scholarly journals Re: The Association Between Hysterectomy and Ovarian Cancer Risk: A Population-Based Record-Linkage Study

2019 ◽  
Vol 111 (12) ◽  
pp. 1361-1361
Author(s):  
Paul J van Diest ◽  
Ronald P Zweemer ◽  
Jurgen M J Piek
Keyword(s):  
Ovarian Cancer ◽  
Cancer Risk ◽  
Record Linkage ◽  
Population Based ◽  
Linkage Study ◽  
Ovarian Cancer Risk

scholarly journals The Association Between Hysterectomy and Ovarian Cancer Risk: A Population-Based Record-Linkage Study

2019 ◽  
Vol 111 (10) ◽  
pp. 1097-1103
Author(s):  
Suzanne C Dixon-Suen ◽  
Penelope M Webb ◽  
Louise F Wilson ◽  
Karen Tuesley ◽  
Louise M Stewart ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Risk ◽  
Record Linkage ◽  
Cox Regression ◽  
Population Based ◽  
Linkage Study ◽  
Ovarian Cancer Risk ◽  
Hazard Ratios ◽  
Time Period ◽  
Hospital Births

Abstract Background Recent studies have called into question the long-held belief that hysterectomy without oophorectomy protects against ovarian cancer. This population-based longitudinal record-linkage study aimed to explore this relationship, overall and by age at hysterectomy, time period, surgery type, and indication for hysterectomy. Methods We followed the female adult Western Australian population (837 942 women) across a 27-year period using linked electoral, hospital, births, deaths, and cancer records. Surgery dates were determined from hospital records, and ovarian cancer diagnoses (n = 1640) were ascertained from cancer registry records. We used Cox regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between hysterectomy and ovarian cancer incidence. Results Hysterectomy without oophorectomy (n = 78 594) was not associated with risk of invasive ovarian cancer overall (HR = 0.98, 95% CI = 0.85 to 1.11) or with the most common serous subtype (HR = 1.05, 95% CI = 0.89 to 1.23). Estimates did not vary statistically significantly by age at procedure, time period, or surgical approach. However, among women with endometriosis (5.8%) or with fibroids (5.7%), hysterectomy was associated with substantially decreased ovarian cancer risk overall (HR = 0.17, 95% CI = 0.12 to 0.24, and HR = 0.27, 95% CI = 0.20 to 0.36, respectively) and across all subtypes. Conclusions Our results suggest that for most women, having a hysterectomy with ovarian conservation is not likely to substantially alter their risk of developing ovarian cancer. However, our results, if confirmed, suggest that ovarian cancer risk reduction could be considered as a possible benefit of hysterectomy when making decisions about surgical management of endometriosis or fibroids.

Adult lifetime alcohol consumption and invasive epithelial ovarian cancer risk in a population-based case–control study

2016 ◽  
Vol 140 (2) ◽  
pp. 277-284 ◽  
Author(s):  
Linda S. Cook ◽  
Andy C.Y. Leung ◽  
Kenneth Swenerton ◽  
Richard P. Gallagher ◽  
Anthony Magliocco ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Alcohol Consumption ◽  
Cancer Risk ◽  
Epithelial Ovarian Cancer ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Ovarian Cancer Risk ◽  
Invasive Epithelial Ovarian Cancer ◽  
Control Study

scholarly journals Alcohol consumption and ovarian cancer risk in a population-based case-control study

2006 ◽  
Vol 119 (10) ◽  
pp. 2423-2427 ◽  
Author(s):  
Neeraja B. Peterson ◽  
Amy Trentham-Dietz ◽  
Polly A. Newcomb ◽  
Zhi Chen ◽  
John M. Hampton ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Alcohol Consumption ◽  
Cancer Risk ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Ovarian Cancer Risk ◽  
Control Study

Association of Parity and Ovarian Cancer Risk by Family History of Breast or Ovarian Cancer in a Population-Based Study of Postmenopausal Women

Epidemiology ◽  
2002 ◽  
Vol 13 (1) ◽  
pp. 66-71 ◽  
Author(s):  
Celine M. Vachon ◽  
Pamela J. Mink ◽  
Carol A. Janney ◽  
Thomas A. Sellers ◽  
James R. Cerhan ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Family History ◽  
Cancer Risk ◽  
Postmenopausal Women ◽  
Population Based ◽  
Ovarian Cancer Risk ◽  
Population Based Study ◽  
History Of

scholarly journals Population-Based, Risk-Stratified Genetic Testing for Ovarian Cancer Risk: A Focus Group Study

2013 ◽  
Vol 16 (4) ◽  
pp. 184-191 ◽  
Author(s):  
S.F. Meisel ◽  
L. Side ◽  
L. Fraser ◽  
S. Gessler ◽  
J. Wardle ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Genetic Testing ◽  
Focus Group ◽  
Cancer Risk ◽  
Population Based ◽  
Ovarian Cancer Risk ◽  
Focus Group Study

Relation of Anthropometric Measurements to Ovarian Cancer Risk in a Population-based Case–control Study (United States)

2006 ◽  
Vol 17 (4) ◽  
pp. 459-467 ◽  
Author(s):  
Neeraja B. Peterson ◽  
Amy Trentham-Dietz ◽  
Polly A. Newcomb ◽  
Zhi Chen ◽  
Tebeb Gebretsadik ◽  
...  
Keyword(s):  
United States ◽  
Ovarian Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Anthropometric Measurements ◽  
Ovarian Cancer Risk ◽  
Control Study

Ovarian cancer risk after salpingectomy for ectopic pregnancy or hydrosalpinx: results of the OCASE nationwide population-based database study

2020 ◽  
Author(s):  
L A M van Lieshout ◽  
J M J Piek ◽  
K Verwijmeren ◽  
S Houterman ◽  
A G Siebers ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Risk ◽  
Ectopic Pregnancy ◽  
Cancer Incidence ◽  
Intervention Group ◽  
Lag Time ◽  
Population Based ◽  
Control Group ◽  
Ovarian Cancer Risk ◽  
And Control

Abstract STUDY QUESTION What is the effect of salpingectomy for ectopic pregnancy or hydrosalpinx at a young age on ovarian cancer risk compared to no salpingectomy for any reason? SUMMARY ANSWER We found no significant reduction in ovarian cancer risk after salpingectomy for ectopic pregnancy or hydrosalpinx. WHAT IS KNOWN ALREADY Salpingectomy may reduce ovarian cancer incidence, although the lag-time between intervention and therapeutic effect remains to be elucidated. STUDY DESIGN, SIZE, DURATION This nationwide population-based database study uses the Dutch pathology database to identify all women who underwent salpingectomy for ectopic pregnancy or hydrosalpinx between January 1990 and December 2012 and compared ovarian cancer incidence to a control group of women who had a benign dermal nevus removed, matched for age at the time and year of procedure. PARTICIPANTS/MATERIALS, SETTING, METHODS After selection and manual control of intervention and control group, ovarian cancer incidence was recorded. Hazard ratios (HRs) with 95% CI for the development of ovarian cancer were calculated with Cox regression analyses, both unadjusted and adjusted for age. Subgroup analyses were performed to investigate lag-time between intervention and protective effect. MAIN RESULTS AND THE ROLE OF CHANCE In all, 18 961 women were included in the intervention group; 17 106 women had a unilateral salpingectomy and 1855 had a bilateral salpingectomy. The control group consisted of 23 686 women. With 14 ovarian cancer cases in the intervention group, the incidence rate (IR) of ovarian cancer was 5.4 (95% CI 3.1–8.9) per 100 000 person-years. In the control group, there were 24 ovarian cancer cases, resulting in an IR of 7.1 (95% CI 4.7–10.5) per 100 000 person-years (P = 0.34). The age-adjusted HR for ovarian cancer was 0.76 (95% CI 0.39–1.47) after salpingectomy. Unilateral salpingectomy resulted in an age-adjusted HR of 0.81 (95% CI 0.41–1.59) and bilateral salpingectomy resulted in an age-adjusted HR of 0.43 (95% CI 0.06–3.16) based on one case. None of our subgroup analysis for lag-time resulted in a significant difference in ovarian cancer incidence between intervention and control group. The difference in ovarian cancer incidence appeared largest in women with at least 8 years of follow-up (P = 0.08). LIMITATIONS, REASONS FOR CAUTION Due to the young population, ovarian cancer incidence is low, even at the end of follow-up. Furthermore, due to the anonymous nature of the pathology registry, we were unable to adjust for confounding factors. WIDER IMPLICATIONS OF THE FINDINGS Although results did not reach statistical significance, they add to the available data on ovarian cancer incidence after salpingectomy. Our subgroup analysis suggests there may be no benefit in the first years following salpingectomy. STUDY FUNDING/COMPETING INTEREST(S) None. TRIAL REGISTRATION NUMBER N/A.

Sign in / Sign up

Export Citation Format

Share Document