Determination of (–)-Quinine and (+)-Quinidine by Liquid Chromatography with Diode-Laser Polarimetric Detection
1999 ◽
Vol 82
(6)
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pp. 1308-1315
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Keyword(s):
Abstract High-performance liquid chromatography using a combination of photometric, fluorimetric, and diode-laser polarimetric detectors in series for the determination of (+)-quinidine and (–)-quinine was investigated. An RP-8 reversed-phase column and methanol-water (80 + 20, v/v) with 0.2% triethylamine as mobile phase at a flow rate of 1 mL/min were used. A dynamic range of 0-200 μg for (+)-quinidine and (+)-quinine was established, with detection limits of 17.0 and 16.7 μg, respectively. An application of this method in spiked rabbit serum was developed.
1994 ◽
Vol 59
(3)
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pp. 569-574
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1977 ◽
Vol 23
(12)
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pp. 2288-2291
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2012 ◽
Vol 95
(4)
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pp. 1064-1068
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1983 ◽
Vol 29
(10)
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pp. 1793-1795
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1991 ◽
Vol 37
(12)
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pp. 2117-2120
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2008 ◽
Vol 91
(6)
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pp. 1339-1343
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