scholarly journals Impacts of Mycoplasma loads and lung lesions on immune and hematological statuses of pigs in an eight-breed cross heterogeneous population

2020 ◽  
Vol 98 (8) ◽  
Author(s):  
Qing Zhang ◽  
Jing Li ◽  
Tao Huang ◽  
Yifeng Zhang ◽  
Wenwu Xu ◽  
...  
Keyword(s):  
Blood Cell ◽  
Neutrophil Count ◽  
Lymphocyte Count ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Volume Distribution ◽  
Mean Corpuscular Hemoglobin Concentration ◽  
Corpuscular Hemoglobin ◽  
Distribution Width ◽  
Lung Lesions

Abstract Developments of pulmonary diseases, often accompanied by infections of bacteria, severely affect the meat production and welfare of pigs. This study investigated 307 pigs at age of 240 d from an eight-breed cross reared under standardized housing conditions for associations among the extent of lung lesions, bacteria load inferred from 16S rRNA sequencing of bronchoalveolar lavage fluid, as well as 57 immune cells and 25 hematological traits. We showed that the pigs under study suffered substantial and varied lung lesions, and the Mycoplasma is the most associated bacteria genera. At a false discovery rate of 0.05 (FDR < 0.05), the severity of lung lesions were significantly associated with greater CD8+ to CD3+ cell ratio, neutrophil-to-lymphocyte ratio (NLR), and standard deviation of red blood cell volume distribution width (RDW-SD), and lower CD4−CD8−/CD3+, CD3+CD4−CD8−/PBMCs (peripheral blood mononuclear cells) and CD14−CD16−/PBMCs cell ratios, mean corpuscular hemoglobin concentration, lymphocyte count, and lymphocyte count percentage, reflecting an status of inflammation, immune suppression, and hypoxia of the pigs accompanying the progression of the lung lesions. The Mycoplasma abundance showed positive correlations with neutrophil count, neutrophil count percentage, NLR, monocyte count, coefficient of variation in red blood cell volume distribution width , and RDW-SD, and negative correlations with mean corpuscular hemoglobin concentration, lymphocyte count, and lymphocyte count percentage; these correlations are largely consistent with those of lung lesions, supporting the comorbidity of lung lesions and Mycoplasma infection. We also observed nonlinear associations that sharp increases in neutrophil count and neutrophil count percentage occurred only when Mycoplasma abundance raised above the population-average level. The results provide helpful insights into the changes of host immune status in response to Mycoplasma relevant lung diseases in pigs.

scholarly journals Complete Blood Count Peculiarities in Pregnant SARS-CoV-2-Infected Patients at Term: A Cohort Study

Diagnostics ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 80
Author(s):  
Roxana Covali ◽  
Demetra Socolov ◽  
Razvan Socolov ◽  
Ioana Pavaleanu ◽  
Alexandru Carauleanu ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Blood Count ◽  
Complete Blood Count ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Mean Corpuscular Hemoglobin Concentration ◽  
Blood Cell Count ◽  
Corpuscular Hemoglobin ◽  
Distribution Width

Background: During viral outbreaks, pregnancy poses an increased risk of infection for women. Methods: In a prospective study, all patients admitted for delivery at term to Elena Doamna Obstetrics and Gynecology University Hospital in Iasi, Romania, between 1 April 2020 and 31 December 2020 were included. There were 457 patients, divided into two groups: group 1, SARS-CoV-2-positive patients (n = 46) and group 2, SARS-CoV-2-negative patients (n = 411). Among other tests, complete blood count was determined upon admittance, and the following values were studied: white blood cell count, lymphocytes, neutrophils, red blood cell count, hemoglobin, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, mean corpuscular volume, red blood cell distribution width, hematocrit, platelet count, mean platelet volume, platelet distribution width, plateletcrit, and platelet large cell ratio. Results: in pregnant SARS-CoV-2-infected patients at term, there was a significant decrease in white blood cell, neutrophil, and lymphocyte count, and an increase in mean corpuscular hemoglobin concentration, compared to healthy pregnant women at term, although all still within normal limits. None of the other components of the complete blood count or fetal outcomes studied was significantly influenced by SARS-CoV-2 infection in pregnant patients at term.

scholarly journals Characteristics of red blood cell populations fractionated with a combination of counterflow centrifugation and Percoll separation

Blood ◽  
1992 ◽  
Vol 79 (1) ◽  
pp. 254-260 ◽  
Author(s):  
FH Bosch ◽  
JM Werre ◽  
B Roerdinkholder-Stoelwinder ◽  
TH Huls ◽  
FL Willekens ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Hemoglobin A1c ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Mean Corpuscular Hemoglobin Concentration ◽  
Corpuscular Hemoglobin ◽  
Cell Age ◽  
Cellular Water ◽  
Hba1c Concentration

Abstract Red blood cell (RBC) fractions were studied after separation of whole blood by means of counterflow centrifugation, Percoll column (Pharmacia, Uppsala, Sweden), and a combination of both separation techniques. Mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH), and hemoglobin A1c (HbA1c) were measured in each fraction. From the results it was obvious that the combination of both techniques was the best separation technique of these three. MCV had a good correlation with cell age as measured with HbA1c concentration gradient; MCH and MCHC less so. MCV and MCH decreased in parallel to an increase in HbA1c. MCHC increased with increasing HbA1c. From these data it is concluded that there is a steadily ongoing loss of cellular hemoglobin and proportionally more cellular water during the life of the RBC.

scholarly journals 725. Complete Blood Count Values Vary in Degree of Change with Day of Fever in Children with Dengue Fever

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S461-S462
Author(s):  
Melissa E Day ◽  
Miguel E Mejia Sang ◽  
Yonairy Collado Puello ◽  
Elvira J Diaz Brockmans ◽  
Stephanie Rivera Defillo ◽  
...  
Keyword(s):  
Dominican Republic ◽  
Blood Cell ◽  
Mean Corpuscular Volume ◽  
Blood Count ◽  
Complete Blood Count ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Volume ◽  
Mean Corpuscular Hemoglobin Concentration ◽  
Corpuscular Hemoglobin

Abstract Background Dengue fever (DF) is an acute viral disease which can lead to severe illness, including dengue hemorrhagic fever, marked by thrombocytopenia and hemolytic anemia, as well as end-organ damage. Despite the well-known presentation and prevalence, changes in hematologic markers across the DF course have not been well-described in children. We sought to investigate the association of clinical laboratory values over time with dengue disease progression and outcome in a pediatric population in the Dominican Republic. Methods Pediatric participants were enrolled at Hospital Infantil Dr. Robert Reid Cabral in Santo Domingo, Dominican Republic, in a prospective, observational case-based study. Laboratory values, including complete blood count (CBC) indices and dengue titer results, were collected over the course of hospital stay. Using linear mixed models, we assessed whether 13 different CBC values and time trajectories differed by dengue status, including age and sex as covariates. To account for multiple testing, p≤0.0033 was considered significant. Results A total of 575 children ages 0 to 211 months met inclusion criteria; 51.8% (n=298) were male, and the median (IQR) age was 59 (14-93) months. Eighty-two percent (n=472) of participants had DF. CBC values across days 1 to 10 of fever in those with and without DF are depicted in Figure 1. Those with DF showed levels dropping more quickly across days of fever for hematocrit and hemoglobin (p≤ 0.002), with a more rapid decline in those with severe DF (p < 0.0001). Those with DF had levels increasing more quickly for mean corpuscular hemoglobin concentration (MCHC), monocyte number, and white blood cell counts (p ≤ 0.003), with those with severe DF having a more rapid increase (p < 0.001). The direction of the change across time differed by DF status for mean corpuscular volume and red blood cell distribution width (RDW) (p ≤ 0.0003), with those with severe DF showing an increase in RDW across day of fever (p= 0.0004). Figure 1. CBC values across day of fever in dengue (blue) and non-dengue (purple) patients. The graph above depicts the following CBC values across day of fever in dengue (blue) and non-dengue (purple) patients: a) white blood cell (WBC) count, b) platelet count, c) monocyte number, d) hemoglobin, e) mean corpuscular hemoglobin concentration (MCHC), and f) mean corpuscular volume (MCV). Values with an asterisk (*) represent significant values (p < 0.0033). Conclusion The trajectory of CBC measures differs between those with and without DF, despite similar clinical presentations. These laboratory differences may facilitate a better understanding of the clinical course of DF and may aid in earlier identification of DF in resource-limited settings. Disclosures Elizabeth P. Schlaudecker, MD, MPH, Pfizer (Grant/Research Support)Sanofi Pasteur (Advisor or Review Panel member)

Impact of weight loss on inflammation and red blood cell biomarkers after laparoscopic gastric banding surgery

2017 ◽  
Vol 66 (2) ◽  
pp. 304-308 ◽  
Author(s):  
Susana Coimbra ◽  
Cátia Ferreira ◽  
Luís Belo ◽  
Petronila Rocha-Pereira ◽  
Alice Catarino ◽  
...  
Keyword(s):  
Weight Loss ◽  
Blood Cell ◽  
Gastric Banding ◽  
Iron Metabolism ◽  
Red Blood Cell ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Obese Patients ◽  
Corpuscular Hemoglobin ◽  
Distribution Width

Adipose tissue produces several adipokines that are enrolled in different metabolic and inflammatory pathways that may disturb iron metabolism and erythropoiesis. Considering that laparoscopic adjustable gastric banding (LAGB) has not been associated with a long-term risk of malabsorption, we performed a 13-month follow-up study in severe obese patients submitted to LAGB in order to clarify its impact on inflammation, iron metabolism and on red blood cell (RBC) biomarkers. Twenty obese patients were enrolled in the study, being clinical and analytically assessed before (T0) and 13 months after LAGB intervention (T1). Inflammation, iron bioavailability and RBC biomarkers were evaluated at T0 and T1. At T1, weight and anthropometric indices decreased significantly; patients showed a significant increase in mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration (MCHC), and a reduction in red cell distribution width, ferritin, hepcidin, tumor necrosis factor-α, interleukin-6 (IL-6) and C-reactive protein. Before LAGB, IL-6 correlated negatively with iron, hemoglobin concentration and MCHC; hepcidin correlated inversely with transferrin. Our data show that 13 months after LAGB, the weight loss is associated with an improvement in inflammation, namely a reduction in IL-6 that may reduce hepcidin production, improving iron availability for erythropoiesis, as shown by more adequate erythrocyte hemoglobinization.

scholarly journals Association of BMI (Body Mass Index) to hemoglobin and red blood cell indices among adolescents.

2020 ◽  
Vol 27 (10) ◽  
pp. 2210-2215
Author(s):  
Saleem Ullah Abro ◽  
Quratulain Saleem ◽  
Amna Begum ◽  
Sarah Azhar ◽  
Amber Naseer ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Red Cell ◽  
Mean Corpuscular Hemoglobin Concentration ◽  
Corpuscular Hemoglobin ◽  
Distribution Width ◽  
Corpuscular Hemoglobin Concentration ◽  
Red Blood Cell Indices

Objectives: Hemoglobin & red blood cell indices (mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, red cell distribution width) among adolescent. Study Design: Cross-Sectional study (Descriptive). Setting: Department of Physiology, Baqai Medical University (BMU) Karachi. Period: 6 months from February to August 2017. Material & Methods: A total of 500 students of MBBS, BDS, DPT with having age ranges from 18-25 years were enrolled in this study. The anthropometric measurement [height (m2) and weight (kg)] was recorded for calculation of the Body Mass Index and Complete blood count i-e Hemoglobin (Hb%), Mean Corpuscular Volume (MCV), Mean corpuscular hemoglobin (MCH), Mean corpuscular hemoglobin concentration (MCHC), Red cell distribution width (RDW) was done and calculated.  Data analysis was done on Microsoft excel & SPSS version 22.0 was used. Results: It was seen that the comparison of Hb%, MCV & RDW had no significant (p>0.001) association of study participants to different categories of Body Mass Index.  Mean corpuscular hemoglobin (MCH) (X²=28.278, p<0.001) and Mean corpuscular hemoglobin concentration (MCHC) (X²=15.659, p=0.016) were statistically significantly association with different categories of Body Mass Index. Conclusion: Mean corpuscular hemoglobin and Mean corpuscular hemoglobin concentration had statistically significant (p<0.001) association with body mass index (BMI).

scholarly journals The Effect of One Bout of Intensive Judo Exercise on Select Hematological and Immunological Parameters in Adolescent Elite Judo Athletes

2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Mohammad-Reza Hazratian ◽  
Hossein Taheri-Chadorneshin ◽  
Asmat Rashidi
Keyword(s):  
Blood Cell ◽  
Hemoglobin Concentration ◽  
Blood Parameters ◽  
Adolescent Male ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Immunological Parameters ◽  
Distribution Width ◽  
Humoral Immune ◽  
Paired Samples

Background: Exercise-related studies do not agree on changes in blood parameters regarding anemia and serum immunoglobulin concentration as adaptive immunity. Objectives: The current study aimed to investigate exercise-induced variations in hematological and immunological parameters in response to one bout of intensive judo exercise in adolescent elite judoka. Methods: Venipuncture was performed on ten adolescent male Iranian elite judoka (age: 15.60 ± 0.69 years; body mass index: 24.15 ± 2.80 kg/m2) before and immediately after one bout of intensive judo protocol. Erythrocyte variables [red blood cell count (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), red distribution width (RDW), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC)], platelets variables [platelet count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), plateletcrit (PCT)], cellular immune variables [white blood cell (WBC), neutrophil (NEU), lymphocyte (LYM)], and humoral immune variables (IgM, IgA, IgG, IgE) were measured. Data were analyzed using Wilcoxon and paired-samples t-test, and P < 0.05 was considered significant. Results: After the plasma volume was corrected using the Dill and Costill equation, the results showed that RBC, HGB, HCT, MCHC, IgA, and IgM decreased significantly immediately after exercise. However, MCH, RDW, PLT, PDW, MPV, PCT, WBC, LYM, NEU, IgG, and IgE did not change significantly. Conclusions: According to the findings, it can be concluded that intensive judo exercise results in transient anemia and suppression of humoral immune response among adolescent elite judoka.

scholarly journals A New Approach to Blood Parameters in Dogs with Hemorrhagic Enteritis

2017 ◽  
Vol 45 (1) ◽  
pp. 6
Author(s):  
Handan Hilal Arslan ◽  
Murat Guzel ◽  
Yucel Meral ◽  
Duygu Dalgin ◽  
Guvenc Gokalp ◽  
...  
Keyword(s):  
Blood Cell ◽  
Hemoglobin Concentration ◽  
Blood Parameters ◽  
Mean Corpuscular Hemoglobin ◽  
Red Cell ◽  
Corpuscular Hemoglobin ◽  
Distribution Width ◽  
Hemorrhagic Enteritis ◽  
And Control

Background: Some blood parameters have diagnostic and prognostic importance for the infections in human medicine. However, there is insufficient research regarding the importance of blood parameters and their correlations in veterinary medicine. Increased blood cell distribution width (RDW) and platelet activity can link with the important inflammatory markers. The main objective of the present study was the evaluation of the relationship among some important blood parameters namely RDW, platelet count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), plateletcrit (PCT), their potential usage in the diagnosis and determination of the clinical severity in dogs with hemorrhagic enteritis.Materials, Methods & Results: In this study, the case records of 29 dogs with hemorrhagic enteritis were evaluated and the records of 10 healthy dogs were used as controls. The animals of the study group were presented at the Ondokuz Mayis University, Veterinary Internal Medicine Clinic. The complete blood count (CBC), which includes the total WBC, RBC, hematocrit (HCT), hemoglobin concentration (Hgb), MCV, mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), RDW, PLT, MPV, PCT, and PDW, was determined. Significant positive correlations between RDW and RBC, HCT, MCHC, PLT and PDW, and a negative correlation with MCV, were determined. PDW was positively correlated with the lymphocyte count, MCHC and RDW, and negatively correlated with PCT. PLT was negatively correlated with MCV and MPV and positively correlated with RBC and RDW. In addition, MPV was positively correlated with MCV and MCH, and negatively correlated with PLT. Furthermore, there were significant differences between the granulocyte, WBC, HCT, RDW and PDW values (P < 0.001) and monocyte count, Hgb and MCV (P < 0.05), of the study and control groups.Discussion: Acute hemorrhagic enteritis has various causes in dogs such as idiopathic hemorrhagic gastroenteritis and a number of viral, bacterial and parasitic agents. Hematological and biochemical parameters are not specific to enteric diseases, but these paremeters can provide clinically helpful information for differential diagnosis, response to treatment, and prognosis. In this frame, the evaluation of MCV and RDW in combination, and the determination of the mean red cell size and the extent of heterogeneity of the red cell population, can be especially useful to the diagnosis of different red blood cell disorders. In the present study, differences in RDW and MCV values were statistically significant between the study and control groups (P < 0.05). Increased RDW and decreased MCV can be good indicators of hemorragic diseases and in the present study, in addition to these findings, decreased Hgb and Hct confirmed anemia in dogs with hemorrhagic enteritis. The other key findings of this study were statistically significant relationships between RDW, PLT and PDW, which could be important indicators of inflammation in dogs with hemorrhagic enteritis. These parameters should be evaluated carefully in clinical cases of hemorrhagic enteritis. However, due to nature of retrospective studies, there were some limitations (the lack of another control group of dogs suffering from other hemorrhagic diseases) lack of serial measurements of the blood parameters and further studies should be carried out on dogs with hemorrhagic enteritis for a more detailed evaluation and confirmation of the findings of this study.

Hematological changes and resistance of erythrocytes of crimean horses in response to 32 km races

2016 ◽  
Vol 3 (1) ◽  
pp. 66-72
Author(s):  
A. Andriichuk ◽  
H. Tkachenko ◽  
I. Tkachova
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Haemoglobin Concentration ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Red Cell ◽  
Cell Distribution ◽  
Mean Corpuscular Hemoglobin Concentration ◽  
Corpuscular Hemoglobin ◽  
Distribution Width

Aim. The aim of the present study was to investigate the alterations of some hematological parameters (hae- matocrit (HCT), haemoglobin concentration (HGB), the count of red blood cells (RBC), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), red cell distribution width (RDW), as well as resistance of erythrocytes to urea and hydrogen peroxide in horses after 32 km endurance race. Methods. Seven horses from Crimea region (Bilohirsk, Crimean region) were involved in this study. Haematological parameters (haematocrit (HCT), haemoglobin concentration (HGB), the count of red blood cells (RBC), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), red cell distribution width (RDW)) were determined with use of hematological and biochemical methods. Blood samples have been investigated by centrifugation at 3,000 g for 15 min. The peroxide and osmotic resistance of erythrocytes were determined spectrophoto- metrically at 540 nm by monitoring the rate of erythrocytes disintegration by hydrogen peroxide. Endurance h orses used in this study are trained and conditioned to perform over long distances at moderate speeds. The prolonged exercises were used in endurance race. The walk about 3 km/h for 20 min, the trot about 7 km/h for 15 min, and the canter about 5 km/h for 15 min) and the walk about 1 km were repeated for 1 h (phase I); rest in an outdoor paddock without access to water for 30 min. And phase II: the walk about 3 km/h for 20 min, the trot about 7 km/h for 15 min, and the canter about 5 km/h for 15 min) and the walk about 1 km was repeated for 1 h. Results. The results of the present study showed that adequate endurance race of low intensity could im- prove oxygen-dependent respiratory function in horses from Crimean region. Furthermore, the non-signifi cant increase of red blood cells indices in endurance horses indicate about good athletic level after 32 km endur- ance ride. Statistically signifi cant differences in the percentage of hemolyzed erythrocytes between pre- and post-ride period were observed and thereby signifying an oxidative stress-dependent impairment of erythrocyte stability. Conclusions. The haematological changes caused by various physical efforts refl ect changes in the functions of different systems and can be used for health control and diagnosis of diseases. It also allow the evaluating the level of sport performance, the accuracy of training, and physiological condition of horses.

scholarly journals Characteristics of red blood cell populations fractionated with a combination of counterflow centrifugation and Percoll separation

Blood ◽  
1992 ◽  
Vol 79 (1) ◽  
pp. 254-260
Author(s):  
FH Bosch ◽  
JM Werre ◽  
B Roerdinkholder-Stoelwinder ◽  
TH Huls ◽  
FL Willekens ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Hemoglobin A1c ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Mean Corpuscular Hemoglobin Concentration ◽  
Corpuscular Hemoglobin ◽  
Cell Age ◽  
Cellular Water ◽  
Hba1c Concentration

Red blood cell (RBC) fractions were studied after separation of whole blood by means of counterflow centrifugation, Percoll column (Pharmacia, Uppsala, Sweden), and a combination of both separation techniques. Mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH), and hemoglobin A1c (HbA1c) were measured in each fraction. From the results it was obvious that the combination of both techniques was the best separation technique of these three. MCV had a good correlation with cell age as measured with HbA1c concentration gradient; MCH and MCHC less so. MCV and MCH decreased in parallel to an increase in HbA1c. MCHC increased with increasing HbA1c. From these data it is concluded that there is a steadily ongoing loss of cellular hemoglobin and proportionally more cellular water during the life of the RBC.

scholarly journals Preoperative Mean Corpuscular Hemoglobin Concentration, Red Cell Distribution Width As Predictive Markers For Pancreatic Cancer Patients Who Underwent Radical Pancreatomy

2020 ◽  
Author(s):  
Dan Wang ◽  
Xiaona Fan ◽  
Lin Fang ◽  
Tianshuo Zhou ◽  
Qingwei Li ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Hemoglobin Concentration ◽  
Red Cell Distribution Width ◽  
Mean Corpuscular Hemoglobin ◽  
Red Cell ◽  
Cell Distribution ◽  
Mean Corpuscular Hemoglobin Concentration ◽  
Corpuscular Hemoglobin ◽  
Distribution Width ◽  
Corpuscular Hemoglobin Concentration

Abstract Objective: To explore the value of mean corpuscular hemoglobin concentration (MCHC) and red cell distribution width (RDW) for overall survival (OS) and progression-free survival (PFS) in patients with pancreatic cancer (PC) who underwent radical pancreatomy.Background: Inflammatory factors are important factors in promoting the occurrence and metastasis of malignant tumors. RDW and MCHC are suggested to be relevant to the prognosis of several malignancies. Such as gastric cancer, colon cancer. However, there are few studies to explore the correlation between them and PC.Methods: This study included 532 patients with PC who underwent radical resection between March 2011 and May 2019. Kaplan-Meier curve method and Cox proportional hazard regression model were applied to analyze prognosis. Correlations between categorical variables were analyzed using Chi squared tests.Results: Survival curve showed that OS and PFS were significantly favorable for resectable PC patients with high preoperative MCHC (P=0.02) (P=0.005), RDW in the normal range (P<0.001) (P<0.001). Multivariate analysis suggested that MCHC (HR: 0.612, 95%CI: 0.426-0.879, P=0.008), and RDW (HR: 3.969, 95%CI: 2.952-5.338, P<0.001) were independent prognostic factors for resectable PC patients. MCHC (HR: 0.657, 95%CI: 0.458-0.943, P=0.023), RDW (HR: 3.915, 95%CI: 2.923-5.243, P < 0.001) were also independent recurrent factors for resectable PC patients. Correlation analysis showed that MCHC was related to tumor size, nerve invasion, and anemia-related indicators, meanwhile RDW was connected with carcinoma-embryonic antigen (CEA) and carbohydrate antigen199 (CA19-9).Conclusion: The preoperative MCHC and RDW were simple and convenient predictive factors for prognosis and progression of patients with PC.

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