Relationship of Subtypes of Hepatitis B Surface Antigen with e Antigen and Its Corresponding Antibody

1978 ◽  
Vol 138 (2) ◽  
pp. 252-256 ◽  
Author(s):  
N. Nath ◽  
C. T. Fang ◽  
R. Ledman ◽  
S. Mazzur ◽  
R. Y. Dodd
Keyword(s):  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Relationship Of

scholarly journals Relationship of large hepatitis B surface antigen polypeptide to human serum albumin

1980 ◽  
Vol 28 (2) ◽  
pp. 459-463
Author(s):  
J W Shih ◽  
P L Tan ◽  
J L Gerin
Keyword(s):  
Molecular Weight ◽  
Human Serum Albumin ◽  
Hepatitis B ◽  
Serum Albumin ◽  
Human Serum ◽  
Surface Antigen ◽  
Plasma Proteins ◽  
Hepatitis B Surface Antigen ◽  
Significant Proportion ◽  
Relationship Of

A significant proportion (20 to 40%) of highly purified 22-nm hepatitis B surface antigen (HBsAg) particles contain human serum albumin (HSA) as demonstrated by specific precipitation of radioiodinated particles by anti-HSA. Preparations of the isolated major HBsAg polypeptides (P-1, P-2, and P-6) were iodinated and analyzed by radiommunoprecipitation for reactivity with rabbit antisera to human plasma proteins. Only the P-6 fraction (molecular weight, 68,000) was precipitated and only by anti-HSA; specific precipitation was observed with guinea pig antisera to P-6 and native HBsAg and goat or rabbit antisera to HSA. Coprecipitation of P-6 with antiserum to HBsAg and with anti-HSA, compared to precipitation with each antiserum alone, indicated that the HBsAg and HSA determinants were on separate molecules. The P-6 polypeptide may represent a precursor protein of the hepatitis B virion.

scholarly journals Antigenic Relationship of a Hepatitis B Surface Antigen-derived Polypeptide and Human Serum Albumin

1980 ◽  
Vol 48 (2) ◽  
pp. 273-283 ◽  
Author(s):  
Y. Sanchez ◽  
I. Ionescu-Matiu ◽  
F. B. Hollinger ◽  
J. L. Melnick ◽  
G. R. Dreesman
Keyword(s):  
Human Serum Albumin ◽  
Hepatitis B ◽  
Serum Albumin ◽  
Human Serum ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Antigenic Relationship ◽  
Relationship Of

IL10 Promotorpolymorphismen beeinflussen die Hepatitis B Surface Antigen und die Hepatitis A spezifische Immunantwort

2015 ◽  
Vol 41 (08) ◽  
Author(s):  
E Reuss ◽  
N Evers ◽  
N Dietrich ◽  
J Vollmar ◽  
PM Schneider ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis A ◽  
Hepatitis B Surface Antigen

Effects of Vancomycin on Platelets, Plasma Proteins and Hepatitis B Surface Antigen

1975 ◽  
Vol 34 (01) ◽  
pp. 083-093 ◽  
Author(s):  
Barry S Coller ◽  
W. B Lundberg ◽  
Harvey R Gralnick
Keyword(s):  
Hepatitis B ◽  
Factor Viii ◽  
Surface Antigen ◽  
Plasma Proteins ◽  
Hepatitis B Surface Antigen ◽  
Infusion Site ◽  
Vancomycin Therapy ◽  
Intravenous Injections ◽  
Low Concentrations ◽  
High Doses

SummaryThe antibiotic vancomycin shares many similarities with ristocetin, an agent noted for its effects on platelets and plasma fibrinogen. Vancomycin did not aggregate platelets as ristocetin, but platelets were incorporated into precipitates induced by vancomycin. Fibrinogen and factor VIII were precipitated from plasma at low concentrations of vancomycin. The precipitated fibrinogen remained clottable. Hepatitis B surface antigen was selectively precipitated from serum and could be recovered from the precipitate. Rabbits receiving bolus intravenous injections of high doses of vancomycin developed hypofibrinogenemia and thrombocytopenia within minutes and often went on to die. Studies with 125I-vancomycin revealed little stable binding of the antibiotic to platelets or fibrinogen. A relationship is suggested between the potent protein precipitating effects and phlebitis at the infusion site commonly associated with vancomycin therapy.

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