Antihistamines Combined with Phenylephrine Hydrochloride and Codeine Phosphate or Dihydrocodeinone Bitartrate in Elixirs

1965 ◽  
Vol 48 (3) ◽  
pp. 594-595
Author(s):  
Rupert Hyatt
Keyword(s):  
Aqueous Solution ◽  
Acetic Anhydride ◽  
Chloroform Solution ◽  
Codeine Phosphate ◽  
Chlorpheniramine Maleate ◽  
Phenylephrine Hydrochloride ◽  
Alkaline Aqueous Solution ◽  
Standard Solution ◽  
Standard Solutions

Abstract The proposed method for combinations of antihistamines with phenylephrine.HCl uses three columns, HC1, NaOH, and H2SO4. Chlorpheniramine and codeine are removed from the columns with a chloroform solution of triethylamine. The chloroform eluates are evaporated and the residues taken up in dilute HCl. They are determined spectrophotometrically by comparison with the appropriate standard solutions. The phenylephrine is acetylated on the column with a chloroform solution of acetic anhydride. The acetylphenylephrine is then eluted with chloroform, and the solvent is evaporated and saponified with alcoholic-KOH. The reformed phenylephrine can then be determined spectrophotometrically in either an acid or alkaline aqueous solution and compared to the appropriate standard solution. The results of eight collaborators and the Associate Referee give the following average recoveries in the assay of an authentic elixir: codeine, 100.3%; phenylephrine.HCl, 97.4%; and chlorpheniramine maleate, 102.5%. The method was adopted as official, first action.

Chromatographic Separation and Spectrophotometry Determination of Phenylephrine Hydrochloride, Codeine Phosphate, and Some Other Pharmaceuticals in a Mixture

1966 ◽  
Vol 49 (3) ◽  
pp. 536-541
Author(s):  
Donald J Smith
Keyword(s):  
Chromatographic Separation ◽  
Codeine Phosphate ◽  
Hydrocortisone Acetate ◽  
Chlorpheniramine Maleate ◽  
Phenylephrine Hydrochloride ◽  
Phenylpropanolamine Hydrochloride

Abstract Codeine phosphate, chlorpheniramine maleate, pyrilamine maleate, phenylpropanolamine hydrochloride, and hydrocortisone acetate were analyzed in samples containing phenylephrine hydrochloride. A series of four columns is used to separate the various pharmaceutical components prior to analysis. Assays of commercial samples ranged from 87.2 to 118% of declared content.

scholarly journals Validated Stability Indicating RP-HPLC Method for Simultaneous Estimation of Codeine Phosphate and Chlorpheniramine Maleate from Their Combined Liquid Dosage Form

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Ramakrishna Kommana ◽  
Praveen Basappa
Keyword(s):  
Limit Of Detection ◽  
Degradation Products ◽  
Hplc Method ◽  
Simultaneous Estimation ◽  
Forced Degradation ◽  
Codeine Phosphate ◽  
Chlorpheniramine Maleate ◽  
Combination Drug ◽  
Stability Indicating ◽  
Rp Hplc

The present paper describes the development of quick stability indicating RP-HPLC method for the simultaneous estimation of codeine phosphate and chlorpheniramine maleate in the presence of its degradation products, generated from forced degradation studies. The developed method separates codeine phosphate and chlorpheniramine maleate in impurities/degradation products. Codeine phosphate and chlorpheniramine maleate and their combination drug product were exposed to acid, base, oxidation, dry heat, and photolytic stress conditions, and the stressed samples were analysed by proposed method. The proposed HPLC method utilizes the Shimadzu HPLC system on a Phenomenex C18 column (, 5 μ) using a mixture of 1% o-phosphoric acid in water : acetonitrile : methanol (78 : 10 : 12) mobile phase with pH adjusted to 3.0 in an isocratic elution mode at a flow rate of 1 mL/min, at 23°C with a load of 20 μL. The detection was carried out at 254 nm. The retention time of codeine phosphate and chlorpheniramine maleate was found to be around 3.47 min and 9.45 min, respectively. The method has been validated with respect to linearity, robustness, precision, accuracy, limit of detection (LOD), and limit of quantification (LOQ). The developed validated stability indicating HPLC method was found to be simple, accurate, and reproducible for the determination of instability of these drugs in bulk and commercial products.

scholarly journals POST-MARKETING SURVEILLANCE STUDY TO SUBSTANTIATE THE EFFICACY AND SAFETY FOR THE COMBINATION OF PARACETAMOL, PHENYLEPHRINE AND CHLORPHENIRAMINE MALEATE IN INDIAN PATIENTS OF COMMON COLD

2021 ◽  
Vol 5 (7) ◽  
Author(s):  
Mayuresh Kiran ◽  
Lalit Pawaskar ◽  
Shaheen Sheikh ◽  
Pramita Waghambare
Keyword(s):  
Common Cold ◽  
Symptomatic Treatment ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Efficacy And Safety ◽  
Chlorpheniramine Maleate ◽  
Phenylephrine Hydrochloride ◽  
Indian Patients ◽  
Post Marketing Surveillance ◽  
Dose Combination

Introduction: Common cold is frequently occurring medical condition in developing countries like India. Common cold is self-limiting in nature so symptomatic treatment is always suggested. This study was conducted to test the efficacy and safety for the fixed dose combination of Paracetamol 500 mg, Phenylephrine Hydrochloride 10 mg and Chlorpheniramine Maleate 2 mg per tablet for the treatment of common cold. Methodology: Total 180 patients were enrolled out of which 159 completed the study. Efficacy assessment was done by decrease in total symptom score (TSS) of common cold at day 3 and 5 as compared to the baseline (day 1). Safety assessment was made by analyzing the reported adverse events through the study. Results: Mean TSS at baseline was 6.62 which was decreased to 3.55 at day 3 and was further decreased to 0.68 at day 5. Majority of patients had complete relief from the symptoms of common cold and nearly all the patients had >50 % reduction in TSS. Also no unexpected or serious adverse event was found to be reported in the study duration of 5 days. Conclusion:  Fixed dose combination of Paracetamol 500 mg, Phenylephrine Hydrochloride 10 mg and Chlorpheniramine Maleate 2 mg per tablet was found to be efficacious and safe for the symptomatic treatment of common cold in Indian patients. Keywords: Common cold, Paracetamol, Chlorpheniramine Maleate and Phenylephrine

Ruthenium catalysed oxidation of cyclohexanol

1982 ◽  
Vol 35 (6) ◽  
pp. 1245 ◽  
Author(s):  
P Becker ◽  
JK Beattie
Keyword(s):  
Aqueous Solution ◽  
Isotope Effect ◽  
Phosphate Buffer ◽  
Hydride Transfer ◽  
Deuterium Isotope Effect ◽  
Rate Law ◽  
Alkaline Aqueous Solution ◽  
Catalysed Oxidation

The oxidation of cyclohexanol by ferricyanide in alkaline aqueous solution is catalysed by micromolar concentrations of K3RuCl6. The rate law at 25.0�C in pH 11.9 phosphate buffer containing 0.50 M NaCl is -d[FeIII]/dt = [Ru](2klk2[alcohol][FeIII])/(2kl[alcohol] + k2[FeIII]) with kl 12 � 2 mol-1 1. s-1 and k2 (2.5 � 0.2) × 102 mol-1 1. s-1. A deuterium isotope effect of about 4 is observed when (D12)cyclohexanol is used. A mechanism consistent with these observations involves reduction of the RuIII catalyst by hydride transfer from the alcohol followed by reoxidation by ferricyanide to the original RulIII state.

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