Effectiveness of two doses of tick-borne encephalitis (TBE) vaccine

Author(s):  
Sarah J Pugh ◽  
Jennifer C Moïsi ◽  
Michael Kundi ◽  
Isabel Santonja ◽  
Wilhelm Erber ◽  
...  

Vaccine effectiveness (VE) was consistently high following two doses (94.6–97.4%) and three doses (96.1%) of the tick-borne encephalitis (TBE) vaccine. These data support the public health value of providing two doses of the TBE vaccine to a traveller to an endemic area presenting with insufficient time to complete the full three-dose primary series.

Vaccine ◽  
2018 ◽  
Vol 36 (19) ◽  
pp. 2523-2528 ◽  
Author(s):  
Susanna Esposito ◽  
Elisabetta Franco ◽  
Gaetan Gavazzi ◽  
Angel Gil de Miguel ◽  
Roland Hardt ◽  
...  

2020 ◽  
Vol 48 (2) ◽  
pp. 279-292 ◽  
Author(s):  
Rebecca L. Haffajee

Opioid litigation continues a growing public health litigation trend in which governments seek to hold companies responsible for population harms related to their products. The litigation can serve to address gaps in regulatory and legislative policymaking and in market self-regulation pervasive in the prescription opioid domain. Moreover, prior opioid settlements have satisfied civil tort litigation objectives of obtaining compensation for injured parties, deterring harmful behavior, and holding certain opioid manufacturers, distributors and pharmacies accountable for their actions. In this way, opioid litigation represents progress over prior public health litigation campaigns involving tobacco, lead paint, and asbestos, which had more limited tort litigation effects. Although opioid litigation is not a comprehensive solution to the opioid crisis, it can complement other strategies and infuse much needed money, behavior changes, and public accountability for prescription opioid and related harms.


2017 ◽  
Vol 6 (1) ◽  
Author(s):  
Ian G Munabi ◽  
Samuel Abilemech Luboga ◽  
Josaphat Byamugisha ◽  
Livingstone Luboobi ◽  
Florence Mirembe

In low resource settings, maternal anthropometry may complicate time based  monitoring of childbirth. We set out to determine the effect of maternal  anthropometry and foetal birth weight on the duration of childbirth. Birth related secondary data from 987 mothers with pregnancies of ≥ 37 weeks, singleton baby and a normal childbirth were obtained. This data was analysed for regression coefficients and Interclass correlations coefficients (ICCs). The mean duration of childbirth was 7.63hours. Each centimetre increase in maternal pelvis height led to a 0.56hours increase for the first stage (P<0.01), 0.05hours reduction for second stage (P<0.01), and 0.46hours increase in total duration of childbirth (p<0.01). For each centimeter increase in maternal height there was a 0.04hours reduction in the first stage (P=0.01) and a 0.005hours increase in second stage (P=0.03). The ICCs with respect to geographical site were 0.40 for stage 1, 0.27 for stage 2 and 0.21 for stage 3. Additional modeling with tribe of mother did not change the ICCs. Maternal pelvis height and maternal height were found to have a significant effect on the duration of the different stages of normal childbirth. Additional study is needed into the public health value of the above measurements in relation to childbirth in these settings.Key words: Humans; anthropometry; childbirth; pelvis height;


2020 ◽  
Vol 110 (4) ◽  
pp. 453-454 ◽  
Author(s):  
Michael Fine

PEDIATRICS ◽  
1970 ◽  
Vol 45 (3) ◽  
pp. 444-448
Author(s):  
George E. Hardy ◽  
Cyrus C. Hopkins ◽  
Calvin C. Linnemann ◽  
Milford H. Hatch ◽  
J. Carroll Chambers ◽  
...  

The Public Health Service Advisory Committee on Immunization Practices (ACIP) and the Committee on Infectious Diseases of the American Academy of Pediatrics have not reached complete agreement in their currently recommended schedules for primary infant immunization with trivalent oral poliovirus vaccine (OPV). To determine which if either of these is the more efficacious, 200 infants were immunized with trivalent OPV. Approximately 50% of these infants completed the 3 dose primary series recommended by the ACIP; remaining infants completed the 4 dose series recommended by the Academy. Microneutralization titers to all three poliovirus types were determined at appropriate time intervals. At the completion of the study, a satisfactory percentage of individuals in both groups exhibited microneutralization titers of 1:10 or greater to all three poliovirus types. During the course of study, minor differences were noted between the two groups in the percentage of individuals with titers against poliovirus types 1 and 3.


2015 ◽  
Vol 62 ◽  
pp. S300-S301
Author(s):  
W. Stevens ◽  
Y. Sanchez ◽  
R. Brookmeyer ◽  
D. Lakdawalla ◽  
S. Marx ◽  
...  

2022 ◽  
Vol 10 (1) ◽  
pp. 127
Author(s):  
Christian Theilacker ◽  
Mark A. Fletcher ◽  
Luis Jodar ◽  
Bradford D. Gessner

The Community-Acquired Pneumonia immunization Trial in Adults (CAPiTA) evaluated older adult pneumococcal vaccination and was one of the largest vaccine clinical trials ever conducted. Among older adults aged ≥65 years, the trial established 13-valent pneumococcal conjugate vaccine (PCV13) efficacy in preventing first episodes of bacteremic and nonbacteremic pneumococcal vaccine serotype (VT) community acquired pneumonia (CAP), and of vaccine serotype invasive pneumococcal disease (VT-IPD). Since the publication of the original trial results, 15 additional publications have extended the analyses. In this review, we summarize and integrate the full body of evidence generated by these studies, contextualize the results in light of their public health relevance, and discuss their implications for the assessment of current and future adult pneumococcal vaccination. This accumulating evidence has helped to better understand PCV13 efficacy, serotype-specific efficacy, efficacy in subgroups, the interpretation of immunogenicity data, and the public health value of adult PCV vaccination.


BMC Medicine ◽  
2017 ◽  
Vol 15 (1) ◽  
Author(s):  
A. Wilder-Smith ◽  
I. Longini ◽  
P. L. Zuber ◽  
T. Bärnighausen ◽  
W. J. Edmunds ◽  
...  

1994 ◽  
Vol 84 (9) ◽  
pp. 1377-1378
Author(s):  
L V Klerman ◽  
J A Klerman

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