scholarly journals 282 Impact of dietary peroxidized lipids and antioxidant supplementation in feed on growth performance and oxidative status of newly weaned piglets

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 117-118
Author(s):  
Ysenia Victoria Silva-Guillen ◽  
Gabriela Martinez ◽  
Consuelo Arellano ◽  
R Dean Boyd ◽  
Eric van Heugten
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Soybean Oil ◽  
Growth Performance ◽  
Serum Vitamin ◽  
Oxidative Status ◽  
Dietary Vitamin ◽  
Weaned Piglets ◽  
Antioxidant Supplementation ◽  
Tocopherol Acetate

Abstract The objective of this study was to evaluate the use of dietary vitamin E (VitE) and polyphenols on growth and oxidative status of weaned piglets fed peroxidized lipids. Pigs (n = 192; 21-d of age; 6.62±1.04 kg BW) were assigned within sex and weight blocks to a 2x3 factorial arrangement using 48 pens (4 pigs/pen; 8 replications/treatment). Factors consisted of lipid peroxidation (6% human-grade soybean oil or 6% peroxidized soybean oil), and antioxidant supplementation (control diet containing 25 IU/kg dl-α-tocopherol-acetate; control with 200 IU/kg additional dl-α-tocopherol-acetate; or control with 400 mg/kg polyphenols). Peroxidation was accomplished by heating control oil at 80°C with constant air flow at 50 L/min for 12 d (initial peroxide, anisidine value, hexanal, and 2,4-decadienal concentrations were 4.1 vs. 141.6 meq/kg, 1.7 vs. 106, < 5 vs. 99 mg/kg, and 8 vs. 720 mg/kg for control and peroxidized oil, respectively). Diets were fed in 2 phases (14 and 21 days). Overall, peroxidized lipids decreased (P < 0.001) BW (23.16 vs. 18.74 kg), ADG (473 vs. 346 g/day), ADFI (658 vs. 535 g/day) and G:F (719 vs. 647 g/kg). Lipid peroxidation decreased serum vitamin E (P < 0.001) and this decrease was larger on d35 (1.82 vs. 0.81 mg/kg) than d14 (1.95 vs. 1.38 mg/kg). Supplemental VitE, but not polyphenols, increased (P < 0.002) serum vitamin E by 84 and 22%, for control and peroxidized diets, respectively (interaction, P = 0.001). Serum malondialdehyde decreased (P < 0.001) with peroxidation on d14, but not d35 and protein carbonyl increased (P < 0.001) with peroxidation on d35, but not d14. Serum 8-hydroxydeoxyguanosine was not affected (P > 0.05). Total antioxidant capacity decreased with peroxidation (P < 0.001) and increased with VitE (P = 0.065) and polyphenols (P = 0.046) in the control oil diet only. Peroxidized lipids reduced growth performance, which could not be corrected with supplemental vitamin E or polyphenols in the diet.

scholarly journals 286 Effects of dietary peroxidized lipids and antioxidant supplementation in the drinking water on growth, oxidative and immune status of newly weaned piglets

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 119-119
Author(s):  
Ysenia Victoria Silva-Guillen ◽  
Gabriela Martinez ◽  
Consuelo Arellano ◽  
Eric van Heugten
Keyword(s):  
Oxidative Stress ◽  
Drinking Water ◽  
Vitamin E ◽  
Soybean Oil ◽  
Immune Status ◽  
Control Diet ◽  
Serum Vitamin ◽  
Interferon Γ ◽  
Protein Carbonyl ◽  
Weaned Piglets

Abstract The objective of the present study was to evaluate the use of vitamin E (VitE) and phytogenic compounds (PHYTO) in drinking water on performance, oxidative stress, and immune status of weaned piglets fed peroxidized lipids. In a 35-day study, 21-d old weaned piglets (n = 96; 6.10±0.64 kg BW) were assigned within sex and BW blocks to 1 of 4 dietary treatments, using 24 pens (4 pigs/pen; 6 replications/treatment). Diets contained either 6% human-grade soybean oil or 6% soybean oil which was peroxidized for 12 d at 80°C with constant air flow at 50 L/min (initial peroxide value, anisidine value, hexanal, and 2,4-decadienal concentrations were 4.1 vs. 141.6 meq/kg, 1.7 vs. 106, < 5 vs. 99 mg/kg, and 8 vs. 720 mg/kg for control and peroxidized oil, respectively). Pigs fed peroxidized lipids received drinking water without (control) or with supplemental VitE (100 IU/L d-α-tocopherol) or PHYTO (60 µL/L from d 1–7; 30 µL/L from d 8–35). Pigs fed control diet received control water only. Overall, peroxidized lipids decreased (P < 0.001) BW (18.20 vs. 21.55 kg) and ADG (347 vs. 441 g/day), and tended to decrease ADFI (P = 0.14; 537 vs. 617 g/day) and G:F (P = 0.07; 645 vs. 715 g/kg). Peroxidation decreased serum vitamin E (P = 0.03) which could be restored (P = 0.01) by VitE in the water, but not PHYTO. Serum concentrations of interferon-γ, interleukin(IL)-1α, IL-1β, IL-1ra, IL2, IL4, IL-6, IL10, IL-12, IL-18, TNF-α, malondialdehyde, protein carbonyl, and total antioxidant capacity were not impacted by treatments (P > 0.05). Serum 8-hydroxydeoxyguanosine was reduced (P = 0.001) with feeding peroxidized lipids and this was not altered by supplemental antioxidants (P = 0.45). Peroxidized lipids clearly reduced growth performance, which did not appear to be related to oxidative stress markers or immune-regulatory cytokines. The negative effects of peroxidized lipids could not be improved by vitamin E or PHYTO supplemented in drinking water.

scholarly journals Protective role of supplemental vitamin E on lipid peroxidation, vitamins E, A and some mineral concentrations of broilers reared under heat stress

2001 ◽  
Vol 46 (No. 5) ◽  
pp. 140-144 ◽  
Author(s):  
K. Sahin ◽  
N. Sahin ◽  
M. Onderci ◽  
S. Yaralioglu ◽  
O. Kucuk
Keyword(s):  
Lipid Peroxidation ◽  
Heat Stress ◽  
Vitamin E ◽  
Management Practice ◽  
Serum Vitamin ◽  
Basal Diet ◽  
Dietary Vitamin ◽  
Broiler Chicks ◽  
Supplemental Vitamin ◽  
Vitamin E Supplementation

An experiment utilizing Cobb-500 male broilers was conducted to evaluate the effects of vitamin E supplementation at various concentrations on malonyldialdehyde (MDA) as an indicator of lipid peroxidation, serum and liver concentrations of antioxidant vitamins and some minerals of broilers reared under heat stress (32°C). One day-old 150 male broilers were randomly assigned to 5 treatment groups, 3 replicates of 10 birds each. The birds received either a basal diet or basal diet supplemented with vitamin E (dl-a-tocopherol acetate) at 62.5, 125, 250, or 500 mg/kg of diet. Increased supplemental vitamin E linearly increased serum vitamin E and A, but decreased (P = 0.001) MDA concentrations. Increasing dietary vitamin E supplementation also resulted in linear increases in liver vitamin E and A concentrations, but linear decreases in MDA concentrations (P = 0.01). Increasing dietary vitamin E caused a linear increase in serum concentrations of Fe and Zn (P= 0.001), but a decrease in serum concentration of Cu (P = 0.001). Results of the present study conclude that in broiler chicks reared under heat stress a 250 mg of vitamin E supplementation can be considered as a protective management practice in a broiler diet, reducing the negative effects of heat stress.

Effects of dietary vitamin E on the growth performance, antioxidative status, and some immunological blood parameters in growing mink (Mustela vison) fed dry feed

2019 ◽  
Vol 99 (4) ◽  
pp. 772-780 ◽  
Author(s):  
Ting Zhang ◽  
Weili Sun ◽  
Yahan Yang ◽  
Wei Zhong ◽  
Kun Bao ◽  
...  
Keyword(s):  
Vitamin E ◽  
Growth Performance ◽  
Interleukin 2 ◽  
Serum Vitamin ◽  
Blood Parameters ◽  
The Body ◽  
Dietary Vitamin ◽  
Feed Ratio ◽  
High Dose ◽  
Antioxidative Status

Ninety standard dark male minks (8 wk of age) were used to investigate the effects of vitamin E (VE) supplementation on growth performance, antioxidative status, and some immunological blood parameters. The dietary treatments included a basal diet (containing 20.86 mg kg−1VE) supplemented with 0 (control), 50, 100, 200, 400, or 800 mg kg−1VE. The results showed that VE supplementation of 200–400 mg kg−1increased (P < 0.05) the body weight, average daily feed intake, average daily gain, and gain to feed ratio of the mink from days 1 to 30. At days 30 and 60, the minks fed diets supplemented with 400 mg kg−1VE had higher (P < 0.05) concentrations of serum superoxide dismutase, glutathione peroxidase, and catalase than either the control or the VE50 groups but had activity levels similar to those of the VE200 and VE800 groups. Feeding a high dose of VE (400–800 mg kg−1diet) resulted in a significant increase in the concentrations of α-tocopherol and a reduction in the reactive oxygen species content in the serum. Vitamin E supplementation of 200–400 mg kg−1increased (P < 0.05) the concentrations of immunoglobulin G, interleukin-2, and soluble CD4/soluble CD8and decreased (P < 0.05) the content of soluble CD8in the serum. Overall, the suitable level of VE supplementation was found to be 200–400 mg kg−1diet for growing mink.

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