Comparison of ovarian stromal blood flow between fertile women with normal ovaries and infertile women with polycystic ovary syndrome

Abstract Introduction In polycystic ovary syndrome, serum vitamin D levels are known to correlate with metabolic conditions such as diabetes mellitus, metabolic syndrome and cardiovascular disease. However, there are not enough studies showing such a relationship with female fertility. We aimed to compare serum vitamin D levels in fertile and infertile women with polycystic ovary syndrome to evaluate whether vitamin D may play a role in the pathogenesis of fertility problems in women with polycystic ovary syndrome. Materials and Methods 274 infertile and 111 fertile women with polycystic ovary syndrome were included in this retrospective study. Infertile and fertile groups were matched by age, body mass index and homeostasis model assessment of insulin resistance. Anthropometric, clinical and laboratory characteristics of the women were recorded. Serum 25(OH)D3 levels were used to assess serum vitamin D levels. Results No significant differences were detected between groups in terms of anthropometric, clinical and laboratory features except for serum 25(OH)D3 levels and the incidence of vitamin D deficiency. Vitamin D levels were significantly lower and vitamin D deficiency was more common in the infertile group compared to the fertile group. When the groups were stratified into obese/non-obese or insulin resistance positive/negative, infertile obese and infertile insulin resistance-positive women had the lowest serum 25(OH)D3 levels. Conclusion Serum vitamin D levels are lower in infertile women with polycystic ovary syndrome compared to fertile women. When insulin resistance or obesity was present, vitamin D levels were reduced further. Thus, in polycystic ovary syndrome, lower vitamin D levels may play a role in the pathogenesis of fertility problems.

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Sexual function in fertile and infertile women with polycystic ovary syndrome

International Journal of Pharmaceutical Research ◽

10.31838/ijpr/2019.11.03.002 ◽

2019 ◽

Vol 11 (3) ◽

Keyword(s):

Polycystic Ovary Syndrome ◽

Sexual Function ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Infertile Women

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The role of metformin in the treatment of infertile women with polycystic ovary syndrome

The Obstetrician & Gynaecologist ◽

10.1576/toag.6.3.145.26996 ◽

2004 ◽

Vol 6 (3) ◽

pp. 145-151 ◽

Cited By ~ 5

Author(s):

William Atiomo ◽

Anju Sinha

Keyword(s):

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Infertile Women

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Sociodemographic Characteristics and Clinical Presentation of Infertile Women with Polycystic Ovary Syndrome in a Tertiary Care Hospital

International Journal of Infertility & Fetal Medicine ◽

10.5005/jp-journals-10016-1165 ◽

2018 ◽

Vol 9 (1) ◽

pp. 14-18 ◽

Cited By ~ 1

Author(s):

Vandana Nimbargi ◽

Asha AM Mangalath ◽

Aswathy Alias ◽

Manjusha Sajith ◽

Shivhar Kumdale

Keyword(s):

Polycystic Ovary Syndrome ◽

Clinical Presentation ◽

Tertiary Care Hospital ◽

Polycystic Ovary ◽

Tertiary Care ◽

Sociodemographic Characteristics ◽

Care Hospital ◽

Ovary Syndrome ◽

Infertile Women

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Insulin resistance in relation to clinical, endocrine and metabolic profile of infertile women with polycystic ovary syndrome

Bangabandhu Sheikh Mujib Medical University Journal ◽

10.3329/bsmmuj.v14i1.50989 ◽

2021 ◽

Vol 14 (1) ◽

pp. 1-6

Author(s):

Shakeela Ishrat ◽

Marufa Hossain ◽

Subrata Kumar Biswas

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Body Mass Index ◽

Waist Circumference ◽

Polycystic Ovary Syndrome ◽

Body Mass ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Infertile Women ◽

Significant Difference

The objective of this study is to explore how hyperinsulinemia and insulin resistance relate to the clinical, endocrine and metabolic factors in the infertile women with polycystic ovary syndrome. This study was conducted on 121 consecutive infertile women with polycystic ovary syndrome attending the Infertility unit from January 2017 to December 2017. They were divided into two groups: insulin resistant and insulin sensitive. There was significant difference in body mass index and waist circumference between the two groups. Serum lipids were not associated with insulin resistance. Hyperinsulinemia was significantly associated with metabolic syndrome. Reducing body mass index and waist circumference may improve insulin resistance in infertile women with polycystic ovary syndrome. Screening the infertile women with polycystic ovary syndrome for hyperinsulinemia and insulin resistance and subsequent counseling is recommended to address the long-term risks of metabolic syndrome.

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Effect of Omega-3 Fatty Acids on Hormonal Profile and Ovarian Stromal Blood Flow in Patients with Polycystic Ovary Syndrome

Evidence Based Women s Health Journal ◽

10.21608/ebwhj.2019.64357 ◽

2019 ◽

Vol 9 (4) ◽

pp. 542-548

Author(s):

Taiseer Maarouf ◽

doaa mohamed ◽

Aalaa Tantawy ◽

Passant Eid

Keyword(s):

Fatty Acids ◽

Blood Flow ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Ovary Syndrome ◽

Hormonal Profile

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Biosimilar FSH Preparations Versus Highly Purified Urinary FSH for Simple Ovulation Induction in Infertile Women with Polycystic Ovary Syndrome

World Journal of Gynecology & Womens Health ◽

10.33552/wjgwh.2018.01.000509 ◽

2018 ◽

Vol 1 (2) ◽

Author(s):

Ahmed M Abbas

Keyword(s):

Polycystic Ovary Syndrome ◽

Ovulation Induction ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Infertile Women ◽

Urinary Fsh

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Mechanisms underlying absent training-induced improvement in insulin action in lean, hyperandrogenic women with polycystic ovary syndrome (PCOS)

10.2337/figshare.12860540 ◽

2020 ◽

Author(s):

Ada Admin ◽

Solvejg L. Hansen ◽

Kirstine N. Bojsen-Møller ◽

Anne-Marie Lundsgaard ◽

Frederikke L. Hendrich ◽

...

Keyword(s):

Skeletal Muscle ◽

Blood Flow ◽

Exercise Training ◽

Polycystic Ovary Syndrome ◽

Glucose Uptake ◽

Insulin Action ◽

Polycystic Ovary ◽

Whole Body ◽

Ovary Syndrome ◽

Leg Blood Flow

Women with polycystic ovary syndrome (PCOS) have been shown to be less insulin sensitive compared with control women, independent of BMI. Training is associated with molecular adaptations in skeletal muscle improving glucose uptake and metabolism in both healthy and type 2 diabetic individuals. In the present study, lean, hyperandrogenic women with PCOS (n=9) and healthy controls (CON, n=9) completed 14 weeks of controlled and supervised exercise training. In CON, the training intervention increased whole body insulin action by 26% and insulin-stimulated leg glucose uptake by 53%, together with increased insulin-stimulated leg blood flow and a more oxidative muscle fiber type distribution. In PCOS, no such changes were found, despite similar training intensity and improvements in maximal oxygen uptake. In skeletal muscle of CON, but not PCOS, training increased GLUT4 and HKII mRNA and protein expressions. These data suggest that the impaired increase in whole body insulin action in women with PCOS with training is caused by an impaired ability to upregulate key glucose handling proteins for insulin-stimulated glucose uptake in skeletal muscle, and insulin-stimulated leg blood flow. Still, other important benefits of exercise training appeared in women with PCOS, including an improvement of the hyperandrogenic state.

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