scholarly journals Mechanisms of Kappa Opioid Receptor Potentiation of Dopamine D2 Receptor Function in Quinpirole-Induced Locomotor Sensitization in Rats

2017 ◽  
Vol 20 (8) ◽  
pp. 660-669 ◽  
Author(s):  
Angélica P Escobar ◽  
Marcela P González ◽  
Rodrigo C Meza ◽  
Verónica Noches ◽  
Pablo Henny ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Kappa Opioid Receptor ◽  
Locomotor Sensitization ◽  
Receptor Function ◽  
Kappa Opioid ◽  
Dopamine D2

scholarly journals Altered dopamine D2 receptor function and binding in obese OLETF rat

2008 ◽  
Vol 75 (1) ◽  
pp. 70-76 ◽  
Author(s):  
Andras Hajnal ◽  
Wojciech M. Margas ◽  
Mihai Covasa
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Function ◽  
Dopamine D2 ◽  
Oletf Rat

scholarly journals Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D2 Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor

Biomolecules ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 368 ◽  
Author(s):  
Vasudevan ◽  
Borroto-Escuela ◽  
Huysentruyt ◽  
Fuxe ◽  
Saini ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Opioid Receptor ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Mu Opioid Receptor ◽  
Potential Threat ◽  
Mu Opioid ◽  
Dopamine D2

The interplay between the dopamine (DA) and opioid systems in the brain is known to modulate the additive effects of substances of abuse. On one hand, opioids serve mankind by their analgesic properties, which are mediated via the mu opioid receptor (MOR), a Class A G protein-coupled receptor (GPCR), but on the other hand, they pose a potential threat by causing undesired side effects such as tolerance and dependence, for which the exact molecular mechanism is still unknown. Using human embryonic kidney 293T (HEK 293T) and HeLa cells transfected with MOR and the dopamine D2 receptor (D2R), we demonstrate that these receptors heterodimerize, using an array of biochemical and biophysical techniques such as coimmunoprecipitation (co-IP), bioluminescence resonance energy transfer (BRET1), Fӧrster resonance energy transfer (FRET), and functional complementation of a split luciferase. Furthermore, live cell imaging revealed that D2LR, when coexpressed with MOR, slowed down internalization of MOR, following activation with the MOR agonist [D-Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO).

scholarly journals Dopamine D2 receptor function is compromised in the brain of the methionine sulfoxide reductase A knockout mouse

2010 ◽  
pp. no-no ◽  
Author(s):  
Derek B. Oien ◽  
Andrea N. Ortiz ◽  
Alexander G. Rittel ◽  
Rick T. Dobrowsky ◽  
Michael A. Johnson ◽  
...  
Keyword(s):  
Knockout Mouse ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Methionine Sulfoxide ◽  
Methionine Sulfoxide Reductase ◽  
Receptor Function ◽  
Methionine Sulfoxide Reductase A ◽  
Dopamine D2 ◽  
The Brain
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