Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies

Abstract “Food for Thought” provides an opportunity for review of pertinent topics to add to updates in areas of concern for professionals involved with feeding and swallowing issues in infants and children. Given the frequency with which speech-language pathologists (SLPs) make decisions to alter feedings when young infants demonstrate silent aspiration on videofluoroscopic swallow studies (VFSS), the need for increased understanding about cough and its development/maturation is a high priority. In addition, understanding of the role(s) of laryngeal chemoreflexes (LCRs), relationships (or lack of relationships) between cough and esophagitis, gastroesophageal reflux (GER), and chronic salivary aspiration is critical. Decision making regarding management must take into account multiple systems and their interactions in order to provide safe feeding for all children to meet nutrition and hydration needs without being at risk for pulmonary problems. The responsibility is huge and should encourage all to search the literature so that clinical practice is as evidence-based as possible; this often requires adequate understanding of developmentally appropriate neurophysiology and function.

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The Language Exposure Questionnaire: Quantifying exposure for research on young infants and children

PsycEXTRA Dataset ◽

10.1037/e500122015-074 ◽

2014 ◽

Author(s):

S. DeAnda ◽

D. Poulin-Dubois ◽

P. Zesiger ◽

M. Friend

Keyword(s):

Infants And Children ◽

Young Infants ◽

Language Exposure

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Platelet reactivity in paediatric cardiac surgery: Should pharmacological platelet protection be performed during cardiopulmonary bypass and hypothermia in young infants?

The Thoracic and Cardiovascular Surgeon ◽

10.1055/s-0029-1191537 ◽

2009 ◽

Vol 56 (S 01) ◽

Author(s):

A Straub ◽

J Smolich ◽

D Schiebold ◽

HP Wendel ◽

G Ziemer ◽

...

Keyword(s):

Cardiac Surgery ◽

Cardiopulmonary Bypass ◽

Platelet Reactivity ◽

Young Infants ◽

Paediatric Cardiac Surgery

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Hearing and Neurodevelopmental Outcomes of Young Infants with Parechovirus-A and Enterovirus Meningitis: Cohort Study in Singapore Children and Literature Review

Journal of Pediatric Neurology ◽

10.1055/s-0040-1716366 ◽

2020 ◽

Author(s):

Elis Yuexian Lee ◽

Jessica Hui Yin Tan ◽

Chew Thye Choong ◽

Nancy Wen Sim Tee ◽

Chia Yin Chong ◽

...

Keyword(s):

Developmental Delay ◽

Oropharyngeal Dysphagia ◽

Significant Risk ◽

Developmental Outcomes ◽

Autism Spectrum ◽

Clinical Findings ◽

Cortical Blindness ◽

Speech Delay ◽

Neurodevelopmental Outcomes ◽

Young Infants

Abstract Parechovirus-A (PeV-A) and Enterovirus (EV) commonly cause childhood aseptic meningitis. Bacterial meningitis in children has been associated with devastating long-term sequelae. However, developmental outcomes are unclear in Parechovirus meningitis. This study aims to review the clinical findings and developmental outcomes of infants with PeV-A and EV meningitis. We performed a retrospective study of infants aged 90 days or younger being admitted to our hospital with PeV-A meningitis between November 2015 and July 2017, with positive cerebrospinal fluid (CSF) PeV-A PCR and negative blood and CSF bacterial cultures. Hearing and neurodevelopmental outcomes were compared with a previous cohort of infants aged 90 days or younger with EV meningitis admitted from January 2015 to December 2015. A total of 161 infants were included in our study, of which 68 infants (42.2%) had PeV-A meningitis and 93 infants (57.8%) had EV meningitis. We assessed their developmental outcome at 6 months, 1 year, and 2 years post-meningitis. At 2 years post-meningitis, three infants with PeV-A meningitis had developmental delay (5.5%), whereas none with EV meningitis had developmental delay. One patient had speech delay and autism spectrum disorder, while two had mild speech delay. When compared with our cohort of EV meningitis ≤90 days old, children with PeV-A meningitis ≤90 days old were more likely to have developmental delay 2 years post-meningitis (odds ratio 2.4, 95% confidence interval 2.0–3.0, p = 0.043). None of the patients with PeV-A or EV meningitis had sensorineural hearing loss or neurological sequelae, such as cortical blindness, oropharyngeal dysphagia, hydrocephalus, epilepsy, or cerebral palsy. Infants with PeV-A meningitis had a significant risk of developmental delay 2 years post-meningitis compared with those with EV meningitis. It is important to follow-up the developmental milestones of infants diagnosed with PeV-A meningitis for at least 2 years; and when they develop developmental delay, to ensure that they receive appropriate intervention.

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Implementation of a Clinical Pathway to Avoid Lumbar Puncture in Febrile Young Infants Aged 29-56 Days Meeting a Set of Low Risk Criteria

PEDIATRICS ◽

10.1542/peds.137.supplement_3.282a ◽

2016 ◽

Vol 137 (Supplement 3) ◽

pp. 282A-282A

Author(s):

Payal K. Gala ◽

Ashlee L Murray ◽

Aileen P. Schast ◽

Christian Minich ◽

Ashley L. Woodford ◽

...

Keyword(s):

Lumbar Puncture ◽

Clinical Pathway ◽

Low Risk ◽

Risk Criteria ◽

Young Infants

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Studying the Oral Performance of Furosemide Using an In Vitro Model Simulating Gastro-Intestinal Digestion and Drug Solubilization in Neonates and Young Infants

10.26226/morressier.57d6b2b6d462b8028d88efec ◽

2016 ◽

Author(s):

Ragna Berthelsen

Keyword(s):

In Vitro Model ◽

Oral Performance ◽

Drug Solubilization ◽

Young Infants ◽

Intestinal Digestion ◽

Vitro Model

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Demographic Factors Associated with Congenital Malformations Among Young Infants in Fallujah Maternity and Children Hospital, Fallujah City, Iraq

10.31487/j.gg.2020.01.03 ◽

2020 ◽

pp. 1-5

Author(s):

Samira T.Abdulghani ◽

Samira T.Abdulghani

Keyword(s):

Developing Countries ◽

Congenital Anomalies ◽

Prevalence Rate ◽

Gestational Hypertension ◽

Heart Defects ◽

Demographic Factors ◽

Cross Sectional ◽

Factors Associated ◽

Young Infants ◽

History Of

Background: Congenital anomalies are a major cause of infant morbidity and mortality in developing countries including our country. Registries and data on these anomalies are still primitive and poorly collated. In this study we aimed to assess the important demographic factors associated with the development of congenital anomalies. Methods: This was a cross-sectional hospital-based study involving 880 infants in the 1st year of life registered in the birth defect unit in Fallujah Maternity and Children Hospital in the period between 1st of January 2017 to the 31st of December 2019. The prevalence rate, the pattern of anomalies and the factors associated with their occurrence were determined. Results: The prevalence rate of the group enrolled in this study was 31/1000 total births, congenital heart defects was the commonest followed by central nervous system anomalies, 58% of the infants were males, 65% had ≥ 2.5 kg birth weight & 95% were singletons. Family history of congenital anomalies was found in 31.25% of cases. The largest group of mothers (55.7%) were 21-30 years old & 92.5% of fathers were less than 45 years old. Parental consanguinity reported in 64.3% of the total cases. Only 4.5% of mothers reported history of fever during pregnancy, and none of them had history of exposure to x-ray or teratogenic drug use. Gestational hypertension was reported in 10% of the total (880) mothers, hypertension and diabetes mellitus in 0.3%, while hepatitis C, hepatitis B, toxoplasmosis and epilepsy, each was reported in only one mother (0.1% of the total). Regarding the outcome of pregnancy, 66.6% were live births, 24.2% were abortions and 9.2% were stillbirths. History of previous abortions was reported in 22% of cases. Urban residents accounted for 63% of the families of congenitally abnormal infants while 37% were rural. Conclusion: Congenital anomalies are still a major cause for concern and tension in Fallujah society, there is serious need to establish a surveillance and good statistical system for congenital anomalies and efforts should be made to raise awareness of their occurrence and the associated risk factors in Iraq and other developing countries.

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