semenov ◽  
Carolina Trevino ◽  
Luigi Ferrucci ◽  
Susan M. Resnick ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Vestibular Function ◽  
Visuospatial Ability ◽  
Baltimore Longitudinal Study

scholarly journals Adverse Childhood Experiences and Rate of Memory Decline From Mid to Later-Life: Evidence From the English Longitudinal Study of Ageing

2021 ◽  
Author(s):  
Brendan Q O’Shea ◽  
Panayotes Demakakos ◽  
Dorina Cadar ◽  
Lindsay C Kobayashi
Keyword(s):  
Longitudinal Study ◽  
Foster Care ◽  
Adverse Childhood Experiences ◽  
Later Life ◽  
Childhood Experiences ◽  
Memory Decline ◽  
Adverse Childhood ◽  
Rate Of Decline ◽  
English Longitudinal Study

Abstract Evidence on the role of early-life adversity in later-life memory decline is conflicting. We investigated the relationships between adverse childhood experiences (ACEs) and memory performance and rate of decline over a ten-year follow-up among mid-to-older adults in England. Data were from biennial interviews with 5,223 participants aged 54+ in the population-representative English Longitudinal Study of Ageing from 2006/07-2016/17. We examined self-reports of nine ACEs prior to age 16, which related to abuse, household dysfunction, and separation from family. Memory was assessed at each time point as immediate and delayed recall of 10 words. Using linear mixed-effects models with person-specific random intercepts and slopes and adjusted for baseline age, age2, sex, ethnicity, and childhood socioeconomic factors, we observed that most individual and cumulative ACE exposures had null-to-weakly negative associations with memory function and rate of decline over the 10-year follow-up. Having lived in residential or foster care was associated with lower baseline memory (adjusted β = -0.124 standard deviation units, 95% confidence interval: -0.273, -0.025), but not memory decline. Our findings suggest potential long-run impacts of residential or foster care on memory, and highlight the need for accurate and detailed exposure measures when studying ACEs in relation to later-life cognitive outcomes.

1344: Metabolic Factors Associated with Benign Prostatic Hyperplasia: The Baltimore Longitudinal Study of Aging

2006 ◽  
Vol 175 (4S) ◽  
pp. 432-433 ◽  
Author(s):  
J. Kellogg Parsons ◽  
H. Ballentine Carter ◽  
Alan W. Partin ◽  
B. Gwen Windham ◽  
E. Jeffrey Metter ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Metabolic Factors ◽  
Factors Associated ◽  
Baltimore Longitudinal Study
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