Metabolism of Gamma-Linolenic Acid in Essential Fatty Acid-deficient Rats

1977 ◽  
Vol 107 (4) ◽  
pp. 519-524 ◽  
Author(s):  
Ahmed G. Hassam ◽  
John P. W. Rivers ◽  
Michael A. Crawford
Keyword(s):  
Fatty Acid ◽  
Linolenic Acid ◽  
Essential Fatty Acid ◽  
Gamma Linolenic Acid ◽  
Essential Fatty Acid Deficient

Gamolenic acid in atopic eczema: ▾ epogam

1990 ◽  
Vol 28 (18) ◽  
pp. 69-70
Keyword(s):  
Fatty Acid ◽  
Linoleic Acid ◽  
Linolenic Acid ◽  
Essential Fatty Acid ◽  
Atopic Eczema ◽  
Conventional Treatment ◽  
Gamma Linolenic Acid ◽  
Evening Primrose

Epogam capsules (Scotia) contain oil from the seed of the evening primrose which is rich in the essential fatty acid linoleic acid and its metabolite gamolenic (gamma-linolenic) acid. Epogam is licensed for use to relieve symptoms in atopic eczema, and is claimed to act at a fundamental metabolic level in this disease. Conventional treatment of eczema is often unsatisfactory, and any claim of an advance must be taken seriously. How well founded are the claims made for Epogam?

Interaction between oxidative stress and gamma-linolenic acid in impaired neurovascular function of diabetic rats

1996 ◽  
Vol 271 (3) ◽  
pp. E471-E476 ◽  
Author(s):  
N. E. Cameron ◽  
M. A. Cotter
Keyword(s):  
Oxidative Stress ◽  
Blood Flow ◽  
Fatty Acid ◽  
Linolenic Acid ◽  
Essential Fatty Acid ◽  
Drug Effects ◽  
Diabetic Rats ◽  
Gamma Linolenic Acid ◽  
Endoneurial Blood Flow ◽  
Joint Treatment

Nerve conduction and perfusion deficits in diabetic rats depend on increased oxidative stress and impaired n-6 essential fatty acid metabolism, which are corrected by free radical scavenger and gamma-linolenic acid (GLA)-rich oil treatments, respectively. We investigated the interaction between these mechanisms on conduction velocity and endoneurial blood flow by use of low-dose antioxidant (BM15.0639) and GLA treatments, alone and in combination. After 8 wk of streptozotocin-induced diabetes, sciatic motor conduction velocity was 20.9% reduced. Treatment with GLA or BM15.0639 for the final 2 wk corrected this deficit by 18.5 and 20.0%, respectively; however, joint treatment caused 71.5% improvement, corresponding to a 7.5-fold amplification of individual drug effects. A 48.3% deficit in sciatic nutritive endoneurial blood flow was corrected by 34.8 and 24.8% with GLA and BM15.0639 treatments, respectively. With joint treatment, the flow improvement of 72.5% was greater than expected from individual drug effects, indicating a facilitatory interaction. Thus the synergistic effect of combined antioxidant and n-6 essential fatty acid treatment could potentially provide increased therapeutic power against diabetic neuropathy.

scholarly journals The influence of α-linolenic acid (18: 3ω3) on the metabolism of γ-linolenic acid (18: 3ω6) in the rat

1977 ◽  
Vol 38 (1) ◽  
pp. 137-140 ◽  
Author(s):  
A. G. Hassam
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acids ◽  
Linolenic Acid ◽  
Essential Fatty Acid ◽  
List Type ◽  
Dietary Energy ◽  
Type Number ◽  
Essential Fatty Acid Deficient ◽  
Long Chain

1.Essential fatty acid-deficient rats were fed γ-linolenic acid (18:3ω6) at 2 % dietary energy and α-linolenic acid (18:3ω3) at 0, 1.6, 2.8 and 4.0 % of the dietary energy.2.18:3ω3 at 1.6% apparently inhibits the synthesis of the C20 and C22 ω6 long-chain polyunsaturated fatty acids (ω6 LC-PUFA) metabolized from 18:3ω6.3.However, increasing the dietary levels of 18:3ω3 from 1.6 to 4.0% has no further influence.4.The results suggest that dietary 18:3ω6 is an efficient precursor for the ω6 LC-PUFA synthesis even in the presence of 18:3ω3.

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