scholarly journals Sex-Specific 25-Hydroxyvitamin D Threshold Concentrations for Functional Outcomes in Older Adults

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 471-471
Author(s):  
Jack Guralnik ◽  
Eleanor Simonsick ◽  
Stephen Kritchevsky ◽  
Peggy Cawthon ◽  
Michelle Shardell
Keyword(s):  
Older Adults ◽  
Functional Outcomes ◽  
Serum Levels ◽  
Community Dwelling ◽  
Validation Sample ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Skeletal Effects ◽  
Intervention Trials ◽  
Community Dwelling Older Adults

Abstract 25-Hydroxyvitamin D [25(OH)D] has extra-skeletal effects, but it is not known whether the minimum sufficient serum levels for such targets, like muscle, differ from those for bone health (typically recommended at 20 or 30 ng/dL). Therefore, we derived and validated sex-specific thresholds for serum 25(OH)D predictive of poor physical function using 5 cohorts comprising 16,388 community-dwelling older adults (60.9% women). Using a cohort-stratified random two-thirds sample, we found incident slow gait was best discriminated by 25(OH)D<24.0 versus 25(OH)D>=24.0 ng/mL among women (Relative Risk=1.29; 95% CI 1.10-1.50) and 25(OH)D<21.0 versus 25(OH)D >=21.0 ng/mL among men (RR=1.43; 95% CI 1.01-2.02). Estimates from the remaining one-third validation sample were similar. Empirically identified and validated sex-specific 25(OH)D thresholds from multiple well-characterized cohorts of older adults may yield more biologically meaningful definitions in important sub-populations. Such thresholds may serve as candidate reference concentrations or inform design of vitamin D intervention trials in older adults.

Biological and Neuroimaging Markers as Predictors of 5-Year Incident Frailty in Older Adults: A Secondary Analysis of the MAPT Study

2020 ◽  
Author(s):  
Wan-Hsuan Lu ◽  
Philipe de Souto Barreto ◽  
Yves Rolland ◽  
Ali Bouyahia ◽  
Clara Fischer ◽  
...  
Keyword(s):  
Older Adults ◽  
Gray Matter ◽  
Hippocampal Volume ◽  
Community Dwelling ◽  
Low Grade ◽  
Omega 3 ◽  
C Reactive Protein ◽  
Hydroxyvitamin D ◽  
Reactive Protein ◽  
25 Hydroxyvitamin D

Abstract Background This study aims to investigate the predictive value of biological and neuroimaging markers to determine incident frailty among older people for a period of 5 years. Methods We included 1394 adults aged 70 years and older from the Multidomain Alzheimer Preventive Trial, who were not frail at baseline (according to Fried’s criteria) and who had at least 1 post-baseline measurement of frailty. Participants who progressed to frailty during the 5-year follow-up were categorized as “incident frailty” and those who remained non-frail were categorized as “without frailty.” The differences of baseline biochemical factors (25-hydroxyvitamin D, homocysteine, omega-3 index, C-reactive protein), other biological markers (Apolipoprotein E genotypes, amyloid-β deposits), and neuroimaging data (gray matter volume, hippocampal volume, white matter hyperintensities) were compared between groups. Cox proportional hazard model was used to evaluate the associations between biomarkers and incident frailty. Results A total of 195 participants (14.0%) became frail over 5 years. Although 25-hydroxyvitamin D deficiency, homocysteine levels, low-grade inflammation (persistently increased C-reactive protein 3–10 mg/L), gray matter, and hippocampal volume were significantly associated with incident frailty in unadjusted models, these associations disappeared after adjustment for age, sex, and other confounders. Omega-3 index was the sole marker that presented a trend of association with incident frailty (hazard ratio: 0.92; 95% confidence interval: 0.83–1.01; p = .082). Conclusions This study failed to identify biomarkers able to predict frailty incidence in community-dwelling older adults for a period of 5 years. Further longitudinal research with multiple measurements of biomarkers and frailty is needed to evaluate the long-term relationships between changes in biomarkers levels and frailty evolution.

Co-morbidity adjustment for functional outcomes in community-dwelling older adults

2002 ◽  
Vol 16 (4) ◽  
pp. 420-428 ◽  
Author(s):  
Sally K Rigler ◽  
Stephanie Studenski ◽  
Dennis Wallace ◽  
Dean M Reker ◽  
Pamela W Duncan
Keyword(s):  
Older Adults ◽  
Functional Outcomes ◽  
Community Dwelling ◽  
Co Morbidity ◽  
Community Dwelling Older Adults

scholarly journals Higher Serum 25-Hydroxyvitamin D and Lower Plasma Glucose Are Associated with Larger Gray Matter Volume but Not with White Matter or Total Brain Volume in Dutch Community-Dwelling Older Adults

2015 ◽  
Vol 145 (8) ◽  
pp. 1817-1823 ◽  
Author(s):  
Elske M Brouwer-Brolsma ◽  
Nikita L van der Zwaluw ◽  
Janneke P van Wijngaarden ◽  
Rosalie A Dhonukshe-Rutten ◽  
Paulette H in 't Veld ◽  
...  
Keyword(s):  
Brain Volume ◽  
Gray Matter Volume ◽  
Community Dwelling ◽  
Lower Plasma ◽  
Total Brain Volume ◽  
Hydroxyvitamin D ◽  
Total Brain ◽  
Lower Plasma Glucose ◽  
25 Hydroxyvitamin D ◽  
Community Dwelling Older Adults
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