Colon and Ovarian Tumor Antigen in Human Colon Tumors Grown In Culture and In Athymlc Mice123

1986 ◽  
Keyword(s):  
Tumor Antigen ◽  
Ovarian Tumor ◽  
Human Colon ◽  
Colon Tumors

Expression of G-protein alpha subunits in normal rat colonocytes, azoxymethane (AOM)-induced colon tumors, and human colon cancer-derived cell lines

1995 ◽  
Vol 108 (4) ◽  
pp. A954 ◽  
Author(s):  
M.J.G. Bolt ◽  
R.J. Mailloux ◽  
R. Wali ◽  
B. Frawley ◽  
B. Scaglione-Sewell ◽  
...  
Keyword(s):  
Colon Cancer ◽  
G Protein ◽  
Cell Lines ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Colon Tumors ◽  
Alpha Subunits ◽  
Normal Rat

HYPOXIC FRACTIONS IN XENOGRAFTED HUMAN COLON TUMORS

1991 ◽  
pp. 464 ◽  
Author(s):  
J.T. LEITH ◽  
F. HSIEH ◽  
L.E. QUARANTO ◽  
G. PADFIELD ◽  
S. MICHELSON
Keyword(s):  
Human Colon ◽  
Colon Tumors

scholarly journals Colon Cancer and Perturbations of the Sphingolipid Metabolism

2019 ◽  
Vol 20 (23) ◽  
pp. 6051 ◽  
Author(s):  
Miroslav Machala ◽  
Jiřina Procházková ◽  
Jiřina Hofmanová ◽  
Lucie Králiková ◽  
Josef Slavík ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Human Colon ◽  
Sphingolipid Metabolism ◽  
Western World ◽  
Colon Cancer Cells ◽  
Colon Tumors ◽  
Metabolism Enzymes

The development and progression of colon cancer (CRC), a major cause of cancer-related death in the western world, is accompanied with alterations of sphingolipid (SL) composition in colon tumors. A number of enzymes involved in the SL metabolism have been found to be deregulated in human colon tumors, in experimental rodent studies, and in human colon cancer cells in vitro. Therefore, the enzymatic pathways that modulate SL levels have received a significant attention, due to their possible contribution to CRC development, or as potential therapeutic targets. Many of these enzymes are associated with an increased sphingosine-1-phosphate/ceramide ratio, which is in turn linked with increased colon cancer cell survival, proliferation and cancer progression. Nevertheless, more attention should also be paid to the more complex SLs, including specific glycosphingolipids, such as lactosylceramides, which can be also deregulated during CRC development. In this review, we focus on the potential roles of individual SLs/SL metabolism enzymes in colon cancer, as well as on the pros and cons of employing the current in vitro models of colon cancer cells for lipidomic studies investigating the SL metabolism in CRC.

scholarly journals Modulation of p38 MAPK signaling enhances dendritic cell activation of human CD4+ Th17 responses to ovarian tumor antigen

2013 ◽  
Vol 62 (5) ◽  
pp. 839-849 ◽  
Author(s):  
Martin J. Cannon ◽  
Hannah E. Goyne ◽  
Pamela J. B. Stone ◽  
Laura J. MacDonald ◽  
Lindsey E. James ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
P38 Mapk ◽  
Tumor Antigen ◽  
Ovarian Tumor ◽  
Cell Activation ◽  
Mapk Signaling ◽  
Dendritic Cell Activation

A novel autologous oxidized whole-tumor antigen vaccine therapy for recurrent ovarian cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 5023-5023
Author(s):  
Lana Kandalaft
Keyword(s):  
Ovarian Cancer ◽  
T Cells ◽  
Dendritic Cell ◽  
Tumor Antigen ◽  
Ovarian Tumor ◽  
Recurrent Ovarian Cancer ◽  
Normal Donor ◽  
Tumor Lysate ◽  
Cell Responses

5023 Background: Despite surgical and chemotherapeutic advances, the death rate from ovarian cancer has not changed. We report here an enhanced dendritic cell vaccine platform developed for clinical testing. Furthermore we report the application of this novel platform comprising of dendritic cell (DC)-based autologous whole tumor antigen vaccination in a pilot study of patients with recurrent ovarian cancer. Methods: To determine the optimal tumor lysate preparation for loading DCs, ovarian tumor lines were prepared by HOCl-oxidation, UVB-irradiation or freeze and thaw. Normal donor DCs were evaluated for tumor lysate uptake, cytokine and chemokine productions and phenotype. The optimal lysate preparation, was used in a phase I study where five patients with recurrent ovarian cancer with available tumor lysate from secondary debulking surgery underwent intranodal vaccination with OC-DC, an autologous DC preparation pulsed with HOCL oxidized autologous tumor cells. Feasibility, safety, and biological and clinical efficacy were evaluated. Results: Normal donor DCs pulsed with HOCl-oxidized tumor lines demonstrated the highest tumor lysate uptake, matured efficiently after LPS and IFN-gamma stimulation, and produced higher levels of proinflammatory cytokines and chemokines. In vitro, these lysates loaded DCs primed T cell responses against ovarian tumor associated antigens and effectively expanded against tumor specific T cells from donors and patients. Therapy was feasible and well tolerated in all subjects. Vaccination with OC-DC produced limited grade 1 toxicities and elicited tumor-specific T cell responses. Moreover specific HLA-A2-restricted responses were documented following vaccination and HER-2/neu specific T cells were expanded following 10 days of in vitro culture. Patients exhibiting immune response demonstrated clinical benefit including two patients who demonstrated remission inversion on vaccine maintenance. Conclusions: We developed a DC-HOCl oxidized whole tumor lysate vaccine which was safe and well-tolerated by patients. The vaccine was highly proinflammatory and elicited cellular and humoral anti-tumor responses establishing a platform for immune-combinatorial therapy.

scholarly journals Human Colon Tumors Express a Dominant-Negative Form of SIGIRR That Promotes Inflammation and Colitis-Associated Colon Cancer in Mice

2015 ◽  
Vol 149 (7) ◽  
pp. 1860-1871.e8 ◽  
Author(s):  
Junjie Zhao ◽  
Katarzyna Bulek ◽  
Muhammet F. Gulen ◽  
Jarod A. Zepp ◽  
Georgio Karagkounis ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Human Colon ◽  
Dominant Negative ◽  
Colon Tumors ◽  
Dominant Negative Form ◽  
Negative Form
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