Simple Colorimetric Method for Determination from Pharmaceutical Preparations

1986 ◽  
Vol 69 (2) ◽  
pp. 186-188 ◽  
Author(s):  
Ramesh T Sane ◽  
Vishwanath B Malkar ◽  
Vinay G Nayak ◽  
Dhananjay S Sapre
Keyword(s):  
Room Temperature ◽  
Colorimetric Method ◽  
Pharmaceutical Preparations ◽  
Statistical Validation ◽  
Terbutaline Sulfate

Abstract A simple colorimetric method is described for the determination of terbutaline sulfate. The method is based on measurement of a colored species formed when terbutaline sulfate is treated with diazotized dapsone and p-nitroaniline at room temperature. Compounds such as starch, talc, and common excipients do not interfere in the reaction. Statistical validation showed that the method was highly precise and accurate. The results agree well with those obtained by other methods reported in the literature.

Simple Colorimetric Method for Determination of Metaproterenol Sulfate in Pharmaceuticals

1984 ◽  
Vol 67 (1) ◽  
pp. 137-138
Author(s):  
Ramesh T Sane ◽  
Satish V Sawant ◽  
Vipul J Doshi ◽  
Jagannath G Mhalas ◽  
Ajay K Paarikh ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Room Temperature ◽  
Colorimetric Method ◽  
Statistical Validation

Abstract A simple coiorimetric method is described for the determination of metaproterenol sulfate (orciprenaline sulfate). The method is based on measurement of a colored species formed when metaproterenol sulfate is treated with diazotized dapsone, p-nitroaniline, or benzocaine at room temperature, followed by treatment with an aqueous solution of trimethylamine in the case of benzocaine. Compounds such as starch, talc, and common excipients do not interfere in the reaction. Statistical validation showed that the method was precise and accurate. The results agree well with those obtained by other methods reported in the literature.

Simple Colorimetric Method for Determination of Pyridoxine Hydrochloride (Vitamin B6) in Pharmaceuticals

1983 ◽  
Vol 66 (1) ◽  
pp. 158-160
Author(s):  
Ramesh T Sane ◽  
Vipul J Doshi ◽  
Sanjay K Joshi
Keyword(s):  
Aqueous Solution ◽  
Sulfuric Acid ◽  
Vitamin B6 ◽  
Trichloroacetic Acid ◽  
Room Temperature ◽  
Colorimetric Method ◽  
Thiamine Hydrochloride ◽  
Pyridoxine Hydrochloride ◽  
Statistical Validation

Abstract A simple colorimetric method is described for the determination of pyridoxine hydrochloride (vitamin B6). The method is based on the measurement of an orange species formed when pyridoxine hydrochloride is treated with diazotized dapsone and sulfanilamide in a mixture of trichloroacetic acid and sulfuric acid at room temperature, followed by treatment with an aqueous solution of sodium carbonate. Compounds such as thiamine hydrochloride, cyanocobalamin, and common excipients such as starch and talc which are present in various formulations with pyridoxine hydrochloride do not interfere in the reaction. Statistical validation showed that the method was highly precise and accurate. Results agree well with those obtained by other methods reported in the literature.

Colorimetric Determination of Terbutaline Sulfate and Orciprenaline Sulfate via Nitrosation and Difference Spectrophotometry

1987 ◽  
Vol 70 (3) ◽  
pp. 568-571 ◽  
Author(s):  
Mohamed E El-Sadek ◽  
Hisham E Abdel Latef ◽  
Afaf A Aboul Khier
Keyword(s):  
Hydrochloric Acid ◽  
Sodium Nitrite ◽  
Colorimetric Method ◽  
Dosage Forms ◽  
Alkaline Media ◽  
Colorimetric Determination ◽  
Pharmaceutical Dosage Forms ◽  
Terbutaline Sulfate ◽  
The Difference

Abstract A colorimetric method is proposed for determination of terbutaline sulfate, orciprenaline sulfate, and their dosage forms. The suggested method depends on nitrosation of the 2 drugs by using sodium nitrite and hydrochloric acid. Addition of sodium hydroxide increases the intensity of the color developed. The difference between absorption values measured in acid and alkaline media is taken as a measure of concentration. Variables were carefully studied and optimized. Results for both compounds adhered to Beer's law over the range 2- 28 μg/mL. The method has proved to be accurate and precise for analysis of pharmaceutical dosage forms.

Simple Colorimetric Method for Determination of Thiamine Hydrochloride in Pharmauceuticals

1985 ◽  
Vol 68 (1) ◽  
pp. 83-85
Author(s):  
Ramesh T Sane ◽  
Vipul J Doshi ◽  
Swati Jukar ◽  
Sanjay K Joshi ◽  
Satish V Sawant ◽  
...  
Keyword(s):  
Liver Extract ◽  
Colorimetric Method ◽  
Dosage Forms ◽  
Vitamin B ◽  
Thiamine Hydrochloride ◽  
Calcium Pantothenate ◽  
Statistical Validation ◽  
Alkaline Conditions ◽  
The Stability

Abstract A simple colorimetric method is described for the determination of thiamine hydrochloride (vitamin B,) in dosage forms. The method is based on measurement of a yellow complex formed when thiamine HC1 is treated with /7-methylaminophenol sulfate (Metol) under alkaline conditions. Compounds such as vitamins A, B2, B6, B,2, C, D, and E, and niacinamide, citric acid, liquid glucose, calcium pantothenate, biotin, liver extract, and folic acid do not interfere in the reaction. Extracting the complex into chloroform before quantitation enhances the stability of the reaction product and removes interference of watersoluble colored constituents in syrup samples. Statistical validation shows that the method is precise and accurate. Results agree well with those obtained by other methods in the literature

Determination of thioguanine in pharmaceutical preparations by paper substrate room temperature phosphorimetry

The Analyst ◽  
2000 ◽  
Vol 125 (7) ◽  
pp. 1327-1330 ◽  
Author(s):  
Dong Chuan ◽  
Yang Pin ◽  
Yuan Wen ◽  
Shuang Shaomin
Keyword(s):  
Room Temperature ◽  
Pharmaceutical Preparations ◽  
Paper Substrate

New colorimetric method for quantitative determination of protein in urine.

1977 ◽  
Vol 23 (5) ◽  
pp. 811-812 ◽  
Author(s):  
H Yatzidis
Keyword(s):  
Quantitative Determination ◽  
Tannic Acid ◽  
Chloride Solution ◽  
Room Temperature ◽  
Colorimetric Method ◽  
Ferric Chloride Solution ◽  
Acid Protein ◽  
Analytical Recovery ◽  
Violet Color

Abstract Total urinary protein is rapidly precipitated at room temperature by tannic acid. The tannic acid/protein precipitate, dissolved in aqueous triethanolamine/ferric chloride solution, gives a purple-violet color of high absorptivity. Absorbance at 510 nm is linearly related to concentration from 0.05 to 1.50 A for a protein content of 0.05 to 1.50 g/liter, and less than 5 mg/liter can be detected. The CV and analytical recovery ranged from 0.5 to 1.8% and 98 to 103%, respectively. Nonprotein urinary constituents do not interfere.

Micelle-stabilized room-temperature phosphorimetric procedure for the determination of naproxen and propranolol in pharmaceutical preparations

The Analyst ◽  
1994 ◽  
Vol 119 (5) ◽  
pp. 1093-1097 ◽  
Author(s):  
I. Rapado Martínez ◽  
R. M. Villanueva Camañas ◽  
M. C. García-Alvarez-Coque
Keyword(s):  
Room Temperature ◽  
Pharmaceutical Preparations
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