scholarly journals REDUCED ENDOTHELIAL FUNCTION IS ASSOCIATED WITH DEEP WHITE MATTER LESION VOLUMES AMONG HEALTHY OLDER ADULTS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S41-S41
Author(s):  
Regina S Wright ◽  
Desiree Bygrave
Keyword(s):  
Older Adults ◽  
White Matter ◽  
Endothelial Function ◽  
White Matter Lesion ◽  
Brain Mri ◽  
Brain Magnetic Resonance Imaging ◽  
Regions Of Interest ◽  
Outcome Variable ◽  
Inverse Association ◽  
Healthy Older Adults

Abstract Reduced endothelial function (EF) is a subclinical cardiovascular disease (CVD) risk factor and precursor to hypertension and atherosclerosis. Among older adults with CVD, reduced EF has been associated with poorer outcomes in a number of cognitive domains, partly explained by the presence of white matter lesion volumes (WMLV) detectable on brain magnetic resonance imaging (MRI). The role of EF as a key, early predictor of brain decrements among older adults without CVD, however, is not well understood. Therefore, the objective of the study was to examine associations between endothelial function and WMLV among cognitively intact older adults free of CVD. A diverse sample of 138 community-based older adults (30.4% male; mean age=68.54y) enrolled in the Healthy Heart & Mind Study underwent cognitive and psychosocial assessment, vascular testing, and brain MRI. Multiple regressions were run to examine associations between endothelial function, as measured by % change in brachial artery flow-mediated dilation (FMD), and MRI-assessed WMLV in brain regions of interest, after controlling for age, sex, race, education, depression, mean arterial pressure, total cholesterol, and hypertension medication use. Results showed a significant inverse association between % FMD change and deep WMLV (p<.05), but no other regions of interest. Results suggest that reduced EF is associated with greater deep WMLV, an outcome variable attributable to small vessel disease and linked to Alzheimer’s disease in previous studies. The implications of this finding for predicting risk for cognitive impairment among healthy older adults will be discussed.

scholarly journals Interaction of Age and Self-reported Physical Sports Activity on White Matter Hyperintensity Volume in Healthy Older Adults

2020 ◽  
Vol 12 ◽  
Author(s):  
Mary Kathryn Franchetti ◽  
Pradyumna K. Bharadwaj ◽  
Lauren A. Nguyen ◽  
Emily J. Van Etten ◽  
Yann C. Klimentidis ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
White Matter Hyperintensity ◽  
Sports Activity ◽  
Healthy Older Adults

Microstructural fronto-striatal and temporo-insular alterations are associated with fatigue in patients with multiple sclerosis independent of white matter lesion load and depression

2019 ◽  
Vol 26 (13) ◽  
pp. 1708-1718 ◽  
Author(s):  
Miklos Palotai ◽  
Michele Cavallari ◽  
Ismail Koubiyr ◽  
Alfredo Morales Pinzon ◽  
Aria Nazeri ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Physical Disability ◽  
Disease Duration ◽  
White Matter Lesion ◽  
Brain Magnetic Resonance Imaging ◽  
Brain Regions ◽  
Specific Substrate ◽  
Patient Stratification ◽  
Lesion Load

Background: Fatigue in multiple sclerosis (MS) has been inconsistently associated with disruption of specific brain circuitries. Temporal fluctuations of fatigue have not been considered. Objective: The aim of this study was to investigate the association of fatigue with brain diffusion abnormalities, using robust criteria for patient stratification based on longitudinal patterns of fatigue. Methods: Patient stratification: (1) sustained fatigue (SF, n = 26): latest two Modified Fatigue Impact Scale (MFIS) ⩾ 38; (2) reversible fatigue (RF, n = 25): latest MFIS < 38 and minimum one previous MFIS ⩾ 38; and (3) never fatigued (NF, n = 42): MFIS always < 38 (five assessments minimum). 3T brain magnetic resonance imaging (MRI) was used to perform voxel-wise comparison of fractional anisotropy (FA) between the groups controlling for age, sex, disease duration, physical disability, white matter lesion load (T2LV), and depression. Results: SF and, to a lesser extent, RF patients showed lower FA in multiple brain regions compared to NF patients, independent of age, sex, disease duration, and physical disability. In cingulo-postcommissural-striato-thalamic regions, the differences in FA between SF and NF (but not between RF and NF or SF) patients were independent of T2LV, and in ventromedial prefronto-precommissuro-striatal and temporo-insular areas, independent of T2LV and depression. Conclusion: Damage to ventromedial prefronto-precommissuro-striatal and temporo-insular pathways appears to be a specific substrate of SF in MS.

Relationship between vitamin D deficiency, post-challenge hyperglycemia, and endothelial function in healthy older adults

2012 ◽  
Vol 4 (1) ◽  
pp. 102-103 ◽  
Author(s):  
Seth I. SOKOL ◽  
Michael GRUSHKO ◽  
Vankeepuram S. SRINIVAS ◽  
Jill P. CRANDALL
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Endothelial Function ◽  
Vitamin D Deficiency ◽  
Post Challenge ◽  
Healthy Older Adults

scholarly journals Non-fasting High-Density Lipoprotein Is Associated With White Matter Microstructure in Healthy Older Adults

2019 ◽  
Vol 11 ◽  
Author(s):  
Nathan F. Johnson ◽  
Brian T. Gold ◽  
Dorothy Ross ◽  
Alison L. Bailey ◽  
Jody L. Clasey ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Healthy Older Adults ◽  
White Matter Microstructure

Vitamin D and white matter abnormalities in older adults: A quantitative volumetric analysis of brain MRI

2015 ◽  
Vol 63 ◽  
pp. 41-47 ◽  
Author(s):  
Cédric Annweiler ◽  
Robert Bartha ◽  
Spyridon N. Karras ◽  
Jennifer Gautier ◽  
Frédéric Roche ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
White Matter ◽  
Brain Mri ◽  
Volumetric Analysis ◽  
White Matter Abnormalities

MRI white matter lesions in pediatric migraine

Cephalalgia ◽  
2013 ◽  
Vol 33 (11) ◽  
pp. 906-913 ◽  
Author(s):  
Tal Eidlitz-Markus ◽  
Avraham Zeharia ◽  
Yishay Haimi-Cohen ◽  
Osnat Konen
Keyword(s):  
White Matter ◽  
Pediatric Patients ◽  
Medical Center ◽  
Brain Mri ◽  
Brain Magnetic Resonance Imaging ◽  
White Matter Lesions ◽  
Pediatric Migraine ◽  
Laboratory Examinations ◽  
Magnetic Resonance Imaging Mri ◽  
Headache Clinic

Objectives: Studies have reported an association between migraine and white matter hyperintensities on T2-weighted brain magnetic resonance imaging (MRI) in adults. The aim of the present study was to evaluate white matter MRI brain findings in pediatric patients with migraine. Methods: The medical files and imaging scans of all 194 patients who underwent brain MRI at the headache clinic of a tertiary medical center in 2008–2011 were reviewed. Results: Mean age was 10.9 ± 3.5 years. Migraine was diagnosed in 131 patients and other disorders in 63. In the migraine group, findings on physical and laboratory examinations were within normal range. White matter lesions were identified on MRI scan in 14 children with migraine (10.6%) and none of the children with other disorders ( p = 0.006). In 13/14 patients, the lesions were focal with a variable distribution; in the remaining patient, confluent periventricular hyperintensities were documented. Conclusions: In a headache clinic of a tertiary pediatric medical center, white matter lesions are found in about 10% of pediatric patients with migraine.

scholarly journals Cerebellar gray and white matter volume and their relation with age and manual motor performance in healthy older adults

2015 ◽  
Vol 36 (6) ◽  
pp. 2352-2363 ◽  
Author(s):  
Vincent Koppelmans ◽  
Sarah Hirsiger ◽  
Susan Mérillat ◽  
Lutz Jäncke ◽  
Rachael D. Seidler
Keyword(s):  
Older Adults ◽  
White Matter ◽  
Motor Performance ◽  
White Matter Volume ◽  
Healthy Older Adults ◽  
Matter Volume

scholarly journals Endothelial Function Is Associated with White Matter Microstructure and Executive Function in Older Adults

2017 ◽  
Vol 9 ◽  
Author(s):  
Nathan F. Johnson ◽  
Brian T. Gold ◽  
Christopher A. Brown ◽  
Emily F. Anggelis ◽  
Alison L. Bailey ◽  
...  
Keyword(s):  
Older Adults ◽  
Executive Function ◽  
White Matter ◽  
Endothelial Function ◽  
White Matter Microstructure
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