Low 25-Hydroxyvitamin D Predicts the Onset of Mobility Limitation and Disability in Community-Dwelling Older Adults: The Health ABC Study

Abstract 25-Hydroxyvitamin D [25(OH)D] has extra-skeletal effects, but it is not known whether the minimum sufficient serum levels for such targets, like muscle, differ from those for bone health (typically recommended at 20 or 30 ng/dL). Therefore, we derived and validated sex-specific thresholds for serum 25(OH)D predictive of poor physical function using 5 cohorts comprising 16,388 community-dwelling older adults (60.9% women). Using a cohort-stratified random two-thirds sample, we found incident slow gait was best discriminated by 25(OH)D<24.0 versus 25(OH)D>=24.0 ng/mL among women (Relative Risk=1.29; 95% CI 1.10-1.50) and 25(OH)D<21.0 versus 25(OH)D >=21.0 ng/mL among men (RR=1.43; 95% CI 1.01-2.02). Estimates from the remaining one-third validation sample were similar. Empirically identified and validated sex-specific 25(OH)D thresholds from multiple well-characterized cohorts of older adults may yield more biologically meaningful definitions in important sub-populations. Such thresholds may serve as candidate reference concentrations or inform design of vitamin D intervention trials in older adults.

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Risk Factors for Mobility Limitation in Community-Dwelling Older Adults: A Social Ecological Perspective

Geriatric Nursing ◽

10.1016/j.gerinurse.2007.07.002 ◽

2008 ◽

Vol 29 (2) ◽

pp. 133-140 ◽

Cited By ~ 72

Author(s):

Hye A. Yeom ◽

Julie Fleury ◽

Colleen Keller

Keyword(s):

Risk Factors ◽

Older Adults ◽

Community Dwelling ◽

Mobility Limitation ◽

Ecological Perspective ◽

Social Ecological ◽

Community Dwelling Older Adults

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Biological and Neuroimaging Markers as Predictors of 5-Year Incident Frailty in Older Adults: A Secondary Analysis of the MAPT Study

The Journals of Gerontology Series A ◽

10.1093/gerona/glaa296 ◽

2020 ◽

Author(s):

Wan-Hsuan Lu ◽

Philipe de Souto Barreto ◽

Yves Rolland ◽

Ali Bouyahia ◽

Clara Fischer ◽

...

Keyword(s):

Older Adults ◽

Gray Matter ◽

Hippocampal Volume ◽

Community Dwelling ◽

Low Grade ◽

Omega 3 ◽

C Reactive Protein ◽

Hydroxyvitamin D ◽

Reactive Protein ◽

25 Hydroxyvitamin D

Abstract Background This study aims to investigate the predictive value of biological and neuroimaging markers to determine incident frailty among older people for a period of 5 years. Methods We included 1394 adults aged 70 years and older from the Multidomain Alzheimer Preventive Trial, who were not frail at baseline (according to Fried’s criteria) and who had at least 1 post-baseline measurement of frailty. Participants who progressed to frailty during the 5-year follow-up were categorized as “incident frailty” and those who remained non-frail were categorized as “without frailty.” The differences of baseline biochemical factors (25-hydroxyvitamin D, homocysteine, omega-3 index, C-reactive protein), other biological markers (Apolipoprotein E genotypes, amyloid-β deposits), and neuroimaging data (gray matter volume, hippocampal volume, white matter hyperintensities) were compared between groups. Cox proportional hazard model was used to evaluate the associations between biomarkers and incident frailty. Results A total of 195 participants (14.0%) became frail over 5 years. Although 25-hydroxyvitamin D deficiency, homocysteine levels, low-grade inflammation (persistently increased C-reactive protein 3–10 mg/L), gray matter, and hippocampal volume were significantly associated with incident frailty in unadjusted models, these associations disappeared after adjustment for age, sex, and other confounders. Omega-3 index was the sole marker that presented a trend of association with incident frailty (hazard ratio: 0.92; 95% confidence interval: 0.83–1.01; p = .082). Conclusions This study failed to identify biomarkers able to predict frailty incidence in community-dwelling older adults for a period of 5 years. Further longitudinal research with multiple measurements of biomarkers and frailty is needed to evaluate the long-term relationships between changes in biomarkers levels and frailty evolution.

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Weight Change, Weight Change Intention, and the Incidence of Mobility Limitation in Well-Functioning Community-Dwelling Older Adults

The Journals of Gerontology Series A ◽

10.1093/gerona/60.8.1007 ◽

2005 ◽

Vol 60 (8) ◽

pp. 1007-1012 ◽

Cited By ~ 54

Author(s):

J. S. Lee ◽

S. B. Kritchevsky ◽

F. Tylavsky ◽

T. Harris ◽

E. M. Simonsick ◽

...

Keyword(s):

Older Adults ◽

Weight Change ◽

Community Dwelling ◽

Mobility Limitation ◽

Community Dwelling Older Adults

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Higher Serum 25-Hydroxyvitamin D and Lower Plasma Glucose Are Associated with Larger Gray Matter Volume but Not with White Matter or Total Brain Volume in Dutch Community-Dwelling Older Adults

Journal of Nutrition ◽

10.3945/jn.115.214197 ◽

2015 ◽

Vol 145 (8) ◽

pp. 1817-1823 ◽

Cited By ~ 10

Author(s):

Elske M Brouwer-Brolsma ◽

Nikita L van der Zwaluw ◽

Janneke P van Wijngaarden ◽

Rosalie A Dhonukshe-Rutten ◽

Paulette H in 't Veld ◽

...

Keyword(s):

Brain Volume ◽

Gray Matter Volume ◽

Community Dwelling ◽

Lower Plasma ◽

Total Brain Volume ◽

Hydroxyvitamin D ◽

Total Brain ◽

Lower Plasma Glucose ◽

25 Hydroxyvitamin D ◽

Community Dwelling Older Adults

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Nutritional Biomarkers and Associated Factors in Community-Dwelling Older Adults: Findings from the SHIELD Study

Nutrients ◽

10.3390/nu12113329 ◽

2020 ◽

Vol 12 (11) ◽

pp. 3329

Author(s):

Magdalin Cheong ◽

Samuel Teong Huang Chew ◽

Jeffery Oliver ◽

Geraldine Baggs ◽

Yen Ling Low ◽

...

Keyword(s):

Older Adults ◽

Nutritional Status ◽

Vitamin B12 ◽

Female Gender ◽

Zinc Level ◽

Community Dwelling ◽

Low Level ◽

Hydroxyvitamin D ◽

Adverse Health Outcomes ◽

Community Dwelling Older Adults

Aging is associated with intrinsic and extrinsic changes which affect the nutrient intake and nutritional status of an older individual. Suboptimal nutritional status is linked with adverse health outcomes. There are limited data in this area for community-dwelling older adults who are not at risk of malnutrition. The objective of this study was to describe the nutritional biomarkers in 400 community-dwelling older adults (aged ≥65 years) with normal nutritional status (Malnutrition Universal Screening Test score of 0) in Singapore and to identify factors associated with these biomarkers. The majority of the participants had normal levels of pre-albumin, albumin, total protein, creatinine, zinc, corrected calcium, vitamin B12, ferritin and hemoglobin. Females had significantly higher levels of corrected calcium and vitamin B12 than males, whereas males had significantly higher levels of pre-albumin, albumin, creatinine, serum ferritin, 25-hydroxyvitamin D (25(OH)D) and hemoglobin than females. About half of the participants (52%) had low level of 25(OH)D (<30 μg/L) and 10% had low zinc level (<724 μg/L). Among those with low level of 25(OH)D, 74% had 25(OH)D insufficiency (20–<30 μg/L) and 26% had 25(OH)D deficiency (<20 μg/L). Younger age, female gender, non-Chinese ethnicity and no intake of vitamin D supplement were associated with lower serum 25(OH)D level, whereas higher body mass index (BMI) was associated with low zinc level. These findings highlight the problem of hidden nutritional insufficiencies can be missed in seemingly normal nourished community-dwelling older adults.

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Instruments to Assess Mobility Limitation in Community-Dwelling Older Adults: A Systematic Review

Journal of Aging and Physical Activity ◽

10.1123/japa.2013-0181 ◽

2015 ◽

Vol 23 (2) ◽

pp. 298-313 ◽

Cited By ~ 21

Author(s):

Jane Chung ◽

George Demiris ◽

Hilaire J. Thompson

Keyword(s):

Older Adults ◽

Community Dwelling ◽

Mobility Limitation ◽

Assessment Tools ◽

Self Report ◽

Clear Understanding ◽

Lower Extremity Function ◽

Search Terms ◽

Community Dwelling Older Adults ◽

Selection Of

Mobility is critical in maintaining independence in older adults. This study aims to systematically review the scientific literature to identify measures of mobility limitation for community-dwelling older adults. A systematic search of PubMed, CINAHL, and psycINFO, using the search terms “mobility limitation”, “mobility disability”, and “mobility difficulty” yielded 1,847 articles from 1990 to 2012; a final selection of 103 articles was used for the present manuscript. Tools to measure mobility were found to be either self-report or performance-based instruments. Commonly measured constructs of mobility included walking, climbing stairs, and lower extremity function. There was heterogeneity in ways of defining and measuring mobility limitation in older adults living in the community. Given the lack of consistency in assessment tools for mobility, a clear understanding and standardization of instruments are required for comparison across studies and for better understanding indicators and outcomes of mobility limitation in community-dwelling older adults.

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