scholarly journals C-REACTIVE PROTEIN AND EPISODIC MEMORY PERFORMANCE IN THE HEALTH AND RETIREMENT STUDY

2015 ◽  
Vol 55 (Suppl_2) ◽  
pp. 180-180
Author(s):  
Heather R Farmer ◽  
Linda A Wray ◽  
Steven A Haas

Abstract Objectives To clarify the relationships among race, gender, and socioeconomic status (SES) with C-reactive protein (CRP). Method The present study analyzed data from 6,521 Black and White respondents aged 51 and older in the Health and Retirement Study, a nationally representative sample of midlife and older adults, to address two aims. We sought to (i) assess the independent associations between race, gender, and SES with CRP concentrations and (ii) test whether race, gender, and SES interacted to produce unequal CRP concentrations cross-sectionally and over a 4-year follow-up. Results The results demonstrated that race, gender, and SES were each independently associated with baseline CRP, but only SES was associated with CRP at follow-up. Furthermore, race, gender, and education interacted to produce differential CRP levels at baseline. There were incremental benefits for each additional level of education for White men and women, but the relationship between education and CRP was more complicated for Black men and women. Compared with other race/gender groups with less than high school, Black women had the highest and Black men had the lowest levels of CRP. There were no apparent benefits to CRP for Black women with college compared with Black women with high school, while Black men with less than high school and college had similar concentrations of CRP. Discussion In clarifying the complexity inherent in CRP disparities, this work contributes to a greater understanding of the biological mechanisms underlying racial disparities in leading causes of morbidity and mortality in the United States.


Gerontology ◽  
2015 ◽  
Vol 61 (3) ◽  
pp. 232-240 ◽  
Author(s):  
Gizem H�l�r ◽  
Christopher Hertzog ◽  
Ann M. Pearman ◽  
Denis Gerstorf

2015 ◽  
Vol 69 (5) ◽  
pp. 442-446 ◽  
Author(s):  
Ross Andel ◽  
Frank J Infurna ◽  
Elizabeth A Hahn Rickenbach ◽  
Michael Crowe ◽  
Lisa Marchiondo ◽  
...  

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 691-691
Author(s):  
Sarah Mawhorter ◽  
Jennifer Ailshire ◽  
Eileen Crimmins

Abstract Researchers consistently find adverse long-term health outcomes among renters as compared with homeowners, yet more proximal health measures are needed to understand whether there is a direct link between tenure and health. In this paper, we compare cardiometabolic risk (CMR) levels among older renters and homeowners, and ask whether this health disparity can be explained by socioeconomic differences between renters and homeowners, or poor housing conditions for renters. Using Health and Retirement Study 2010/2012 biomarker data for adults aged 50-84 (N=10,480), we measure CMR by a scale of C-reactive protein, hemoglobin A1C, cholesterol, heart rate, blood pressure, and waist circumference metrics. We find that renters have greater CMR, even accounting for socioeconomic characteristics and health behaviors. Certain housing and neighborhood conditions, such as perceived safety, are associated with CMR. These results suggest potential pathways through which homeownership confers health advantages over renting.


2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 362-362
Author(s):  
Emily Morris ◽  
Laura Zahodne

Abstract Objective: Previous research suggests that chronic stress is associated with worse cognitive aging, but minimal research has examined potential mechanisms and moderators of these associations. Chronic stress is known to increase inflammation (e.g., C-reactive protein [CRP]), which has in turn been associated with worse cognition among older adults. The present study examined whether (1) CRP mediates associations between chronic stress and episodic memory and verbal fluency; and (2) these relationships differ by race/ethnicity. Methods: Participants included 18,968 adults (64% non-Hispanic White; 19% non-Hispanic Black; 14% Hispanic; 3% non-Hispanic other race/ethnicity; Mage=71.8; SDage=6.0) from the Health and Retirement Study. Chronic stress was operationalized as the occurrence and impact of eight ongoing stressors. Cross-sectional, stratified mediation models were conducted for three cognitive outcomes: immediate recall, delayed recall, and verbal fluency. Covariates included sociodemographics and vascular disease burden. Results: Chronic stress was associated worse immediate recall (beta=-.028). Higher CRP was not associated with any cognitive domains. Non-Hispanic Black participants reported more chronic stress than non-Hispanic White and Hispanic participants. Chronic stress was less strongly associated with higher CRP in non-Hispanic Black (beta=-.035) participants than non-Hispanic White (beta=.046) or Hispanic (beta=.059) participants. Discussion: Chronic stress may negatively influence episodic memory, but findings do not suggest that CRP mediates links between chronic stress and cognition. CRP may not track as closely with chronic stress among non-Hispanic Black older adults who may experience additional risk factors for inflammation and/or adapt to increased chronic stress.


2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 344-344
Author(s):  
Lauren Parker ◽  
Roland Thorpe ◽  
Ryon Cobb

Abstract This study examines the relationship between self-reported instances of major discrimination and inflammation among older adults, and explores whether this relationship varies in accordance with race/ethnicity. Data from 2006/2008 Health and Retirement Study was used to collect measures of self-reported instances of major discrimination and high-risk C-reactive protein (CRP), which was assayed from blood samples. Modified Poisson regression with robust standard errors was applied to estimate the prevalence ratios of self-reported instances of major discrimination, as it relates to high-risk CRP (CRP ≥ 22 kg/m2), and test whether this relationship varies by race/ethnicity. Respondents who experienced any instances of major discrimination had a higher likelihood of high-risk CRP (prevalence ratio [PR]: 1.14, 95% confidence interval [CI] = 1.07–1.22) than those who did not report experiencing any instances of major discrimination. This relationship was weaker for blacks than whites (PR: 0.81, 95% CI = 0.69–0.95).


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