Spectrophotometric Determination of Some Benzene Sulfonamides with 7,7,8,8-Tetracyanoquinodimethane

1989 ◽  
Vol 72 (6) ◽  
pp. 885-889 ◽  
Author(s):  
Abdel-Maboud I Mohamed
Keyword(s):  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Analytical Data ◽  
Pharmaceutical Preparations ◽  
Pure Form ◽  
Wide Range ◽  
Beer's Law ◽  
Beer’S Law ◽  
Good Agreement

Abstract A new spectrophotometric method for the determination of some unsubstituted benzene sulfonamides is presented. The method is based on the interaction of these derivatives with 7,7,8,8-tetracyanoquinodimethane at pH 9.0-9.5 to produce intense blue products. The quantitation of the products was carried out at 578 nm. Beer’s law was obeyed over a wide range of concentrations for all sulfonamide compounds studied. Optimum analytical conditions were determined, and the color produced was stable for at least 90 min at 25 °C. Analytical data for determination of sulfonamide compounds in pure form are presented together with application of the proposed method for analysis of some commercially available pharmaceutical preparations. The results are in good agreement with those obtained by official procedures.

scholarly journals Spectrophotometric Determination of Famciclovir and Racecodotril Using 2, 6-Dichloroquinone–Chlorimide

2007 ◽  
Vol 4 (1) ◽  
pp. 50-52 ◽  
Author(s):  
M. Vamsi Krishna ◽  
P. V. Madhavi Latha ◽  
D. Gowri Sankar
Keyword(s):  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Oxidative Coupling ◽  
Pharmaceutical Preparations ◽  
Coupling Product ◽  
Beer's Law ◽  
Beer’S Law ◽  
Sensitive Spectrophotometric Method

A simple, sensitive spectrophotometric method for the determination of Famciclovir and Racecodotril is developed. It is based on the formation of a colored oxidative coupling product between 2,6-dichloroquinone-chlorimide and the drug is described. The method has been extended to pharmaceutical preparations. The absorption maxima and Beer’s law limits for Famciclovir are 500 nm, 20-100 µg/mL and for Racecodotril are 460 nm, 12.5-62.5 µg/mL.

scholarly journals Spectrophotometric Determination of Paracetamol in bulk and Pharmaceutical Preparations

2015 ◽  
Vol 12 (2) ◽  
pp. 317-323
Author(s):  
Baghdad Science Journal
Keyword(s):  
Sodium Hydroxide ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Pharmaceutical Preparations ◽  
Coupling Reaction ◽  
Reaction Conditions ◽  
Accuracy And Precision ◽  
Beer's Law ◽  
Beer’S Law

A simple, and rapid spectrophotometric method for the estimation of paracetamol has been developed. The methods is based on diazotisation of 2,4-dichloroaniline followed by a coupling reaction with paracetamol in sodium hydroxide medium. All variables affecting the reaction conditions were carefully studied. Beer's law is obeyed in the concentration range of 4-350 ?gml?1 at 490 nm .The method is successfully employed for the determination of paracetamol in pharmaceutical preparations. No interferes observed in the proposed method. Analytical parameters such as accuracy and precision have been established for the method and evaluated statistically to assess the application of the method.

scholarly journals Rapid and Selective UV Spectrophotometric Method for the Analysis of Ceftazidime

2009 ◽  
Vol 92 (3) ◽  
pp. 820-823 ◽  
Author(s):  
Andréia de Haro Moreno ◽  
Hérida Regina Nunes Salgado
Keyword(s):  
Standard Deviation ◽  
Relative Standard Deviation ◽  
Quantitative Evaluation ◽  
Spectrophotometric Method ◽  
Pharmaceutical Preparations ◽  
Pure Form ◽  
Uv Detector ◽  
Relative Standard ◽  
Beer's Law ◽  
Beer’S Law

Abstract A new UV spectrophotometric method was developed for quantitative evaluation of ceftazidime preparations. The UV detector was set at 255 nm. Beer's law is obeyed in the concentration range of 7.014.0 g/mL. The method was found to be selective, linear, accurate, and precise in the specified ranges. Intra- and interday variability for the method were <2 relative standard deviation. Common excipients used as additives in pharmaceutical preparations do not interfere with the proposed method. This method was successfully used for quantification of ceftazidime in pure form and in pharmaceutical preparations.

scholarly journals Spectrophotometric Determination of Aciclovir, Cefepirne Hydrochloride, Etamsylate and Metoclopramide Hydrochloride Usina 1,10 Phenanttrroline—Fe(lll) Reaqent

2004 ◽  
Vol 72 (1) ◽  
pp. 73-86 ◽  
Author(s):  
Marwa S. Elazazy ◽  
Abdalla Shalaby ◽  
M. N. Elbolkiny ◽  
Hawa M. Khalil
Keyword(s):  
Spectrophotometric Determination ◽  
Pharmaceutical Formulations ◽  
Accurate Method ◽  
Pure Form ◽  
Reagent Blank ◽  
Experimental Conditions ◽  
Beer's Law ◽  
Beer’S Law ◽  
Metoclopramide Hydrochloride

A simple, rapid, sensitive and accurate method for the determination of aciclovir, cefepime HCI, etamsylate and metoclopramide HCI in pure form and in pharmaceutical formulations is developed.The method is based on the fomabon of tris(o-phenanthroline) iron(ll) complex (Ferroin) upon the reaction of the ated drugs wrth iron(lll )-o- phenanthroline mixture. The ferroin complex is colorimetncally measured at λmax 510 nm against a reagent blank. 0ptimization of the experimental conditions is described. Beer's law is obeyed in the concentration range from 0.25–30 µg ml−1 with molar absorpitivities (ε) ranging from 4.796 x 103–9.51 2 x 104 L.mol−1.cm−1 and Sandell sensitivities (S) of 2.129 x 10−3–34.5 x 10−3 µg cm−2. The developed method is applied successfully for the determination of the cited drugs in pure forms and in the corresponding pharmaceutical formulations without any interferences from common excipients.

Spectrophotometric Determination of Menadione and Menadione Sodium Bisulfite

1982 ◽  
Vol 65 (1) ◽  
pp. 141-143
Author(s):  
Madiha B Sidhom ◽  
Michel E El-Kommos
Keyword(s):  
Alkaline Medium ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Sodium Bisulfite ◽  
Routine Analysis ◽  
Menadione Sodium Bisulfite ◽  
Beer's Law ◽  
Violet Color ◽  
Beer’S Law

Abstract A spectrophotometric method is described for the determination of menadione and menadione sodium bisulfite in bulk and in solution for injection. The method measures the intensity of the violet color (λmax 540 nm) developed when menadione reacts with thiosemicarbazide in alkaline medium. Beer's law is obeyed in the concentration range 4-40 μg/m L (r = 0.9995). The method is simple, sensitive, and particularly suited for routine analysis of official menadione sodium bisulfite injection. Results are comparable with the USP method.

scholarly journals Development of Method for Extractive Spectrophotometric Determination of Fe(III) with 2-Hydroxy-1-Naphthalene Carboxaldehyde Phenyl Hydrazone as an Analytical Reagent

2013 ◽  
Vol 14 ◽  
pp. 7-12
Author(s):  
Ratnamala P. Sonawane ◽  
R.S. Lokhande ◽  
Utkarsha M. Chavan
Keyword(s):  
Ethyl Acetate ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Molar Absorptivity ◽  
Beer's Law ◽  
Beer’S Law ◽  
Coloured Complex ◽  
Analytical Reagent

A spectrophotometric method has been developed for the determination of Fe(III) using 2-Hydroxy-1-Naphthalene carboxaldehyde phenyl hydrazone as an extractive reagent. The reagent forms a coloured complex, which has been quantitatively extracted into ethyl acetate at pH 6. The method obeys Beer’s law over arrange from 1 to 7 ppm. The Molar absorptivity and Sandell’s sensitivity were 0.31 × 104 L mol-1cm-1 and 0.13 μg cm-2 respectively. The proposed method is very sensitive and selective. The method has been successfully applied to synthetic and commercial samples.

scholarly journals Spectrophotometric determination of Clinidipine, Efavirenz, Prazosin drugs by using Folin-Ciocalteu Reagent

2020 ◽  
Vol 13 (3) ◽  
pp. 210-217
Author(s):  
Naveen Reddy Pailla ◽  
Bhaskar Kuthati
Keyword(s):  
Alkaline Medium ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Absorption Maximum ◽  
Ich Guidelines ◽  
Beer's Law ◽  
Beer’S Law

For the determination of three drugs namely Cilnidipine (CDP), Efavirenz (EVZ), Prazosin (PRZ), a simple, fast, selective and accurate spectrophotometric method has been outlined. This method is based on the development of blue coloured chromogen due to reduction of tungstate and/ or molybdate in Folin-Ciocalteu reagent by Drug in alkaline medium. The coloured species has an absorption maximum at 730 nm, 745 nm and 770 nm and the Beer’s law obeys over the concentration range of 12-72 μg/mL, 10-70 μg/mL, 3-21 μg/mL respectively for the drugs CDP, EVZ, PRZ. This method has been validated according to ICH guidelines and applied to the analysis of pharmaceuticals.

scholarly journals Simple UV Spectrophotometric Determination of Rosuvastatin Calcium in Pure Form and in Pharmaceutical Formulations

2009 ◽  
Vol 6 (1) ◽  
pp. 89-92 ◽  
Author(s):  
Alka Gupta ◽  
P. Mishra ◽  
K. Shah
Keyword(s):  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Pure Form ◽  
Ultraviolet Region ◽  
Rosuvastatin Calcium ◽  
Sensitive Spectrophotometric Method

A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of rosuvastatin calcium in bulk and in pharmaceutical formulations. Rosuvastatin exhibits absorption maxima at 244 nm with apparent molar absorptivity of 7.2345 ×104L/mol.cm in methanol. Beer’s law was found to be obeyed in the concentration range of 2-18 µg/mL. The method is accurate, precise and economical. This method is extended to pharmaceutical preparations. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically and by recovery studies

scholarly journals VALIDATED SPECTROPHOTOMETRIC METHOD TO DETERMINE VARDENAFIL AND SILDENAFIL IN PHARMACEUTICAL FORMS USING POTASSIUM IODIDE AND POTASSIUM IODATE

2017 ◽  
Vol 9 (10) ◽  
pp. 65 ◽  
Author(s):  
Amir Alhaj Sakur ◽  
Shaza Affas
Keyword(s):  
Potassium Iodide ◽  
Spectrophotometric Method ◽  
Molar Absorptivity ◽  
Dosage Forms ◽  
Potassium Iodate ◽  
Average Recovery ◽  
Beer's Law ◽  
Beer’S Law ◽  
Good Agreement

Objective: To develop and validate simple, sensitive, precise and free of organic solvents method for the determination of sildenafil (SIL) and vardenafil (VAR) in bulk and pharmaceutical formulation.Methods: The method is based on the reaction of studied drugs with a mixture of potassium iodide and potassium iodate in an aqueous medium at (25±2 °C) to form yellow coloured triiodide ions (I3-) within 45 min. The reaction is followed spectrophotometrically by measuring the absorbance at 288, 351 nm and 285, 351 nm for sildenafil and vardenafil respectively.Results: The effects of analytical parameters on the reported systems were investigated. Beer's law of SIL was obeyed in the range of (0.4-12) μg ml-1and (0.6-16) μg ml-1. Molar absorptivity was found to be (67.659 ×103) lmol/cmand (37.955×103) lmol/cm at 288 nm, 351 nm respectively. Beer's law of VAR was obeyed in the range of (0.2-13) μg/mland (0.5-40) μg/ml. Moreover, molar absorptivity’s were found to be (68.719 ×103) l mol-1 cm-1and (26.691×103) l mol-1 cm-1 at 285 nm, 351 nm respectively.Conclusion: The proposed method has been applied to determine the components in dosage forms with an average recovery of 98.15% to 103.45% and the results have been found in good agreement with those results obtained by the reference methods.

Spectrophotometric Determination of Piperazine in Pharmaceutical Preparations

1974 ◽  
Vol 57 (5) ◽  
pp. 1144-1146
Author(s):  
Tulsidas R Baggi ◽  
Surinder N Mahajan ◽  
G Ramana Rao
Keyword(s):  
Spectrophotometric Determination ◽  
Pharmaceutical Preparations ◽  
Analytical Control ◽  
Beer's Law ◽  
Beer’S Law

Abstract A solution of piperazine or its salts is heated with 2,6-dichloroquinonechlorimide, and the color produced is measured at 525 nm to obtain the concentration of piperazine. The color developed obeys Beer’s law in the concentration range of 6.4–51.2 μg piperazine/ml. The results of the proposed method agree with those of the official methods within ± 1.0% for piperazine and its salts and ± 2.0% for formulations. The method is rapid and precise and gives reproducible results. It is suitable for the analytical control of piperazine or its salts and their formulations.

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