scholarly journals Spectrophotometric Determination of Aciclovir, Cefepirne Hydrochloride, Etamsylate and Metoclopramide Hydrochloride Usina 1,10 Phenanttrroline—Fe(lll) Reaqent

2004 ◽  
Vol 72 (1) ◽  
pp. 73-86 ◽  
Author(s):  
Marwa S. Elazazy ◽  
Abdalla Shalaby ◽  
M. N. Elbolkiny ◽  
Hawa M. Khalil
Keyword(s):  
Spectrophotometric Determination ◽  
Pharmaceutical Formulations ◽  
Accurate Method ◽  
Pure Form ◽  
Reagent Blank ◽  
Experimental Conditions ◽  
Beer's Law ◽  
Beer’S Law ◽  
Metoclopramide Hydrochloride

A simple, rapid, sensitive and accurate method for the determination of aciclovir, cefepime HCI, etamsylate and metoclopramide HCI in pure form and in pharmaceutical formulations is developed.The method is based on the fomabon of tris(o-phenanthroline) iron(ll) complex (Ferroin) upon the reaction of the ated drugs wrth iron(lll )-o- phenanthroline mixture. The ferroin complex is colorimetncally measured at λmax 510 nm against a reagent blank. 0ptimization of the experimental conditions is described. Beer's law is obeyed in the concentration range from 0.25–30 µg ml−1 with molar absorpitivities (ε) ranging from 4.796 x 103–9.51 2 x 104 L.mol−1.cm−1 and Sandell sensitivities (S) of 2.129 x 10−3–34.5 x 10−3 µg cm−2. The developed method is applied successfully for the determination of the cited drugs in pure forms and in the corresponding pharmaceutical formulations without any interferences from common excipients.

scholarly journals Spectrophotometric Determination of Ziram in a Commercial Sample and Wheat by Extraction of Its Copper Dimethyldithiocarbamate Complex into Molten Naphthalene

2002 ◽  
Vol 85 (1) ◽  
pp. 146-148
Author(s):  
Ashok Kumar Malik ◽  
Avasarla L J Rao
Keyword(s):  
Spectrophotometric Determination ◽  
Final Solution ◽  
Wheat Grain ◽  
Reagent Blank ◽  
Commercial Sample ◽  
Dithiocarbamate Complex ◽  
Beer's Law ◽  
Beer’S Law

Abstract A method was developed for the determination of zinc(II) dimethyldithiocarbamate by converting it into the copper(II) dithiocarbamate complex, which is then extracted into molten naphthalene. The absorbance is measured at 430 nm versus a reagent blank. Beer's law is obeyed for concentrations of 0.63 × 10−3 to 17.2 × 10−3 g/L in the final solution. The method is sensitive and was applied to the determination of ziram in a commercial sample and in wheat grain.

Spectrophotometric Determination of Some Benzene Sulfonamides with 7,7,8,8-Tetracyanoquinodimethane

1989 ◽  
Vol 72 (6) ◽  
pp. 885-889 ◽  
Author(s):  
Abdel-Maboud I Mohamed
Keyword(s):  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Analytical Data ◽  
Pharmaceutical Preparations ◽  
Pure Form ◽  
Wide Range ◽  
Beer's Law ◽  
Beer’S Law ◽  
Good Agreement

Abstract A new spectrophotometric method for the determination of some unsubstituted benzene sulfonamides is presented. The method is based on the interaction of these derivatives with 7,7,8,8-tetracyanoquinodimethane at pH 9.0-9.5 to produce intense blue products. The quantitation of the products was carried out at 578 nm. Beer’s law was obeyed over a wide range of concentrations for all sulfonamide compounds studied. Optimum analytical conditions were determined, and the color produced was stable for at least 90 min at 25 °C. Analytical data for determination of sulfonamide compounds in pure form are presented together with application of the proposed method for analysis of some commercially available pharmaceutical preparations. The results are in good agreement with those obtained by official procedures.

scholarly journals Rapid Spectrophotometric Determination of Phenoxazine

2010 ◽  
Vol 7 (2) ◽  
pp. 1001-1005
Author(s):  
Baghdad Science Journal
Keyword(s):  
Detection Limit ◽  
Spectrophotometric Determination ◽  
Acidic Medium ◽  
Absorption Maximum ◽  
Aqueous Samples ◽  
Economic Method ◽  
Beer's Law ◽  
Beer’S Law ◽  
The Stability

A rapid high sensitive and inexpensive economic method has been developed for the Determination of phenoxazine by using molecular spectrophotometry. The method is based on the oxidation of phenoxazine by potassium (meta)periodate in acidic medium. The oxidation conditions were selected to enhance the sensitivity and the stability of the pink colored species which shows an absorption maximum at 530 nm. The Beer’s law was obeyed for phenoxazine concentration range from 1 to 6 µg mL-1 with 0.003 µg mL-1 detection limit and provided variation coefficients between 0.4 to 1.7 %. This method was successfully applied for the determination of phenoxazine in aqueous samples

THE DETERMINATION OF PHOSPHOLIPID PHOSPHORUS

1949 ◽  
Vol 27e (3) ◽  
pp. 159-163 ◽  
Author(s):  
J. M. R. Beveridge ◽  
S. E. Johnson
Keyword(s):  
Color Stability ◽  
Accurate Method ◽  
Inorganic Phosphorus ◽  
Strict Adherence ◽  
Beer's Law ◽  
Beer’S Law ◽  
Excellent Color ◽  
Colorimetric Procedure

A simple accurate method for the determination of phospholipid phosphorus is described. Conditions for the digestion of phospholipid have been developed permitting the utilization of a colorimetric procedure for inorganic phosphorus that is characterized by excellent color stability and strict adherence to Beer's law over a range of 0 to 65 μgm. of phosphorus.

Spectrophotometric Determination of Lanthanum in Raffinate with Tribromoarsenazo

2014 ◽  
Vol 675-677 ◽  
pp. 1429-1432
Author(s):  
Xing Xin Chen ◽  
Kui Liu ◽  
Li Fang Kuang ◽  
Hua Long
Keyword(s):  
Ascorbic Acid ◽  
Hydrochloric Acid ◽  
Correlation Coefficient ◽  
Wavelength Range ◽  
Spectrophotometric Determination ◽  
Linear Relation ◽  
Acidic Environment ◽  
Beer's Law ◽  
Beer’S Law

Determination of lanthanum in the raffinate by spectrophotometry was studied, using tribromoarsenazo as chromogenic reagent. The addition of ascorbic acid can mask the interference of other metal cations in the solution. Under the conditions of ascorbic acid (10g·L-1) 5 mL, hydrochloric acid 0.04 mol·L-1 and tribromoarsenazo (0.5g·L-1) 2 mL, Beer’s law is obeyed in the range of 0-10 μg·(25mL)-1 for lanthanum, with correlation coefficient higher than 0.99. Beer’s law can be applicable for the wavelength range of 580-660 nm. There is no linear relation at too high or too low acidic environment.

scholarly journals Micro Spectrophotometric Determination and Cloud Point Extraction of Sulphadimidine Sodium in Pure form and Pharmaceutical Drug

2019 ◽  
Vol 16 (2) ◽  
pp. 0332
Author(s):  
Dhahir Et al.
Keyword(s):  
Detection Limit ◽  
Cloud Point ◽  
Cloud Point Extraction ◽  
Pharmaceutical Preparation ◽  
Pure Form ◽  
Basic Medium ◽  
Limit Of Quantitation ◽  
Beer's Law ◽  
Beer’S Law

Two simple, rapid, and useful spectrophotometric methods were suggest or the determination of sulphadimidine sodium (SDMS) with and without using cloud point extraction technique in pure form and pharmaceutical preparation. The first  method was based on  diazotization of the Sulphdimidine Sodium drug by sodium nitrite at 5 ºC, followed by coupling with α –Naphthol in basic medium to form an orange colored product . The product was stabilized and its absorption was measured at 473 nm. Beer’s law was obeyed in the concentration range of (1-12) μg∙ml-1. Sandell’s sensitivity was 0.03012 μg∙cm-1, the detection limit was 0.0277 μg∙ml-1, and the limit of Quantitation was 0.03605μg∙ml-1.The second method was the cloud point extraction (CPE) using Trtion X-114 as surfactant. Beer’s law was obeyed in the concentration range of (1-12) μg∙ml-1. Sandell’s sensitivity was 0.02958 μg∙cm-1, the detection limit was 0.01745 μg∙ml-1, and the limit of quantitation was 0.028303 μg∙ml-1. All variables including the reagent concentration, reaction time, color stability period, and mole ratio were studied in order to optimize the reaction conditions. The mole ratio for the composition of product is (1:1). Both methods were effectively useful to the determination of sulphdimidine sodium in pharmaceutical dose form.  The attained results were in a good agreement with the official and other methods in the literature .No interference were observed from the commonly encountered additives and excipients.

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