scholarly journals Expression Pattern of Chemoresistance-related Genes in Human Malignant Brain Tumors: A Working Knowledge for Proper Selection of Anticancer Drugs

1999 ◽  
Vol 29 (11) ◽  
pp. 527-534 ◽  
Author(s):  
M. Nagane ◽  
A. Asai ◽  
S. Shibui ◽  
H. Oyama ◽  
K. Nomura ◽  
...  
2017 ◽  
Vol 10 (1) ◽  
pp. 32-52
Author(s):  
Bonnie White

In 1917 the British government began making plans for post-war adjustments to the economy, which included the migration of surplus women to the dominions. The Society for the Overseas Settlement of British Women was established in 1920 to facilitate the migration of female workers to the dominions. Earlier studies have argued that overseas emigration efforts purposefully directed women into domestic service as surplus commodities, thus alleviating the female ‘surplus’ and easing economic hardships of the post-war period. This article argues that as Publicity Officer for the SOSBW, Meriel Talbot targeted women she believed would be ideal candidates for emigration, including former members of the Women's Land Army and affiliated groups. With the proper selection of female migrants, Talbot sought to expand work opportunities for women in the dominions beyond domestic service, while reducing the female surplus at home and servicing the connection between state and empire. Dominion authorities, whose demands for migrant labour vacillated between agricultural workers during the war years and domestic servants after 1920, disapproved of Talbot's efforts to migrate women for work in agriculture. Divergent policies led to the early failure of the SOSBW in 1923.


2018 ◽  
Vol 64 (1) ◽  
pp. 54-61
Author(s):  
A. Ryabova ◽  
O. Gribova ◽  
V. Novikov ◽  
E. Choinzonov ◽  
Zh. Starceva ◽  
...  

Unsatisfactory results of complex treatment for malignant brain tumors stimulate search of new effective methods of treatment. Radiation therapy is an integral part of the combined treatment but often does not influence lethally on resistant tumor cells. Thereby in recent decades there has been an active search for different modifiers, which can increase the sensitivity of tumors to chemotherapy and radiotherapy. One of the universal sensitizers is the local hyperthermia. Experimental data showed that the effect of high temperatures had both a direct damaging effect on tumor cells and a sensitizing effect. The literature review given in the article provides an overview of the existing methods of the local hyperthermia for brain tumors treatment.


Author(s):  
D. Josephine Selvarani Ruth

AbstractNickel Titanium Naval Ordinance Laboratory (NiTiNOL) is widely called as a shape memory alloy (SMA), a class of nonlinear smart material inherited with the functionally programmed property of varying electrical resistance during the transformation enabling to be positioned as a sensing element. The major challenge to instrument the SMA wires is to suppress the wires’ nonlinearity by proper selection of two important factors. The first factor is influenced by the mechanical biasing element and the other is to identify the sensing current for the sensing device (SMA wires + biasing). This paper focuses on developing SMA wires for sensing in different orientation types and configurations by removing the non-linearity in the system’s output by introducing inverse hysteresis to the wires through the passive mechanical element.


Author(s):  
J Stephen Nix ◽  
Cristiane M Ida

Abstract Molecular testing has become part of the routine diagnostic workup of brain tumors after the implementation of integrated histomolecular diagnoses in the 2016 WHO classification update. It is important for every neuropathologist to be aware of practical preanalytical, analytical, and postanalytical factors that impact the performance and interpretation of molecular tests. Prior to testing, optimizing tumor purity and tumor amount increases the ability of the molecular test to detect the genetic alteration of interest. Recognizing basic molecular testing platform analytical characteristics allows selection of the optimal platform for each clinicopathological scenario. Finally, postanalytical considerations to properly interpret molecular test results include understanding the clinical significance of the detected genetic alteration, recognizing that detected clinically significant genetic alterations are occasionally germline constitutional rather than somatic tumor-specific, and being cognizant that recommended and commonly used genetic nomenclature may differ. Potential pitfalls in brain tumor molecular diagnosis are also discussed.


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